niman Posted January 30, 2020 Report Posted January 30, 2020 (edited) The Centers for Disease Control and Prevention (CDC) will provide an update on the 2019 Novel Coronavirus response (Chicago Cluster announced) Edited January 30, 2020 by niman
niman Posted January 30, 2020 Author Report Posted January 30, 2020 WhatThe Centers for Disease Control and Prevention (CDC) will provide an update on the 2019 Novel Coronavirus response. Who Robert R. Redfield, M.D., Director, Centers for Disease Control and Prevention Nancy Messonnier, M.D., Director, National Center for Immunization and Respiratory Diseases When12:30 p.m. ET Thursday, January 30, 2020 Dial-In Media: 800-857-9756 International Media: 1-212-287-1647 PASSCODE: CDC Media Non-Media: 888-795-0855 International Non-Media: 1-630-395-0498 PASSCODE: 1792134 Important Instructions Due to anticipated high volume, please plan to dial in to the telebriefing 15 minutes before the start time. If you would like to ask a question during the call, press *1 on your touchtone phone. Press *2 to withdraw your question. You may queue up at any time. You will hear a tone to indicate your question is pending. TRANSCRIPTA transcript will be available following the briefing at CDC’s web site: www.cdc.gov/media.
realauren Posted January 30, 2020 Report Posted January 30, 2020 I'm actually in the telecall and will be posting my notes if you are ok with that for up to date information.
niman Posted January 30, 2020 Author Report Posted January 30, 2020 Spouse of index Did not travel to China
niman Posted January 30, 2020 Author Report Posted January 30, 2020 21 under investigation in Illinois
niman Posted January 30, 2020 Author Report Posted January 30, 2020 2nd case actually husband of index
niman Posted January 30, 2020 Author Report Posted January 30, 2020 Sequence of index case had evidence of a MIXED infection. Shared mutations with Shenzhen cluster described in Lancet
niman Posted January 30, 2020 Author Report Posted January 30, 2020 Index was 63F Virus detail Virus name: BetaCoV/USA/IL1/2020 Accession ID: EPI_ISL_404253 Type: unclassified betacoronavirus Passage details/history: Original Sample information Collection date: 2020-01-21 Location: USA / Illinois /Chicago Host: Human Additional location information: Gender: Female Patient age: 63 Patient status: unknown Specimen source: sputum Additional host information: Outbreak: Last vaccinated: Treatment: Sequencing technology: Sanger; Nanopore Assembly method: minimap 2.17 Coverage: >20X Institute information Originating lab: IL Department of Public Health Chicago Laboratory Address: 2121 West Taylor, Chicago IL 60612 Sample ID given by the sample provider: C200009352 Submitting lab: Pathogen Discovery, Respiratory Viruses Branch, Division of Viral Diseases, Centers for Dieases Control and Prevention Address: 1600 Clifton Rd NE, Atlanta GA 30329 Sample ID given by the submitting laboratory: Authors: Ying Tao, Krista Queen, Clinton R. Paden, Jing Zhang, Yan Li, Anna Uehara, Xiaoyan Lu, Brian Lynch, Senthil Kumar K. Sakthivel, Brett L. Whitaker, Shifaq Kamili, Lijuan Wang, Janna' R. Murray, Susan I. Gerber, Stephen Lindstrom, Suxiang Tong Submitter information Submitter: Queen, Krista Submission Date: 2020-01-25 Address: FASTA >BetaCoV/USA/IL1/2020|EPI_ISL_404253
niman Posted January 30, 2020 Author Report Posted January 30, 2020 In addition to two shared mutations, including orf 8 This sequence had 3 additional mutations shared with the Los Angeles case. An sixth mutation was shared with another sequence from Shenzhen (Shenzhen 3) and Foshan (Foshan 207). This constellation has clear evidence of recombination.
niman Posted January 30, 2020 Author Report Posted January 30, 2020 Interview describing mutations and recombination in index case (63F) shortly
Admin Posted January 30, 2020 Report Posted January 30, 2020 Press Release For Immediate ReleaseThursday, Jan. 30, 2020 Contact: CDC Media Relations(404) 639-3286 CDC Confirms Person-to-Person Spread of New Coronavirus in the United States The Centers for Disease Control and Prevention (CDC) today confirmed that the 2019 Novel Coronavirus (2019-nCoV) has spread between two people in the United States, representing the first instance of person-to-person spread with this new virus here. Previously, all confirmed U.S. cases had been associated with travel to Wuhan, China, where an outbreak of respiratory illness caused by this novel coronavirus has been ongoing since December 2019. However, this latest 2019-nCoV patient has no history of travel to Wuhan, but shared a household with the patient diagnosed with 2019-nCoV infection on January 21, 2020. Recognizing early on that the 2019-nCoV could potentially spread between people, CDC has been working closely with state and local partners to identify close contacts of confirmed 2019-nCoV cases. Public health officials identified this Illinois resident through contact tracing. Both patients are in stable condition. “Given what we’ve seen in China and other countries with the novel coronavirus, CDC experts have expected some person-to-person spread in the US,” said CDC Director Robert R. Redfield, M.D. “We understand that this may be concerning, but based on what we know now, we still believe the immediate risk to the American public is low.” Limited person-to-person spread with 2019-nCoV has been seen among close contacts of infected travelers in other countries where imported cases from China have been detected. The full picture of how easily and sustainably the 2019-nCoV spreads is still unclear. Person-to-person spread can happen on a continuum, with some viruses being highly contagious (like measles) and other viruses being less so. MERS and SARS, the other two coronaviruses that have emerged to cause serious illness in people, have been known to cause some person-to-person spread. With both those viruses, person-to-person spread most often occurred between close contacts, such as healthcare workers and those caring for or living with an infected person. CDC has been proactively preparing for the introduction of 2019-nCoV in the U.S. for weeks, including: First alerting clinicians on January 8 to be on the look-out for patients with respiratory symptoms and a history of travel to Wuhan, China. Developing guidance for preventing 2019 novel coronavirus (2019-nCoV) from spreading to others in homes and communities. Developing guidance for clinicians for testing and management of 2019-nCoV, as well as guidance for infection control of patients hospitalized or being evaluated by a health care provider. CDC is working closely with Illinois health officials and other local partners. A CDC team has been on the ground since the first 2019-nCoV-positive case was identified and is supporting an ongoing investigation to determine whether further spread with this virus has occurred. It is likely there will be more cases of 2019-nCoV reported in the U.S. in the coming days and weeks, including more person-to-person spread. CDC will continue to update the public as we learn more about this coronavirus. The best way to prevent infection is to avoid being exposed to this virus. Right now, 2019-nCoV has not been found to be spreading widely in the United States, so CDC deems the immediate risk from this virus to the general public to be low. However, risk is dependent on exposure, and people who are in contact with people with 2019-nCoV are likely to be at greater risk of infection and should take the precautions outlined in CDC’s guidance for preventing spread in homes and communities. For the general public, no additional precautions are recommended at this time beyond the simple daily precautions that everyone should always take. It is currently flu and respiratory disease season, and CDC recommends getting vaccinated, taking everyday preventive actions to stop the spread of germs, and taking flu antivirals if prescribed. Right now, CDC recommends travelers avoid all nonessential travel to China. For more information about the current outbreak in China, visit https://www.cdc.gov/coronavirus/2019-ncov/index.html. For travel health information, visit https://wwwnc.cdc.gov/travel/notices/watch/pneumonia-china. ### U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES CDC works 24/7 protecting America’s health, safety, and security. Whether diseases start at home or abroad, are curable or preventable, chronic or acute, or from human activity or deliberate attack, CDC responds to America’s most pressing health threats. CDC is headquartered in Atlanta and has experts located throughout the United States and the world.
niman Posted January 30, 2020 Author Report Posted January 30, 2020 Description of sequence from index case (63F) in Chicago nCoV cluster http://recombinomics.co/thedrnimanshow/2020/01/013020.mp3
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