niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 As of 4 September 2023, there are 34 BA.2.86 sequenced cases in England, with cases located in East of England, London, and North West England. Of 34 total cases in England, 5 were hospitalised (2 have unknown hospitalisation status), and no deaths due to COVID-19 have been reported. These cases include 28 sequenced as part of an investigation of an outbreak in a care home which reported a high attack rate. https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-technical-briefings/sars-cov-2-variant-surveillance-and-assessment-technical-briefing-53 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 On 21 August 2023 UKHSA was notified of an outbreak in a care home in the East of England with reports of an increased number of cases and increased severity compared to previous outbreaks at the home. All residents and symptomatic or lateral flow device (LFD) positive staff members were polymerase chain reaction (PCR) tested and PCR positive samples were referred to UKHSA for sequencing. As of 5 September 2023, 33 out of 38 residents have tested positive for SARS-CoV-2 (attack rate 86.6%). Of the 33 positive residents, 19 (57.6%) were symptomatic with symptom onset between the 20 August 2023 and 28 August 2023; 29 of the residents have now recovered, while 4 remain unwell. One resident was hospitalised as a result of their illness (hospitalisation rate, 3.0%), and no deaths due to COVID-19 have been reported. Twelve staff tested positive either by LFD and/or PCR, and all have now recovered. No staff members were hospitalised. https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-technical-briefings/sars-cov-2-variant-surveillance-and-assessment-technical-briefing-53 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 Note that the combination of NSP3:P153L (ORF1ab:P971L) with S:P681R identifies the England cluster as well as 12,504 Delta sequences circulating in circa 2021 (including 6,560 in USA) Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YREUP/2023 East of England 8/26/23 collection S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.42812397490462%2C0.22807734341037111&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YKTG8/2023 East of England 8/26/23 collection S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.427245147395865%2C0.12370636988726869&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YFM4D/2023 East of England 8/26/23 collection S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.28874394238443%2C0.14293244410601869&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7Y8E1Z/2023 East of England 8/26/23 collection S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.3029707598419%2C0.5741458230122687&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 Of the 34 cases in England, 28 cases were from a single outbreak at a care home in Norfolk. Specialists from UKHSA have been working with Norfolk County Council to offer infection control advice and support. Staff and residents of the care home were asked to undergo polymerase chain reaction (PCR) testing by local health protection officials when an unusually high number of people became unwell. Positive samples were sent for whole genome sequencing at UKHSA laboratories, where BA.2.86 was confirmed in the majority of samples. Based on the information from this incident, it is too early to draw any conclusions about how BA.2.86 will behave in the wider UK population, but it is an early indicator that it may be sufficiently transmissible to have impact in close contact settings. UKHSA scientists are investigating this and will publish further analysis in future technical briefings. This variant has been detected in a number of countries globally. https://www.gov.uk/government/news/covid-19-variants-identified-in-the-uk-latest-update Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YREUP/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.56350449895464%2C1.0589175515278937&z=10 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YKTG8/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.657566707679834%2C1.0012393288716437&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YFM4D/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.47196620727823%2C0.8593703144969789&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7Y8E1Z/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.37495989527911%2C0.9060622090282289&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YFOFH/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.53050329056678%2C1.0445274538549976&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YEMGS/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 map update https://www.google.com/maps/d/u/1/edit?mid=1OCfYIWOx61CCNsWu-FDaiTeSYn066gY&ll=52.675124048651796%2C1.0917693796875128&z=9 Link to comment Share on other sites More sharing options...
niman Posted September 8, 2023 Author Report Share Posted September 8, 2023 England/CLIMB-CM7YKJPS/2023 Norfolk 8/26/23 collection S: ins16 not detected S:V483del NSP3:P153L NSP2:Y441C NSP3:K1155R BA.2.86.1 Link to comment Share on other sites More sharing options...
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