Dr. Niman's Corner

The sequence from a microcephalic brain has 4 nonsynonymous changes, compared to the consensus sequence from recent isolates from Brazil, Suriname, Haiti, Puerto Rico,and Guatemala. Three of these changes are in the NS1 protein,while the fourth change is in NS4B.

University of Wisconsin has released partial Zika sequences from Noverber 2015 transmission in Sincelejo, Colombia http://www.ncbi.nlm.nih.gov/nuccore/KU646827.1 http://www.ncbi.nlm.nih.gov/nuccore/KU646828.1

Faculte de Medecine de Marseille has released a full Zika sequence from a patient in December 2015 Martinique outbreak.http://www.ncbi.nlm.nih.gov/nuccore/KU647676.1

CDC has release a full Zika sequence from a December 2015 collection from Guatemala outbreak http://www.ncbi.nlm.nih.gov/nuccore/KU501216.1

CDC has released a full Zika sequence from November 2015 Guatemala outbreak http://www.ncbi.nlm.nih.gov/nuccore/KU501217.1

University of Florida has released a full Zika sequence from a December 2014 Haiti outbreak, which is virtually identical to the 2015 sequence from Brazil, ZikaSPH2015. http://www.ncbi.nlm.nih.gov/nuccore/KU509998.1

CDC has released full Zika sequence from December 2015 Puerto Rico outbreak http://www.ncbi.nlm.nih.gov/nuccore/KU501215.1

Evandro Chagas Institute has released four full Zika sequences from Brazil.

Canadian Zika presser at 1:00 PM January 29.

CDC is holding a Zika 101 presser at 11 AM EST today.

Ultrasound paper on two infants from Brazil that were PCR confirmed for Zika virus. http://onlinelibrary.wiley.com/doi/10.1002/uog.15831/abstract

CDC has developed Zika virus interim guidelines for pregnant women in the US - early release MMWR. http://www.cdc.gov/mmwr/volumes/65/wr/mm6502e1.htm

CDC has put out an MMWR early release on Zika virus spread. http://www.cdc.gov/mmwr/volumes/65/wr/mm6503e1er.htm?s_cid=mm6503e1er.htm_w

University of Sao Paulo has released a full 2015 Zika sequence from Brazil.

Prior to the recently released sequences from wild birds, all H5N8 sequences had 8 gene segments from Asia. However, in the recently released APHIS sequences a Canada goose and wigeon hunter harvested on January 18 in Klamath County Oregon had a North American PA (same PA as found in H5N1 in Whatcom County, Washington. These two isolates also had a North American wild bird PB1.

Recent paper on 2015 H5N8 in Taiwan describes sequences that match prior H5N8 constellation with PB1 and NP segments from wild birds. http://www.sciencedirect.com/science/article/pii/S1567134815300721

N2 in H5N2 Alaska wild bird sequences collected in the fall of 2014 match the N2 in Fujian clade 2.3.4.4 in North America in the 2014/2015 season.

Institut Pasteur de la Guyane in French Guiana has released a full 2015 Zika sequence from Suriname.

Kunming University of Science and Technology in Yunnan has released 2015 poultry an environmental H5N6 sequences.

Centre of Influenza Research & State Key Laboratory of Emerging Infectious Diseases at Hong Kong University has released a large series of MERS, alph which is human 229E-like from camels in Saudi Arabia.

USDA has released Fujian clade 2.3.4.4 H5N1 sequences from wigeons in Whatcom County Washingtopn.

APHIS has released a series of H5N2 and H5N8 wild bird sequences including Morrow County, Oregon.

Recent paper on 2015 H5N8 in Taiwan describes sequences that match prior H5N8 constellation with PB1 and NP segments from wild birds. http://www.sciencedirect.com/science/article/pii/S1567134815300721

January 17 2015 H5N8 sequences (33 full sets) from Taiwan have two constellations. One matches Crane in all 8 gene segments.The other has Asian wild bird sequences for PB1 and NP. http://www.sciencedirect.com/science/article/pii/S1567134815300721

A full S gene sequences as well as a a partial ORF1b sequences from Nigeria-HKU004,as well as closely related partial S gene sequences from camels in Nigeria in association with Eurosurveillance paper have been released. http://eurosurveillance.org/ViewArticle.aspx?ArticleId=21327