H3N2v Case In New Jersey - No Direct Swine Contact

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CDC's week 52 FluView cites first H3N2v case in New Jersey -no direct swine contact.

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Novel Influenza A Virus:

One human infection with a novel influenza A virus was reported by the state of New Jersey. The person was infected with an influenza A (H3N2) variant (H3N2v) virus. The patient was not hospitalized and has fully recovered from their illness. The patient visited a farm near where swine are frequently housed but no direct contact with swine was reported in the week prior to illness onset. No ongoing human-to-human transmission has been identified.

Early identification and investigation of human infections with novel influenza A viruses are critical so that the risk of infection can be more fully appreciated and appropriate public health measures can be taken. Additional information on influenza in swine, variant influenza infection in humans, and strategies to interact safely with swine can be found at http://www.cdc.gov/flu/swineflu/index.htm.

http://www.cdc.gov/flu/weekly/

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Case Count: Detected U.S. Human Infections with H3N2v by State since August 2011

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Table 1. Case Count: Detected U.S. Human Infections with H3N2v by State since August 2011

States Reporting H3N2v Cases	Cases in 2011	Cases in 2012	Cases in 2013	Cases in 2014	Cases in 2015
Hawaii		1
Illinois		4	1
Indiana	2	138	14
Iowa	3	1	1
Maine	2
Maryland		12
Michigan		6	2		1
Minnesota		5			1
Ohio		107	1	2
Pennsylvania	3	11
Utah		1*
West Virginia	2	3
Wisconsin		20		1
Total	12	309	19	3	2

* Case in Utah occurred in April 2012.

This chart indicates the number of CDC-reported infections with H3N2v variant influenza A viruses since August 2011 and is current as of September 4, 2015. This case count will be updated each Friday as new cases are reported.

NOTE: The state totals reported by CDC may not always be consistent with those reported by state health departments. If there is a discrepancy between these two counts, data from the state health departments should be used as the most accurate number.

Table 2. H3N2v Hospitalizations and Deaths Since July 2012*

H3N2v Hospitalizations and Deaths Since July 2012	Cases in 2012	Cases in 2013	Cases in 2014	Cases in 2015
Hospitalizations	16	1	1	2
Deaths	1	0	0	0

* As reported by states to CDC. This chart indicates the number of CDC-reported infections with H3N2v variant influenza A viruses since July 2012 and is current as of September 4, 2015. This case count will be not be updated again until new cases are reported.

See Reported Infections with Variant Influenza Viruses in the United States since 2005 for a complete list of human infections with all variant viruses since 2005.

 

http://www.cdc.gov/flu/swineflu/h3n2v-case-count.htm

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CDC has released sequence for 6 segments,and the N2 traces back to seasonal flu in the 1990's,in contrast to to recent human H3N2v cases which trace back to seasonal flu from 2003.

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Isolate detail

Isolate name:

A/New Jersey/53/2015

Isolate ID:   EPI_ISL_205586      Passage details/history:   OR

Type:   A / H3N2      Lineage:

Sample information

 

Collection date:   2015-12-26      Host   Human      Additional host information:         Zip code:         Patient status:         Last vaccinated:         In-vivo pathogenicity test:

Location:   United States / New Jersey      Additional location information:         Patient age:         Gender:         Outbreak:         Treatment:         Specimen source:

Institute information

 

Originating lab:   New Jersey Department of Health & Senior Services   Sample ID given by the sample provider:   15-1622 ORIGINAL

Address:   New Jersey Department of Health & Senior Services 369 S Warren St Health & Agriculture Bldg Trenton, 08625-0361 United States

Submitting lab:   Centers for Disease Control and Prevention   Sample ID given by the submitting laboratory:   3000411568      Authors:

Address:   Centers for Disease Control and Prevention WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Influenza Division 1600 Clifton Road, N.E. Atlanta, GA 30333 United States

Publication

Publication

In vivo antiviral resistance

 

• Phenotype
• Genotype
• Unspecified

Antiviral resistance tested by experimental procedures

Adamantanes:

Unknown

Oseltamivir:

Unknown

Zanamivir:

Unknown

Peramivir:

Unknown

Other:

Unknown

Additional information

Antigenic characterization:

Note:

 

Sequence

 

	segment	identifier	length	accession #	INSDC	Sequence
	PB2	3000411568_283434_v1_1	2286	EPI685731
	PA	3000411568_283434_v1_3	2227	EPI685730
	HA	3000411568_283434_v1_4	1737	EPI685734
	NP	3000411568_283434_v1_5	1552	EPI685727
	NA	3000411568_283434_v1_6	1391	EPI685733
	MP	3000411568_283434_v1_7	977	EPI685729

Submitter information

 

Submitter:   Jang, Yunho       Submission Date:   2016-01-11      Last modifier:   Jang, Yunho       Last modified:   2016-01-15

Address:   Centers for Disease Control and Prevention WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Influenza Division 1600 Clifton Road, N.E. Atlanta, GA 30333 United States

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Zika_seq_10272 alignment-20_tree-2 (3).pdf