niman

Denmark/DCGC-659145/2023 collected 8/28/23 NSP3 K1155R BA.2.86.1

NSP12 G671S @GISAID BA.2.86 =1 Delta = 4,467,866

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=-26.25894758327452%2C28.024281458958956&z=10

P323L/G671S mutation in NSP12 provides significant replication advantages in the upper respiratory tract to become prevalent relative to other strains in an in vivo competitive transmission assay with NSP12 wild-type (WT) or NSP12 mutant-containing reverse genetic (RG) SARS-CoV-2 viruses. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01088-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723010884%3Fshowall%3Dtrue

South Africa/NHLS_NCV1886/2023 Gauteng collected 8/15/23 NSP12 G671S

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=-26.25894758327452%2C28.024281458958956&z=10

South Africa/NHLS_NCV1886/2023 Gauteng collected 8/15/23

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=51.60585617190745%2C-0.24485829634731449&z=12

England/CLIMB-CM7YK96Y/2023 England Collected 9/1/23 NSP3 K1155R BA.2.86.1 H/T @OliasDave https://ukcovid.xyz/ba_2_86_daily.php

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=51.60393704580627%2C-0.23112538619106449&z=12

England/CLIMB-CM7YRDUI/2023 England Collected 8/31/23 NS7a E22D H/T @OliasDave https://ukcovid.xyz/ba_2_86_daily.php

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=51.56489765451267%2C-0.24794820113247074&z=12

England/CLIMB-CM7Y8R56/2023 collected 8/28/23 NSP3 K1155R BA.2.86.1 H/T @OliasDave https://ukcovid.xyz/ba_2_86_daily.php

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=51.56873894762583%2C-0.26511433882778324&z=12

England/CLIMB-CM7YFGBC/2023 collected 8/16/23 NSP3 K1155R BA.2.86.1 H/T @OliasDave https://ukcovid.xyz/ba_2_86_daily.php

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=48.379296617340586%2C10.793114416601556&z=11

Germany/BY-RKI-I-1137445/2023 Bavaria collected 8/21/23 S:ins16MPLF, V483del NSP3:K1155R BA.2.86.1

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.38320292502088%2C1.3332724967999843&z=9

England/CLIMB-CM7Y8QQI/2023 Norfolk collected 8/28/23 NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1

Of the 34 cases in England, 28 cases were from a single outbreak at a care home in Norfolk. Specialists from UKHSA have been working with Norfolk County Council to offer infection control advice and support. Staff and residents of the care home were asked to undergo polymerase chain reaction (PCR) testing by local health protection officials when an unusually high number of people became unwell. Positive samples were sent for whole genome sequencing at UKHSA laboratories, where BA.2.86 was confirmed in the majority of samples. Based on the information from this incident, it is too early to draw any conclusions about how BA.2.86 will behave in the wider UK population, but it is an early indicator that it may be sufficiently transmissible to have impact in close contact settings. UKHSA scientists are investigating this and will publish further analysis in future technical briefings. This variant has been detected in a number of countries globally. https://www.gov.uk/government/news/covid-19-variants-identified-in-the-uk-latest-update

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.26013615853829%2C0.7100108039062647&z=9

England/CLIMB-CM7YKSNI/2023 Norfolk 8/27/2023 collection S:D1139N S:V283del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1

Of the 34 cases in England, 28 cases were from a single outbreak at a care home in Norfolk. Specialists from UKHSA have been working with Norfolk County Council to offer infection control advice and support. Staff and residents of the care home were asked to undergo polymerase chain reaction (PCR) testing by local health protection officials when an unusually high number of people became unwell. Positive samples were sent for whole genome sequencing at UKHSA laboratories, where BA.2.86 was confirmed in the majority of samples. Based on the information from this incident, it is too early to draw any conclusions about how BA.2.86 will behave in the wider UK population, but it is an early indicator that it may be sufficiently transmissible to have impact in close contact settings. UKHSA scientists are investigating this and will publish further analysis in future technical briefings. This variant has been detected in a number of countries globally. https://www.gov.uk/government/news/covid-19-variants-identified-in-the-uk-latest-update

map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.25257080484408%2C0.6166270031249788&z=9

England/CLIMB-CM7YR8JE/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1