niman Posted February 4, 2020 Report Share Posted February 4, 2020 (edited) The University of Washington has released sequences at GISAID from two isolates (BetaCoV/USA/WA1-F6/2020 and BetaCoV/USA/WA1-A12/2020) from the first confirmed nCoV case (35M) from Snohomish County,WA. They match the original sequence which has the orf8 mutation and is the same lineage as sequences from Shenzhen, Chicago, Yorkshire clusters,and other US sequences (from CA and AZ) and other sequences from China (Shenzhen and Wohan) and the first sequence from South Korea. Edited March 6, 2020 by niman Link to comment Share on other sites More sharing options...
niman Posted February 4, 2020 Author Report Share Posted February 4, 2020 (edited) Virus detail Virus name: BetaCoV/USA/WA1-F6/2020 Accession ID: EPI_ISL_407215 Type: betacoronavirus Passage details/history: Vero p1 Sample information Collection date: 2020-01-25 Location: North America / USA / Washington Host: human Edited March 6, 2020 by niman Link to comment Share on other sites More sharing options...
niman Posted February 4, 2020 Author Report Share Posted February 4, 2020 (edited) Virus detail Virus name: BetaCoV/USA/WA1-A12/2020 Accession ID: EPI_ISL_407214 Type: betacoronavirus Passage details/history: Vero p1 Sample information Collection date: 2020-01-25 Location: North America / USA / Washington Host: human I Edited March 6, 2020 by niman Link to comment Share on other sites More sharing options...
CoffeeLover Posted February 4, 2020 Report Share Posted February 4, 2020 What does that mean? orf 8....virulence, contagion, high CFR, one step away from pandemic? Link to comment Share on other sites More sharing options...
niman Posted February 4, 2020 Author Report Share Posted February 4, 2020 In 2003, a 29 nt deletion in orf 8 was associated with increased transmission and virulence which lead to international spread via guests and visitors at the Metropole Hotel. Link to comment Share on other sites More sharing options...
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