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Pandemic Potentials Blog

London COVID Variant Missing Spike Y145 Deletion

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UK COVID variants have significant heterogeneity.  A recent (collected Dec 7) isolate from London, hCoV-19/England/LOND-12F102B/2020, has the two Spike deletions (at positions 69 and 70) as well as most of the nonsynonymous Spike changes and other mutations, including the 3 amino acid deletion in NSB 6, but does not have the Spike deletion at position 145 (Y145del), strongly suggesting rapid recombination.

Edited by niman

Thank you for the term “rapid recombination “because those two words are the most important to a lay person.

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