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Media Myth On Tamiflu Resistance In HPAI H7N9

39 posts in this topic

Isolate detail
Isolate name:
 
A/Anhui/60931/2016 
 
 
Isolate ID:
 
EPI_ISL_242895 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-13 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
73 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60931_2016_DEC-PB2
 
2280
 
EPI888033
 
 
 
 
PB1
 
A_ANHUI_60931_2016_DEC-PB1
 
2274
 
EPI888034
 
 
 
 
PA
 
A_ANHUI_60931_2016_DEC-PA
 
2151
 
EPI888032
 
 
 
 
HA
 
A_ANHUI_60931_2016_DEC-HA
 
1683
 
EPI888036
 
 
 
 
NP
 
A_ANHUI_60931_2016_DEC-NP
 
1497
 
EPI888029
 
 
 
 
NA
 
A_ANHUI_60931_2016_DEC-NA
 
1398
 
EPI888035
 
 
 
 
MP
 
A_ANHUI_60931_2016_DEC-MP
 
982
 
EPI888031
 
 
 
 
NS
 
A_ANHUI_60931_2016_DEC-NS
 
838
 
EPI888030
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Anhui/60932/2016 
 
 
Isolate ID:
 
EPI_ISL_242894 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-19 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
60 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60932_2016_DEC-PB2
 
2280
 
EPI888025
 
 
 
 
PB1
 
A_ANHUI_60932_2016_DEC-PB1
 
2274
 
EPI888026
 
 
 
 
PA
 
A_ANHUI_60932_2016_DEC-PA
 
2151
 
EPI888024
 
 
 
 
HA
 
A_ANHUI_60932_2016_DEC-HA
 
1683
 
EPI888028
 
 
 
 
NP
 
A_ANHUI_60932_2016_DEC-NP
 
1497
 
EPI888021
 
 
 
 
NA
 
A_ANHUI_60932_2016_DEC-NA
 
1398
 
EPI888027
 
 
 
 
MP
 
A_ANHUI_60932_2016_DEC-MP
 
982
 
EPI888023
 
 
 
 
NS
 
A_ANHUI_60932_2016_DEC-NS
 
838
 
EPI888022
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Anhui/60929/2016 
 
 
Isolate ID:
 
EPI_ISL_242893 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-15 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
65 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60929_2016_DEC-PB2
 
2280
 
EPI888017
 
 
 
 
PB1
 
A_ANHUI_60929_2016_DEC-PB1
 
2274
 
EPI888018
 
 
 
 
PA
 
A_ANHUI_60929_2016_DEC-PA
 
2151
 
EPI888016
 
 
 
 
HA
 
A_ANHUI_60929_2016_DEC-HA
 
1683
 
EPI888020
 
 
 
 
NP
 
A_ANHUI_60929_2016_DEC-NP
 
1497
 
EPI888013
 
 
 
 
NA
 
A_ANHUI_60929_2016_DEC-NA
 
1398
 
EPI888019
 
 
 
 
MP
 
A_ANHUI_60929_2016_DEC-MP
 
982
 
EPI888015
 
 
 
 
NS
 
A_ANHUI_60929_2016_DEC-NS
 
838
 
EPI888014
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Anhui/60925/2016 
 
 
Isolate ID:
 
EPI_ISL_242891 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-21 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
66 Year(s) 
 
 
Gender:
 
Female 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60925_2016_DEC-PB2
 
2280
 
EPI888001
 
 
 
 
PB1
 
A_ANHUI_60925_2016_DEC-PB1
 
2274
 
EPI888002
 
 
 
 
PA
 
A_ANHUI_60925_2016_DEC-PA
 
2151
 
EPI888000
 
 
 
 
HA
 
A_ANHUI_60925_2016_DEC-HA
 
1683
 
EPI888004
 
 
 
 
NP
 
A_ANHUI_60925_2016_DEC-NP
 
1497
 
EPI887997
 
 
 
 
NA
 
A_ANHUI_60925_2016_DEC-NA
 
1398
 
EPI888003
 
 
 
 
MP
 
A_ANHUI_60925_2016_DEC-MP
 
982
 
EPI887999
 
 
 
 
NS
 
A_ANHUI_60925_2016_DEC-NS
 
838
 
EPI887998
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Anhui/60928/2016 
 
 
Isolate ID:
 
EPI_ISL_242892 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-15 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
 
 
 
Gender:
 
 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60928_2016_DEC-PB2
 
2280
 
EPI888009
 
 
 
 
PB1
 
A_ANHUI_60928_2016_DEC-PB1
 
2274
 
EPI888010
 
 
 
 
PA
 
A_ANHUI_60928_2016_DEC-PA
 
2151
 
EPI888008
 
 
 
 
HA
 
A_ANHUI_60928_2016_DEC-HA
 
1683
 
EPI888012
 
 
 
 
NP
 
A_ANHUI_60928_2016_DEC-NP
 
1497
 
EPI888005
 
 
 
 
NA
 
A_ANHUI_60928_2016_DEC-NA
 
1398
 
EPI888011
 
 
 
 
MP
 
A_ANHUI_60928_2016_DEC-MP
 
982
 
EPI888007
 
 
 
 
NS
 
A_ANHUI_60928_2016_DEC-NS
 
838
 
EPI888006
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Anhui/60924/2016 
 
 
Isolate ID:
 
EPI_ISL_242890 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-22 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
55 Year(s) 
 
 
Gender:
 
Female 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60924_2016_DEC-PB2
 
2280
 
EPI887993
 
 
 
 
PB1
 
A_ANHUI_60924_2016_DEC-PB1
 
2274
 
EPI887994
 
 
 
 
PA
 
A_ANHUI_60924_2016_DEC-PA
 
2151
 
EPI887992
 
 
 
 
HA
 
A_ANHUI_60924_2016_DEC-HA
 
1683
 
EPI887996
 
 
 
 
NP
 
A_ANHUI_60924_2016_DEC-NP
 
1497
 
EPI887989
 
 
 
 
NA
 
A_ANHUI_60924_2016_DEC-NA
 
1398
 
EPI887995
 
 
 
 
MP
 
A_ANHUI_60924_2016_DEC-MP
 
982
 
EPI887991
 
 
 
 
NS
 
A_ANHUI_60924_2016_DEC-NS
 
838
 
EPI887990
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

Share this post


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Isolate detail
Isolate name:
 
A/Anhui/60927/2016 
 
 
Isolate ID:
 
EPI_ISL_242889 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-18 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Anhui 
 
 
Patient age:
 
53 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_ANHUI_60927_2016_DEC-PB2
 
2280
 
EPI887985
 
 
 
 
PB1
 
A_ANHUI_60927_2016_DEC-PB1
 
2274
 
EPI887986
 
 
 
 
PA
 
A_ANHUI_60927_2016_DEC-PA
 
2151
 
EPI887984
 
 
 
 
HA
 
A_ANHUI_60927_2016_DEC-HA
 
1683
 
EPI887988
 
 
 
 
NP
 
A_ANHUI_60927_2016_DEC-NP
 
1497
 
EPI887981
 
 
 
 
NA
 
A_ANHUI_60927_2016_DEC-NA
 
1398
 
EPI887987
 
 
 
 
MP
 
A_ANHUI_60927_2016_DEC-MP
 
982
 
EPI887983
 
 
 
 
NS
 
A_ANHUI_60927_2016_DEC-NS
 
838
 
EPI887982
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Guangdong/60061/2016 
 
 
Isolate ID:
 
EPI_ISL_242888 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-13 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Guangdong 
 
 
Patient age:
 
49 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 
Guandong Centers for Disease Control
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 
Guandong Centers for Disease Control
 176 Xingang Western Road ,  
Guangzhou 
China
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_GUANGDONG_60061_2016_DEC-PB2
 
2280
 
EPI887977
 
 
 
 
PB1
 
A_GUANGDONG_60061_2016_DEC-PB1
 
2274
 
EPI887978
 
 
 
 
PA
 
A_GUANGDONG_60061_2016_DEC-PA
 
2151
 
EPI887976
 
 
 
 
HA
 
A_GUANGDONG_60061_2016_DEC-HA
 
1683
 
EPI887980
 
 
 
 
NP
 
A_GUANGDONG_60061_2016_DEC-NP
 
1497
 
EPI887973
 
 
 
 
NA
 
A_GUANGDONG_60061_2016_DEC-NA
 
1398
 
EPI887979
 
 
 
 
MP
 
A_GUANGDONG_60061_2016_DEC-MP
 
982
 
EPI887975
 
 
 
 
NS
 
A_GUANGDONG_60061_2016_DEC-NS
 
838
 
EPI887974
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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Isolate detail
Isolate name:
 
A/Jiangsu/60447/2016 
 
 
Isolate ID:
 
EPI_ISL_242887 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-16 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Jiangsu 
 
 
Patient age:
 
73 Year(s) 
 
 
Gender:
 
Female 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown 
 
 
Additional information
Antigenic characterization:
 
 
 
 
Note:
 

 
 
 
Sequence

 

segment identifier length accession # INSDC Sequence
 
PB2
 
A_JIANGSU_60447_2016_DEC-PB2
 
2280
 
EPI887969
 
 
 
 
PB1
 
A_JIANGSU_60447_2016_DEC-PB1
 
2274
 
EPI887970
 
 
 
 
PA
 
A_JIANGSU_60447_2016_DEC-PA
 
2151
 
EPI887968
 
 
 
 
HA
 
A_JIANGSU_60447_2016_DEC-HA
 
1683
 
EPI887972
 
 
 
 
NP
 
A_JIANGSU_60447_2016_DEC-NP
 
1497
 
EPI887965
 
 
 
 
NA
 
A_JIANGSU_60447_2016_DEC-NA
 
1398
 
EPI887971
 
 
 
 
MP
 
A_JIANGSU_60447_2016_DEC-MP
 
982
 
EPI887967
 
 
 
 
NS
 
A_JIANGSU_60447_2016_DEC-NS
 
838
 
EPI887966
 
 
 
Submitter information

 

Submitter:
 
Yang, Lei  
 
 
Submission Date:
 
2017-01-25 
 
 
Last modifier:
 
Yang, Lei  
 
 
Last modified:
 
2017-01-25 
 
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China

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HEALTH

CDC Concerned by H7N9 Bird Flu’s Sudden Spread in China

A sudden surge in cases of H7N9 bird flu in China is a "cause for concern," the Centers for Disease Control and Prevention said Friday.

It's infected 460 people just since October, the CDC said in a report. "It's by far the largest epidemic wave since 2013," said CDC flu expert Dr. Tim Uyeki.

Image: Health officials in protective suits put a goose into a sack as part of preventive measures against the H7N9 bird flu at a poultry market in Zhuji
 
Health officials in protective suits put a goose into a sack as part of preventive measures against the H7N9 bird flu at a poultry market in Zhuji, Zhejiang province on Jan. 5, 2014. Reuters file

The CDC has been working on a vaccine against H7N9 just in case it's ever needed and is starting work on a second one now because it's started to mutate.

"It's a cause for concern, that's for sure," Uyeki told NBC News. "The surge in numbers of human H7N9 cases in China is definitely a concern."

The CDC issued a travel notice in January, cautioning travelers to China to stay away from live bird markets. Uyeki said travelers do not need to avoid China but they should be aware that poultry can spread the virus.

Related: WHO Says Watch Out for Bird Flu

Since 2013, H7N9 bird flu has infected 1,258 people, the CDC said. So 460 cases in just five months account for a third of all the cases over four years.

Earlier this week the World Health Organization held a meeting on H7N9 and then issued public reassurances, saying the virus did not appear to have changed in a way that would make it more likely to spread to people or to make it more dangerous to people.

Instead, the changes make the virus more dangerous to birds — which could be a good thing.

"These changes make the virus highly pathogenic in birds, meaning that it can cause some severe disease in birds," Dr. Wenqing Zhang, head of WHO's global influenza program, told reporters.

"Previously, H7N9 had only been observed to be 'low pathogenic' in birds, meaning the virus did not cause visible outbreaks of disease in birds," Zhang said.

If an avian influenza virus kills birds, it's bad for poultry farmers but it can give a warning that the virus is spreading. The problem with H7N9 has been that it does not make poultry sick, so it can spread among flocks without people knowing it.

a_30stk_bird_flu_150519.nbcnews-ux-1080-
 Can You Catch Bird Flu? 0:42

Uyeki is worried that H7N9 has become more widespread in China, spreading silently and infecting more people because it's infecting more birds.

"You could have more cases of human infection even if the risk of poultry-to-human transmission has not changed," he said.

China has been publishing genetic sequences of the H7N9 virus in public databases, but it has not been sharing actual samples of the virus, so it's not possible for U.S. labs to test the virus themselves to see whether it's changed and if so, whether it's more dangerous.

But it's already dangerous. H7N9 is considered a moderate to high pandemic threat, although the CDC and WHO do not think an H7N9 pandemic is about to happen, or even that it is certain to happen.

Related: CDC Issues H7N9 Travel Warning

H7N9 is one of several strains of bird flu that officials are watching because they have the potential to cause a human pandemic.

So far, H7N9 doesn't seem to infect people easily and people who are infected do not seem to spread it to others much. But influenza viruses change quickly and unpredictably, and if one starts passing easily from one person to another it could spread.

"From what we understand, there have been no real changes in the epidemiology or mortality of hospitalized H7N9 cases," Uyeki said.

H7N9 can be deadly when people do get it. It kills more than 40 percent of people who get sick enough to go to the hospital.

Related: H7N9 has cost billions

"Early symptoms are similar to those of seasonal flu and may include fever, cough, sore throat, muscle aches and fatigue, loss of appetite, and runny or stuffy nose," CDC said.

It often progresses to pneumonia. And hospitals or clinics treating people infected with H7N9 need to take precautions to make sure patients do not infect anyone else.

"Clinicians should consider the possibility of avian influenza A (H7N9) virus infection in people presenting with respiratory illness within 10 days of travel to China, particularly if the patient reports exposure to birds or poultry markets," the CDC says.

The CDC and WHO are watching the spread of several bird flu viruses that are known to infect people, including H5N1 and H7N2.

Related: Vet Catches Bird Flu From Cats

"Although the current risk to the public's health from A(H7N9) viruses is low, among the 12 novel influenza A viruses evaluated ... A(H7N9) viruses have the highest risk score and are characterized as posing moder­ate-high potential pandemic risk," the CDC team said in the report released Friday. 

http://www.nbcnews.com/health/health-news/cdc-concerned-h7n9-bird-flu-s-sudden-spread-china-n728946

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Isolate detail
Isolate name:
 
A/Jiangsu/60450/2016 
 
 
Isolate ID:
 
EPI_ISL_242886 
 
 
Passage details/history:
 
E1 
 
 
Type:
 
A / H7N9 
 
 
Lineage:
 
 
Sample information

 

Collection date:
 
2016-12-19 
 
 
Host
 
Human 
 
 
Additional host information:
 
 
 
 
Zip code:
 
 
 
 
Patient status:
 
 
 
 
Last vaccinated:
 
 
 
 
In-vivo pathogenicity test:
 
 
 
 
Location:
 
China 
 
 
Additional location information:
 
Jiangsu 
 
 
Patient age:
 
23 Year(s) 
 
 
Gender:
 
Male 
 
 
Outbreak:
 
 
 
 
Treatment:
 
 
 
 
Specimen source:
 
 
 
 
Institute information

 

Originating lab:
 

 
 
Sample ID given by the sample provider:
 
 
 
 
Address:
 

 
 
Submitting lab:
 
WHO Chinese National Influenza Center
 
Sample ID given by the submitting laboratory:
 
 
 
 
Authors:
 
Wang,Dayan;
Zhou,Shumei;
Li,Xiyan;
Li,Xiaodan;
Zhang,Ye;
Bo,Hong;
Shu,Yuelong
 
Address:
 
WHO Chinese National Influenza Center
Virology Institute, Chinese CDC
 155 Changbai Road, Changping District,  
Beijing 102206
China
 
Publication
Publication
 
In vivo antiviral resistance

 

Antiviral resistance tested by experimental procedures
 
Adamantanes:
 
Unknown 
 
 
Oseltamivir:
 
Unknown 
 
 
Zanamivir:
 
Unknown 
 
 
Peramivir:
 
Unknown 
 
 
Other:
 
Unknown