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Pregnant women are among nearly four dozen cases of the Zika virus reported in Illinois, the Illinois Department of Public Health said Thursday. The department reported 46 total cases of the virus statewide, with eight women listed in the Zika Virus Pregnancy Registry. A spokesperson for the department initially said the eight women were confirmed to have Zika virus, but later said five cases remained unclear. According to Divya Little with the IDPH, those five cases tested positive for a flavivirus, but Centers for Disease Control and Prevention officials could not determine whether the women had Zika virus or Dengue fever. Source: 46 Cases of Zika Virus Reported in Illinois, Health Officials Say | NBC Chicago http://www.nbcchicago.com/news/health/8-pregnant-women-in-illinois-have-zika-virus-health-officials-say-389219261.html#ixzz4GSh9dDIZ Follow us: @nbcchicago on Twitter | nbcchicago on Facebook

Two babies born with Zika-related microcephaly in California Filed Under: Zika Stephanie Soucheray | News Reporter | CIDRAP News | Aug 04, 2016 Share Tweet LinkedIn Email Print & PDF newborn_head-brennaval.jpg brennaval / Flickr cc Today the California Department of Public Health (CDPH) reported that two babies have been born with Zika-related microcephaly in that state. Officials said in a news release that both babies were born to mothers who acquired the infection outside of the United States. One of the mothers returned with her infant to her home country, while the other is still in California, according to CDPH officials. "This is a sobering reminder for Californians that Zika can cause serious harm to a developing fetus," said CDPH Director and State Health Officer Karen Smith, PhD. "We join the Centers for Disease Control and Prevention (CDC) in urging pregnant women to avoid travel to areas with known Zika transmission. Pregnant women who must travel to one of these areas should strictly follow steps to prevent mosquito bites and speak with a health care provider upon return." Pregnant women can also contract the virus through sexual contact with infected partners. The CDC recommends that all pregnant women with partners who may be at risk for Zika virus use condoms or abstain from sex throughout their pregnancy. While Aedes aegypti mosquitoes, the vectors for Zika, have been found in 12 California counties, the CDPH said there was no sign of local transmission with the two cases reported today. As of Jul 29, there were 114 travel-related Zika cases in California, 21 in pregnant women. New US cases According to the CDC, as of today there are 479 pregnant women in the 50 states who've tested positive for Zika virus and 493 in US territories. Those numbers are up by 46 and 61 women, respectively. In addition, 15 babies have been born in the United States with Zika-related birth defects, along with 6 pregnancy losses related to Zika virus, the CDC said in its weekly update today. Last week the agency reported 13 babies with birth defects. The number of poor pregnancy outcomes in US territories remained at 1, a pregnancy loss. In the past week the number of Zika cases in US territories—almost all in Puerto Rico—jumped again. The CDC noted 819 new cases, bringing the total to 5,548. The previous week saw a spike of 914 cases. In US states the number climbed by 168, to 1,825. The CDC said all but 6 of those cases are travel related. Florida has reported 15 locally acquired cases, but the CDC has confirmed just 6 of them. The CDC is reporting five cases of Guillain-Barre syndrome (GBS), a neurologic disorder. New York has the highest incidence of Zika virus infection, with 491 cases, followed by Florida, at 322. Microcephaly investigation in Brazil Yesterday Brazil's Ministry of Health announced an investigation into the 1,749 Zika-related microcephaly cases that country has seen since the epidemic began in October of 2015. The vast majority (1,400) of the birth defects are in the northeast part of the country, in and around the city of Salvador. According to CNN, researchers are tracking 1,200 babies with microcephaly in that city to better understand the disease and its link to Zika virus. They are also trying to develop interventions that will help babies with microcephaly. According to a story in Canada's Globe & Mail, the investigation will help answer why the microcephaly cases are clustered, if other illnesses are at play, and whether race, age, or economic status are influencing cases. A representative from the Ministry of Health is quoted in that story as saying the current "central theory" used to explain the Salvador cluster is that pregnant women are co-infected with chikungunya or dengue virus as well as Zika. WHO: More microcephaly Finally today, the World Health Organization (WHO) released its Zika situation report, stating there is no evident decline in the outbreak. As of Aug 3, 14 countries or territories reported Zika-related microcephaly. Brazil had the most (1,749) followed by Colombia (21) and the United States (19, which doesn't include the 2 reported by the CDC today). A total of 68 countries have reported Zika cases. Though microcephaly is the most severe outcome associated with Zika, the WHO reports that 16 countries also have documented cases of Zika-related GBS. See also: Aug 4 CDPH news release Aug 4 WHO situation report Aug 3 Globe & Mail article Aug 3 CNN story Aug 3 CDC Zika case counts Aug 4 CDC Zika in pregnancy counts Aug 4 CDC Zika birth defects counts http://www.cidrap.umn.edu/news-perspective/2016/08/two-babies-born-zika-related-microcephaly-california

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As of Thursday, August 4, 2016, VDH has reported 56 cases of Zika virus disease in Virginia residents to the CDC ( 7 in Northwest Region, 28 in Northern Region, 4 in Eastern Region, 10 in Central Region and 7 in Southwest Region). CDC has issued a travel alert (Level 2-Practice Enhanced Precautions) for people traveling to regions and certain countries where Zika virus transmission is ongoing. http://www.vdh.virginia.gov/zika/zika-virus-update/

As of Thursday, August 4, 2016, VDH has reported 56 cases of Zika virus disease in Virginia residents to the CDC ( 7 in Northwest Region, 28 in Northern Region, 4 in Eastern Region, 10 in Central Region and 7 in Southwest Region). CDC has issued a travel alert (Level 2-Practice Enhanced Precautions) for people traveling to regions and certain countries where Zika virus transmission is ongoing. *Updated weekly. Week runs Thursday – Wednesday.

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POSTED:AUG 04 2016 07:50PM PDT UPDATED:AUG 04 2016 10:22PM PDT SACRAMENTO, Calif. (KTVU & AP) -- The California Department of Public Health said Thursday that California now has two cases of babies born with birth defects due to the Zika virus. One of the affected babies was born in the past six months at Alta Bates Summit Medical Center in Berkeley with severe microcephly, a source told KTVU, and the mother had apparently traveled to Guatemala. http://www.ktvu.com/news/ktvu-local-news/185529083-story

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POSTED:AUG 04 2016 07:50PM PDT UPDATED:AUG 04 2016 10:22PM PDT SACRAMENTO, Calif. (KTVU & AP) -- The California Department of Public Health said Thursday that California now has two cases of babies born with birth defects due to the Zika virus. One of the affected babies was born in the past six months at Alta Bates Summit Medical Center in Berkeley with severe microcephly, a source told KTVU, and the mother had apparently traveled to Guatemala. http://www.ktvu.com/news/ktvu-local-news/185529083-story

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The Illinois Department of Public Health is reporting 46 cases of Zika virus disease statewide. http://www.dph.illinois.gov/topics-services/diseases-and-conditions/zika

The Illinois Department of Public Health is reporting 46 cases of Zika virus disease statewide.

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Zika Cases in New Jersey New Jersey County Confirmed Travel-Related Cases Bergen 15 Passaic 15 Middlesex 7 Burlington 5 Gloucester 1 Hudson 8 Essex 7 Union 6 Camden 4 Morris 4 Monmouth 2 Ocean 1 Hunterdon 2 Mercer 3 TOTAL 80 Last Updated: August 04, 2016 http://www.nj.gov/health/cd/zika/case_count.shtml

Zika Cases in New Jersey New Jersey County Confirmed Travel-Related Cases Bergen 15 Passaic 15 Middlesex 7 Burlington 5 Gloucester 1 Hudson 8 Essex 7 Union 6 Camden 4 Morris 4 Monmouth 2 Ocean 1 Hunterdon 2 Mercer 3 TOTAL 80 Last Updated: August 04, 2016

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Number of cases reported County/Area Today Year to Date (8/2-4/16) Albany 0 3 Broome 0 1 Clinton 0 1 Columbia 0 1 Dutchess 0 5 Erie 0 4 Lewis 0 1 Monroe 1 6 Nassau 1 31 Niagara 0 1 Oneida 1 3 Onondaga 0 5 Ontario 0 3 Orange 1 4 Otsego 0 1 Putnam 0 1 Rockland 0 7 St Lawrence 0 1 Schenectady 0 1 Suffolk 1 31 Tompkins 0 2 Westchester 0 14 NYS (ex NYC) 4 127 NYC 17 431 NYS Total Confirmed 21 558 NYS Pregnant Registry 0 25 NYS Total 21 583

The California Department of Public Health (CDPH) reported today that two infants with Zika-related microcephaly have been born in California to women who had Zika virus infections during pregnancy after spending time in a country where the virus is endemic. While mosquitoes that can carry the virus have been found in 12 California counties, there is no evidence these mosquitoes are transmitting Zika in the state at this time.“This is a sobering reminder for Californians that Zika can cause serious harm to a developing fetus,” said CDPH Director and State Health Officer Dr. Karen Smith. “We join the Centers for Disease Control and Prevention (CDC) in urging pregnant women to avoid travel to areas with known Zika transmission. Pregnant women who must travel to one of these areas should strictly follow steps to prevent mosquito bites and speak with a health care provider upon return.” http://www.cdph.ca.gov/Pages/NR16-47.aspx

http://www.cdc.gov/zika/geo/pregnancy-outcomes.html Pregnancy Outcomes in the United States and the District of Columbia Liveborn infants with birth defects* 15 Includes aggregated data reported to the US Zika Pregnancy Registry as of July 28, 2016 Pregnancy losses with birth defects** 6 Includes aggregated data reported to the US Zika Pregnancy Registry as of July 28, 2016 Pregnancy Outcomes in the United States Territories Liveborn infants with birth defects* 0 Includes aggregated data from the US territories reported to the US Zika Pregnancy Registry and data from Puerto Rico reported to the Zika Active Pregnancy Surveillance System as of July 28, 2016 Pregnancy losses with birth defects** 1 Includes aggregated data from the US territories reported to the US Zika Pregnancy Registry and data from Puerto Rico reported to the Zika Active Pregnancy Surveillance System as of July 28, 2016 What these numbers show These numbers reflect poor outcomes among pregnancies with laboratory evidence of possible Zika virus infection reported to the US Zika Pregnancy Registry. The number of live-born infants and pregnancy losses with birth defects are combined for the 50 US states, the District of Columbia, and the US territories. To protect the privacy of the women and children affected by Zika, CDC is not reporting individual state, tribal, territorial or jurisdictional level data. The poor birth outcomes reported include those that have been detected in infants infected with Zika before or during birth, including microcephaly, calcium deposits in the brain indicating possible brain damage, excess fluid in the brain cavities and surrounding the brain, absent or poorly formed brain structures, abnormal eye development, or other problems resulting from damage to brain that affects nerves, muscles and bones, such as clubfoot or inflexible joints. What these new numbers do not show These numbers are not real time estimates. They will reflect the outcomes of pregnancies reported with any laboratory evidence of possible Zika virus infection as of 12 noon every Thursday the week prior; numbers will be delayed one week. These numbers do not reflect outcomes among ongoing pregnancies. Although these outcomes occurred in pregnancies with laboratory evidence of Zika virus infection, we do not know whether they were caused by Zika virus infection or other factors. Where do these numbers come from? These data reflect pregnancies reported to the US Zika Pregnancy Registry. CDC, in collaboration with state, local, tribal and territorial health departments, established this registry for comprehensive monitoring of pregnancy and infant outcomes following Zika virus infection. The data collected through this system will be used to update recommendations for clinical care, to plan for services and support for pregnant women and families affected by Zika virus, and to improve prevention of Zika virus infection during pregnancy. These registries are covered by an assurance of confidentiality. This protection requires us to safeguard the information collected for the pregnant women and infants in the registries. * Includes microcephaly, calcium deposits in the brain indicating possible brain damage, excess fluid in the brain cavities and surrounding the brain, absent or poorly formed brain structures, abnormal eye development, or other problems resulting from damage to the brain that affects nerves, muscles and bones, such as clubfoot or inflexible joints. **Includes miscarriage, stillbirths, and terminations with evidence of the birth defects mentioned above Page last reviewed: June 15, 2016 Page last updated: August 4, 2016

Pregnancy Outcomes in the United States and the District of Columbia Liveborn infants with birth defects* 15 Includes aggregated data reported to the US Zika Pregnancy Registry as of July 28, 2016 Pregnancy losses with birth defects** 6 Includes aggregated data reported to the US Zika Pregnancy Registry as of July 28, 2016

As of August 3, 2016 (5 am EST) Zika virus disease and Zika virus congenital infection are nationally notifiable conditions. This update from the CDC Arboviral Disease Branch includes provisional data reported to ArboNET for January 01, 2015 – August 3, 2016. US States Locally acquired mosquito-borne cases reported: 6 Travel-associated cases reported: 1,818 Laboratory acquired cases reported: 1 Total: 1,825 Sexually transmitted: 16 Guillain-Barré syndrome: 5 US Territories Locally acquired cases reported: 5,525 Travel-associated cases reported: 23 Total: 5,548* Guillain-Barré syndrome: 18 *Sexually transmitted cases are not reported for areas with local mosquito-borne transmission of Zika virus because it is not possible to determine whether infection occurred due to mosquito-borne or sexual transmission. Laboratory-confirmed Zika virus disease cases reported to ArboNET by state or territory — United States, 2015–2016 (as of August 3, 2016) States Travel-associated cases* No. (% of cases in states) (N=1,819) Locally acquired cases† No. (% of cases in states) (N=6) Alabama 11 (1) 0 (0) Arizona 10 (1) 0 (0) Arkansas 5 (<1) 0 (0) California 87 (5) 0 (0) Colorado 19 (1) 0 (0) Connecticut 39 (2) 0 (0) Delaware 10 (1) 0 (0) District of Columbia 10 (1) 0 (0) Florida 322 (18) 6 (100) Georgia 42 (2) 0 (0) Hawaii 10 (1) 0 (0) Illinois 33 (2) 0 (0) Indiana 20 (1) 0 (0) Iowa 9 (1) 0 (0) Kansas 8 (<1) 0 (0) Kentucky 10 (1) 0 (0) Louisiana 9 (<1) 0 (0) Maine 9 (<1) 0 (0) Maryland 54 (3) 0 (0) Massachusetts 54 (3) 0 (0) Michigan 17 (1) 0 (0) Minnesota 29 (2) 0 (0) Mississippi 14 (1) 0 (0) Missouri 10 (<1) 0 (0) Montana 1 (<1) 0 (0) Nebraska 4 (<1) 0 (0) Nevada 11 (1) 0 (0) New Hampshire 8 (<1) 0 (0) New Jersey 50 (3) 0 (0) New Mexico 3 (<1) 0 (0) New York 491 (27) 0 (0) North Carolina 30 (1) 0 (0) North Dakota 1 (<1) 0 (0) Ohio 26 (1) 0 (0) Oklahoma 13 (1) 0 (0) Oregon 14 (1) 0 (0) Pennsylvania†† 58 (3) 0 (0) Rhode Island 18 (1) 0 (0) South Carolina 28 (2) 0 (0) Tennessee 22 (1) 0 (0) Texas 89 (5) 0 (0) Utah 6 (<1) 0 (0) Vermont 6 (<1) 0 (0) Virginia 57 (3) 0 (0) Washington 16 (1) 0 (0) West Virginia 9 (1) 0 (0) Wisconsin 17 (1) 0 (0) Territories Travel-associated cases* No. (% of cases in territories) (N=23) Locally acquired cases† No. (% of cases in territories) (N=5,525) American Samoa 0 (0) 44 (1) Puerto Rico 22 (96) 5,460 (99) US Virgin Islands 1 (4) 21 (<1) *Travelers returning from affected areas, their sexual contacts, or infants infected in utero †Presumed local mosquito-borne transmission †† One additional case acquired through laboratory transmission Page last reviewed: February 4, 2016 Page last updated: August 4, 2016

Pregnant Women with Any Laboratory Evidence of Possible Zika Virus Infection US States and the District of Columbia* 479 *Includes aggregated data reported to the US Zika Pregnancy Registry as of July 28, 2016 US Territories** 493 **Includes aggregated data from the US territories reported to the US Zika Pregnancy Registry and data from Puerto Rico reported to the Zika Active Pregnancy Surveillance System as of July 28, 2016

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