Circulating vaccine-derived poliovirus type 2 – Republic of Ghana

In Nigeria and West Africa, a cVDPV2 outbreak originating from Jigawa state, Nigeria, continues to spread. In Ghana, cVDPV2 was isolated from an acute flaccid paralysis (AFP) case in Ando-Nyamanu, Chereponi district, Northern Region, bordering Togo. The case was a two-year old girl who had experienced onset of paralysis on 27 July 2019. Stool samples were taken on 27 and 28 July 2019, and sent to the National Polio Laboratory at the Noguchi Memorial Institute for Medical Research for further laboratory investigations. The sample tested positive for cVDPV2 on 17 August 2019. Sequencing of the sample from the AFP case revealed 25 nucleotide differences compared to the reference Sabin 2 and 6 nucleotides, with the closest sequencing match made with an AFP case originating from Jigsaw state, Nigeria from 2018. Earlier, a related cVDPV2 strain had been isolated from an environmental sample, collected on 11 June 2019, from Northern Region in Ghana. Both isolated viruses were linked to an outbreak originating in Jigawa, Nigeria, in 2018. In the past, this same strain had spread within Nigeria, and internationally to the Republic of Niger, Benin, and Cameroon.

The last indigenous wild poliovirus was reported in 2000. This is the first ever reported cVDPV2 outbreak reported in the country.

View the full article