niman

414,583 TOTAL 329,731 CONFIRMED 84,852 PROBABLE LAST 14 DAYS 55,978 CASES 258,291 TESTED (DIAGNOSTIC) *TOTAL HOSPITALIZATIONS To Date Updates M-F at 3 p.m. 38,450 STATEWIDE DEATHS 5,945 TOTAL 4,977 CONFIRMED 968 PROBABLE TOTAL TESTED 1,999,693 DIAGNOSTIC 94,965 ANTIBODY PRESUMED RECOVERIES Updated Weekly 221,961 STATEWIDE https://alpublichealth.maps.arcgis.com/apps/opsdashboard/index.html#/6d2771faa9da4a2786a509d82c8cf0f7

https://www.azdhs.gov/preparedness/epidemiology-disease-control/infectious-disease-epidemiology/covid-19/dashboards/index.php

https://covid19.ncdhhs.gov/dashboard/cases

https://www.tn.gov/content/tn/health/cedep/ncov/data.html

https://covid19.colorado.gov/data

New Tests Administered 51,592 08/25/2020 ... 01/13/2021 12,561 New Individuals Tested New Positive Cases 4,411 01/13/2021 ... 01/13/2021 Positivity - All Tests 15.3 %7-Day Rate 01/01/2021 ... 01/07/2021 10.9 % cumulative rate New Deaths 40 12/31/2020 ... 01/13/2021 Total Confirmed COVID-19 Counts Total Tests Administered 6,271,603 02/26/2020 ... 01/13/2021 2,792,291 Individuals Tested Total Positive Cases 578,494 03/06/2020 ... 01/13/2021 Positivity - Unique Individuals 26.3 %7-Day Rate 01/01/2021 ... 01/07/2021 20.7 % cumulative rate Total Deaths 8,830 03/15/2020 ... 01/13/2021 https://www.coronavirus.in.gov/

https://www.vdh.virginia.gov/coronavirus/covid-19-in-virginia/

714,168 Confirmed Cases 93,125 CDC Expanded Case Definition (Probable) 807,293 Total Cases 42,491 Number of Hospitalizations in Ohio 8,974 Confirmed Deaths 1,016 CDC Expanded Death Definition (Probable) 9,990 Total Deaths 6,289 Number of ICU Admissions <1-111 Age Range 43 Median Age 46%* Sex - Males 53%* Sex - Females LAST UPDATED 01/14/2021 (UPDATED DAILY AT 2 P.M.) *1% SEX NOT REPORTED

Number of confirmed cases : 317,815 Number of persons tested negative : 2,679,345 Total testing volume : 6,298,178 Daily testing volume : 43,826 Number of confirmed deaths : 6,277 Number of probable deaths : 172 Currently hospitalized : 1,843 Acute care : 1,418 Intensive care : 425 Ever hospitalized : 29,123 Released from isolation : 9,443 Cases and Deaths Data Breakdown: Parenthesis = Confirmed death, laboratory-confirmed positive COVID-19 test result Asterisk = Probable death, death certificate lists COVID-19 as the cause of death but not yet confirmed by a laboratory test NH = Non-Hispanic By County County Cases Deaths Allegany 5,814 (164) 0* Anne Arundel 29,016 (396) 14* Baltimore City 34,907 (735) 21* Baltimore County 43,103 (1,006) 31* Calvert 2,850 (46) 1* Caroline 1,575 (13) 0* Carroll 6,139 (174) 5* Cecil 4,213 (84) 2* Charles 6,957 (131) 1* Dorchester 1,732 (24) 0* Frederick 13,836 (209) 8* Garrett 1,665 (56) 1* Harford 9,926 (178) 4* Howard 13,070 (182) 6* Kent 892 (28) 2* Montgomery 52,842 (1,167) 44* Prince George's 61,516 (1,128) 27* Queen Anne's 2,058 (32) 1* St. Mary's 3,948 (94) 0* Somerset 2,047 (23) 0* Talbot 1,441 (12) 0* Washington 10,122 (177) 3* Wicomico 5,473 (98) 0* Worcester 2,673 (61) 1* Data not available 0 (59) 0* By Age Range and Gender Age/Gender Cases Deaths 0-9 14,892 (1) 0* 10-19 29,454 (5) 1* 20-29 58,464 (30) 1* 30-39 55,448 (65) 6* 40-49 48,930 (183) 4* 50-59 47,857 (485) 22* 60-69 32,074 (982) 17* 70-79 18,350 (1,589) 31* 80+ 12,346 (2,935) 90* Data not available 0 (2) 0* Female 166,676 (3,019) 84* Male 151,139 (3,258) 88* By Race and Ethnicity Race/Ethnicity Cases Deaths African-American (NH) 90,196 (2,253) 61* Asian (NH) 6,783 (210) 7* White (NH) 106,595 (3,082) 89* Hispanic 53,182 (600) 15* Other (NH) 14,861 (64) 0* Data not available 46,198 (68) 0* https://coronavirus.maryland.gov/

https://dph.georgia.gov/covid-19-daily-status-report

Harris County Confirmed Cases 269,089 Dallas County Confirmed Cases 199,948 Tarrant County Confirmed Cases 158,423 Bexar County Confirmed Cases 114,768 El Paso County Confirmed Cases 105,347 Travis County Confirmed Cases 58,286 Collin County Confirmed Cases 53,282 Lubbock County Confirmed Cases 44,897 Hidalgo County Confirmed Cases 38,937 Fort Bend County Confirmed Cases 37,080 Denton County Confirmed Cases 36,467 Webb County Confirmed Cases 32,658 Cameron County Confirmed Cases 32,176 Montgomery County Confirmed Cases 27,515 Williamson County Confirmed Cases 25,199 Galveston County Confirmed Cases 23,158 Nueces County Confirmed Cases 22,814 Brazoria County Confirmed Cases 22,271 McLennan County Confirmed Cases 21,407 Bell County Confirmed Cases 16,144 Potter County Confirmed Cases 15,829 Jefferson County Confirmed Cases 15,642 Randall County Confirmed Cases 15,012 Ellis County Confirmed Cases 14,197 Brazos County Confirmed Cases 13,486 Midland County Confirmed Cases 13,165 Wichita County Confirmed Cases 12,912 Hays County Confirmed Cases 12,623 Johnson County Confirmed Cases 12,591 Kaufman County Confirmed Cases 9,838 Parker County Confirmed Cases 9,235 Grayson County Confirmed Cases 8,458 Smith County Confirmed Cases 8,243 Maverick County Confirmed Cases 7,678 Guadalupe County Confirmed Cases 7,344 Rockwall County Confirmed Cases 6,738 Victoria County Confirmed Cases 6,554 Ector County Confirmed Cases 6,457 Walker County Confirmed Cases 6,185 Starr County Confirmed Cases 5,785 Taylor County Confirmed Cases 5,761 Hale County Confirmed Cases 5,596 Val Verde County Confirmed Cases 5,278 Gregg County Confirmed Cases 4,618 Wise County Confirmed Cases 4,500 Anderson County Confirmed Cases 4,467 Hunt County Confirmed Cases 4,440 Tom Green County Confirmed Cases 4,180 Coryell County Confirmed Cases 4,082 Comal County Confirmed Cases 4,081 Angelina County Confirmed Cases 4,012 Liberty County Confirmed Cases 3,896 Orange County Confirmed Cases 3,419 Bowie County Confirmed Cases 3,362 Chambers County Confirmed Cases 3,346 Hood County Confirmed Cases 3,287 Bastrop County Confirmed Cases 3,273 Navarro County Confirmed Cases 2,985 Jim Wells County Confirmed Cases 2,905 Henderson County Confirmed Cases 2,889 Atascosa County Confirmed Cases 2,855 Howard County Confirmed Cases 2,683 Nacogdoches County Confirmed Cases 2,678 Bee County Confirmed Cases 2,645 Wharton County Confirmed Cases 2,564 Caldwell County Confirmed Cases 2,532 San Patricio County Confirmed Cases 2,485 Cooke County Confirmed Cases 2,465 Uvalde County Confirmed Cases 2,427 Medina County Confirmed Cases 2,362 Erath County Confirmed Cases 2,335 Titus County Confirmed Cases 2,328 Lamar County Confirmed Cases 2,287 Scurry County Confirmed Cases 2,255 Waller County Confirmed Cases 2,252 Wilson County Confirmed Cases 2,172 Hardin County Confirmed Cases 2,125 Cherokee County Confirmed Cases 2,085 Fannin County Confirmed Cases 2,020 Palo Pinto County Confirmed Cases 1,997 Burnet County Confirmed Cases 1,985 Matagorda County Confirmed Cases 1,984 Hill County Confirmed Cases 1,951 Jones County Confirmed Cases 1,926 Moore County Confirmed Cases 1,859 Deaf Smith County Confirmed Cases 1,839 Van Zandt County Confirmed Cases 1,830 Hockley County Confirmed Cases 1,815 Gonzales County Confirmed Cases 1,803 Kerr County Confirmed Cases 1,771 Willacy County Confirmed Cases 1,767 Grimes County Confirmed Cases 1,753 Harrison County Confirmed Cases 1,742 Frio County Confirmed Cases 1,728 Rusk County Confirmed Cases 1,686 Lavaca County Confirmed Cases 1,641 Brown County Confirmed Cases 1,604 Dawson County Confirmed Cases 1,560 Andrews County Confirmed Cases 1,558 DeWitt County Confirmed Cases 1,548 Gray County Confirmed Cases 1,534 Kleberg County Confirmed Cases 1,515 Terry County Confirmed Cases 1,475 Young County Confirmed Cases 1,474 Montague County Confirmed Cases 1,438 Lamb County Confirmed Cases 1,390 Nolan County Confirmed Cases 1,381 Wood County Confirmed Cases 1,378 Gillespie County Confirmed Cases 1,349 Wilbarger County Confirmed Cases 1,322 Karnes County Confirmed Cases 1,321 Gaines County Confirmed Cases 1,295 Hopkins County Confirmed Cases 1,273 Washington County Confirmed Cases 1,268 Childress County Confirmed Cases 1,231 Calhoun County Confirmed Cases 1,228 Falls County Confirmed Cases 1,226 Polk County Confirmed Cases 1,226 Austin County Confirmed Cases 1,164 Jackson County Confirmed Cases 1,160 Limestone County Confirmed Cases 1,149 Pecos County Confirmed Cases 1,142 Zapata County Confirmed Cases 1,126 Kendall County Confirmed Cases 1,109 Zavala County Confirmed Cases 1,082 Colorado County Confirmed Cases 1,044 Madison County Confirmed Cases 997 Cass County Confirmed Cases 960 Duval County Confirmed Cases 948 Milam County Confirmed Cases 936 Upshur County Confirmed Cases 927 Comanche County Confirmed Cases 913 Hutchinson County Confirmed Cases 896 Burleson County Confirmed Cases 891 Brewster County Confirmed Cases 888 Ochiltree County Confirmed Cases 865 Reeves County Confirmed Cases 813 Clay County Confirmed Cases 810 Fayette County Confirmed Cases 803 Parmer County Confirmed Cases 803 Yoakum County Confirmed Cases 801 Dimmit County Confirmed Cases 796 Bosque County Confirmed Cases 790 Lampasas County Confirmed Cases 782 Robertson County Confirmed Cases 777 Panola County Confirmed Cases 776 Jasper County Confirmed Cases 762 Live Oak County Confirmed Cases 747 Shelby County Confirmed Cases 741 Houston County Confirmed Cases 729 Eastland County Confirmed Cases 698 Camp County Confirmed Cases 665 Freestone County Confirmed Cases 659 Runnels County Confirmed Cases 657 Leon County Confirmed Cases 637 Aransas County Confirmed Cases 636 Bandera County Confirmed Cases 626 Presidio County Confirmed Cases 614 Archer County Confirmed Cases 605 Castro County Confirmed Cases 600 La Salle County Confirmed Cases 587 Brooks County Confirmed Cases 579 Lynn County Confirmed Cases 568 Ward County Confirmed Cases 560 Bailey County Confirmed Cases 554 Llano County Confirmed Cases 532 Mitchell County Confirmed Cases 532 Hamilton County Confirmed Cases 482 Somervell County Confirmed Cases 480 Refugio County Confirmed Cases 479 Callahan County Confirmed Cases 475 Lee County Confirmed Cases 471 Hudspeth County Confirmed Cases 465 Jack County Confirmed Cases 460 Winkler County Confirmed Cases 455 Tyler County Confirmed Cases 454 Morris County Confirmed Cases 439 Dallam County Confirmed Cases 430 San Jacinto County Confirmed Cases 415 Hemphill County Confirmed Cases 406 Jim Hogg County Confirmed Cases 405 Coleman County Confirmed Cases 404 Stephens County Confirmed Cases 397 Franklin County Confirmed Cases 386 Wheeler County Confirmed Cases 385 San Saba County Confirmed Cases 371 McCulloch County Confirmed Cases 357 Swisher County Confirmed Cases 355 Martin County Confirmed Cases 338 Red River County Confirmed Cases 336 Trinity County Confirmed Cases 335 San Augustine County Confirmed Cases 316 Hansford County Confirmed Cases 315 Rains County Confirmed Cases 296 Hartley County Confirmed Cases 292 Mills County Confirmed Cases 277 Culberson County Confirmed Cases 270 Floyd County Confirmed Cases 269 Fisher County Confirmed Cases 261 Blanco County Confirmed Cases 260 Crosby County Confirmed Cases 258 Hardeman County Confirmed Cases 257 Marion County Confirmed Cases 257 Hall County Confirmed Cases 252 Kinney County Confirmed Cases 243 Real County Confirmed Cases 241 Crockett County Confirmed Cases 240 Sutton County Confirmed Cases 240 Newton County Confirmed Cases 234 Coke County Confirmed Cases 229 Lipscomb County Confirmed Cases 226 Goliad County Confirmed Cases 220 Mason County Confirmed Cases 205 Cochran County Confirmed Cases 201 Carson County Confirmed Cases 197 Garza County Confirmed Cases 191 Reagan County Confirmed Cases 189 Kimble County Confirmed Cases 186 Crane County Confirmed Cases 182 Edwards County Confirmed Cases 181 Haskell County Confirmed Cases 170 Collingsworth County Confirmed Cases 168 Sabine County Confirmed Cases 167 Knox County Confirmed Cases 142 Concho County Confirmed Cases 141 Donley County Confirmed Cases 137 Cottle County Confirmed Cases 130 Menard County Confirmed Cases 130 Delta County Confirmed Cases 111 Baylor County Confirmed Cases 106 Schleicher County Confirmed Cases 105 Sherman County Confirmed Cases 101 Jeff Davis County Confirmed Cases 98 Shackelford County Confirmed Cases 91 Dickens County Confirmed Cases 90 Oldham County Confirmed Cases 90 Armstrong County Confirmed Cases 83 Terrell County Confirmed Cases 65 Briscoe County Confirmed Cases 64 Upton County Confirmed Cases 61 McMullen County Confirmed Cases 55 Foard County Confirmed Cases 54 Roberts County Confirmed Cases 46 Stonewall County Confirmed Cases 46 Sterling County Confirmed Cases 43 Glasscock County Confirmed Cases 42 Irion County Confirmed Cases 37 Throckmorton County Confirmed Cases 35 Kent County Confirmed Cases 32 Motley County Confirmed Cases 31 Kenedy County Confirmed Cases 15 Borden County Confirmed Cases 12 King County Confirmed Cases 4 Loving County Confirmed Cases 1 https://txdshs.maps.arcgis.com/apps/opsdashboard/index.html#/ed483ecd702b4298ab01e8b9cafc8b83

https://portal.ct.gov/Coronavirus/COVID-19-Data-Tracker

New Cases* 5,318 New Deaths* 58 New Tests* 48,118 Total Cases 361,148 Total Deaths 8,080 Total Tests 4,805,202 320,462 Confirmed 40,686 Probable 7,631 Confirmed 449 Probable 4,523,263 Molecular 281,939 Antigen COVID Patients 1,975 in Hospitals* COVID Patients 245 on Ventilators* Presumed Recovered 298,614 as of January 11th* https://ldh.la.gov/coronavirus/

Regional Metrics can be found here. Mitigations can be found here Vaccines Administered 414,296 Click Here for Vaccination Details Total Cases 1,052,682 Confirmed Deaths 17,928 Probable Deaths 1,796 http://www.dph.illinois.gov/covid19#tab-0-0 Total Tests Performed* 14,457,620 Recovery Rate** 98% *Total molecular and antigen tests performed and reported electronically for testing of COVID-19 at IDPH, commercial or hospital laboratories. All numbers displayed are provisional and will change. ** Recovered cases are defined as persons with initial positive specimen collection date > 42 days who have not expired. Recovery rate is calculated as the recovered cases divided by the sum of recovered cases and deceased cases. Information regarding the number of persons under investigation updated on 1/14/2021. Information to be updated daily.

https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html

https://covid19tracker.health.ny.gov/views/NYS-COVID19-Tracker/NYSDOHCOVID-19Tracker-Map?%3Aembed=yes&%3Atoolbar=no&%3Atabs=n

https://www.mass.gov/info-details/covid-19-response-reporting

Middlesex County 611 New Confirmed Cases 1,567 Confirmed Deaths 73 New Probable Cases 52,202 Total Confirmed Cases 216 Probable Deaths 3,508 Total Probable Cases Essex County 591 New Confirmed Cases 2,202 Confirmed Deaths 101 New Probable Cases 53,161 Total Confirmed Cases 257 Probable Deaths 4,350 Total Probable Cases Bergen County 573 New Confirmed Cases 2,130 Confirmed Deaths 236 New Probable Cases 53,264 Total Confirmed Cases 267 Probable Deaths 5,838 Total Probable Cases Monmouth County 524 New Confirmed Cases 1,038 Confirmed Deaths 93 New Probable Cases 38,325 Total Confirmed Cases 102 Probable Deaths 3,411 Total Probable Cases Hudson County 519 New Confirmed Cases 1,599 Confirmed Deaths 122 New Probable Cases 50,262 Total Confirmed Cases 170 Probable Deaths 3,994 Total Probable Cases Ocean County 499 New Confirmed Cases 1,410 Confirmed Deaths 144 New Probable Cases 38,405 Total Confirmed Cases 91 Probable Deaths 4,295 Total Probable Cases Camden County 342 New Confirmed Cases 845 Confirmed Deaths 73 New Probable Cases 32,833 Total Confirmed Cases 67 Probable Deaths 3,034 Total Probable Cases Union County 335 New Confirmed Cases 1,421 Confirmed Deaths 120 New Probable Cases 40,694 Total Confirmed Cases 186 Probable Deaths 5,658 Total Probable Cases Passaic County 301 New Confirmed Cases 1,365 Confirmed Deaths 73 New Probable Cases 43,423 Total Confirmed Cases 159 Probable Deaths 3,465 Total Probable Cases Morris County 284 New Confirmed Cases 817 Confirmed Deaths 69 New Probable Cases 23,620 Total Confirmed Cases 194 Probable Deaths 3,682 Total Probable Cases Burlington County 230 New Confirmed Cases 607 Confirmed Deaths 51 New Probable Cases 24,973 Total Confirmed Cases 52 Probable Deaths 2,491 Total Probable Cases Gloucester County 219 New Confirmed Cases 419 Confirmed Deaths 20 New Probable Cases 16,755 Total Confirmed Cases 21 Probable Deaths 2,127 Total Probable Cases Atlantic County 216 New Confirmed Cases 382 Confirmed Deaths 56 New Probable Cases 14,583 Total Confirmed Cases 18 Probable Deaths 3,565 Total Probable Cases Mercer County 160 New Confirmed Cases 726 Confirmed Deaths 12 New Probable Cases 21,161 Total Confirmed Cases 38 Probable Deaths 1,095 Total Probable Cases Somerset County 149 New Confirmed Cases 612 Confirmed Deaths 78 New Probable Cases 14,456 Total Confirmed Cases 94 Probable Deaths 3,059 Total Probable Cases Cumberland County 106 New Confirmed Cases 243 Confirmed Deaths 23 New Probable Cases 9,270 Total Confirmed Cases 12 Probable Deaths 1,682 Total Probable Cases Sussex County 78 New Confirmed Cases 183 Confirmed Deaths 30 New Probable Cases 5,677 Total Confirmed Cases 51 Probable Deaths 722 Total Probable Cases Warren County 59 New Confirmed Cases 173 Confirmed Deaths 14 New Probable Cases 4,704 Total Confirmed Cases 14 Probable Deaths 489 Total Probable Cases Hunterdon County 51 New Confirmed Cases 88 Confirmed Deaths 11 New Probable Cases 4,572 Total Confirmed Cases 54 Probable Deaths 439 Total Probable Cases Salem County 48 New Confirmed Cases 113 Confirmed Deaths 3 New Probable Cases 3,410 Total Confirmed Cases 8 Probable Deaths 364 Total Probable Cases Cape May County 41 New Confirmed Cases 130 Confirmed Deaths 33 New Probable Cases 2,780 Total Confirmed Cases 20 Probable Deaths 2,555 Total Probable Cases https://www.nj.gov/health/cd/topics/covid2019_dashboard.shtml

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization View ORCID ProfileZhuoming Liu, Laura A. VanBlargan, Louis-Marie Bloyet, View ORCID ProfilePaul W. Rothlauf, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, View ORCID ProfileElitza S. Theel, Mariel J. Liebeskind, Brynn Alford, William J. Buchser, View ORCID ProfileAli H. Ellebedy, View ORCID ProfileDaved H. Fremont, View ORCID ProfileMichael S. Diamond, View ORCID ProfileSean P. J. Whelan doi: https://doi.org/10.1101/2020.11.06.372037 This article is a preprint and has not been certified by peer review [what does this mean?]. Abstract Full Text Info/History Metrics Preview PDF ABSTRACT Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19 vaccines and have received emergency use authorization as therapeutics, viral escape mutants could compromise their efficacy. To define the immune-selected mutational landscape in S protein, we used a VSV-eGFP-SARS-CoV-2-S chimeric virus and 19 neutralizing monoclonal antibodies (mAbs) against the receptor-binding domain (RBD) to generate 50 different escape mutants. The variants were mapped onto the RBD structure and evaluated for cross-resistance to mAbs and convalescent human sera. Each mAb had a unique resistance profile, although many shared residues within an epitope. Some variants (e.g., S477N) were resistant to neutralization by multiple mAbs, whereas others (e.g., E484K) escaped neutralization by convalescent sera, suggesting some humans induce a narrow repertoire of neutralizing antibodies. Comparing the antibody-mediated mutational landscape in S with sequence variation in circulating SARS-CoV-2, we define substitutions that may attenuate neutralizing immune responses in some humans. https://www.biorxiv.org/content/10.1101/2020.11.06.372037v2.full

Wales/PHWC-4AF5F1/2020 12/29 matched UK variant with 3 AAs deleted in Spike protein, 3 AAs deleted in NSP6 and Q27 stop codon in NS8. map update https://www.google.com/maps/d/u/1/edit?mid=1aQDSL2LwQFbuoCAg_nIOPK8D-LIJ5MYd&ll=51.58432417696227%2C-3.543659028436452&z=9

COG-UK has released (at GISAID) a UK Variant B.1.1.7 SARS CoV2 sequence, Wales/PHWC-4AF5F1/2020, from Wales, which had acquired Spike E484K.

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization View ORCID ProfileZhuoming Liu, Laura A. VanBlargan, Louis-Marie Bloyet, View ORCID ProfilePaul W. Rothlauf, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, View ORCID ProfileElitza S. Theel, Mariel J. Liebeskind, Brynn Alford, William J. Buchser, View ORCID ProfileAli H. Ellebedy, View ORCID ProfileDaved H. Fremont, View ORCID ProfileMichael S. Diamond, View ORCID ProfileSean P. J. Whelan doi: https://doi.org/10.1101/2020.11.06.372037 This article is a preprint and has not been certified by peer review [what does this mean?]. Abstract Full Text Info/History Metrics Preview PDF ABSTRACT Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19 vaccines and have received emergency use authorization as therapeutics, viral escape mutants could compromise their efficacy. To define the immune-selected mutational landscape in S protein, we used a VSV-eGFP-SARS-CoV-2-S chimeric virus and 19 neutralizing monoclonal antibodies (mAbs) against the receptor-binding domain (RBD) to generate 50 different escape mutants. The variants were mapped onto the RBD structure and evaluated for cross-resistance to mAbs and convalescent human sera. Each mAb had a unique resistance profile, although many shared residues within an epitope. Some variants (e.g., S477N) were resistant to neutralization by multiple mAbs, whereas others (e.g., E484K) escaped neutralization by convalescent sera, suggesting some humans induce a narrow repertoire of neutralizing antibodies. Comparing the antibody-mediated mutational landscape in S with sequence variation in circulating SARS-CoV-2, we define substitutions that may attenuate neutralizing immune responses in some humans. https://www.biorxiv.org/content/10.1101/2020.11.06.372037v2.full

England/EXET-1405B9/2020 12/26 matched UK variant with 3 AAs deleted in Spike protein, 3 AAs deleted in NSP6 and Q27 stop codon in NS8. map update https://www.google.com/maps/d/u/1/edit?mid=1aQDSL2LwQFbuoCAg_nIOPK8D-LIJ5MYd&ll=50.7436685025219%2C-3.6669996410059476&z=10

COG-UK has released (at GISAID) a UK Variant B.1.1.7 SARS CoV2 sequences, England/EXET-1405B9/2020, from Exeter, which had acquired Spike E484G.

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization View ORCID ProfileZhuoming Liu, Laura A. VanBlargan, Louis-Marie Bloyet, View ORCID ProfilePaul W. Rothlauf, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, View ORCID ProfileElitza S. Theel, Mariel J. Liebeskind, Brynn Alford, William J. Buchser, View ORCID ProfileAli H. Ellebedy, View ORCID ProfileDaved H. Fremont, View ORCID ProfileMichael S. Diamond, View ORCID ProfileSean P. J. Whelan doi: https://doi.org/10.1101/2020.11.06.372037 This article is a preprint and has not been certified by peer review [what does this mean?]. Abstract Full Text Info/History Metrics Preview PDF ABSTRACT Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19 vaccines and have received emergency use authorization as therapeutics, viral escape mutants could compromise their efficacy. To define the immune-selected mutational landscape in S protein, we used a VSV-eGFP-SARS-CoV-2-S chimeric virus and 19 neutralizing monoclonal antibodies (mAbs) against the receptor-binding domain (RBD) to generate 50 different escape mutants. The variants were mapped onto the RBD structure and evaluated for cross-resistance to mAbs and convalescent human sera. Each mAb had a unique resistance profile, although many shared residues within an epitope. Some variants (e.g., S477N) were resistant to neutralization by multiple mAbs, whereas others (e.g., E484K) escaped neutralization by convalescent sera, suggesting some humans induce a narrow repertoire of neutralizing antibodies. Comparing the antibody-mediated mutational landscape in S with sequence variation in circulating SARS-CoV-2, we define substitutions that may attenuate neutralizing immune responses in some humans. https://www.biorxiv.org/content/10.1101/2020.11.06.372037v2.full