Bavaria nCoV Cluster Grows To Ten Cases In Three Countries

[niman]

Confirmation of nCoV in a Webasto company employee, 33M, from Munich increases the cluster to 10 including a business associate in Shanghai, a child of one of the employees, and an employee/tourist in the Canary Islands.  The 10 person cluster is spread over six cities (Shanghai, Stockdorf, Fürstenfeldbruck, Traustein, Munich, La Gomera) in three countries (China ,Germany, Spain)

 

https://www.bild.de/news/inland/news-inland/coronavirus-usa-verhaengen-einreiseverbote-der-live-ticker-68532120.bild.html

[niman]

Eighth Corona Virus Case in Bavaria

There is another employee of the company Webasto ++ Tests of further employees still pending ++ Air force jet from Wuhan back in Germany ++ Eleven people in university clinic

Source: BILD0:42 min.

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It is the eighth case - and again it is an employee of the Webasto company.

In Bavaria, the coronavirus has once again been detected in a human. The infected person is a 33-year-old man from Munich, said the Bavarian Ministry of Health on Saturday evening. He is like six other Corona sick employees of the Webasto company in Stockdorf in the Starnberg district.

In addition to the company's seven employees, a child of one of the patients had also been tested positive for the new lung disease. The Webasto company had carried out extensive tests in the past few days, the results of which are still pending.

Edited February 1, 2020 by niman

[niman]

CORRESPONDENCE

Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany

TO THE EDITOR:

The novel coronavirus (2019-nCoV) from Wuhan is currently causing concern in the medical community as the virus is spreading around the world.¹ Since its identification in late December 2019, the number of cases from China that have been imported into other countries is on the rise, and the epidemiologic picture is changing on a daily basis. We are reporting a case of 2019-nCoV infection acquired outside of Asia in which transmission appears to have occurred during the incubation period in the index patient.

A 33-year-old otherwise healthy German businessman (Patient 1) became ill with a sore throat, chills, and myalgias on January 24, 2020. The following day, a fever of 39.1°C (102.4°F) developed, along with a productive cough. By the evening of the next day, he started feeling better and went back to work on January 27.

Figure 1.Timeline of Exposure to Index Patient with Asymptomatic 2019-CoV Infection in Germany.

Before the onset of symptoms, he had attended meetings with a Chinese business partner at his company near Munich on January 20 and 21. The business partner, a Shanghai resident, had visited Germany between Jan. 19 and 22. During her stay, she had been well with no signs or symptoms of infection but had become ill on her flight back to China, where she tested positive for 2019-nCoV on January 26 (index patient in Figure 1).

On January 27, she informed the company about her illness. Contact tracing was started, and the above-mentioned colleague was sent to the Division of Infectious Diseases and Tropical Medicine in Munich for further assessment. At presentation, he was afebrile and well. He reported no previous or chronic illnesses and had no history of foreign travel within 14 days before the onset of symptoms. Two nasopharyngeal swabs and one sputum sample were obtained and were found to be positive for 2019-nCoV on quantitative reverse-transcriptase–polymerase-chain-reaction (qRT-PCR) assay.² Follow-up qRT-PCR assay revealed a high viral load of 10⁸ copies per milliliter in his sputum during the following days, with the last available result on January 29.

On January 28, three additional employees at the company tested positive for 2019-nCoV (Patients 2 through 4 in Figure 1). Of these patients, only Patient 2 had contact with the index patient; the other two patients had contact only with Patient 1. In accordance with the health authorities, all the patients with confirmed 2019-nCoV infection were admitted to a Munich infectious diseases unit for clinical monitoring and isolation. So far, none of the four confirmed patients show signs of severe clinical illness.

This case of 2019-nCoV infection was diagnosed in Germany and transmitted outside of Asia. However, it is notable that the infection appears to have been transmitted during the incubation period of the index patient, in whom the illness was brief and nonspecific.³

The fact that asymptomatic persons are potential sources of 2019-nCoV infection may warrant a reassessment of transmission dynamics of the current outbreak. In this context, the detection of 2019-nCoV and a high sputum viral load in a convalescent patient (Patient 1) arouse concern about prolonged shedding of 2019-nCoV after recovery. Yet, the viability of 2019-nCoV detected on qRT-PCR in this patient remains to be proved by means of viral culture.

Despite these concerns, all four patients who were seen in Munich have had mild cases and were hospitalized primarily for public health purposes. Since hospital capacities are limited — in particular, given the concurrent peak of the influenza season in the northern hemisphere — research is needed to determine whether such patients can be treated with appropriate guidance and oversight outside the hospital.

Camilla Rothe, M.D.
Mirjam Schunk, M.D.
Peter Sothmann, M.D.
Gisela Bretzel, M.D.
Guenter Froeschl, M.D.
Claudia Wallrauch, M.D.
Thorbjörn Zimmer, M.D.
Verena Thiel, M.D.
Christian Janke, M.D.
University Hospital LMU Munich, Munich, Germany
[email protected]

Wolfgang Guggemos, M.D.
Michael Seilmaier, M.D.
Klinikum München-Schwabing, Munich, Germany

Christian Drosten, M.D.
Charité Universitätsmedizin Berlin, Berlin, Germany

Patrick Vollmar, M.D.
Katrin Zwirglmaier, Ph.D.
Sabine Zange, M.D.
Roman Wölfel, M.D.
Bundeswehr Institute of Microbiology, Munich, Germany

Michael Hoelscher, M.D., Ph.D.
University Hospital LMU Munich, Munich, Germany

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

This letter was published on January 30, 2020, at NEJM.org.

3 References

1. 1.Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. DOI: 10.1056/NEJMoa2001017.

   • Free Full Text
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2. 2.Corman V, Bleicker T, Brünink S, et al. Diagnostic detection of Wuhan coronavirus 2019 by real-time RT-PCR. Geneva: World Health Organization, January 13, 2020 (https://www.who.int/docs/default-source/coronaviruse/wuhan-virus-assay-v1991527e5122341d99287a1b17c111902.pdf. opens in new tab).

   • Google Scholar. opens in new tab

3. 3.Callaway E, Cyranoski D. China coronavirus: six questions scientists are asking. Nature 2020;577:605-607.

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https://t.co/jzMvGHBmiV?amp=1

[niman]

Virus detail
Virus name:	BetaCoV/Germany/BavPat1/2020
Accession ID:	EPI_ISL_406862
Type:	betacoronavirus
Passage details/history:	Original
Sample information
Collection date:	2020-01-28
Location:	Germany / Bavaria / Munich
Host:	Human
Additional location information:
Gender:	male
Patient age:	NA
Patient status:	hospitalized
Specimen source:	Sputum
Additional host information:
Outbreak:	Bavaria cluster patient 1
Last vaccinated:
Treatment:
Sequencing technology:	Illumina MiSeq, Nanopore MinION
Assembly method:	Geneious v9
Coverage:
Institute information
Originating lab:	Charité Universitätsmedizin Berlin, Institute of Virology; Institut für Mikrobiologie der Bundeswehr, Munich
Address:	Institute of Virology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Institut für Mikrobiologie der Bundeswehr, Neuherbergstraße 11, 80937 Munich, Germany
Sample ID given by the sample provider:
Submitting lab:	Charité Universitätsmedizin Berlin, Institute of Virology
Address:	Charitéplatz 1, 10117 Berlin, Germany
Sample ID given by the submitting laboratory:	ChVir929
Authors:	Victor M Corman, Julia Schneider, Talitha Veith, Barbara Mühlemann, Markus Antwerpen, Christian Drosten, Roman Wölfel
Submitter information
Submitter:	Barbara Muehlemann
Submission Date:	2020-01-31
Address:	Institute of Virology, Charité Universitätsmedizin Berlin

FASTA

>BetaCoV/Germany/BavPat1/2020|EPI_ISL_406862

[niman]

Confirmed the coronavirus in a German tourist in La Gomera

This is the analysis performed on one of the samples sent from La Gomera (Canary Islands). The patient is admitted and isolated in a hospital of the island.

 IN SUMMARY

 

• The affected had had direct contact with a person infected in Germany

 

 

First case of coronavirus in Spain. The National Center for Microbiology has confirmed its presence in samples sent from La Gomera (Canary Islands).

The patient is admitted and isolated in a hospital of the island. It is part of the group of five tourists who were already under observation on the island. Two of them had been in contact in Germany with a patient diagnosed with coronavirus infection.

These people were located on the afternoon of Wednesday once the Ministry of Health of the Canary Islands Government was alerted by Health that these two people were in the Canary Islands.

As foreseen in the protocol that has been explained these days, this Saturday there will be a ministerial meeting of evaluation and monitoring of the coronavirus, chaired by the minister, Salvador Illa, after which all available information on the case will be offered.

There are currently more than 75,000 cases under study in Wuhan. In Europe there are already positives in the United Kingdom, France. Germany, Italy, Sweden and Finland.

https://www.antena3.com/noticias/sociedad/confirmado-caso-coronavirus-gomera_202001315e34a9380cf2cfb788f47b07.html

[niman]

press release

 

• 01/02/2020
• No. 21 / GP
• Download PDF

 

Current information on the coronavirus situation in Bavaria - Bavarian Ministry of Health: 8th case confirmed - 33-year-old man from Munich

The Bavarian Ministry of Health informed on Saturday evening about the current development of the new corona virus in Bavaria. A ministry spokesman said in Munich that, according to the State Office for Health and Food Safety (LGL), another coronavirus case in Bavaria had been confirmed. It is a 33-year-old man who lives in the city of Munich. He is an employee of the company from the district of Starnberg, which also employs six of the previously known coronavirus cases.

There are currently eight known coronavirus cases in Bavaria (as of 6:00 p.m.). The seventh case was announced on Friday evening. It is a 52-year-old man who lives in the Fürstenfeldbruck district. The sixth case had been confirmed on Friday afternoon. It is a child of the man from the district of Traunstein, the positive finding of which was published late Thursday evening.

A test campaign for employees took place in the company from the district of Starnberg on Wednesday, Thursday and Friday. There are now 139 negative results and 2 positive results. The positive findings come from the man from Munich and the man from the Fürstenfeldbruck district.

The Bavarian Ministry of Health will provide further information on the subject of coronavirus on Sunday.

https://www.stmgp.bayern.de/presse/aktuelle-informationen-zur-coronavirus-lage-in-bayern-bayerisches-gesundheitsministerium-8/

[niman]

press release

 

• 02/02/2020
• No. 22 / GP
• Download PDF

 

Current information on the coronavirus situation in Bavaria - Bavarian Ministry of Health: All eight cases in stable health condition

The Bavarian Ministry of Health informed on Sunday about the current development in cases with the novel corona virus in Bavaria. A ministry spokesman in Munich said that on Sunday morning, according to doctors, all eight cases were in a stable condition.

This also applies to the eighth case, which became known on Saturday evening. According to the State Office for Health and Food Safety (LGL), it is a 33-year-old man who lives in the city of Munich. He is an employee of the company from the district of Starnberg, which also employs six of the previously known coronavirus cases. Like five other cases, he is in the Munich Clinic Schwabing.

The seventh case was announced on Friday evening. It is a 52-year-old man who lives in the Fürstenfeldbruck district. The sixth case had been confirmed on Friday afternoon. It is a child of the man from the district of Traunstein, the positive finding of which was published late Thursday evening. The father and the child are in a stable state of health in Trostberg in the hospital.

Chief Physician Prof. Dr. med. Clemens Wendtner from the Clinic for Infectious Diseases at the Munich Clinic Schwabing emphasized on Sunday: “We are in close contact with national and international medical experts from universities and the WHO. All six cases with evidence of the coronavirus (2019-nCoV) are in a clinically stable condition, sometimes showed flu-like symptoms and are currently largely symptom-free. All patients remain with us for clinical observation. "

A test campaign for employees took place last Wednesday, Thursday and Friday in the company from the district of Starnberg. There are now 139 negative results and 2 positive results. The positive findings come from the man from Munich and the man from the Fürstenfeldbruck district.

https://www.stmgp.bayern.de/presse/aktuelle-informationen-zur-coronavirus-lage-in-bayern-bayerisches-gesundheitsministerium-5/