Christer Svensson Posted March 1, 2020 Report Share Posted March 1, 2020 As a comment and inquiry refering to this and earlier articles regarding pulmonary autopsy of COVID-19 patients showing obstructed alveoli https://www.globaltimes.cn/content/1181121.shtml Background It is suported by forensic autopsies that alveoli are blocked from effective gas exchange by the formation of mucus in COVID 19 and if I recall correctly other articles mention fibrinous plack formation in SARS hindering oxygen and carbon dioxide perfusion through the semipermeable membrane of the alveoli. A mucolytic treatment strategy For this reason it would in theory be valuable to be able to apply mucus and fibrin solvents "anticoagulants" for coagulatory complexes eg. fibrin and enzymes e.g. [amylase for splitting up mucus carbohydrates] etc. along the air path side to the alveoli [Non mebrane crossing Von vilibrandt factor antagonists] perhaps also on the airway side for solving mucus if extant if and only if these anticoagulants and enzymes, were of a kind that do not cross a semipermeable membrane. For instance [a non membrane crossing modified heparin like molecule ...] Something for Big Pharma to work on. also in conjunction with [ an aerosol mucal solvent treatment ] the manipulation of patient position utilising gravity to empty the visceral pleural sacs of disolved excess mucus fluid. as a hypothetical treatment strategy with the added benefit of bringing more blood and therefore also oxygen to the brain of a patient. Mucus hypersecretionEdit "In the lower respiratory tract excessive mucus production in the bronchi and bronchioles is known as mucus hypersecretion.[10] Chronic mucus hypersecretion results in the chronic productive cough of chronic bronchitis,[15] and is generally synonomous with this.[16] Excess mucus can narrow the airways, limit airflow, and accelerate a decline in lung function.[10]" wikipedia Regarding glycoproteins such as lactoferrin[1] "Binding of biotin-heparin to immobilized lactoferrin" The lactoferrin -heparin interaction may perhaps contribute to incresing mucus viscosity that may interfere with gas perfusion ? https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1239-z Link to comment Share on other sites More sharing options...
Christer Svensson Posted March 10, 2020 Author Report Share Posted March 10, 2020 The linked article: presents "clinical observations" showing a correlation between high BP and complication risks in COVID-19 ""Of a group of 170 patients who died in January in Wuhan - the first wave of casualties caused by a pathogen that's now raced around the world - nearly half had hypertension."That's a very high ratio," said Du Bin, director of the intensive care unit at Peking Union Medical College Hospital,"" https://gulfnews.com/world/asia/coronavirus-doctor-says-high-blood-pressure-a-major-death-risk-1.1583772143148 As a comment on implications of the above finding: it is known that the elderly are higher in BP and lower in androgens than the general the adult population. Also COVID-19 seems to affect men more severely than women Regarding BP: Conclusions: Bloodpressure regulating effect of androgens is largely missing in the elderly. ▪ "The vasorelaxation induced by androgens is mainly mediated by blocking L-VOCCs" https://www.tandfonline.com/doi/abs/10.1080/07435800.2018.1448868?journalCode=ierc20 Regarding Low androgens: Hypothesis: The immunosupressive effect of "DHT absence", in elderly males due to low levels being produced has effect on COVID-19 prognosis "A number of studies have found strong correlations between low testosterone and elevated numbers of B cells (75–79), and high testosterone levels in men correlates with poorer antibody responses to vaccination (80), suggesting that androgens inhibit B lymphopoiesis." It is also known that androgens e.g DHT supress the B-Cell count in males" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932344/ Measures Since B cells are capable of producing cytokines: Elevated Cytokine levels may possibly be reduced by DHT suplementation e.g. testosterone patch. Thus the medical community needs to study and evaluate and perhaps consider the role of androgen supplementation in the treatment of COVID-19 Link to comment Share on other sites More sharing options...
Christer Svensson Posted March 11, 2020 Author Report Share Posted March 11, 2020 The usefullness of Chloroquinine Phosphate + Zink is under investigation in the context of Corona virus ▪ Zink plus "the iononophore" chloroquine diphosphate may block the viral RNA dependent RNA polymerase https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/ ▪ Chloroquine diphosphate https://m.youtube.com/watch?v=U7F1cnWup9M Link to comment Share on other sites More sharing options...
Christer Svensson Posted April 10, 2020 Author Report Share Posted April 10, 2020 https://www.bidmc.org/about-bidmc/news/2020/04/covid-19-anti-clotting-medication Link to comment Share on other sites More sharing options...
Christer Svensson Posted April 10, 2020 Author Report Share Posted April 10, 2020 http://web.archive.org/web/20200405061401/https://medium.com/@agaiziunas/covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret-91182386efcb Link to comment Share on other sites More sharing options...
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