Zika First Trimester Infection Increases Microcephaly Risk

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Zika in Q1 raises risk of microcephaly

Pedro.Saude fourth April 6, 2016 - 07:54:13

 

 

 

 

 

 

First results of the Brazil-US partnership are still preliminary; another study shows pregnant rate with symptoms 

(CCM Health) - The Health Ministry announced on Tuesday (5) the first results of research on the zika virus in partnership with the Disease Control and Prevention Center (CDC) from United States. The study, done in the state of Paraiba, seems to show that infection zika in the first trimester of pregnancy increases the risk of development ofmicrocephaly baby. The federal alert body to the preliminary results, which have yet to be proven.The research, US-Brazil partnership fruit to study zika virus signed in February, is being held with 165 women who had children born with microcephaly and 446 whose babies do not have the malformation in 56 municipalities of the state of the Northeast. "The study gave an agile, ethical and effective. The teams have taken important steps in the search for answers to this problem that concerns the world," says Antonio Nardi, Surveillance Secretary of Health Ministry. Although this hypothesis was disproved by studies of the World Health Organization (WHO), Paraiba study also showed no association between cases alteration of the central nervous system of babies and the use of larvicides, said the Ministry of Health. in parallel to the Brazil-US research, joint work of experts from the Oswaldo Cruz Foundation (Fiocruz), wHO, Brazilian universities and Tropical Medicine School of London, England, evaluated 100 mothers of children with microcephaly and found that 59 of them had rashes during pregnancy. The so-called skin rashes are the main symptoms of infection zika virus.

 

http://saude.ccm.net/news/650-zika-no-1-trimestre-eleva-risco-de-microcefalia

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MICROCEPHALY: study shows that Q1 may be at higher risk for pregnant women

 

Data are from research conducted by the Ministry of Health and the US CDC in Paraiba. The new release are 4,046 cases microcephaly research, 1,046 confirmed and 1,814 discarded

The case-control study in Paraíba shows preliminarily that mothers who had the Zika virus in the first trimester of pregnancy were more likely to have children with microcephaly. The Ministry of Health, in partnership with the Government of Paraiba and Center for Disease Control and Prevention of Diseases (CDC) of the United States, continues with the analysis of blood samples collected from the mothers and babies paraibanos. Only after this phase, the final results will be announced. The initial result of the study, presented in João Pessoa (PB), also found no association of microcephaly with the exhibition of products such as insecticides, for example.

"It's part of this study to investigate people who were not affected by microcephaly. Only after processing the collected blood samples, comparing cases and controls, can we estimate more clearly the risk of being affected by the disease and Zika's relationship with microcephaly, "said the aide Surveillance Secretariat of Health the Ministry of Health, Eduardo Hage, highlighting the commitment of the teams in the field phase of the research. "The study gave an agile, ethical and effective manner. The teams have taken important steps in the search for answers to the problem that concerns the world, "the Secretary of Health Surveillance, Ministry of Health, Antonio Nardi.

The research, which began on 22 February, featured the work of eight teams - composed by the institutions involved - who investigated the proportion of infants born with microcephaly associated with Zika, and the risk of virus infection in 56 municipalities state. Overall, respondents were 165 cases of mothers who had babies with microcephaly and 446 control (mothers and babies in the same area without microcephaly). Among the babies, 52% are female and 48% male, in the age group 0-7 months.

NEW RELEASE  - In Brazil, 4,046 suspected cases of microcephaly are under investigation, according to a new report released on Tuesday (5) by the Ministry of Health since the beginning of the investigation, in October 2015, by 2. April - were 6,906 notifications in 1,307 municipalities of all units of the federation. Cases already completed, 1,814 have been discarded and 1,046 were confirmed to microcephaly and other nervous system disorders, suggestive of congenital infection.

Of these, 170 have had laboratory confirmation to the Zika virus. In these cases, it performed specific laboratory test for the Zika virus. However, the Ministry of Health points out that this figure does not represent adequately the total number of cases related to the virus. That is, the folder considers that there was infection Zika most of the mothers who had babies with a final diagnosis of microcephaly.

Until April 2, there were 227 deaths (fetal or neonatal) microcephaly suspects and / or alteration of the central nervous system after birth or during pregnancy (miscarriage or stillbirth). Of these, 51 were confirmed to microcephaly and / or alteration of the central nervous system. Other 148 are still under investigation and 28 were discarded.

It should be noted that the Ministry of Health is investigating all cases of microcephaly and other disorders of the central nervous system, informed by the states, and the possible relationship with the Zika virus and other congenital infections. Microcephaly may be caused by, various infectious agents beyond Zika as Syphilis, Toxoplasmosis, Other Infectious Agents, Rubella, Cytomegalovirus and Herpes Viral.

The Ministry of Health advises pregnant women to adopt measures to reduce the presence of Aedes aegypti, with the elimination of breeding sites, and protect themselves from mosquito exposure, keeping doors and closed or screened windows, wear pants and long-sleeved shirt and use repellents allowed for pregnant women.

RESEARCH - Another study by a research group on the Zika epidemic (MERG) pointed out that 100 mothers of children with microcephaly interviews in the state of Pernambuco, 59 noted the presence of rash (rash) during pregnancy, common symptom in people infected by Zika virus. The research was published in a journal of the Center for Communicable Disease Control and Prevention (CDC), the United States.

This group, specialist Oswaldo Cruz Pernambuco Foundation - Aggeu Magalhães Research Center (Fiocruz / CPqAM), the Pan American Health Organization / World Health Organization (PAHO / WHO), the Ministry of Health, the Institute of Medicine integral professor Fernando Figueira (IMIP), the Federal University of Pernambuco Federal University of Rio Grande do Sul, the Secretary of State of Pernambuco Health, the Federal Border South University, the University of Pernambuco, the Evaluation Institute of Technology Health and the London School of Hygiene & Tropical Medicine.

Distribution of reported cases of microcephaly by UF until April 2, 2016

Regions and Federative Units	Microcephaly cases and / or malformations suggestive of congenital infection			Total accumulated 1of reported cases from 2015 to 2016
	research	confirmed 2.3	discarded 4
Brazil	4,046	1,046	1,814	6906
Alagoas	72	52	131	255
Bahia	663	194	134	991
Ceará	247	76	114	437
Maranhão	135	66	34	235
Paraíba	386	103	364	853
Pernambuco	1,053	303	490	1,846
Piauí	31	70	49	150
large northern river	290	83	35	408
Sergipe	157	31	17	205
Northeast	3,034	978	1,368	5,380
Holy Spirit	91	4	18	113
Minas Gerais	28	two	46	76
Rio de Janeiro	297	21	62	380
Sao Paulo	162 * 5	0	94	256
Southeast region	578	27	220	825
Acre	30	1	two	33
Amapá	two	3	0	5
Amazon	11	1	1	13
For	23	1	0	24
Rondônia	5	3	4	12
Roraima * 6	16	0	0	16
Tocantins	116	0	17	133
North region	203	9	24	236
Federal district	1	4	32	37
Goiás	82	9	30	121
Mato Grosso	113	14	71	198
Mato Grosso do Sul	5	two	11	18
Midwest region	201	29	144	374
Paraná	5	1	25	31
Santa Catarina	0	0	3	3
Rio Grande do Sul	25	two	30	57
South region	30	3	58	91

Source: Health Departments of the States and the Federal District (updated data until 02/27/2016).

1 Cumulative number of reported cases that met the definition of previous operating case (33 cm), and the definitions adopted in Surveillance Protocol (from 12/09/2015) that defined the Head Circumference 32 cm for newborns 37 or more weeks of gestation and other protocol definitions.

2 present typical changes: indicative of congenital infection, such as intracranial calcifications, dilation of cerebral ventricles or changes in posterior fossa and other clinical signs observed by any imaging method or identification of Zika virus in laboratory tests.

3 were confirmed 82 cases by specific laboratory criteria for Zika (PCR and serology technique) virus.

4 Discarded have normal exams by presenting microcephaly and / or congenital malformations by non-infectious causes or does not meet the case definitions.

* 5 As stated by the Epidemiological Surveillance Center "Prof. Alexandre Vranjac ", the State Secretary of Health of São Paulo, 162 cases are under investigation for congenital infection. Of these, 39 are possibly associated with infection by Zika virus, but have not yet been finalized investigations.

* 6 Roraima data related to SE 12, until March 23. (Not updated). 

Source: Health Departments of the States and the Federal District (updated data until 02/04/2016).

Amanda Mendes Health Agency 
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http://combateaedes.saude.gov.br/noticias/510-microcefalia-estudo-aponta-que-1-trimestre-pode-ser-de-maior-risco-para-gravidas