The Dr. Niman Show 11202024

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You
Good evening and welcome to the doctor Niman show today is Wednesday, November 20, 202 4 here for our latest addition and to give the talk tonight is as usual doctor 

Dr. Niman
Thanks I thought tonight I've been a couple different development development on new sequences that have been uploaded Kind of indirectly related to the mystery cases there's unclear where they got affect H5 and one, but I'll start with the sequences that we uploaded today There were two sequences that came from British Columbia poultry and these were a little bit different because they're the most recent both both samples were collected this spot. One was November 1. The other was November 7. They was a chicken farm. The other was a turkey farm and. I looked at those and compared them to the other sequences that were up there that were also The D1 one and they were very similar, and then she said, usually adds new sequences onto their tree, and I looked, and they had put the turkey sequence top of this, and all said next to the turkey sequence towards newly added And I was a bit surprised this evening. I actually saw that. Lab and on Twitter Had indicated that the Two sequences of H2 75 Y which is a very well known Tamiflu resistance marker and I double check to see and it is really easy to see because of the H is normally sitting between two white so it's YH Y Or the ace change why you get three wise in a row and it's really easy to see just glancing at the secrets whether it's got them or not, but I actually did a little search to see if it was in any of the wild birds which I didn't really expect or the other D1 that one sequences, which which of course would include the The teenager and It was and it was only in these two, and that was kind of on. I mean, it's not unusual to see it, and the virus is found in humans because fluid is frequently used to treat humans and and therefore it can select for for the resistance and the fact that was happening in seasonal flu, which is each one and one. Just before the 2009 pandemic and I was actually monitoring sequences were coming in and the levels kept on going up and I my recollection is it was getting close to almost 100 % so all of the seasonal A1 one had 8275 Y and the pandemic cable log in that just totally wiped out seasonal flu so seasonal season eight for season eight for one is gone. It is no walker circulating and. Tammy resistance concert was one of the unexpected benefits of the pandemic, but it turns out that Tamiflu is used for the colors. The colors generally get offered a prophylactic dose of. Tammy flew in. They finished calling so that they in case they got affected right before they they laughed. They would have the Tamiflu to prevent them from developing. Any flu with the H5N one or if they did, it would be a milder version and but but this wasn't in humans that the virus had the resistance that was in the chickens in the turkey and out I gotta put up a post questioning whether the colors that might have H5 and one but maybe at a low level but enough to in fact Birds that they weren't necessarily calling they might be working on nearby farms and there are a lot of fires in southern British Columbia and I could've. I could see some of the colors basically having. Other jobs that had uninfected, turkey and chicken and or or Somehow, I'm not sure how it would get from a color with resistance to the turkeys in the chickens. There may be an intermediate that something else got affected by them, but they went and got into the. Feed of the turkey with the chickens and managed to contaminate those birds or maybe the colors were in charge of the defeating and somehow they had a try that one they could've coughed on the feed anyway That was one of the development and I double checked to see if it was legal to use Tammy through on poultry and in Canada possibly I thought that was highly unlikely because you would get this type of situation where you might have culture that would have a low level of virus because they had gotten Tamiflu and and so they weren't really sewing symptoms, but they nonetheless had had the virus and I mean, they wouldn't have the symptoms because that would take care of most of the virus so they would have a low level of virus which is unlikely that it would really even work that well but apparently there were accusations made back in 2 005 that Vietnam was trying to protector Their poultry that's where they had a lot of things and one there they denied it and and I think the US the FDA had regulations to pass right about that time 2005 or 200 6 they did prohibit the use of Tammy flew and poultry in the United states But For whatever reason it still speculation is that how it happened these chickens chicken Farm a turkey farm is like two out of two these are the two most recent ones so I don't know how widespread this is but the two most recent collections from British Columbia on commercial farms and the commercial farms go out every day. I think they're up to 44 farms now and I think they were. I think they went out by three today there was one announcement with Quebec and British Columbia. The second announcement to British Columbia sucks anyway the total is 44 whether it's three today or Some of those were yesterday that they're going up dramatically and these year aren't even that recent now these are these were collected what I'm almost 3 weeks ago and the other one about two weeks ago, but but they they may be assigned things to come. It'll be interesting. This is a pretty quick upload and I'm sure that they know about it although they're not Martin she said which which is kind of surprising because they did mark the ones from the humans but those are two different labs so this would be done more on the agricultural side and the The ones that had it marked from Washington state with a be in the US to be there beat the CDC and Tammy food resistance that's up to you necessarily see a lot Poetry, it's all that was one set of sequence is the other set of sequences a couple of sequence that I've been looking for for a while and if you recall HI and one was identified in swine farm in crooks County, Oregon and The sequence still hasn't been released on the swine, but in the table from the USDA they they did list the swine that we're on the backyard farm and they said that it was The 1 2 based on the sequence of the poultry, so I thought there'd be a reasonable chance for the poultry to show up and again they showed up on the table. I'm sorry of the tree that she said maintains and. They were there they were there last week and they had been there two weeks ago, but they were there a while ago and I kept searching the database to find out if they were there and I kept getting no I couldn't find it so I thought I actually Wrote an inquiry to she said this morning saying that's on your tree but it's not in either the search database or the blast database and they showed up today so at least two of them That was a goose and a duck. They were positive so I did the I. Looked at the PA segment because the PA segment in it is really the only difference between the one that one and you want that too and this is different that I mean there there were no other H5 sequence that matched these two these two were exact matches with each other and they matched Other wild birds, I think the closest match were mallards from from British Columbia actually and they were H3 and eight serotypes so they're really weren't in the H5 that ones that were Close and then I went through the taking you to the sequences and showing what the closest sequences were and in all cases that the team from British Columbia really wasn't that far away. It was relatively close to related to all of these. DY2 sequence that kinda highlights, the fact that Do you want that rose from the D1 that one sequence and all it did is swap out the PAC segment so the other seven segments are had the same origin and that's exactly what the data show are. Those got posted today and then. Talked a little bit more about the The toddler from Alameda and there's still a bunch of questions on the toddler. They didn't seem to be any new information. But that was one of the questions is why is it taking so long to confirm and just go over that real briefly that typically to be a confirmed case it's going to be Positive twice once by the state lab and then they take their positive and send it to the CDC for confirmation and same thing happen with the Canada The provincial lab the initial and then they said I'm the Winnipeg to the national for confirmation and that's what took a little bit of time for the teen didn't take that long actually they're pretty quick and that was one of the reasons I was thinking there will be another secret from the key at least that would be by the Winnipeg does the national labs, but that hasn't happy I've been getting back to the toddler from California There there's that That sequence was kind of weak in the press releases as how it was described and and it was sent to the CDC for confirmation And then The press release indicated that the child had been been given Tammy flu and then was tested four days later and was negative for the virus. That's kind of what you would expect if the viral was slower then he got treated and that's one of the reasons they recommend treatment with that 48 hours it's the symptoms so if you got. The toddler was treated at an earlier stage There'll be a good chance that Tyler negative fairly quickly but the questions is still remain is a wise. Is it taking so long for the confirmation to come back and because it's obviously already been four days since The first sample was taken, and They got a negative on it already. Usually the confirmation would come within that time so it last I looked a few hours ago the the. Child is still positive, but it's unclear What the infection was the infection was supposed to be in not only the toddler but also the toddler's parents and that's actually still persisting and all they said about the cold infection was considered produces cold and flu like symptoms And it seemed that it was Covid. They were actually just said it was Covid but if it was seasonal flu, they might not. Cannot say that because there be some alarm bell so they have a toddler infected both with HI and one and see flu, which is what the concerns because if that happens, they create a reassortment where they would swap the segments and The 858 one could pick up some human segments that human segments clear Couldn't make the virus more adapted towards humans and that's definitely what they don't wanna see happen so and if they were, if they had identified feasible fluid with the child they might Or not announce that until they were sure that they weren't getting a reassurance But They haven't said anything just that there was a second agent that the child God after the five so that's another question and then the other question is why why did they test this Tyler for 85 that toddlers generally have a lot of colds and like symptoms especially if they're going to daycare So there'll be a lot of calories that would have some kind of flu like symptoms that they don't bother the test for because they get those all the time is not clear why the toddler was chosen to be tested and And it's taking a while And they don't really know Where the batteries originated and start kind of anxious to see the secrets in and of course, there hasn't been sequence yet either and so that's the things that are kinda out there I mean there's This was in the Bay East Bay, which is I guess Oakland and so it's a little bit north of where both of the dairy cat are, but they probably get milk from those dairy cattle and it's kinda in the path of the wild birds that continue to migrate south and continue to have a lot of outbreaks and there were a lot of new wild birds that were reported today I think they were like 1 00 or so and I think they covered all four fly ways of the wild burns are definitely. I'm moving in the United States from Canada and there's also several additional. Farms that were uploaded today and they didn't need only one upload one new Actually, a new dairy yard in California so that I was a little surprised didn't he jumped a lot over the weekend and hasn't really added that much this week so far and they have been a whole lot of new human cases in the last couple of days but might very well be the car before the storm and just to add one more technical note the fact that the The toddler had a low signal, doesn't necessarily mean that the toddler didn't have a higher signal before they were tested And so the signal doesn't really mean too much and The test is reliable. It's a PCR testing and this case was done by California with this got a lot of experience doing PCR test lately between the dairy hurts and in between the number of human cases and and so. Their results should be pretty accurate and they got a positive and the CDC's having trouble is probably more because the level is low that it is the positive fault So those are the color and have much to maybe it's not real that that's unlikely to be the cases more likely that even if the CDC has trouble Confirming get that they'll still try to grow the virus and try to get it a secret one way or the other and and it happened a few times at the present deposits wasn't referred by the CBC but the states that have those still the list them on their website and they're just listed as probable instead of confirmed though they don't believe that the negative result by the CBC is real they think that the negative result is simply because there wasn't that much virus and they got first crackhead Anyway, that's where things stand right now. Quick little update that Tammy fluid is kind of the big piece of news and I haven't heard a good explanation of why turkey and chicken tuna poultry Farm would. Beta food resistant usually get to fruit resistance and humans that were treated with Tamiflu so that's it for tonight 

You
OK, thank you for the information. We will have another update tomorrow and have a good night.