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University of Pittsburgh researcher recovers from Zika infectionJune 9, 2016 11:14 PM U.S. Centers for Disease Control and PreventionA female Aedes aegypti mosquito By Jill Daly / Pittsburgh Post-GazetteA University of Pittsburgh researcher is back at work conducting experiments with the Zika virus after becoming infected with the disease in the laboratory, Pitt and the Allegheny County Health Department reported Thursday. Identified only as female, she was the county’s fourth confirmed infection. Health officials said the researcher has recovered with no remaining symptoms and is doing well. Pitt spokesman Joe Miksch said she accidentally stuck herself with a needle on May 23 and developed symptoms on June 1. A blood sample was collected, and the case was reported to the county health department. When Zika was confirmed Wednesday, Mr. Miksch said, the university informed the county. Free of fever by Monday, the researcher returned to work, according to Mr. Miksch, and is following advice to wear long sleeves and pants and wear insect repellent for three weeks after the date of the needle stick, to prevent possible mosquito exposure to the virus. As part of an international research collaboration, Cura Zika, a number of Pitt researchers are involved in projects to track and mitigate infections, develop a vaccine and find ways to block the virus from breaching the barrier in the placenta to cause neurological damage in newborns. The Zika patient had not traveled to an affected area and was not infected through sexual transmission, according to the health department. “We want to remind residents that, despite this rare incident, there is still no current risk of contracting Zika from mosquitoes in Allegheny County,” Health Director Karen Hacker said in the announcement. “For those traveling to countries affected by Zika, we urge caution. Pregnant women particularly should avoid travel to affected countries.” Although the type of mosquito identified as spreading the virus is not common in the area, officials urge people to protect themselves from mosquitoes by using insect repellent containing DEET and removing standing water from outdoor property to reduce mosquito breeding. The most common symptoms of Zika are fever, rash, joint pain and conjunctivitis. People who have traveled to affected areas who have symptoms or are pregnant should contact their doctor or call the Allegheny County Health Department at 412-687-ACHD (2243). As of Thursday, 109 county residents have been approved for Zika testing. Updates on confirmed cases are posted on the Health Department’s website, www.achd.net. The CDC provides guidance for labs working with Zika: http://www.cdc.gov/zika/state-labs/biosafety-guidance.html. Jill Daly: [email protected], 412-263-1596. http://www.post-gazette.com/news/health/2016/06/09/Fourth-case-of-Zika-virus-reported-in-Allegheny-County/stories/201606090159

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June 9, 2016 Tests confirm two travelers infected with Zika virusThe Missouri Department of Health and Senior Services confirmed two additional cases of Zika virus. One case is a male Missouri resident who had travelled to the Dominican Republic. Another is a male Massachusetts resident visiting Missouri who sought assistance from a health care provider. The Massachusetts resident had travelled to Puerto Rico. Officials from the Missouri Department of Health and Senior Services have been in contact with their counterparts in Massachusetts. Nearly 80 percent of people infected with the virus will have no symptoms. Typically, symptoms are mild and include fever, rash, joint soreness and/or redness of eyes. International health officials have found a connection between pregnant women contracting the virus and a birth defect called microcephaly in their newborn infants. According to the CDC, babies with microcephaly often have smaller head sizes and brains that might not have developed properly. According to the CDC, Zika virus has the potential to be spread through a mosquito bite, through unprotected sexual contact, through blood transfusion and an infected pregnant woman can pass Zika virus to her fetus during pregnancy. There is not currently a vaccine for Zika virus. The best prevention measure is to avoid mosquito bites in areas with ongoing transmission. There have been no reported cases of Zika virus contracted from a mosquito bite in Missouri. Ways to avoid mosquito bites while outdoors include wearing EPA-registered insect repellent with DEET, wearing pants and long sleeves, or remaining indoors in an air conditioned environment. The CDC is recommending pregnant women avoid traveling to Zika-affected areas which include countries ranging from Mexico into the Caribbean, Central American and South America. Since the beginning of the year, DHSS has regularly updated health care providers and the public about Zika virus in addition to coordinating the approval of Missourians for testing by the CDC. Please consult CDC resources for a listing of all areas and other information about Zika virus:http://www.cdc.gov/zika/

The Missouri Department of Health and Senior Services confirmed two additional cases of Zika virus. One case is a male Missouri resident who had travelled to the Dominican Republic. Another is a male Massachusetts resident visiting Missouri who sought assistance from a health care provider. The Massachusetts resident had travelled to Puerto Rico. http://health.mo.gov/information/news/2016/zika6916

WHO says delaying pregnancy option for women in Zika areasBy LAURAN NEERGAARDJune 10, 2016 3:49 amShare FILE - In this Jan. 27, 2016, file photo, an Aedes aegypti mosquito is photographed through a microscope at the Fiocruz institute in Recife, Pernambuco state, Brazil. The World Health Organization says women who live in... WASHINGTON (AP) — The World Health Organization says women who live in areas where Zika is spreading should consider delaying pregnancy, since there’s no other sure way to avoid the virus’ devastating birth defects. The WHO stopped short of recommending that couples put pregnancy on hold. “It’s not saying they should delay. They should be given the information about it and offered that as an option,” WHO spokeswoman Nyka Alexander said Thursday. Zika is rapidly spreading through Latin America and the Caribbean, and health officials in several affected countries have made similar recommendations. But the WHO’s guidelines, updated last week, could affect millions of couples who live in outbreak areas. Zika causes only a mild and brief illness, at worst, in most people. But it can cause fetal death and severe brain defects in the children of women infected during pregnancy. There is no vaccine. In outbreak areas, the main defense is to avoid mosquito bites. But Zika also can be spread through unprotected sex with a man who was infected. Around the world, health officials have advised pregnant women not to travel to areas where Zika is spreading. And the U.S. Centers for Disease Control and Prevention has additional advice for non-pregnant travelers: Women should wait at least eight weeks after a Zika illness, or possible exposure to the virus, before trying to conceive. Men who had symptoms should wait at least six months before trying, the CDC recommends. In response to the WHO’s new guidelines, the CDC said health care providers should discuss Zika’s risks and how to prevent infection, and provide information about contraception. “As part of their pregnancy planning and counseling with their health care providers, some women and their partners residing in areas with active Zika virus transmission might decide to delay pregnancy,” the agency said in a statement. Zika also can be a hazard to the scientists studying it. The University of Pittsburgh said Thursday one of its researchers accidentally stuck herself with a needle during a Zika experiment and went on to develop symptoms. Pitt officials said the lab accident occurred last month and the researcher has recovered and returned to work. Nearly 700 infections have been reported in U.S. states. All were people who had traveled abroad, or who had sex with someone who did. The virus is spreading in Puerto Rico and health officials say clusters of illnesses are likely in the mainland U.S. as mosquito season heats up. On Thursday, CDC Director Tom Frieden made another plea for Congress to quickly provide funding needed to battle Zika. “Give us the money so we can work with American women and children and families to monitor the effects of Zika, so we can do a better job at killing mosquitoes to protect American women, and so we can develop better tools to diagnose Zika, to control mosquitoes and ultimately, with NIH in the lead, to find a vaccine to protect women,” Frieden said. The White House on Thursday hosted a video teleconference involving administration officials, the CDC and Southern governors such as Rick Scott of Florida to go over Zika response planning as the likelihood of Zika cases is increasing with the summer heat. “We are likely to see single cases of transmission and we could certainly see clusters in some at-risk communities, and we want to make sure we do everything possible to get ahead of them,” Frieden told reporters later. Frieden said a key element of the federal response is CDC rapid response teams when cases arise. The Obama administration requested $1.9 billion in February, to allow officials to continue Zika prevention efforts and begin studying long-term effects of people infected by the disease. In Congress, the House and Senate each passed Zika bills that would provide funding at levels lower than the administration’s request. The Senate voted late Wednesday to begin talks with the House on compromise legislation. The Senate proposal includes $1.1 billion without spending cuts to offset the expense, while the House has backed a $622 million measure with cuts elsewhere. ___ Associated Press writers Mike Stobbe in New York, Kathleen Foody in Atlanta and Andrew Taylor in Washington contributed to this report. http://wtop.com/dc/2016/06/who-says-delaying-pregnancy-option-for-women-in-zika-areas-2/

Pittsburgh researcher infected with Zika in lab accidentBy MIKE STOBBE Jun. 9, 2016 5:03 PM EDT NEW YORK (AP) — The University of Pittsburgh says one of its researchers became infected with the Zika virus in a lab accident. The scientist accidentally stuck herself with a needle last month during a Zika experiment. She developed Zika symptoms last week and lab tests confirmed the infection. Pitt officials on Thursday said the researcher has recovered and returned to work. The virus is spread mainly through the bite of a tropical mosquito. It causes only a mild and brief illness, at worst, in most people. But it can cause fetal deaths and severe birth defects in the children of women infected during pregnancy. Nearly 700 infections have been reported in the 50 states. All were people who had traveled abroad, or who had sex with someone who did. http://bigstory.ap.org/article/fa641974dd1a4f8d8891a1eb794e2118/pittsburgh-researcher-infected-zika-lab-accident

World Health Organisation advises people to delay pregnancy in Zika transmission countriesZika outbreak: how the virus has spread - in 90 secondsPlay!01:32 Barney Henderson, new york 9 JUNE 2016 • 9:09PMThe World Health Organisation has concluded that people living in areas where Zika transmission is ongoing should consider delaying pregnancy, in new advice that could affect millions of couples. The Zika virus, which can lead to severe brain damage among babies, is prevalent in 46 countries across Latin America and the Caribbean. It has so far infected more than 7,000 babies worldwide. The new advice from the WHO is effectively an acknowledgment that, with no vaccine available, delaying pregnancy is the best option for couples in those countries to avoid having babies with birth defects. What is the Zika virus and how can you avoid catching it?Play!01:33 "In order to prevent adverse pregnancy and fetal outcomes, men and women of reproductive age, living in areas where local transmission of Zika virus is known to occur, [should] be correctly informed and oriented to consider delaying pregnancy," the WHO guidelines clarified on Thursday. The governments of five countries in the region have so far issued similar advice independently, but this is the first time such a sweeping recommendation with the potential for affecting millions of people has been made by the world health body. The WHO declared last month that the Zika virus is expected to spread to Europe in coming months, with some of the most popular holiday destinations for Britons likely to carry risks of disease transmission. The rapid spread of Zika has caused fears ahead of the Olympics in Rio, which start in less than two months, with several athletes deciding not to travel to Brazil, the country hardest hit by Zika. The WHO will convene experts next week to discuss the Zika outbreak, including its impact on the Rio Olympics. Brazilian authorities have confirmed more than 1,400 cases of microcephaly in babies whose mothers were exposed to Zika during pregnancy. The group of independent experts will "look at evidence around the Olympics and most likely review the travel guidance around that," Christian Lindmeier, WHO spokesman, said. A letter signed by more than 200 bioethicists and health experts has called for the WHO to recommend postponing or moving the Olympics to prevent an acceleration of the epidemic's spread. The WHO has rejected the call, saying the Games would not have a significant public health impact. But last week, the agency said it would take up the issue during its emergency committee meeting. Experts state the mosquito-born virus is to blame for a surge in cases of microcephaly - a serious birth defect in which babies are born with unusually small heads and brains. As a result, all experts state that pregnant women should avoid travel to any country with active Zika transmission. http://www.telegraph.co.uk/news/2016/06/09/world-health-organisation-advises-people-to-delay-pregnancy-in-z/

Researcher Infected With Zika Virus During Laboratory Accident in PittsburghBy MICHAEL NEDELMAN Jun 9, 2016, 6:07 PM ET Press Association Images via AP PhotoWATCH Researcher Infected With Zika Virus During Lab Accident773SHARES EmailA female researcher was accidentally infected with the Zika virus during a laboratory experiment at the University of Pittsburgh, marking the first reported case of someone getting the virus through a needle stick, university officials said today. The researcher accidentally pricked herself with a needle on May 23 and developed symptoms on June 1, according to a university statement. She returned to work five days later when she no longer had a fever, according to the statement. “We want to remind residents that, despite this rare incident, there is still no current risk of contracting Zika from mosquitoes in Allegheny County,” Dr. Karen Hacker, director of the Allegheny County Health Department, said in a separate statement today. Even so, the researcher plans to wear insect repellent, long sleeves and pants for three weeks, according to the University of Pittsburgh. This aligns with recommendations from the U.S. Centers for Disease Control and Prevention for all returning travelers, even if they do not feel sick, to prevent spreading the virus through mosquitoes that have been previously foundin about 30 states, including Pennsylvania. The concern is that if one of those mosquitoes bites someone infected with the Zika virus, then it could be transmitted to another person through that mosquito's bite. Hacker said that Allegheny County has not seen the mosquitoes so far this year that are known to carry the Zika virus, but that they are monitoring for it. “The areas of the country where people are more concerned are in the more humid and tropical areas of the country,” Hacker told ABC News. “I think there’s a lot more attention there than the northern climes.” Common symptoms of the virus include fever, rash, joint pain, red eyes, muscle pain and headache. However, the majority of infected people experience no symptoms at all. The virus has been linked to a serious birth defect called microcephaly, characterized by an abnormally small head and brain, with significant developmental issues. Hacker confirmed that the laboratory researcher had not traveled to an endemic area, nor had she acquired the virus through sexual contact. The three other known Zika cases in Allegheny County were men who had contracted the virus abroad, she said. The Zika virus is known to spread through mosquito bite, unprotected sex, from mother to child, and through blood transfusion, according to the CDC, which has not recorded any cases of Zika transmission through blood transfusion or mosquito bites in the U.S. “We continue to believe that the risk of contracting Zika from mosquitoes is relatively low -- extremely low -- for our county,” Hacker said. http://abcnews.go.com/Health/researcher-infected-zika-virus-laboratory-accident-pittsburgh/story?id=39736836

Fri Jun 10, 2016 1:53am EDTRelated: U.S., HEALTHU.S. researcher contracts Zika during experiment: media Aedes aegypti mosquitoes are seen at the Laboratory of Entomology and Ecology of the Dengue Branch of the U.S. Centers for Disease Control and Prevention in San Juan, March 6, 2016.REUTERS/ALVIN BAEZ A United States laboratory researcher was back at work after contracting the Zika virus by pricking herself with a needle during an experiment last month, broadcaster ABC News said on Thursday. There is no vaccine or treatment for Zika, which is a close cousin of diseases such as dengue and chikungunya, and causes mild fever, rash and red eyes. An estimated 80 percent of those infected have no symptoms. The unidentified researcher at the University of Pittsburgh pricked herself on May 23 and showed symptoms on June 1, returning to work five days later when she no longer had a fever, ABC News said, citing a statement from the school. School officials were not immediately available for comment. The incident was the fourth confirmed case of the Zika virus in Allegheny County, its health department said, without giving details of the accident. "Despite this rare incident, there is still no current risk of contracting Zika from mosquitos in Allegheny County," department director Karen Hacker said in a statement. U.S. health officials have concluded that Zika infections in pregnant women can cause microcephaly, a birth defect marked by small head size that can lead to severe developmental problems in babies. The World Health Organization has said there is strong scientific consensus that Zika can also cause Guillain-Barre, a rare neurological syndrome that causes temporary paralysis in adults. The connection between Zika and microcephaly first came to light last fall in Brazil, which has now confirmed more than 1,400 cases of microcephaly that it considers to be related to Zika infections in the mothers. To reduce the chance of virus transmission, the Pittsburgh researcher is using insect repellent to avoid mosquito bites, besides wearing garments with long sleeves and trousers, ABC News added. (Reporting by Brendan O'Brien in Milwaukee; Editing by Clarence Fernandez) http://www.reuters.com/article/us-health-zika-pittsburgh-idUSKCN0YW0E7

WHO Says People Living in Areas With Zika Should Delay PregnancyAlexandra Sifferlin @acsifferlinJune 9, 2016 The World Health Organization clarifies its adviceMen and women who are living in areas where Zika is actively spreading should consider delaying pregnancy, according to the World Health Organization (WHO). On Thursday, the agency released a correction to its guidance for preventing sexual transmission of Zika. “In order to prevent adverse pregnancy and fetal outcomes, men and women of reproductive age, living in areas where local transmission of Zika virus is known to occur, be correctly informed and oriented to consider delaying pregnancy,” the agency wrote. The agency said that the update to the recommendation was meant to make the agency’s recommendation to delay pregnancy more clear. “This was the original intention of the guidance,” the WHO said in a press release. The guidance was released last week, but the update added more clarity for people living in countries with active transmission compared to travelers. Other countries, like El Salvador, have been recommending that people delay pregnancies for quite some time. The country recommends people put off pregnancy for two years. Zika has now spread to close to 50 countries. In June it was reported that a baby was born in New Jersey with Zika-related microcephaly. http://time.com/4363441/world-health-organization-zika-delay-pregnancy/?xid=time_socialflow_twitter

Delay Pregnancy in Areas With Zika, W.H.O. SuggestsBy DONALD G. McNEIL Jr.JUNE 9, 2016 Continue reading the main storyShare This PageShareTweetEmailMorePeople living in areas where the Zika virus is circulating should consider delaying pregnancy to avoid having babies with birth defects, the World Health Organization has concluded. The advice affects millions of couples in 46 countries across Latin America and the Caribbean where Zika transmission is occurring or expected. According to a recent study, more than five million babies are born each year in parts of the Western Hemisphere where the mosquitoes known to spread the virus are found. At the moment, Puerto Rico, the United States Virgin Islands and American Samoa are the only parts of the United States with local transmission of the virus. But clusters of cases are expected to appear in Florida and along the Gulf Coast this summer. The governments of five countries have issued similar advice, as has the health secretary of Puerto Rico, but the Centers for Disease Control and Prevention has decided against this approach on the grounds that government doctors should not intrude on personal decisions best made by women and their partners. The virus, carried by the yellow fever mosquito, has been linked to abnormally small heads and brain damage in infants, a condition called microcephaly. In rare cases, the infection has caused paralysis and sometimes fatal complications in adults. The W.H.O.’s new guidelines essentially acknowledge that, with no vaccine available and mosquito eradication efforts failing to stem the spread of the infection, delaying pregnancy may be the best way that women in affected areas can avoid having children with severe brain damage. More than 1,500 babies have been born with microcephaly in Brazil. Six other countries and Puerto Rico have reported cases of microcephaly resulting from locally acquired Zika infections. The W.H.O. says men and women of reproductive age “should be correctly informed and oriented to consider delaying pregnancy.” The guidance was originally issued last week but did not garner wide notice among experts until Thursday, when the W.H.O. issued a clarification, distinguishing between people who visit Zika-affected countries and those who live in them. People living in those countries are not advised to delay for any specific amount of time, but that guidance “means delaying until we have more answers, more evidence, more science,” said Nyka Alexander, a W.H.O. spokeswoman. “But it’s important to understand that this is not the W.H.O. saying, ‘Hey everybody, don’t get pregnant.’ It’s that they should be advised about this, so they themselves can make the final decision.” Dr. Peter J. Hotez, dean of the National School of Tropical Medicine at the Baylor College of Medicine, said of the W.H.O. recommendation, “It’s about time.” His medical school is in Houston, and he has urged that women in areas where the virus is circulating or may circulate this summer avoid pregnancy if they can. “What happens when Zika hits Texas and the Gulf Coast this summer?” he asked. Dr. William Schaffner, head of preventive medicine at Vanderbilt University School of Medicine, called the W.H.O.’s advice “excellent.” “Now we just have to provide both the education and the means so that couples can implement,” he added. Brazil has noted the W.H.O.’s new guidance in a statement for its citizens, a spokesman for the Health Ministry said. But the ministry itself has now taken a softer stance, saying, “Pregnancy is a personal decision that should be evaluated and considered by a woman together with her family.” Some Brazilian virologists have pushed for emphatic advice to delay. The W.H.O. guidelines “understand the gravity of the situation,” said Dr. Artur Timerman, president of the Brazilian Society of Dengue and Arbovirus. His society recommends that women living in areas of active transmission postpone getting pregnant and that men who return from such areas use condoms for six months. Brazilian health officials did not provide enough leadership on the issue, he said. Dr. Celso Granato, a virologist at the Federal University of São Paulo, called the new W.H.O. guidelines “an important recommendation.” “At this moment, what we know for sure is that the infection of the fetus may be catastrophic,” he said, “so I think that all the possible ways to avoid these situations have to be taken.” In Atlanta, a C.D.C. spokeswoman said officials thought the W.H.O. guidelines were largely in line with the C.D.C.’s. On the issue of how long a man should wear a condom after visiting a Zika-affected country, they are now identical, which they were not before. For people living in areas with Zika transmission, C.D.C. guidelines say doctors or nurses “should discuss the risks of Zika, emphasize ways to prevent Zika virus infection, and provide information about safe and effective contraceptive methods.” Some women and their partners, they note, “may decide to delay pregnancy.” When the epidemic began, health officials in Brazil, Ecuador, Colombia,Jamaica and El Salvador asked women in their countries to delay pregnancy if they could. In some cases, they suggested waiting a few months; officials in Jamaica suggested a year, and those in El Salvador suggested waiting until 2018. The advice was sharply criticized by reproductive rights’ groups, which said it was hypocritical coming from governments that often outlawed abortion and made it difficult for women to get birth control. Some Roman Catholic archbishops also objected. Some infectious disease experts, however, said delaying pregnancy is the only sure way to prevent birth defects. Mosquito control had not previously stopped mosquito-borne viruses such as dengue or chikungunya, they pointed out, and a Zika vaccine is years away. If women were able to delay pregnancy for just one season in which Zika was widely transmitted, it is likely that so many people would gain immunity from having been bitten that the virus would either completely disappear — as happened in previous Pacific island outbreaks — or would circulate at only very low levels the following year. From the outset, the W.H.O. did endorse making birth control more available. Until recently, however, it had stopped short of advising women to consider delaying pregnancy. “Theoretically, many have thought it may work,” Dr. Bruce Aylward, the organization’s chief of emergency responses, said in February. But, he said, at that time experts thought the best approach was to fight mosquitoes while scientists worked on a vaccine. The revised guidelines are a result of meetings of global experts in mid-March “and further input from experts in the editing process,” said Ms. Alexander of the W.H.O. They were issued May 30, and the recommendation that some couples be “oriented” to consider delaying pregnancy was included in Section 4, Paragraph 1.c. But the agency drew no attention to it, and the new section was confusingly worded. On Thursday, the W.H.O. issued a clarification saying: “Men and women of reproductive age living in affected areas should be informed and orientated to consider delaying pregnancy. This was the original intention of the guidance. The correction makes this more clear.” Later Ms. Alexander said, “We should have done a better job of highlighting it.” Simon Romero and Vinod Sreeharsha contributed reporting. Like the Science Times page on Facebook. | Sign up for the Science Times newsletter. A version of this article appears in print on June 10, 2016, on page A1 of the New York edition with the headline: Delays Pregnancy in Zika Regions, W.H.O. Suggests. Order Reprints| Today's Paper|Subscribe

OverviewThe primary transmission route of Zika virus is via the Aedes mosquito. However, mounting evidence has shown that sexual transmission of Zika virus is possible and more common than previously assumed. This is of concern due to an association between Zika virus infection and adverse pregnancy and fetal outcomes, including microcephaly, neurological complications and Guillain-Barré syndrome. The current evidence base on Zika virus remains limited. This guidance will be reviewed and the recommendations updated as new evidence emerges. Related linksAll publications, technical guidances on Zika virusZika virus and potential complications

Prevention of sexual transmission of Zika virusInterim guidanceShare PrintAuthors: World Health Organization Publication detailsNumber of pages: 5 Publication date: Updated 7 June 2016 Languages: English WHO reference number:WHO/ZIKV/MOC/16.1 Rev.2 DownloadsPrevention of sexual transmission of Zika virushttp://www.who.int/csr/resources/publications/zika/sexual-transmission-prevention/en/

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State totals do not include recently reported pregnancy registry cases StatesCDCStatesStatesStatesStatesStatesCDCStates 1-Jun2-Jun2-Jun3-Jun6-Jun7-Jun8-Jun9-Jun9-JunAL525555525AR545555555AZ434444424CA504450535353534853CO222222244CT1911919191920120DE333333344DC566666666FL162128165165166171172132172GA171717171717181718HI98999991010IL181618181818181618IN677777777IA666777777KS222222222KY656666666LA444444444MD171919191919192121MA161717171717172017ME555555566MI466666677MN171717171717171717MO444444444MS333333333MT111111111NC121212121212121112ND101111101NE222222222NH444444444NJ161419201616211721NM112333333NV666666666NY183130184186189191204164208OH121212131414141414OK444444455OR1061010101012612PA191919191919192323RI444444444SC111111111TN344444444TX543654545454544054UT222222222VA181820202020202025VT111111111WA748888949WI222222222WV666666666 758618777786787794818691840

Pregnant Women with Any Laboratory Evidence of Possible Zika Virus InfectionUS States and the District of Columbia Pregnant women with any laboratory evidence of possible Zika virus infection: 206**This update includes aggregated data reported to the US Zika Pregnancy Registry as of June 2, 2016. US Territories Pregnant women with any laboratory evidence of possible Zika virus infection: 166**This update includes data from the US territories reported to the US Zika Pregnancy Registry and data from Puerto Rico reported to the Zika Active Pregnancy Surveillance System as of June 2, 2016. About These NumbersWhat these updated numbers show These updated numbers reflect counts of pregnant women in the United States with any laboratory evidence of possible Zika virus infection, with or without symptoms. Pregnant women with laboratory evidence include those in whom viral particles have been detected and those with evidence of an immune reaction to a recent virus that is likely to be Zika.This information will help healthcare providers as they counsel pregnant women affected by Zika and is essential for planning at the federal, state, and local levels for clinical, public health, and other services needed to support pregnant women and families affected by Zika.What these new numbers do not show These new numbers are not comparable to the previous reports. These updated numbers reflect a different, broader population of pregnant women.These updated numbers are not real time estimates. They will reflect the number of pregnant women reported with any laboratory evidence of possible Zika virus infection as of 12 noon every Thursday the week prior; numbers will be delayed one week.Where do these numbers come from? These data reflect pregnant women in the US Zika Pregnancy Registry and the Zika Active Pregnancy Surveillance System in Puerto Rico. CDC, in collaboration with state, local, tribal and territorial health departments, established these registries for comprehensive monitoring of pregnancy and infant outcomes following Zika virus infection. The data collected through these registries will be used to update recommendations for clinical care, to plan for services and support for pregnant women and families affected by Zika virus, and to improve prevention of Zika virus infection during pregnancy. Page last reviewed: May 20, 2016Page last updated: June 9, 2016

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Laboratory-confirmed Zika virus disease cases reported to ArboNET by state or territory — United States, 2015–2016 (as of June 08, 2016) http://www.cdc.gov/zika/geo/united-states.html StatesTravel-associated cases* No. (%) (N=691)Locally acquired cases† No. (%) (N=0)Alabama2 (<1)0 (0)Arizona2 (<1)0 (0)Arkansas5 (1)0 (0)California48 (7)0 (0)Colorado4 (1)0 (0)Connecticut1 (<1)0 (0)Delaware4 (1)0 (0)District of Columbia6 (1)0 (0)Florida132 (19)0 (0)Georgia17 (3)0 (0)Hawaii10 (2)0 (0)Illinois16 (2)0 (0)Indiana7 (1)0 (0)Iowa7 (1)0 (0)Kansas2 (<1)0 (0)Kentucky6 (1)0 (0)Louisiana4 (1)0 (0)Maine6 (1)0 (0)Maryland21 (3)0 (0)Massachusetts20 (3)0 (0)Michigan7 (1)0 (0)Minnesota17 (3)0 (0)Mississippi3 (<1)0 (0)Missouri4 (1)0 (0)Montana1 (<1)0 (0)Nebraska2 (<1)0 (0)Nevada6 (1)0 (0)New Hampshire4 (1)0 (0)New Jersey17 (3)0 (0)New Mexico3 (<1)0 (0)New York164 (24)0 (0)North Carolina11 (2)0 (0)Ohio14 (2)0 (0)Oklahoma5 (1)0 (0)Oregon6 (1)0 (0)Pennsylvania23 (3)0 (0)

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Laboratory-confirmed Zika virus disease cases reported to ArboNET by state or territory — United States, 2015–2016 (as of June 08, 2016) http://www.cdc.gov/zika/geo/united-states.html StatesTravel-associated cases* No. (%) (N=691)Locally acquired cases† No. (%) (N=0)Alabama2 (<1)0 (0)Arizona2 (<1)0 (0)Arkansas5 (1)0 (0)California48 (7)0 (0)Colorado4 (1)0 (0)Connecticut1 (<1)0 (0)Delaware4 (1)0 (0)District of Columbia6 (1)0 (0)Florida132 (19)0 (0)Georgia17 (3)0 (0)Hawaii10 (2)0 (0)Illinois16 (2)0 (0)Indiana7 (1)0 (0)Iowa7 (1)0 (0)Kansas2 (<1)0 (0)Kentucky6 (1)0 (0)Louisiana4 (1)0 (0)Maine6 (1)0 (0)Maryland21 (3)0 (0)Massachusetts20 (3)0 (0)Michigan7 (1)0 (0)Minnesota17 (3)0 (0)Mississippi3 (<1)0 (0)Missouri4 (1)0 (0)Montana1 (<1)0 (0)Nebraska2 (<1)0 (0)Nevada6 (1)0 (0)New Hampshire4 (1)0 (0)New Jersey17 (3)0 (0)New Mexico3 (<1)0 (0)New York164 (24)0 (0)North Carolina11 (2)0 (0)Ohio14 (2)0 (0)Oklahoma5 (1)0 (0)

Laboratory-confirmed Zika virus disease cases reported to ArboNET by state or territory — United States, 2015–2016 (as of June 08, 2016) http://www.cdc.gov/zika/geo/united-states.html StatesTravel-associated cases* No. (%) (N=691)Locally acquired cases† No. (%) (N=0)Alabama2 (<1)0 (0)Arizona2 (<1)0 (0)Arkansas5 (1)0 (0)California48 (7)0 (0)Colorado4 (1)0 (0)Connecticut1 (<1)0 (0)Delaware4 (1)0 (0)District of Columbia6 (1)0 (0)Florida132 (19)0 (0)Georgia17 (3)0 (0)Hawaii10 (2)0 (0)Illinois16 (2)0 (0)Indiana7 (1)0 (0)Iowa7 (1)0 (0)Kansas2 (<1)0 (0)Kentucky6 (1)0 (0)Louisiana4 (1)0 (0)Maine6 (1)0 (0)Maryland21 (3)0 (0)Massachusetts20 (3)0 (0)Michigan7 (1)0 (0)Minnesota17 (3)0 (0)Mississippi3 (<1)0 (0)Missouri4 (1)0 (0)Montana1 (<1)0 (0)Nebraska2 (<1)0 (0)Nevada6 (1)0 (0)New Hampshire4 (1)0 (0)New Jersey17 (3)0 (0)New Mexico3 (<1)0 (0)

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