Zika Linked Microcephaly Ljubljana Slovenia ex-Brazil

[niman]

In mid-October 2015, a 25-year-old previously healthy European woman came to the Department of Perinatology at the University Medical Center in Ljubljana, Slovenia, because of assumed fetal anomalies. Since December 2013, she had lived and worked as a volunteer in Natal, the capital of Rio Grande do Norte state. She had become pregnant at the end of February 2015. During the 13th week of gestation, she had become ill with high fever, which was followed by severe musculoskeletal and retroocular pain and an itching, generalized maculopapular rash. Since there was a ZIKV epidemic in the community, infection with the virus was suspected, but no virologic diagnostic testing was performed. Ultrasonography that was performed at 14 and 20 weeks of gestation showed normal fetal growth and anatomy. The patient returned to Europe at 28 weeks of gestation. Ultrasonographic examination that was performed at 29 weeks of gestation showed the first signs of fetal anomalies, and she was referred to the Department of Perinatology. At that time, she also noticed reduced fetal movements. Ultrasonography that was performed at 32 weeks of gestation confirmed intrauterine growth retardation (estimated third percentile of fetal weight) with normal amniotic fluid, a placenta measuring 3.5 cm in thickness (normal size) with numerous calcifications, a head circumference below the second percentile for gestation (microcephaly), moderate ventriculomegaly, and a transcerebellar diameter below the second percentile. Brain structures were blurred, and there were numerous calcifications in various parts of the brain (Fig. 1A and 1B). There were no other obvious fetal structural abnormalities. Fetal, umbilical, and uterine blood flows were normal on Doppler ultrasonography

http://www.nejm.org/doi/pdf/10.1056/NEJMoa1600651

 

[niman]

MC/FBDS Map Update

https://www.google.com/maps/d/u/1/edit?hl=en&hl=en&authuser=1&mid=zv94AJqgUct4.kjKUkEcBCVeI

 

[niman]

LOCUS       KU527068               10808 bp    RNA     linear   VRL 11-FEB-2016
DEFINITION  Zika virus strain Natal RGN, complete genome.
ACCESSION   KU527068
VERSION     KU527068.1  GI:982894594
KEYWORDS    .
SOURCE      Zika virus
  ORGANISM  Zika virus
            Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA
            stage; Flaviviridae; Flavivirus.
REFERENCE   1  (bases 1 to 10808)
  AUTHORS   Mlakar,J., Korva,M., Tul,N., Popovic,M., Poljsak-Prijatelj,M.,
            Mraz,J., Kolenc,M., Resman Rus,K., Vesnaver Vipotnik,T., Fabjan
            Vodusek,V., Vizjak,A., Pizem,J., Petrovec,M. and Avsic Zupanc,T.
  TITLE     Zika Virus Associated with Microcephaly
  JOURNAL   N. Engl. J. Med. (2016) In press
   PUBMED   26862926
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 10808)
  AUTHORS   Avsic Zupanc,T. and Korva,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2016) Institute of Microbiology and Immunology,
            University of Ljubljana, Faculty of Medicine, Vrazov trg 2,
            Ljubljana 1000, Slovenia
FEATURES             Location/Qualifiers
     source          1..10808
                     /organism="Zika virus"
                     /mol_type="genomic RNA"
                     /strain="Natal RGN"
                     /isolation_source="fetus' brain autopsy"
                     /host="Homo sapiens"
                     /db_xref="taxon:64320"
                     /country="Brazil: Rio Grande do Norte, Natal"
                     /collection_date="2015"

http://www.ncbi.nlm.nih.gov/nuccore/KU527068