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SARS-CoV2 BA.2.86 Derivative Sequences Map

Six UK COVID Variants At Capodichino Airport Near Naples Italy ex-London

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niman Grand Master

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TIGEM has deposited 6 UK Variant sequences at GISAID (collected Dec 21) Italy/CAM-TIGEM-174/2020, Italy/CAM-TIGEM-175/2020, Italy/CAM-TIGEM-176/2020, Italy/CAM-TIGEM-178/2020, Italy/CAM-TIGEM-179/2020, Italy/CAM-TIGEM-181/2020, from passengers arriving from London at Capodichino Airport.

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niman Grand Master

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A group of experienced genomic sequencing researchers coordinated by Professor Davide Cacchiarelli at the Telethon Institute of Genetics and Medicine in Pozzuoli, Tigem, determined the complete sequence of the viral genome in 115 positive swabs for SARS-CoV-2 performed in the last months in the region.

Among these samples it was also possible to analyze 6 swabs recently obtained at the Capodichino airport in people from London: among these the presence of the so-called "English variant" of SARS-Cov2 was found, on which many scientific aspects still remain to be clarify to assess their actual impact on public health. In the remaining samples analyzed, a total of 8 different variants were identified, all belonging to the "type B", widespread in Europe.

I study

The study, the results of which have been deposited in Gisaid (the world reference database for sequences of viral genomes), therefore provides a first map of the Sars-CoV2 variants present in Campania and underlines the importance of viral genome analysis for the characterization of the evolution of the pandemic. "At TIGEM we have developed a technology that now allows us to analyze, with high precision and reliability, the viral genome in a high number of swabs per day. By 31 December - said Professor Davide Cacchiarelli, coordinator of the Covid19 genomic sequencing unit at TIGEM - we plan to sequence the viral genome in over 1000 SARS-CoV-2 positive swabs. "

"This important result - declared Antonio Limone, director of the Zooprophylactic Institute - is the result of the enormous effort that all the staff of the Zooprophylactic Institute, coordinated by Pellegrino Cerino, has been doing for months in Campania, processing, in our laboratories, over 400 thousand tampons and carrying out, thanks to specialized operational units, targeted interventions in the management of emergencies in the Campania region ".

Andrea Ballabio, director of TIGEM and coordinator of the research project on Covid19 funded by the Campania Region underlined that "the emergency of this pandemic has pushed us Telethon researchers to take the field in the fight against Covid19 by exploiting our genetic skills. The discovery of the so-called English variant of SARS-CoV-2 in the swabs of people arriving from London at Capodichino airport underlines even more the importance of studying the evolution of the viral genome, both to decide the containment measures to be adopted , both in the future to monitor the possible onset of aggressive or resistant variants to vaccines. From now on - concluded Ballabio - the diagnostic response that we will be required to give to a person who performs the swab will not beonly if SARS-CoV-2 is present or not, but which variant is it ".

"The identification of the six positive cases - declared the President Vincenzo De Luca - is subsequent to the ordinance of the Region with which flights from the United Kingdom were blocked immediately after the news of the discovery of the new variant. It will continue in the coming days. a careful work of control and filtering with respect to the arrivals and the evolution of the epidemic, to ensure maximum safety conditions. This survey developed by our centers is of great scientific importance and of great support for the work to come. excellence in the research funded by the Region in March ".

https://napoli.repubblica.it/cronaca/2020/12/26/news/covid_campania_passeggeri_arrivati_da_londra_positivi_alla_variante_inglese-279940835/

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26/12/2020 - Six passengers from the United Kingdom tested positive for the so-called English variant of Covid-19 because they have the S gene mutations typical of this variant. The news emerged following the work carried out by the researchers of the Experimental Zooprophylactic Institute of the South, in synergy with Tigem and Ceinge. Further studies are underway in close collaboration with researchers from the Spallanzani Institute.

In fact, since Sunday 20, all passengers from the United Kingdom have been subjected to a molecular nasopharyngeal swab and the positives have been promptly identified and monitored. Immediately, sequencing was performed to ascertain whether the strain belonged to the English variant. After the relentless work of the researchers, it emerged that 6 have the S gene mutations typical of the variant.
The study is part of the Gencovid project, which started from the Campania Region in the first months of the pandemic with the aim of studying the virus in depth through the timeliness of sampling on the territory, the identification of outbreaks and the phylogenetic reconstruction of the virus and its spread. . A scientific boarding of the best Campania research institutions which, thanks to the synergy of the researchers, has allowed the Campania Region to identify and sequence about 2000 samples in the various phases of the pandemic, data that will be published in a few days on the international Gisaid platform and made available of the international scientific community. Gencovid was born from the Izsm which, with 400,000 swabs analyzed in the laboratories of Portici and with specialized operating units, allowed targeted and immediate interventions in the management of emergencies. Once the RNA was extracted and prepared, the Italian excellence Tigem for molecular biology took care of the sequencing, a further aliquot of sample, in collaboration with the CEINGE researchers, was also used to isolate the viral strains and experimentally test in vitro, on cellular models, the efficacy of different molecules with potential inhibitory activity of the replicative capacity of the virus.

"The identification of the six positive cases - declared the President Vincenzo De Luca - is subsequent to the ordinance of the Region with which flights from the United Kingdom were blocked immediately after the news of the discovery of the new variant. It will continue in the coming days. a careful work of control and filter with respect to the arrivals and the evolution of the epidemic, to ensure maximum safety conditions. This survey developed by our centers of excellence is of great scientific importance and great support for the work to come. as part of the research funded by the Region in March ".

http://www.regione.campania.it/regione/it/news/primo-piano/covid-19-6-passeggeri-arrivati-da-londra-positivi-alla-variante-inglese-de-luca-risultato-importante-proseguono-i-controlli-e-la-ricerca

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The English variant

The "English variant" of Sars-CoV-2, the Covid-19 virus, was found in Veneto (3 cases), Campania (6 cases) and Abruzzo (one case). Two cases had been ascertained yesterday in Puglia . The variant, as is known, is more contagious, not more serious, and is called "English" because it was found for the first time in Great Britain. The variant is characterized by a combination of deletions (absence of small pieces of the viral genome) and mutations in the S protein (spikes) that make it unique within the panorama of the many variants circulating in the world.

 

For the Veneto, it was communicated by the president of the Region, Luca Zaia, in the usual press point of the Civil Protection of Marghera. The discovery, explained Zaia, was made on Christmas Eve by the Zooprophylactic Institute of the Venezie. "We have scientifically proven that the summer virus had nothing to do with either the first phase or the current one," Zaia said. The presence of the variant, explained Francesca Russo, director of prevention of the Region, was found in two women and a man from the United Kingdom: "Patients are fine, only one person has a little fever", said Russo . The Higher Institute of Health (ISS) and the Ministry of Health were informed of the discovery.

The "English variant" of the virus has also been identified in Campania . Six swab-positive passengers from the UK have S gene mutations typical of this variant. This was ascertained by the researchers of the genomic disequencing group coordinated by Davide Cacchiarelli at the Telethon Institute of Genetics and Medicine in Pozzuoli, ilTigem. Further studies are underway in close collaboration with the Spallanzani Institute in Rome. The six travelers, returning from London, had been checked at Capodichino airport in Naples before flights to the United Kingdom were suspended. In the remaining samples analyzed, 8 different variants of the new coronavirus were identified, all belonging to the "type B", widespread in Europe.

A case of "English variant" has also been identified in Abruzzo . The experimental zooprophylactic institute of Abruzzo and Molise identified it in a patient from the province of Chieti.

https://www.avvenire.it/attualita/pagine/coronavirus-26-12-variante-inglese-veneto-campania?utm_medium=Social&utm_source=Twitter#Echobox=1608994334

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