Pasteur Institute has deposited full sequences from patients in Paris. The two sequences do not match the Shenzhen cluster,but do match each other - 32M matches 31F

Edited January 29, 20206 yr by niman

Virus detail
Virus name:	BetaCoV/France/IDF0373/2020
Accession ID:	EPI_ISL_406597
Type:	betacoronavirus
Passage details/history:	Original
Sample information
Collection date:	2020-01-23
Location:	France / Ile-de-France / Paris
Host:	Human
Additional location information:

Edited March 6, 20206 yr by niman

Virus detail
Virus name:	BetaCoV/France/IDF0372/2020
Accession ID:	EPI_ISL_406596
Type:	betacoronavirus
Passage details/history:	Original
Sample information
Collection date:	2020-01-23
Location:	France / Ile-de-France / Paris
Host:	Human
Additional location information:

Edited March 6, 20206 yr by niman

1 hour ago, niman said:

Pasteur Institute has deposited full sequences from patients in Paris. The two sequences do not match the Shenzhen cluster,but do match each other - 32M matches 31F

What exactly does that mean? 

19 minutes ago, realauren said:

What exactly does that mean? 

One infected the other or both infected by a common source.

6 minutes ago, niman said:

One infected the other or both infected by a common source.

So this is a mutation from the original  Shenzhen cluster or is there a lot more to this than my decaffeinated brain is trying to understand. 

No, this one is not related to the Shenzhen cluster lineage.

Forgive my ignorance but does that mean there's more than one strain of this virus or that it's mutated?

There is one strain (2019-nCoV) that is rapidly evolving in many directions.

Did you see the WHO press conference today? Dr. Michael Ryan completely avoided the question about whether the latest sequences show any significant changes by talking instead about how transparent and diligent China has been. It's at 14:50 in the video:  https://www.pscp.tv/w/1OdJrqEvgaeGX

The main thing he said which stood out in my mind is, "We have a chance."

With the rapid evolving in many directions, what is the likelihood of a second  recombination along with the orf-8?  And is there a quasi-predictable timeframe?

"...(2019-nCoV) that is rapidly evolving in many directions...."

So, based on your experience, do virii evolve to become more lethal or to survive longer? In other words, do you see a stronger threat in the future?

33 minutes ago, osgo said:

"...(2019-nCoV) that is rapidly evolving in many directions...."

So, based on your experience, do virii evolve to become more lethal or to survive longer? In other words, do you see a stronger threat in the future?

With sars the was a deletion of 29 nt in orf 8 which was associated with increased transmission and virulence.  At this date in 2003 (prior to the deletion) there were 300 SARS cases and 5 deaths (over a 3 month time frame).

56 minutes ago, CoffeeLover said:

With the rapid evolving in many directions, what is the likelihood of a second  recombination along with the orf-8?  And is there a quasi-predictable timeframe?

A sequence released today, SZTH-001,which has the 2nd and 3rd Shenzhen mutation, including orf8, but the upsteam mutation was over-written with a segment with 22 mutations.

 

On 1/29/2020 at 11:26 PM, niman said:

A sequence released today, SZTH-001,which has the 2nd and 3rd Shenzhen mutation, including orf8, but the upsteam mutation was over-written with a segment with 22 mutations.

 

Here is my ultimate question. Does these mutations have the possibility to effect current vaccine developments that are underway? 

On 1/30/2020 at 1:20 AM, niman said:

There is one strain (2019-nCoV) that is rapidly evolving in many directions.

Thank you.

15 minutes ago, realauren said:

Here is my ultimate question. Does these mutations have the possibility to effect current vaccine developments that are underway? 

Vaccine will target S (spike) gene. The cited mutations generally are not in S gene

1 minute ago, niman said:

Vaccine will target S (spike) gene. The cited mutations generally are not in S gene

Ok, I know vaccines are way above my understanding outside of general immunological benefits. I really need to read up on how they go about doing it. But thank you for the clarification. 

Also note that Paris lineage matches CA2 (Orange County) and TW2 (Taiwan)

In layman's terms.  There is rate of communicability and and the effect of the virus - recover or not.  Is there something specific to watch for in the sequences or evolvement that would give definitive information that the virus has reached the tipping point, or does the lay observer just watch for the statistics to speak.  Thank you.

I think that the rate of increase in cases and CFR in China and exports will speak volumes