The Dr. Niman Show 11222024

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Good day and welcome to the doctor Niman show today is Friday, November 22 2 4 On today's edition of the podcast, Dr. Niman will be talking about some milestones and some other interesting things about the H5 and one virus that has been occurring Dr. Niman take it away 

Dr. Niman
Thanks, Ryan yeah, I thought I'd pulled up to a podcast this morning and hit a couple milestones of the number of confirmed Gary Hertz in California is now tapped 400. It got up to 398 yesterday and four more we're headed today so it's 40 2. And today I think it was last night. The British Columbia hit another milestone that they're there up to 50 confirmed cases this season and tell those numbers go up on a daily basis also and there's been quite a bit of activity and in both wild birds and off for flyways. And on both commercial and backyard farms, most of them have been in the Pacific flyway but they're starting to show up in all four flyweights. Now it's getting to be that time of year where the. The H5 that one just said the wild bird in Alaska and Northern Canada start to head south for winter and start showing up in southern Canada and then on into the United States there there been a few others and in Canada besides British Columbia I think there were seven other ones three in Quebec and three and Alberta one in Saskatchewan so they had 57 And they are all 50 of them are concentrated in British Columbia, which is kind of what is expected Activities is getting into the news now and There's been quite a few stories that came out this week on the British Columbia teen. They did get into a little bit of detail about the three different changes. But what typically happens on media reports as soon as they start getting in the sequence, Citizen individual changes the media reports usually kind of Go off the rail to a degree and I think they might spend more confusion than actually getting the readers to understand what's going on some of the report that came out today this week talked to all them talked about the DC team and Sound just talked about the two receptor by don't maintain this and didn't talk about 67 K what are the reports actually was talking about the first case in the Our worker in the dairy farms, who There was a paper nature that came out it was to see whether The that particular genotype that B3. 13 Since it was in mammals, it wasn't in cows, whether it could transmit in mammals more efficiently that's one of these spirit studies that essentially infects the ferret with the Virus in question and then has ferritin cages next to the They got the injection to see if the virus was able to travel from one ferret to the other fair without physical contact so the case desire are separated and injected Or put virus into the air and if it transmissible To the other ferret, that way, the other ferret will develop symptom that did indicate that the did the virus was somewhat more transmissible through the air with regard to the ferrets and one of the Outcomes was the parents that were injected with a virus. They all died and done. The virus did have E627 K and they mentioned that in the nature report. But they kinda added the caveat that well this is the first time they had seen it, but they haven't seen one since so it may not be that much of a concern and then a week or two after that Words of assurance the BC teen Was in the news and the team actually did have E 67K and it was a different background. It was on the wild bird, the one that one, and so that that was quite notable at the same changed that was mail and adaptation a pair appeared in and B3 13 and then shortly thereafter it also appeared in. One I got one but one of the stories to cover both didn't mention that the E627K was in the team. They just talked about the the two that were involved in the receptor body domain, and then another article that talked about all three of them. Didn't talk that much about that. They just said that there were three changes and they said that all three had to do with the virus. Getting into the salad, there are recognizing the surface receptors of the surface and a reality is just the tooth that the chain on H5 that we're involved with that recognition. The other one is the E 67K is on a preliminaries which is an enzyme that's involved with copying the genetic information are really had nothing to do with binding on the on the cell surface but That's not unusual that usually don't talk about the specifics and when they try to generalize and talk about dysfunction day a frequently get the story a little bit rock so there will be a lot of news though and these new cases Are are probably set for creating more human cases the odd it seems in the dairy sequence is showing up more in poultry because of their spill so especially in in California there has been a large number of increase Increases in Chicken broiler and chicken layers as well as turkey farms that's a little hard to figure out exactly Where those are because if it's a These 3. 13 sequence USDA that aren't really give the collection date. The collection date is 202 4 and they don't really give the location. The location is USA so it's a little hard to figure out whether these chicken and poultry sequences are B3.13 are coming from California since that's where so many cases are they probably are but I just gotta make things difficult by withholding that information to to get a better idea which ones are in California and which ones are in you know Idaho, which it's got a dairy cattle and They've had new cases or even Utah, which didn't have any cases and they had the sequence show up in a large layer fire that they are ordered testing of all the Dairy farms in cache county, which is where the layer farm was and they immediately found eight positives and they added four more so they got a dozen in a heartbeat and the difference between having a dozen of having zero is it's actually testing so the testing still an issue and Hopefully that start increasing I think Pennsylvania is gonna be start doing bulk screening so the bill will be tested for H5 and one to see if there are dairy in Pennsylvania today there are none or none reported and And hopefully other states will start doing that I mean, part of the problem is is testing and that's actually part of the reason that California is up to 40 2. There's only a little over 1100 in there number one in the country and they've got over 35 % of the farms have been affected and a very high percentage actually are infected that the 4 00 that was. Passed today was half of that 30 days ago so month doubled and that's the pretty dramatic increase so when you start getting big numbers like this, it's it's pretty easy to continue with exponential growth and then one other area I wanted to go into a little bit of detail goes back to British Columbia and It has to do with Tammy flu resistance I think of the last update I met that The change which is 8 H2 75 Y in the amine was detected in poultry in British Columbia and that I think I meant the last time, but that's very unusual usually Tammy flu resistance shows up in patient that have the flu and are taking Tamiflu and then that puts Selection pressure on I changed it all out the the virus to escape from the effects of the Tamiflu and changing the H2O Wyatt position 275 does that and so you can see that developed but it's very unusual for it to be in the actual chickens because That would imply that some type of selection pressure on the chickens for cab flu resistance, and you can use your imagination to try to figure out how that would happen to me when I guess could be that there's a lot of Tammy flew on the farm that are being called at the The colors generally are offered Prophylactic heavy flu if There are cases that are identified during the calling Or sometimes they're just given it because I mean a lot of these layer farms are liar. Say that they have several hundred thousand actually they're really closer to 1 million so some of the larger farms are between 1 million and 5 million birds so that there's a lot of virus there because the virus spreads extremely quickly through poultry and turkeys and so there's there's a lot of candy in the colors and weather somehow the flu. Colors decided that he took a few of the 10 tablets he took a few of them. Men need to have symptoms anyway, and maybe discarded the other ones and the other one somehow made it into the water of the birds or the feed of the birds that are. The color is actually did get the The infection and went to work at another fireman, ended up coughing into the feed that he was carrying or something along those lines and and all that it only needs to happen once that There for in British Columbia in British Columbia is very densely Popular with the farms and and so it's very easy for the infection to go from one farm to the other, even though after me to limit that it was limiting movement, but he got some type of barriers to keep wild birds out, but what seems to happen is the virus can actually infect us smaller birds stick and kinda get through the Through the netting or they can actually have mice to get infected so they can get into the bar and With the dairy that the cats are getting, but that's that's not an issue with British Columbia. The only the US has the. d3.13 but they've got the D 1. one and that's the hardest outbreak in in the US that happened just across the border and in Washington and Franklin County and There they had actually 14 colors were PCR positive and 11 to the 14 were confirmed by the CDC and I'm pretty sure that all of them were at the at the same layer farm that had 800, 000 layers and sold even with PPE's head with goggles The colors seem to still get infected and that's a concern now because that particular virus that there was present in Franklin County is now present throughout the Pacific flyway and so it's it's causing the problems In British Columbia and the The resistant marker is in the one that one sequences it's all the idea so somehow Some birds in the area they could've even been local birds are could be some of the other animals that Kinda can get go from farm to farm ended up, bringing down that virus into the poultry house. That's the alternate way directly from Tamlu getting in there and that they got the Tamiflu resistance from. Same type of thing somehow the Tamlu leading to the resistance on dumb, wild or something and then Get into the fireman and once it gets into one The turkeys and the chickens don't have much resistance. The virus goes through them very quickly, and as I mentioned it, specially with farms close together, it is not that hard to end.