niman Posted June 15, 2016 Report Posted June 15, 2016 University Hospital of Vigo has released a partial Zika sequence from the amniotic fluid from a pregnant case in Spain, ex-Venezuela.
niman Posted June 15, 2016 Author Report Posted June 15, 2016 (edited) LOCUS KX358623 191 bp RNA linear VRL 12-JUN-2016 DEFINITION Zika virus isolate AF01 nonstructural protein 5 gene, partial cds. ACCESSION KX358623 VERSION KX358623.1 GI:1035155861 KEYWORDS . SOURCE Zika virus ORGANISM Zika virus Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus. REFERENCE 1 (bases 1 to 191) AUTHORS Perez,S. TITLE Confirmed case of Zika virus congenital infection in Spain JOURNAL Unpublished REFERENCE 2 (bases 1 to 191) AUTHORS Perez,S. TITLE Direct Submission JOURNAL Submitted (06-JUN-2016) Department of Microbiology, University Hospital of Vigo, Hospital Meixoeiro, Apartado Oficial s/n, Vigo, Pontevedra 36200, Spain COMMENT ##Assembly-Data-START## Sequencing Technology :: Sanger dideoxy sequencing ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..191 /organism="Zika virus" /mol_type="genomic RNA" /isolate="AF01" /isolation_source="amniotic fluid" /host="Homo sapiens; female" /db_xref="taxon:64320" /country="Venezuela" /collection_date="29-Mar-2016" /note="subtype: Asian Clade" CDS <1..>191 /note="NS5" /codon_start=2 /product="nonstructural protein 5" /protein_id="ANI87834.1" /db_xref="GI:1035155862" /translation="LGFLNEDHWMGRENSGGGVEGLGLQRLGYVLEEMSRIPGGRMYA DDTAGWDTRISRFDLENEA" ORIGIN 1 ccttggattc ttgaacgagg atcactggat ggggagagag aactcaggag gtggtgttga 61 agggctggga ttacaaagac tcggatatgt cctagaagag atgagtcgca taccaggagg 121 aaggatgtat gcagatgaca ctgctggctg ggacacccgc atcagcaggt ttgatctgga 181 gaatgaagct c Edited June 15, 2016 by niman
niman Posted June 15, 2016 Author Report Posted June 15, 2016 Sequences producing significant alignments:Select:AllNone Selected:0AlignmentsDownloadGenBankGraphicsDistance tree of resultsShow/hide columns of the table presenting sequences producing significant alignmentsSequences producing significant alignments:Select for downloading or viewing reportsDescriptionMax scoreTotal scoreQuery coverE valueIdentAccessionSelect seq gb|KU866423.2|Zika virus isolate Zika virus/SZ01/2016/China polyprotein gene, complete cds345345100%2e-91100%KU866423.2Select seq gb|KX358623.1|Zika virus isolate AF01 nonstructural protein 5 gene, partial cds345345100%2e-91100%KX358623.1Select seq gb|KX280026.1|Zika virus isolate Paraiba_01, complete genome345345100%2e-91100%KX280026.1Select seq gb|KX253996.1|Zika virus isolate ZKC2/2016, complete genome345345100%2e-91100%KX253996.1Select seq gb|KX197192.1|Zika virus isolate ZIKV/H.sapiens/Brazil/PE243/2015, complete genome345345100%2e-91100%KX197192.1Select seq gb|KX185891.1|Zika virus isolate Zika virus/CN/SZ02/2016 polyprotein gene, complete cds345345100%2e-91100%KX185891.1Select seq gb|KX101067.1|Zika virus isolate Bahia12, partial genome345345100%2e-91100%KX101067.1Select seq gb|KX101064.1|Zika virus isolate Bahia11, partial genome345345100%2e-91100%KX101064.1Select seq gb|KX101060.1|Zika virus isolate Bahia02, partial genome345345100%2e-91100%KX101060.1Select seq gb|KX117076.1|Zika virus isolate Zhejiang04, complete genome345345100%2e-91100%KX117076.1Select seq gb|KX059014.1|Zika virus isolate Haiti/1230/2014 NS5 gene, partial cds345345100%2e-91100%KX059014.1Select seq gb|KX059013.1|Zika virus isolate Haiti/1227/2014 NS5 gene, partial cds345345100%2e-91100%KX059013.1Select seq gb|KX051563.1|Zika virus isolate Haiti/1/2016, complete genome345345100%2e-91100%KX051563.1Select seq gb|KU509998.3|Zika virus strain Haiti/1225/2014, complete genome345345100%2e-91100%KU509998.3Select seq gb|KU963796.1|Zika virus isolate SZ-WIV01 polyprotein gene, complete cds345345100%2e-91100%KU963796.1Select seq gb|KU940228.1|Zika virus isolate Bahia07, partial genome345345100%2e-91100%KU940228.1Select seq gb|KU940224.1|Zika virus isolate Bahia09, partial genome345345100%2e-91100%KU940224.1Select seq gb|KU955589.1|Zika virus isolate Z16006 polyprotein gene, complete cds345345100%2e-91100%KU955589.1Select seq gb|KU926310.1|Zika virus isolate Rio-S1, complete genome345345100%2e-91100%KU926310.1Select seq gb|KU926309.1|Zika virus isolate Rio-U1, complete genome345345100%2e-91100%KU926309.1Select seq gb|KU820899.2|Zika virus isolate ZJ03, complete genome345345100%2e-91100%KU820899.2Select seq gb|KU729217.2|Zika virus isolate BeH823339 polyprotein gene, complete cds345345100%2e-91100%KU729217.2Select seq gb|KU729218.1|Zika virus isolate BeH828305 polyprotein gene, complete cds345345100%2e-91100%KU729218.1Select seq gb|KU744693.1|Zika virus isolate VE_Ganxian, complete genome345345100%2e-91100%KU744693.1Select seq gb|KU497555.1|Zika virus isolate Brazil-ZKV2015, complete genome345345100%2e-91100%KU497555.1Select seq gb|KU232300.1|Zika virus isolate 067ZV_PEBR15 NS5 protein gene, partial cds345345100%2e-91100%KU232300.1Select seq gb|KU232298.1|Zika virus isolate 050ZV_PEBR15 NS5 protein gene, partial cds345345100%2e-91100%KU232298.1Select seq gb|KU232297.1|Zika virus isolate 049ZV_PEBR15 NS5 protein gene, partial cds345345100%2e-91100%KU232297.1Select seq gb|KU232294.1|Zika virus isolate 061ZV_PEBR15 NS5 protein gene, partial cds345345100%2e-91100%KU232294.1Select seq gb|KU232292.1|Zika virus isolate 054ZV_PEBR15 NS5 protein gene, partial cds345345100%2e-91100%KU232292.1Select seq gb|KU232290.1|Zika virus isolate 036ZV_PEBR15 NS5 protein gene, partial cds345345100%2e-91100%KU232290.1Select seq gb|KU556802.1|Zika virus isolate MEX/InDRE/14/2015 NS5 protein gene, partial cds345345100%2e-91100%KU556802.1Select seq gb|KU647676.1|Zika virus strain MRS_OPY_Martinique_PaRi_2015 polyprotein gene, complete cds345345100%2e-91100%KU647676.1Select seq gb|KU321639.1|Zika virus strain ZikaSPH2015, complete genome345345100%2e-91100%KU321639.1Select seq gb|KM078970.1|Zika virus strain CHI2490414 NS5 protein gene, partial cds345345100%2e-91100%KM078970.1Select seq gb|KM078961.1|Zika virus strain CHI2612114 NS5 protein gene, partial cds345345100%2e-91100%KM078961.1Select seq gb|KM078936.1|Zika virus strain CHI1410214 NS5 protein gene, partial cds345345100%2e-91100%KM078936.1Select seq gb|KM078933.1|Zika virus strain CHI1058514 NS5 protein gene, partial cds345345100%2e-91100%KM078933.1Select seq gb|KM078930.1|Zika virus strain CHI2283714 NS5 protein gene, partial cds345345100%2e-91100%KM078930.1Select seq gb|KM078929.1|Zika virus strain CHI1805214 NS5 protein gene, partial cds345345100%2e-91100%KM078929.1Select seq gb|KF993678.1|Zika virus strain PLCal_ZV from Canada polyprotein gene, partial cds345345100%2e-91100%KF993678.1Select seq gb|KJ776791.1|Zika virus strain H/PF/2013 polyprotein gene, complete cds345345100%2e-91100%KJ776791.1Select seq gb|KU232296.1|Zika virus isolate 045ZV_PEBR15 NS5 protein gene, partial cds34234298%2e-90100%KU232296.1Select seq gb|KU232293.1|Zika virus isolate 057ZV_PEBR15 NS5 protein gene, partial cds34234298%2e-90100%KU232293.1Select seq gb|KM078971.1|Zika virus strain CHI2613014 NS5 protein gene, partial cds342342100%2e-9099%KM078971.1Select seq gb|KU820897.3|Zika virus isolate FLR polyprotein gene, complete cds340340100%7e-9099%KU820897.3Select seq gb|KX262887.1|Zika virus isolate 103451, complete genome340340100%7e-9099%KX262887.1Select seq gb|KX247646.1|Zika virus isolate Zika virus/Homo sapiens/COL/UF-1/2016, complete genome340340100%7e-9099%KX247646.1Select seq gb|KX198135.1|Zika virus strain ZIKV/Homo sapiens/PAN/BEI-259634_V4/2016, complete genome340340100%7e-9099%KX198135.1Select seq gb|KX156776.1|Zika virus strain ZIKV/Homo sapiens/PAN/CDC-259364_V1-V2/2015, complete genome340340100%7e-9099%KX156776.1Select seq gb|KX156775.1|Zika virus strain ZIKV/Homo sapiens/PAN/CDC-259249_V1-V3/2015, complete genome340340100%7e-9099%KX156775.1Select seq gb|KX156774.1|Zika virus strain ZIKV/Homo sapiens/PAN/CDC-259359_V1-V3/2015, complete genome340340100%7e-9099%KX156774.1Select seq gb|KX087102.1|Zika virus strain ZIKV/Homo sapiens/COL/FLR/2015, complete genome340340100%7e-9099%KX087102.1Select seq gb|KU991811.1|Zika virus isolate Brazil/2016/INMI1 polyprotein gene, complete cds340340100%7e-9099%KU991811.1Select seq gb|KU985087.1|Zika virus isolate MEX/InDRE/Zika-2/2015 nonstructural protein 5 gene, partial cds340340100%7e-9099%KU985087.1Select seq gb|KU870645.1|Zika virus isolate FB-GWUH-2016, complete genome340340100%7e-9099%KU870645.1Select seq gb|KU179098.1|Zika virus isolate JMB-185 nonstructural protein 5 gene, partial cds340340100%7e-9099%KU179098.1Select seq gb|KU707826.1|Zika virus isolate SSABR1, complete genome340340100%7e-9099%KU707826.1Select seq gb|KU527068.1|Zika virus strain Natal RGN, complete genome340340100%7e-9099%KU527068.1Select seq gb|KU501217.1|Zika virus strain 8375 polyprotein gene, complete cds340340100%7e-9099%KU501217.1Select seq gb|KU501216.1|Zika virus strain 103344 polyprotein gene, complete cds340340100%7e-9099%KU501216.1Select seq gb|KU365780.1|Zika virus strain BeH815744 polyprotein gene, complete cds340340100%7e-9099%KU365780.1Select seq gb|KU365779.1|Zika virus strain BeH819966 polyprotein gene, complete cds340340100%7e-9099%KU365779.1Select seq gb|KU365777.1|Zika virus strain BeH818995 polyprotein gene, complete cds340340100%7e-9099%KU365777.1Select seq gb|KU232295.1|Zika virus isolate 068ZV_PEBR15 NS5 protein gene, partial cds33833897%2e-89100%KU232295.1Select seq gb|KU758877.1|Zika virus isolate 17271 polyprotein gene, complete cds336336100%8e-8999%KU758877.1Select seq gb|KX247632.1|Zika virus isolate MEX_I_7 polyprotein gene, complete cds336336100%8e-8999%KX247632.1Select seq gb|KX087101.2|Zika virus strain ZIKV/Homo sapiens/PRI/PRVABC59/2015, complete genome336336100%8e-8999%KX087101.2Select seq gb|KX056898.1|Zika virus isolate Zika virus/GZ02/2016 polyprotein gene, complete cds336336100%8e-8999%KX056898.1Select seq gb|KU955590.1|Zika virus isolate Z16019 polyprotein gene, complete cds336336100%8e-8999%KU955590.1Select seq gb|KU922960.1|Zika virus isolate MEX/InDRE/Sm/2016, complete genome336336100%8e-8999%KU922960.1Select seq gb|KU922923.1|Zika virus isolate MEX/InDRE/Lm/2016, complete genome336336100%8e-8999%KU922923.1Select seq gb|KU820898.1|Zika virus isolate GZ01 polyprotein gene, complete cds336336100%8e-8999%KU820898.1Select seq gb|KU740184.2|Zika virus isolate GD01 polyprotein gene, complete cds336336100%8e-8999%KU740184.2Select seq gb|KU853013.1|Zika virus isolate Dominican Republic/2016/PD2, complete genome336336100%8e-8999%KU853013.1Select seq gb|KU853012.1|Zika virus isolate Dominican Republic/2016/PD1, complete genome336336100%8e-8999%KU853012.1Select seq gb|KU761564.1|Zika virus isolate GDZ16001 polyprotein gene, complete cds336336100%8e-8999%KU761564.1Select seq gb|KU501215.1|Zika virus strain PRVABC59, complete genome336336100%8e-8999%KU501215.1Select seq gb|KU365778.1|Zika virus strain BeH819015 polyprotein gene, complete cds336336100%8e-8999%KU365778.1Select seq gb|KU312312.1|Zika virus isolate Z1106033 polyprotein gene, complete cds336336100%8e-8999%KU312312.1Select seq gb|KU681081.3|Zika virus isolate Zika virus/H.sapiens-tc/THA/2014/SV0127- 14, complete genome33433499%3e-8899%KU681081.3Select seq gb|KU232289.1|Zika virus isolate 020ZV_PEBR15 NS5 protein gene, partial cds33133195%3e-87100%KU232289.1Select seq gb|KU232288.1|Zika virus isolate 001ZV_PEBR15 NS5 protein gene, partial cds33133195%3e-87100%KU232288.1Select seq gb|EU545988.1|Zika virus polyprotein gene, complete cds331331100%3e-8798%EU545988.1Select seq gb|KU232299.1|Zika virus isolate 015ZV_PEBR15 NS5 protein gene, partial cds32932995%1e-86100%KU232299.1Select seq gb|KJ873160.1|Zika virus isolate NC14-03042014-3481 nonstructural protein 5 gene, partial cds32932995%1e-86100%KJ873160.1Select seq gb|KU937936.1|Zika virus isolate ZIKVNL00013 polyprotein gene, complete cds327327100%4e-8698%KU937936.1Select seq gb|KU940227.1|Zika virus isolate Bahia08, partial genome32732794%4e-86100%KU940227.1Select seq gb|KU955593.1|Zika virus isolate Zika virus/H.sapiens-tc/KHM/2010/FSS13025, complete genome327327100%4e-8698%KU955593.1Select seq gb|JN860885.1|Zika virus isolate FSS13025 polyprotein gene, partial cds327327100%4e-8698%JN860885.1Select seq gb|KU232291.1|Zika virus isolate 051ZV_PEBR15 NS5 protein gene, partial cds32432496%5e-8599%KU232291.1Select seq gb|KU681082.3|Zika virus isolate Zika virus/H.sapiens-tc/PHL/2012/CPC-0740, complete genome322322100%2e-8497%KU681082.3Select seq gb|KU752544.1|Zika virus isolate PoHuZV469196 nonstructural protein 5 gene, partial cds31331390%9e-82100%KU752544.1Select seq gb|KU752545.1|Zika virus isolate PoHuZV472846 nonstructural protein 5 gene, partial cds30730790%4e-8099%KU752545.1Select seq gb|HQ234499.1|Zika virus isolate P6-740 polyprotein gene, partial cds300300100%6e-7895%HQ234499.1Select seq gb|KF258813.1|Zika virus isolate Java non-structural protein 5 mRNA, partial cds29129188%3e-7598%KF258813.1Select seq gb|KX198134.1|Zika virus strain ZIKV/Aedes africanus/SEN/DAK-AR-41524_A1C1-V2/1984, complete genome25025098%9e-6389%KX198134.1Select seq gb|KU955595.1|Zika virus isolate Zika virus/A.taylori-tc/SEN/1984/41671-DAK, complete genome25025098%9e-6389%KU955595.1Select seq gb|KU955592.1|Zika virus isolate Zika virus/A.taylori-tc/SEN/1984/41662-DAK, complete genome25025098%9e-6389%KU955592.1Select seq gb|KU955591.1|Zika virus isolate Zika virus/A.africanus-tc/SEN/1984/41525-DAK, complete genome25025098%9e-6389%KU955591.1Select seq gb|KJ873161.1|Zika virus isolate NC14-02042014-3220 nonstructural protein 5 gene, partial cds25025072%9e-63100%KJ873161.1Select seq gb|KF383107.1|Zika virus strain ArA27407 nonstructural protein 5 gene, partial cds25025098%9e-6389%KF383107.1Select seq gb|KF383106.1|Zika virus strain ArA27443 nonstructural protein 5 gene, partial cds25025098%9e-6389%KF383106.1Select seq gb|HQ234501.1|Zika virus isolate ArD_41519 polyprotein gene, partial cds25025098%9e-6389%HQ234501.1Select seq gb|DQ859059.1|Zika virus strain MR 766 polyprotein gene, complete cds24624698%1e-6189%DQ859059.1Select seq gb|KF383117.1|Zika virus strain ArD128000 polyprotein gene, complete cds24424498%4e-6189%KF383117.1Select seq gb|KF383116.1|Zika virus strain ArD7117 polyprotein gene, complete cds24424498%4e-6189%KF383116.1Select seq gb|KF383114.1|Zika virus strain AnD30332 nonstructural protein 5 gene, partial cds24424498%4e-6189%KF383114.1Select seq gb|KF383101.1|Zika virus strain ArD127710 nonstructural protein 5 gene, partial cds24424498%4e-6189%KF383101.1Select seq gb|KF383099.1|Zika virus strain ArD127987 nonstructural protein 5 gene, partial cds24424498%4e-6189%KF383099.1Select seq gb|KF383098.1|Zika virus strain ArD127988 nonstructural protein 5 gene, partial cds24424498%4e-6189%KF383098.1Select seq gb|KF383097.1|Zika virus strain ArD127994 nonstructural protein 5 gene, partial cds24424498%4e-6189%KF383097.1Select seq gb|KF383089.1|Zika virus strain ArD165531 nonstructural protein 5 gene, partial cds24424498%4e-6189%KF383089.1Select seq gb|KF383085.1|Zika virus strain ArD9957 nonstructural protein 5 gene, partial cds24424498%4e-6189%KF383085.1Select seq gb|KU963573.1|Zika virus isolate ZIKV/Macaca mulatta/UGA/MR-766_SM150-V8/1947 polyprotein (GP1) gene, complete cds241241100%5e-6088%KU963573.1Select seq gb|KU955594.1|Zika virus isolate Zika virus/M.mulatta-tc/UGA/1947/MR-766, complete genome241241100%5e-6088%KU955594.1Select seq gb|KU720415.1|Zika virus strain MR 766 polyprotein gene, complete cds241241100%5e-6088%KU720415.1Select seq dbj|LC002520.1|Zika virus genomic RNA, complete genome, strain: MR766-NIID241241100%5e-6088%LC002520.1Select seq gb|KF383088.1|Zika virus strain ArD30101 nonstructural protein 5 gene, partial cds24124198%5e-6088%KF383088.1Select seq gb|KF383087.1|Zika virus strain ArD30156 nonstructural protein 5 gene, partial cds24124198%5e-6088%KF383087.1Select seq gb|HQ234498.1|Zika virus isolate MR_766 polyprotein gene, partial cds241241100%5e-6088%HQ234498.1Select seq gb|AY632535.2|Zika virus strain MR 766, complete genome241241100%5e-6088%AY632535.2Select seq gb|AF013415.1|Zika virus strain MR-766 NS5 protein (NS5) gene, partial cds241241100%5e-6088%AF013415.1Select seq gb|KF383104.1|Zika virus strain ArA982 nonstructural protein 5 gene, partial cds23923999%2e-5988%KF383104.1Select seq gb|KF383103.1|Zika virus strain ArA986 nonstructural protein 5 gene, partial cds23923999%2e-5988%KF383103.1Select seq gb|KF383086.1|Zika virus strain ArA975 nonstructural protein 5 gene, partial cds23923999%2e-5988%KF383086.1Select seq gb|KF268950.1|Zika virus isolate ARB7701 polyprotein gene, complete cds23723798%6e-5988%KF268950.1Select seq gb|KF268948.1|Zika virus isolate ARB13565 polyprotein gene, complete cds23723798%6e-5988%KF268948.1Select seq gb|KF383121.1|Zika virus strain ArD158095 polyprotein gene, partial cds23023099%9e-5787%KF383121.1Select seq gb|KF383119.1|Zika virus strain ArD158084 polyprotein gene, complete cds23023099%9e-5787%KF383119.1Select seq gb|KF268949.1|Zika virus isolate ARB15076 polyprotein gene, complete cds22822898%3e-5687%KF268949.1Select seq gb|KU963574.1|Zika virus isolate ZIKV/Homo sapiens/NGA/IbH-30656_SM21V1-V3/1968 polyprotein (GP1) gene, complete cds22322398%1e-5486%KU963574.1Select seq gb|KF383115.1|Zika virus strain ArB1362 polyprotein gene, complete cds22322393%1e-5488%KF383115.1Select seq gb|KF383084.1|Zika virus strain HD78788 nonstructural protein 5 gene, partial cds22322393%1e-5488%KF383084.1Select seq gb|HQ234500.1|Zika virus isolate IbH_30656 polyprotein gene, partial cds22322398%1e-5486%HQ234500.1Select seq gb|KF383118.1|Zika virus strain ArD157995 polyprotein gene, complete cds21021093%8e-5186%KF383118.1Select seq gb|KX101065.1|Zika virus isolate Bahia15, partial genome20320358%1e-48100%KX101065.1Select seq gb|KF383113.1|Zika virus strain ArA1465 nonstructural protein 5 gene, partial cds19919993%1e-4785%KF383113.1Select seq gb|KF383120.1|Zika virus strain ArD142623 nonfunctional polyprotein gene, partial sequence18718793%9e-4483%KF383120.1Select seq gb|KF383095.1|Zika virus strain ArD132915 nonstructural protein 5 gene, partial cds17817893%5e-4182%KF383095.1Select seq gb|KF383093.1|Zika virus strain ArD149810 nonstructural protein 5 gene, partial cds17817893%5e-4182%KF383093.1Select seq gb|KF383092.1|Zika virus strain ArD147917 nonstructural protein 5 gene, partial cds17817893%5e-4182%KF383092.1Select seq gb|KF383091.1|Zika virus strain ArD149938 nonstructural protein 5 gene, partial cds17817893%5e-4182%KF383091.1Select seq gb|EU074027.1|Zika virus strain MR 766 NS5 gene, partial cds16816871%2e-3888%EU074027.1Select seq gb|HM147822.1|West Nile virus from South Africa, complete genome14014098%1e-2977%HM147822.1Select seq gb|KX101061.1|Zika virus isolate Bahia03, partial genome13821561%4e-29100%KX101061.1
niman Posted June 15, 2016 Author Report Posted June 15, 2016 Sequence Map Updatehttps://www.google.com/maps/d/u/0/edit?hl=en&mid=1XSxKe6FIecV8f33cQwyc7uylxeU
niman Posted June 17, 2016 Author Report Posted June 17, 2016 Eurosurveillance, Volume 21, Issue 24, 16 June 2016Rapid communication CONFIRMED CASE OF ZIKA VIRUS CONGENITAL INFECTION, SPAIN, MARCH 2016 S Perez 1 , R Tato 2 , JJ Cabrera 1 , A Lopez 3 , O Robles 4 , E Paz 3 , A Coira 5 , MP Sanchez-Seco 6 , A Vazquez 6 , R Carballo 1 , C Quintas 7 , A Pousa 8+ Author affiliations1. Microbiology Department, University Hospital of Vigo, Spain2. Microbiology Department, University Hospital of Pontevedra, Spain3. Gynecology Department, Lucus Augusti Hospital, Lugo, Spain4. Pathology Department, Lucus Augusti Hospital, Lugo, Spain5. Microbiology Department, Lucus Augusti Hospital, Lugo, Spain6. Arbovirus and Imported Viral Diseases, Virology Area, National Center of Microbiology (CNM), Carlos III Health Institute (ISCIII), Majadahonda, Madrid, Spain7. Preventive Medicine Department, Lucus Augusti Hospital, Lugo, Spain8. General Subdirection for Epidemiology and Information Systems, General Direction of Public Health, Consellería de Sanidade, Santiago de Compostela, Spain Correspondence: Sonia Perez ([email protected])http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=22506 Citation style for this article: Perez S, Tato R, Cabrera JJ, Lopez A, Robles O, Paz E, Coira A, Sanchez-Seco MP, Vazquez A, Carballo R, Quintas C, Pousa A. Confirmed case of Zika virus congenital infection, Spain, March 2016. Euro Surveill. 2016;21(24):pii=30261. DOI: http://dx.doi.org/10.2807/1560-7917.ES.2016.21.24.30261Received:07 June 2016; Accepted:16 June 2016 We describe Zika virus (ZIKV) vertical transmission in an imported case in Spain, in a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected in serum in week 17. At 19 weeks, ultrasound scan revealed fetal malformations and ZIKV was detected in the amniotic fluid. Pregnancy was terminated at week 21; autopsy of the fetus revealed bilateral hydrocephalus, brain microcalcifications and arthrogryposis multiplex congenita. ZIKV was detected in the umbilical cord and brain tissue.
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