nCoV Sequences of Isolates From First US Case - Have orf8 Mutation

[niman]

The University of Washington has released sequences  at GISAID from two isolates (BetaCoV/USA/WA1-F6/2020 and BetaCoV/USA/WA1-A12/2020) from the first confirmed nCoV case (35M) from Snohomish County,WA.  They match the original sequence which has the orf8 mutation and is the same lineage as sequences from Shenzhen, Chicago, Yorkshire clusters,and other US sequences (from CA and AZ) and other sequences from China (Shenzhen and Wohan) and the first sequence from South Korea.

Edited March 6, 2020 by niman

[niman]

Virus detail
Virus name:	BetaCoV/USA/WA1-F6/2020
Accession ID:	EPI_ISL_407215
Type:	betacoronavirus
Passage details/history:	Vero p1
Sample information
Collection date:	2020-01-25
Location:	North America / USA / Washington
Host:	human

Edited March 6, 2020 by niman

[niman]

Virus detail
Virus name:	BetaCoV/USA/WA1-A12/2020
Accession ID:	EPI_ISL_407214
Type:	betacoronavirus
Passage details/history:	Vero p1
Sample information
Collection date:	2020-01-25
Location:	North America / USA / Washington
Host:	human
I

Edited March 6, 2020 by niman

[CoffeeLover]

What does that mean?  orf 8....virulence, contagion, high CFR, one step away from pandemic?

[niman]

In 2003, a 29 nt deletion in orf 8 was associated with increased transmission and virulence which lead to international spread via guests and visitors at the Metropole Hotel.