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niman

Media Myth On Tamiflu Resistance In HPAI H7N9

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The release of HPAI sequences (at GISAID) from birds or people linked to Guangdong, China has raised concerns.  Currently four human sequences have been made public and all four have the same poly-basic cleavage site in H7 and the Tamiflu resistance marker in N9, R292K.  This is in marked contrast to seven avian HPAI sequences and over 60 recent human LPAI H7N9 sequences, all of which are Tamiflu sensitive.

This linkage between the resistance and human HPAI sequences was actively ignored at the recent WHO presser, even though the vast majority of the above sequences were generated by the WHO regional influenza center in Beijing, who was one of the two presenters at the presser. The presser noted that 7% of recent human sequences were Tamiflu resistant, but failed to note that 7% of the human sequences were HPAI and the frequency was the same as Tamiflu resistance because 100% of the human HPAI sequences had R282K and 0% of the LPAI H7N9 had this change (even though both populations were treated with Tamiflu).

Although the presser was actively covered in subsequent media reports, the dramatic correlation between Tamiflu resistance and human HPAI was not cited, raising serious transparency concerns.

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Posted (edited)

All of the above sequences were submitted to GISAID by the WHO influenza Center in Beijing.  The first sequences (7 environmental and 2 human) have an HA size of 1695 (due to the polybasic cleavage site created by the insertion of 12 nucleotides).  The next 60 sequence are human low path with an HA size of 1683.  These sequences were from samples collected in late 2016 (Nov & Dec) and early 2017 (Jan).  This sequences were made public prior to the WHO pressor on March 1.

Edited by niman

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Isolate name:
 
A/Environment/Guangdong/C162811110/2016(H7,H9,N2,N9) 
 
 
Isolate ID:
 
EPI_ISL_249316 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-11-07 
 
 
Host
 
Environment 
 
 
Additional host information:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
HA
 
A/Environment/Guangdong/C162811110/2016-HA
 
1695
 
EPI919627
 
 
 
 
NA
 
A/Environment/Guangdong/C162811110/2016-NA
 
1398
 
EPI919626
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-20 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Environment/Guangdong/C16283219/2016(H7,H9,N2,N9) 
 
 
Isolate ID:
 
EPI_ISL_249315 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-11-02 
 
 
Host
 
Environment 
 
 
Additional host information:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
HA
 
A/Environment/Guangdong/C16283219/2016-HA
 
1695
 
EPI919625
 
 
 
 
NA
 
A/Environment/Guangdong/C16283219/2016-NA
 
1398
 
EPI919624
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-20 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Environment/Guangdong/C16283277/2016(H7,H9,N2,N9) 
 
 
Isolate ID:
 
EPI_ISL_249314 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-07 
 
 
Host
 
Environment 
 
 
Additional host information:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
HA
 
A/Environment/Guangdong/C16283277/2016-HA
 
1695
 
EPI919623
 
 
 
 
NA
 
A/Environment/Guangdong/C16283277/2016-NA
 
1398
 
EPI919622
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-20 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

Share this post


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Isolate detail
Isolate name:
 
A/Environment/Guangdong/KGZ4048/2016(H7,H9,N2,N9) 
 
 
Isolate ID:
 
EPI_ISL_249313 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-12 
 
 
Host
 
Environment 
 
 
Additional host information:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
HA
 
A/Environment/Guangdong/KGZ4048/2016-HA
 
1695
 
EPI919621
 
 
 
 
NA
 
A/Environment/Guangdong/KGZ4048/2016-NA
 
1398
 
EPI919620
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-20 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Environment/Guangdong/KGZ4068/2016(H7,H9,N2,N9) 
 
 
Isolate ID:
 
EPI_ISL_249312 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-12 
 
 
Host
 
Environment 
 
 
Additional host information:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
HA
 
A/Environment/Guangdong/KGZ4068/2016-HA
 
1695
 
EPI919619
 
 
 
 
NA
 
A/Environment/Guangdong/KGZ4068/2016-NA
 
1398
 
EPI919618
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-20 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Environment/Guangdong/KGZ4075/2016(H7,H9,N2,N9) 
 
 
Isolate ID:
 
EPI_ISL_249311 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-12 
 
 
Host
 
Environment 
 
 
Additional host information:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
HA
 
A/Environment/Guangdong/KGZ4075/2016-HA
 
1695
 
EPI919617
 
 
 
 
NA
 
A/Environment/Guangdong/KGZ4075/2016-NA
 
1398
 
EPI919616
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-20 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

Share this post


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Isolate detail
Isolate name:
 
A/Environment/Guangdong/C16283222/2016 
 
 
Isolate ID:
 
EPI_ISL_249310 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-11-07 
 
 
Host
 
Environment 
 
 
Additional host information:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A/Environment/Guangdong/C16283222/2016-PB2
 
2280
 
EPI919612
 
 
 
 
PB1
 
A/Environment/Guangdong/C16283222/2016-PB1
 
2274
 
EPI919613
 
 
 
 
PA
 
A/Environment/Guangdong/C16283222/2016-PA
 
2151
 
EPI919611
 
 
 
 
HA
 
A/Environment/Guangdong/C16283222/2016-HA
 
1695
 
EPI919615
 
 
 
 
NP
 
A/Environment/Guangdong/C16283222/2016-NP
 
1497
 
EPI919608
 
 
 
 
NA
 
A/Environment/Guangdong/C16283222/2016-NA
 
1398
 
EPI919614
 
 
 
 
MP
 
A/Environment/Guangdong/C16283222/2016-MP
 
982
 
EPI919610
 
 
 
 
NS
 
A/Environment/Guangdong/C16283222/2016-NS
 
838
 
EPI919609
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-20 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Guangdong/17SF003/2016 
 
 
Isolate ID:
 
EPI_ISL_249309 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2017-01-03 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Patient age:
 
43 Year(s) 
 
 
Gender:
 
Female 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A/Guangdong/17SF003/2016-PB2
 
2280
 
EPI919604
 
 
 
 
PB1
 
A/Guangdong/17SF003/2016-PB1
 
2274
 
EPI919605
 
 
 
 
PA
 
A/Guangdong/17SF003/2016-PA
 
2151
 
EPI919603
 
 
 
 
HA
 
A/Guangdong/17SF003/2016-HA
 
1695
 
EPI919607
 
 
 
 
NP
 
A/Guangdong/17SF003/2016-NP
 
1497
 
EPI919600
 
 
 
 
NA
 
A/Guangdong/17SF003/2016-NA
 
1398
 
EPI919606
 
 
 
 
MP
 
A/Guangdong/17SF003/2016-MP
 
982
 
EPI919602
 
 
 
 
NS
 
A/Guangdong/17SF003/2016-NS
 
838
 
EPI919601
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-21 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Guangdong/17SF006/2017 
 
 
Isolate ID:
 
EPI_ISL_249308 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2017-01-12 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Patient age:
 
57 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 

 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A/Guangdong/17SF006/2017-PB2
 
2280
 
EPI919596
 
 
 
 
PB1
 
A/Guangdong/17SF006/2017-PB1
 
2274
 
EPI919597
 
 
 
 
PA
 
A/Guangdong/17SF006/2017-PA
 
2151
 
EPI919595
 
 
 
 
HA
 
A/Guangdong/17SF006/2017-HA
 
1695
 
EPI919599
 
 
 
 
NP
 
A/Guangdong/17SF006/2017-NP
 
1497
 
EPI919592
 
 
 
 
NA
 
A/Guangdong/17SF006/2017-NA
 
1398
 
EPI919598
 
 
 
 
MP
 
A/Guangdong/17SF006/2017-MP
 
982
 
EPI919594
 
 
 
 
NS
 
A/Guangdong/17SF006/2017-NS
 
838
 
EPI919593
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-02-20 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-02-21 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Fujian/54840/2016 
 
 
Isolate ID:
 
EPI_ISL_242901 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-11-16 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Fujian 
 
 
Patient age:
 
60 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_FUJIAN_54840_2016_NOV-PB2
 
2280
 
EPI888081
 
 
 
 
PB1
 
A_FUJIAN_54840_2016_NOV-PB1
 
2274
 
EPI888082
 
 
 
 
PA
 
A_FUJIAN_54840_2016_NOV-PA
 
2151
 
EPI888080
 
 
 
 
HA
 
A_FUJIAN_54840_2016_NOV-HA
 
1683
 
EPI888084
 
 
 
 
NP
 
A_FUJIAN_54840_2016_NOV-NP
 
1497
 
EPI888077
 
 
 
 
NA
 
A_FUJIAN_54840_2016_NOV-NA
 
1398
 
EPI888083
 
 
 
 
MP
 
A_FUJIAN_54840_2016_NOV-MP
 
982
 
EPI888079
 
 
 
 
NS
 
A_FUJIAN_54840_2016_NOV-NS
 
838
 
EPI888078
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Anhui/60926/2016 
 
 
Isolate ID:
 
EPI_ISL_242900 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-21 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
66 Year(s) 
 
 
Gender:
 
Female 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60926_2016_DEC-PB2
 
2280
 
EPI888073
 
 
 
 
PB1
 
A_ANHUI_60926_2016_DEC-PB1
 
2274
 
EPI888074
 
 
 
 
PA
 
A_ANHUI_60926_2016_DEC-PA
 
2151
 
EPI888072
 
 
 
 
HA
 
A_ANHUI_60926_2016_DEC-HA
 
1683
 
EPI888076
 
 
 
 
NP
 
A_ANHUI_60926_2016_DEC-NP
 
1497
 
EPI888069
 
 
 
 
NA
 
A_ANHUI_60926_2016_DEC-NA
 
1398
 
EPI888075
 
 
 
 
MP
 
A_ANHUI_60926_2016_DEC-MP
 
982
 
EPI888071
 
 
 
 
NS
 
A_ANHUI_60926_2016_DEC-NS
 
838
 
EPI888070