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On 3 March 2020, the Ethiopian Public Health Institute (EPHI) reported three suspected yellow fever cases in Enor Ener Woreda, Gurage zone, SNNPR. The three reported cases were members of the same household (father, mother and son) located in a rural kebele. Two of three samples tested positive at national level by reverse transcriptase-polymerase chain reaction (RT-PCR) and were subsequently confirmed positive by plaque reduction neutralization testing (PRNT) at the regional reference laboratory, Uganda Viral Research Institute (UVRI) on 28 March 2020.

In response to the positive RT-PCR results, the EPHI and Ministry of Health performed an in-depth investigation and response, supported by partners including WHO.

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