Guangdong Province

WHO Chinese National Influenza Center Virology Institute has released full H7N9 sequence (at GISAID) from 43F in Guangdong collected December 29, 2016, A/Guangdong/17SF003/2016, with HPAI polybasic cleavage site KRKRTAR and Tamiflu resistance R292K in N9.

WHO has reported a cluster involving sisters (45F & 43F) who were reported by CHP as being in Zhaoqing (likely hospitalization location). Index case has died, while sister discharged. Sequence from sister was HPAI and Tamiflu resistance (but did not have E627K).

The status of the HPAI H7N9 case(s)/cluster in Qingyuan remains confused. CHP initially reported a case (57M) in Qingyaun, Guangdong province as "under investigation. On Feb 19 the Guangdong (GD) CDC released a full H7N9 sequence from Qingyuan that was HPAI (poly-basic cleavage site) with Tamiflu resistance (R292K) and PB2 mammalian adaptation (E627K). The collection date was Jan 14 from a fatal case (56M) which was similar to the above CHP case. On Feb 20 WHO (Beijing) release a full sequence which was vitually identical to the above sequence.Segments were identical (H7,MP,NP,NS), had a single difference (N9,PB2,PA) or 2 differences (PB1) suggesting the seq…

Guangzhou Institute of Respiratory Disease has released a full set of H7N9 sequences from a fatal case in Qingyuan, Guangdong. The H5 has the same polybasic cleavage site, KRKRTAR seen in the case from Taiwan ex-Guangdong Province.

WHO Beijing Center has released 6 additional sets of H7 and N9 HPAI sequences collected between Nov 7 and Dec 12. All have polybasic cleavage site KRKRTAR in H7 and wild type (R292) for Tamiflu resistance.

On February 16 Taiwan CDC released a full H7N9 from a businessman who developed bird flu symptoms after traveling to Guangdong Province, The H7 sequence had a polybasic cleavage site indicating it was HPAI and the N9 sequence had R229K indicating it was Tamiflu resustant (and the PB2 had E627K signaling mammalian adaptation. This was followed by release of a similar sequence (by GD-CDC) from a fatal case, which had teh same markers cited above, although the constellations differed suggesting the HPAI was widespread. This was confirmed by the release of two more human sequences by WHO Beijing. One sequence matched the fatal case, while the other was from a mild…

The recently release H7N9 sequences from Guangdong and Taiwan cases with polybasic cleavage site, KRKRTAR also have R292K in the N9 sequences. Media reports suggest that the two additional cases in Guangdong Province also have R292K.

WHO Chinese National Influenza Center has released a full H7N9 environment sample, A/Environment/Guangdong/C16283222/2016, collected on November 7, 2016 with polybasic cleavage site KRKRTAR. Sequences are wild type/avian for H7 226, PB2 627 N9 292.

Two cases of disease before the incidence of bird exposure history, and in the exposure of poultry birds have occurred in the phenomenon of death. http://www.cdcp.org.cn/gdsjbyfkzzx/gnwxx001/201702/ce3a2125d5dc46e1b2e906ee42d42c2d.shtml

In January 2017, Guangdong Provincial Center for Disease Control and Disease on the two cases of human infection H7N9 cases were isolated virus gene sequencing analysis, found in the two strains of hemagglutinin link peptide position of the gene insertion mutation occurred, the test results Has been confirmed by the National Center for Viral Disease National Influenza Center. I center experts to judge and communicate with the relevant experts in the agricultural sector that H7N9 virus in the hemagglutinin link peptide position of the gene insertion mutation, suggesting that the virus mutation to the highly pathogenic virus against birds; http://www.cdcp.org.cn/g…

WHO Chinese National Influenza Center has released Dec 2016 full H7N9 sequence, A/Guangdong/60923/2016, (at GISAID) from 80M Guangdong.

220137 Confirmed Asia/China/MeizhouNationalGuangdong Sheng / Lat.: 24.162855, Long.: 116.14896709/12/201609/12/2016Influenza - AvianH7N9 LPAI 1 Human Geocoords. Quality: Centroid Admin2 http://empres-i.fao.org/eipws3g/