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On 2 December 2015, the National IHR Focal Point (NFP) of Panama notified PAHO/WHO of the first 3 laboratory-confirmed cases of Zika virus disease.

On 27 November, the Ministry of Health (MoH) of Panama was informed of 68 patients with fever and exanthema in Ustupu island, Alligandi district, Guna Yala province. Serum samples were taken from 43 patients, 30 of whom were symptomatic, and sent for testing to the Commemorative Gorgas Institute for Health Studies. All samples, which were analyzed using the algorithm proposed by PAHO/WHO (see related links), resulted negative for dengue and chikungunya. Out of the samples taken from the 30 symptomatic patients, 3 tested positive for Zika virus by reverse transcription polymerase chain reaction (RT-PCR). The 3 laboratory-confirmed cases are females aged 29, 48, and 58 years old.

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