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Summary What is already known about this topic? An outbreak of coronavirus disease 2019 (COVID-19) has spread throughout China and to 31 other countries and territories, including the United States. What is added by this report? Fourteen cases have been diagnosed in the United States, in addition to 39 cases among repatriated persons from high-risk settings, for a current total of 53 cases within the United States. The U.S. government and public health partners are implementing aggressive measures to slow and contain transmission of COVID-19 in the United States. What are the implications for public health practice? Interim guidance is available at https://www.cdc.gov/coronavirus/index.html. As more is learned about this virus and the outbreak, CDC will rapidly incorporate new knowledge into guidance for action.

Update: Public Health Response to the Coronavirus Disease 2019 Outbreak — United States, February 24, 2020 Early Release / February 25, 2020 / 69 Daniel B. Jernigan, MD1; CDC COVID-19 Response Team (View author affiliations) https://www.cdc.gov/mmwr/volumes/69/wr/mm6908e1.htm?s_cid=mm6908e1_w#contribAff

These measures require the identification of cases and contacts of persons with COVID-19 in the United States and the recommended assessment, monitoring, and care of travelers arriving from areas with substantial COVID-19 transmission.” Although these measures might not prevent widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare state and local health departments, health care systems, businesses, educational organizations, and the general public in the event that widespread transmission occurs; and 3) better characterize COVID-19 to guide public health recommendations and the development and deployment of medical countermeasures, including diagnostics, therapeutics, and vaccines.

This report summarizes the aggressive measures (2,3) that CDC, state and local health departments, multiple other federal agencies, and other partners are implementing to slow and to try contain transmission of COVID-19 in the United States.

3 further deaths in coronavirus outbreak in northern Italy Tue 25 Feb 2020 17:19:19 GMT Author: Greg Michalowski | Category: News share Italy's health minister speaking on coronavirus Italy's health minister is on the wires is speaking on coronavirus saying: 3 further deaths incoronavirus outbreak in northern Italy There is commitment by countries bordering with Italy to keep borders open Italy has 322 confirmed virus cases with 10 dead

3 further deaths in coronavirus outbreak in northern Italy Italy has 322 confirmed virus cases with 10 dead https://www.forexlive.com/news/!/3-further-deaths-and-coronavirus-outbreak-in-northern-italy-20200225

The case of coronavirus in Catalonia and that of the doctor's wife raise the cases to 5 The Government of Italy accuses the expansion of hospital mismanagement that did not follow the protocols Giuseppe Conte says that if the regions cannot coordinate to fight the virus, the government will assume health control The Department of Catalan Salut has confirmed the first case of coronavirus in Catalonia , fifth in Spain , after the three detected in the Canary Islands and another in Palma de Mallorca. ADVERTISING Seven deaths from coronavirus and more than 230 confirmed cases in Italy . The situation has strained relations between the central government and that of Lombardy, after the president of the Council, Giuseppe Conte, assured in an interview that the focus emerged and expanded because of a management by one of the hospitals "unwise." In Lombardy alone there are 212 cases.

The case of coronavirus in Catalonia and that of the doctor's wife raise the cases to 5 https://www.telecinco.es/informativos/salud/coronavirus-italia-ultima-noticia-epidemia-china_18_2905095017.html

CFR? Early cases severe and get high CFR Coming late for treatment Underlying conditions have impact CFR may be higher in countries that lack resources (like ventilators)

Antibody test? Recently licensed two tests (in China) Determine level of transmission Help in reopening schools Look at high density transmission vs low to validate

Higher CFR in Wuhan? Started fast in Wuhan Scale of outbreak Severe disease is what set off alarm bells

Natural history 88% fever 68% dry cough 4% runny nose fatigue, myalgia, unwell Initially 80% mild 15% severe 5% critical

Mild cases? During community transmission found many cases Mild cases were rare (same true for asymptomatic)

Return to work? Phased re-opening to manage risk

HCWs? Most infected in community HCWs infected in non-COVID areas in hospitals Initially, not all HCWs had proper PPEs

In China main driver was households Tested over 320,000 Positive rate was 0.49% initially

The corona virus has reached the Italian-speaking part of Switzerland. The first infection was recorded there in Switzerland. The Health Minister, Alain Berset, told the media that the country is well prepared and the government is keeping a close eye on the situation. The virus was detected in the southern canton of Ticino. Almost 70,000 people go from Italy to Ticino, who speaks Italian, every day to work there. According to Berset, no travel restrictions apply. Ticino is a sort of cove in the Italian region of Lombardy. Most of the coronavirus cases were found there in Italy. https://nieuws.marokko.nl/61631/coronavirus-bereikt-zwitserland/?utm_source=twitter

Switzerland confirms first coronavirus case THIS CONTENT WAS PUBLISHED ON FEBRUARY 25, 2020 4:13 PMFEB 25, 2020 - 16:13 Swiss guards on the border with neighbouring Italy on February 25 (Keystone / Pablo Gianinazzi) Switzerland reported its first coronavirus case on Tuesday in canton Ticino in the south of the country. The Federal Office of Public Health (FOPH) is due to give more information at a press conference in Bern at 5pm (Swiss time). Laboratory tests carried out in Geneva uncovered a coronavirus case in canton Ticino, authorities told the Keystone-SDA News Agency on Tuesday. So far, about 300 suspected cases of Covid-19 have been tested in Switzerland, but there had been no confirmed cases until now, according to the interior ministry. On Monday the Swiss authorities announced that they were beefing up measures to prevent the spread of coronavirus from neighbouring Italy, while stressing that the situation in Switzerland is under control. Tests for the Covid-19 virus will also be made available to people who have flu-like symptoms but have not necessarily been in close contact with infected patients, according to the interior ministryexternal link. An information campaign as well as advisory servicesexternal link will be boosted in the next few days. COVID-19Swiss step up precautions to prevent spread of coronavirus Authorities say measures to prevent the spread of coronavirus from Italy are stepped up, but the situation in Switzerland is under control. This content was published on February 24, 2020 3:55 PM The Swiss announcement comes as neighbouring Austria also reported its first two confirmed cases on Tuesday. The two patients are Italians who live in the border province of Tyrol and recently travelled to Lombardy, one of the two regions at the epicentre of the Italian outbreak.

Switzerland reported its first coronavirus case on Tuesday in canton Ticino in the south of the country https://www.swissinfo.ch/eng/politics/covid-19_switzerland-confirms-first-coronavirus-case/45579278

China used systematic approach to control COVID Differentiated approach - individual cases, family clusters, community transmission Mobilized collective action 4,000 HCWs from other parts of China to get control in Wuhan Re-purposed machinery of government Turbo-charged response Big data /AI for contact tracing Re-purpose Hospitals into response hospitals Keep control over every day life (like food) Science driven response

وزارة الصحة | مملكة البحرين @MOH_Bahrain · 1h Ministry of Health: The nine new registered cases were detected among four female Bahraini nationals, three male Bahraini nationals, and two female Saudi nationals, all arriving from Iran via Dubai or Sharjah

MoH notes that COVID confirmed cases increased to 13 including a couple from Iran https://www.facebook.com/mohapuae/photos/pcb.3008178809232874/3008178602566228/?type=3&theater

About death of patient associated with cruise ship under quarantine at Yokohama Port 　We are pleased to announce that a cruise ship-related patient who has been quarantined at Yokohama Port has died today (February 25). I pray for the soul of the deceased. When reporting, please give due consideration to the privacy of the deceased and the bereaved. Patients (4th death) 1 Summary (1) Age: 80s (2) Gender: Male (3) Place of residence: Tokyo (4) Diabetes 2 Diabetes 2 Cause of death Pneumonia 3 Progress February 3 Yokohama Port Quarantine Quarantine started at anchorage. February 5 Cruise ship returns to Yokohama. February 9 PCR specimens were collected as a patient and transported to a medical institution. He was hospitalized under the Infectious Diseases Act. Pneumonia was confirmed by diagnostic imaging, and oxygen administration was started. February 10 New coronavirus was found positive by PCR. The respiratory condition is bad, and artificial respiration management is started. The condition did not improve after treatment with pneumonia such as an antiviral agent. February 25 Death confirmed.

Patients (4th death)1 Summary(1) Age: 80s(2) Gender: Male(3) Place of residence: Tokyo(4) Diabetes https://www.mhlw.go.jp/stf/newpage_09745.html