The D614G change is almost always accompanied by three other mutations: a C-to-T mutation in the 5’ UTR (position 241 relative to the Wuhan reference sequence), a silent C-to-T mutation at position 3,037; and a C-to-T mutation at position 14,408 that results in an amino acid change in RNA-dependent RNA polymerase (RdRp P323L). The haplotype comprising these 4 genetically linked mutations is now the globally dominant form.

https://www.cell.com/cell/pdf/S0092-8674(20)30820-5.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420308205%3Fshowall%3Dtrue

Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus

B. Korber, W.M. Fischer, S. Gnanakaran, H. Yoon, J. Theiler, W. Abfalterer, N. Hengartner, E.E. Giorgi, T. Bhattacharya, B. Foley, K.M. Hastie, M.D. Parker, D.G. Partridge, C.M. Evans, T.M. Freeman, T.I. de Silva, C. McDanal, L.G. Perez, H. Tang, A. Moon-Walker, S.P. Whelan, C.C. LaBranche, E.O. Saphire, D.C. Montefiori, on behalf of the Sheffield COVID-19 Genomics Group PII: S0092-8674(20)30820-5 DOI: https://doi.org/10.1016/j.cell.2020.06.043 Reference: CELL 11502

To appear in: Cell Received Date: 29 April 2020 Revised Date: 10 June 2020 Accepted Date: 26 June 2020

Please cite this article as: Korber, B, Fischer, W., Gnanakaran, S, Yoon, H, Theiler, J, Abfalterer, W, Hengartner, N, Giorgi, E., Bhattacharya, T, Foley, B, Hastie, K., Parker, M., Partridge, D., Evans, C., Freeman, T., de Silva, T., McDanal, C, Perez, L., Tang, H, Moon-Walker, A, Whelan, S., LaBranche, C., Saphire, E., Montefiori, D., on behalf of the Sheffield COVID-19 Genomics Group, Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus, Cell (2020), doi: https://doi.org/10.1016/j.cell.2020.06.043.