niman Posted December 23, 2020 Report Share Posted December 23, 2020 Recently release sequences (at GISAID) provide compelling evidence that the UK variant is rapidly evolving via recombination. An isolate from Scotland (hCoV-19/Scotland/CVR6032/2020) has 8 of the 10 Spike mutations - it is missing the 6 BP deletion that encodes H69 and V70. Moreover, it is missing the 9 BP deletion in NSB 6. The presence and absence of these well established deletions in the UK variants is most easily explained by rapid recombination. Link to comment Share on other sites More sharing options...
niman Posted December 23, 2020 Author Report Share Posted December 23, 2020 Another isolate from Scotland (hCoV-19/Scotland/CVR5974/2020) has the same constellation (the common 7 Spike non-synonymous changes and the Y145 deletion but no deletion of position 69/70 and no deletion in NSB 6. Link to comment Share on other sites More sharing options...
niman Posted December 23, 2020 Author Report Share Posted December 23, 2020 Same constellation for hCoV-19/Scotland/CVR6031/2020 Link to comment Share on other sites More sharing options...
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