niman Posted January 24, 2020 Report Posted January 24, 2020 Guangdong Province has 10 nCov clusters involving 27 confirmed cases. Largest reported cluster is family of 5 in Shenzhen 66M, 65F, 63F, 36M, 10M. Sequences from the three oldest have been deposited at GISAID http://www.bjnews.com.cn/news/2020/01/24/679032.html
niman Posted January 24, 2020 Author Report Posted January 24, 2020 The five cases of family cluster epidemic were 66-year-old male patient, his wife (65 years old), son-in-law's mother (63 years old) and son-in-law (36 years old) and grandson (10 years old) living abroad in Shenzhen, except for son-in-law Other than his mother, other people went to Wuhan to visit relatives on December 29, 2019. They became ill from January 1 to 4 or in Wuhan or after returning to Shenzhen. They were admitted to the hospital for treatment from 10 to 11. The son-in-law's mother lived with her son after returning from Wuhan on the 4th. She developed low fever, shortness of breath, and pleural effusion on the 8th. She was admitted to the hospital on the 14th. The 10-year-old patient has recovered and was discharged on the 23rd. The son-in-law's condition is relatively mild and stable.
niman Posted January 24, 2020 Author Report Posted January 24, 2020 The three full sequences at GSAID have mutations in 3 genes and are identical in all three samples (from the older adults) BetaCoV/Guangdong/20SF025/2020 EPI_ISL_403935 Original 2020-01-15 Human Guangdong Provincial Center for Diseases Control and Prevention; Guangdong Provincial Public Health Department of Microbiology, Guangdong Provincial Center for Diseases Control and Prevention BetaCoV/Guangdong/20SF013/2020 EPI_ISL_403933 Original 2020-01-15 Human Guangdong Provincial Center for Diseases Control and Prevention; Guangdong Provincial Public Health Department of Microbiology, Guangdong Provincial Center for Diseases Control and Prevention BetaCoV/Guangdong/20SF012/2020 EPI_ISL_403932 Original 2020-01-14 Human Guangdong Provincial Center for Diseases Control and Prevention; Guangdong Provincial Public Health Department of Microbiology, Guangdong Provincial Center for Diseases Control and Prevention
niman Posted January 24, 2020 Author Report Posted January 24, 2020 (edited) Virus detail Virus name: BetaCoV/Guangdong/20SF025/2020 Accession ID: EPI_ISL_403935 Type: betacoronavirus Passage details/history: Original Sample information Collection date: 2020-01-15 Location: Guangdong, China Host: Human Additional location information: Shenzhen City Edited March 6, 2020 by niman
niman Posted January 24, 2020 Author Report Posted January 24, 2020 (edited) Virus detail Virus name: BetaCoV/Guangdong/20SF013/2020 Accession ID: EPI_ISL_403933 Type: betacoronavirus Passage details/history: Original Sample information Collection date: 2020-01-15 Location: Guangdong, China Host: Human Additional location information: Shenzhen City Edited March 6, 2020 by niman
niman Posted January 24, 2020 Author Report Posted January 24, 2020 (edited) Virus detail Virus name: BetaCoV/Guangdong/20SF012/2020 Accession ID: EPI_ISL_403932 Type: betacoronavirus Passage details/history: Original Sample information Collection date: 2020-01-14 Location: Guangdong, China Host: Human Additional location information: Shenzhen City Edited March 6, 2020 by niman
niman Posted January 24, 2020 Author Report Posted January 24, 2020 The above family is described in Lancet https://www.thelancet.com/pb-assets/Lancet/pdfs/S0140673620301549.pdf
niman Posted January 24, 2020 Author Report Posted January 24, 2020 Summary Background An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, Hubei province, China. Affected patients were geographically linked with a local wet market as a potential source. No data on person-to-person or nosocomial transmission have been published to date. Methods In this study, we report the epidemiological, clinical, laboratory, radiological, and microbiological findings of five patients in a family cluster who presented with unexplained pneumonia after returning to Shenzhen, Guangdong province, China, after a visit to Wuhan, and an additional family member who did not travel to Wuhan. Phylogenetic analysis of genetic sequences from these patients were done. Findings From Jan 10, 2020, we enrolled a family of six patients who travelled to Wuhan from Shenzhen between Dec 29, 2019 and Jan 4, 2020. Of six family members who travelled to Wuhan, five were identified as infected with the novel coronavirus. Additionally, one family member, who did not travel to Wuhan, became infected with the virus after several days of contact with four of the family members. None of the family members had contacts with Wuhan markets or animals, although two had visited a Wuhan hospital. Five family members (aged 36–66 years) presented with fever, upper or lower respiratory tract symptoms, or diarrhoea, or a combination of these 3–6 days after exposure. They presented to our hospital (The University of Hong Kong-Shenzhen Hospital, Shenzhen) 6–10 days after symptom onset. They and one asymptomatic child (aged 10 years) had radiological ground-glass lung opacities. Older patients (aged >60 years) had more systemic symptoms, extensive radiological ground-glass lung changes, lymphopenia, thrombocytopenia, and increased C-reactive protein and lactate dehydrogenase levels. The nasopharyngeal or throat swabs of these six patients were negative for known respiratory microbes by point-of-care multiplex RT-PCR, but five patients (four adults and the child) were RT-PCR positive for genes encoding the internal RNA-dependent RNA polymerase and surface Spike protein of this novel coronavirus, which were confirmed by Sanger sequencing. Phylogenetic analysis of these five patients’ RT-PCR amplicons and two full genomes by nextgeneration sequencing showed that this is a novel coronavirus, which is closest to the bat severe acute respiatory syndrome (SARS)-related coronaviruses found in Chinese horseshoe bats. Interpretation Our findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
niman Posted January 24, 2020 Author Report Posted January 24, 2020 A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Jasper Fuk-Woo Chan*, Shuofeng Yuan*, Kin-Hang Kok*, Kelvin Kai-Wang To*, Hin Chu*, Jin Yang, Fanfan Xing, Jieling Liu, Cyril Chik-Yan Yip, Rosana Wing-Shan Poon, Hoi-Wah Tsoi, Simon Kam-Fai Lo, Kwok-Hung Chan, Vincent Kwok-Man Poon, Wan-Mui Chan, Jonathan Daniel Ip, Jian-Piao Cai, Vincent Chi-Chung Cheng, Honglin Chen, Christopher Kim-Ming Hui, Kwok-Yung Yuen
niman Posted January 24, 2020 Author Report Posted January 24, 2020 Interpretation Our findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
niman Posted January 25, 2020 Author Report Posted January 25, 2020 Jan 24 Interview Case Fatality Rate Suspect Cases Shenzhen Cluster In Lancet paper US Sequence (Seattle ex-Wuhan) Sharing of orf8 mutation between US and Shenzhen Sequences orf8 29 nt deletion in SARS at Metropole Hotel and International spread http://recombinomics.co/thedrnimanshow/2020/01/012420.mp3
niman Posted January 25, 2020 Author Report Posted January 25, 2020 11 PM ET Tonight Dr. Henry Niman PhDSARS 2.0 Complete Out Of Control... The Latest News
niman Posted January 26, 2020 Author Report Posted January 26, 2020 On 1/24/2020 at 11:04 PM, niman said: 11 PM ET Tonight Dr. Henry Niman PhDSARS 2.0 Complete Out Of Control... The Latest News http://mediaarchives.gsradio.net/rense/special/rense_012420_hr3.mp3
niman Posted January 30, 2020 Author Report Posted January 30, 2020 Hosted by: theresa58x Produced by: KBOO Program:: Presswatch Air date: Thu, 01/30/2020 - 9:00am to 9:30am virus More Images: Henry Niman, Ph.D. Wuhan Coronavirus: how dangerous is it? As we go to press the Wuhan Novel Coronavirus has infected thousands and slipped the bonds of massive quarantines in China. How dangerous is it, how is it likely to spread, and what can you do about it (if anything)? Join me as I welcome Dr. Henry Niman, Ph.D., internationally consulted virus researcher, as heard on KBOO in 2009 about the Swine Flu pandemic, and during 2014 during the Ebola outbreak. KBOO brings you the news you're not supposed to know, the analysis borne of decades of inquiry into our corporate-biased press. https://kboo.fm/media/78400-presswatch-possible-pandemic
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