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Pandemic Potentials Blog

xander77

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  1. Covid-19 Furin Cleavage Site

    xander77 replied to khs's topic in Coronavirus (COVID)
    > Acquisition of a polybasic cleavage site is in many high path viruses, including H5 and H7 influenza or Newcastle virus Interesting that a coronavirus could have acquired the furin cleavage site, and enhanced RBDs. Now it can leverage ACE2 and CD147. Do you think it translocated with a lentivirus? RaTG13 is the closest known bat-CoV and it's spike is perhaps as divergent as 93%. In what species could a bat-CoV translocate with a lentivirus, whilst obtaining a significant number of synonymous substitutions?

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