niman Posted January 29, 2020 Report Posted January 29, 2020 (edited) Pasteur Institute has deposited full sequences from patients in Paris. The two sequences do not match the Shenzhen cluster,but do match each other - 32M matches 31F Edited January 29, 2020 by niman
niman Posted January 29, 2020 Author Report Posted January 29, 2020 (edited) Virus detail Virus name: BetaCoV/France/IDF0373/2020 Accession ID: EPI_ISL_406597 Type: betacoronavirus Passage details/history: Original Sample information Collection date: 2020-01-23 Location: France / Ile-de-France / Paris Host: Human Additional location information: Edited March 6, 2020 by niman
niman Posted January 29, 2020 Author Report Posted January 29, 2020 (edited) Virus detail Virus name: BetaCoV/France/IDF0372/2020 Accession ID: EPI_ISL_406596 Type: betacoronavirus Passage details/history: Original Sample information Collection date: 2020-01-23 Location: France / Ile-de-France / Paris Host: Human Additional location information: Edited March 6, 2020 by niman
realauren Posted January 29, 2020 Report Posted January 29, 2020 1 hour ago, niman said: Pasteur Institute has deposited full sequences from patients in Paris. The two sequences do not match the Shenzhen cluster,but do match each other - 32M matches 31F What exactly does that mean?
niman Posted January 29, 2020 Author Report Posted January 29, 2020 19 minutes ago, realauren said: What exactly does that mean? One infected the other or both infected by a common source.
realauren Posted January 29, 2020 Report Posted January 29, 2020 6 minutes ago, niman said: One infected the other or both infected by a common source. So this is a mutation from the original Shenzhen cluster or is there a lot more to this than my decaffeinated brain is trying to understand.
niman Posted January 29, 2020 Author Report Posted January 29, 2020 No, this one is not related to the Shenzhen cluster lineage.
psk Posted January 29, 2020 Report Posted January 29, 2020 Forgive my ignorance but does that mean there's more than one strain of this virus or that it's mutated?
niman Posted January 30, 2020 Author Report Posted January 30, 2020 There is one strain (2019-nCoV) that is rapidly evolving in many directions.
Jon Schultz Posted January 30, 2020 Report Posted January 30, 2020 Did you see the WHO press conference today? Dr. Michael Ryan completely avoided the question about whether the latest sequences show any significant changes by talking instead about how transparent and diligent China has been. It's at 14:50 in the video: https://www.pscp.tv/w/1OdJrqEvgaeGX The main thing he said which stood out in my mind is, "We have a chance."
CoffeeLover Posted January 30, 2020 Report Posted January 30, 2020 With the rapid evolving in many directions, what is the likelihood of a second recombination along with the orf-8? And is there a quasi-predictable timeframe?
osgo Posted January 30, 2020 Report Posted January 30, 2020 "...(2019-nCoV) that is rapidly evolving in many directions...." So, based on your experience, do virii evolve to become more lethal or to survive longer? In other words, do you see a stronger threat in the future?
niman Posted January 30, 2020 Author Report Posted January 30, 2020 33 minutes ago, osgo said: "...(2019-nCoV) that is rapidly evolving in many directions...." So, based on your experience, do virii evolve to become more lethal or to survive longer? In other words, do you see a stronger threat in the future? With sars the was a deletion of 29 nt in orf 8 which was associated with increased transmission and virulence. At this date in 2003 (prior to the deletion) there were 300 SARS cases and 5 deaths (over a 3 month time frame).
niman Posted January 30, 2020 Author Report Posted January 30, 2020 56 minutes ago, CoffeeLover said: With the rapid evolving in many directions, what is the likelihood of a second recombination along with the orf-8? And is there a quasi-predictable timeframe? A sequence released today, SZTH-001,which has the 2nd and 3rd Shenzhen mutation, including orf8, but the upsteam mutation was over-written with a segment with 22 mutations.
realauren Posted January 31, 2020 Report Posted January 31, 2020 On 1/29/2020 at 11:26 PM, niman said: A sequence released today, SZTH-001,which has the 2nd and 3rd Shenzhen mutation, including orf8, but the upsteam mutation was over-written with a segment with 22 mutations. Here is my ultimate question. Does these mutations have the possibility to effect current vaccine developments that are underway?
psk Posted January 31, 2020 Report Posted January 31, 2020 On 1/30/2020 at 1:20 AM, niman said: There is one strain (2019-nCoV) that is rapidly evolving in many directions. Thank you.
niman Posted January 31, 2020 Author Report Posted January 31, 2020 15 minutes ago, realauren said: Here is my ultimate question. Does these mutations have the possibility to effect current vaccine developments that are underway? Vaccine will target S (spike) gene. The cited mutations generally are not in S gene
realauren Posted January 31, 2020 Report Posted January 31, 2020 1 minute ago, niman said: Vaccine will target S (spike) gene. The cited mutations generally are not in S gene Ok, I know vaccines are way above my understanding outside of general immunological benefits. I really need to read up on how they go about doing it. But thank you for the clarification.
niman Posted January 31, 2020 Author Report Posted January 31, 2020 Also note that Paris lineage matches CA2 (Orange County) and TW2 (Taiwan)
CoffeeLover Posted January 31, 2020 Report Posted January 31, 2020 In layman's terms. There is rate of communicability and and the effect of the virus - recover or not. Is there something specific to watch for in the sequences or evolvement that would give definitive information that the virus has reached the tipping point, or does the lay observer just watch for the statistics to speak. Thank you.
niman Posted January 31, 2020 Author Report Posted January 31, 2020 I think that the rate of increase in cases and CFR in China and exports will speak volumes
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