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November 15, 2016 Department of Health Daily Zika Update Contact: Communications [email protected] (850) 245-4111 Tallahassee, Fla.—In an effort to keep Florida residents and visitors safe and aware about the status of the Zika virus, the department will issue a Zika virus update each week day. Updates will include a Zika case count by county and information to keep Floridians informed and prepared. In order to keep the public informed, the department has posted our investigation process here. There are five new travel-related cases with three in Miami-Dade, one in Broward and one in Polk. There is one locally acquired case today. The person is a Miami-Dade County resident and the department is investigating to determine where exposure occurred. Additionally, there is one new case in a Florida resident who had traveled to Miami and to an area outside of Florida with widespread Zika transmission. This case is being added to the undetermined category as the exact location of exposure is inconclusive. The total number of Zika cases reported in Florida as of today is 1,165. Infection Type Infection Count Travel-Related Infections of Zika 927 Locally Acquired Infections of Zika 225 Undetermined 13 Pregnant Women with Lab-Evidence of Zika 153 Note, these categories are not mutually exclusive and cannot be added together. Please visit our website to see the full list of travel-related cases by county. DOH continues outreach and targeted testing in Miami-Dade County and mosquito abatement and reduction activities are also taking place around the locations that are being investigated. DOH believes ongoing transmission is only taking place within the identified area in Miami Beach and Little River in Miami-Dade County, see maps below. One case does not mean ongoing active transmission is taking place. DOH conducts a thorough investigation by sampling close contacts and community members around each case to determine if additional people are infected. If DOH finds evidence that active transmission is occurring in an area, the media and the public will be notified. The timelines below are as of Nov. 14. Note: asymptomatic cases are not reflected as they do not have symptom on-set dates. click image above to enlarge click image above to enlarge click image above to enlarge The department is currently conducting 13 active investigations. The department has closed 37 investigations. Information regarding the investigations can be found here. If investigations reveal additional areas of active transmission, the department will announce a defined area of concern. The department has conducted Zika virus testing for more than 10,232 people statewide. Florida currently has the capacity to test 6,758 people for active Zika virus and 5,549 for Zika antibodies. At Governor Scott’s direction, all county health departments now offer free Zika risk assessment and testing to pregnant women. Florida’s small case cluster is not considered widespread transmission, however, pregnant women are advised to avoid non-essential travel to the impacted area in Miami-Dade County (see map below). If you are pregnant and must travel or if you live or work in the impacted area, protect yourself from mosquito bites by wearing insect repellent, long clothing and limiting your time outdoors. According to CDC guidance, providers should test all pregnant women who lived in, traveled to or whose partner traveled to Miami-Dade County after Aug. 1, 2016. It is also recommended that all pregnant women who reside in or travel frequently to the area where active transmission is likely occurring be tested for Zika in the first and second trimester. Pregnant women in the identified area can contact their medical provider or their local county health department to be tested and receive a Zika prevention kit. CDC recommends that a pregnant woman with a history of Zika virus and her provider should consider additional ultrasounds. Additionally, the department is working closely with the Healthy Start Coalition of Miami-Dade County to identify pregnant women in the impacted areas to ensure they have access to resources and information to protect themselves. CDC recommends that a pregnant woman with a history of Zika virus and her provider should consider additional ultrasounds. Pregnant women can contact their local county health department for Zika risk assessment and testing hours and information. A Zika risk assessment will be conducted by county health department staff and blood and/or urine samples may be collected and sent to labs for testing. It may take one to two weeks to receive results. Florida has been monitoring pregnant women with evidence of Zika regardless of symptoms. The total number of pregnant women who have been or are being monitored is 153. On Feb. 12, Governor Scott directed the State Surgeon General to activate a Zika Virus Information Hotline for current Florida residents and visitors, as well as anyone planning on traveling to Florida in the near future. The hotline, managed by the Department of Health, has assisted 7,363 callers since it launched. The number for the Zika Virus Information Hotline is 1-855-622-6735. The department urges Floridians to drain standing water weekly, no matter how seemingly small. A couple drops of water in a bottle cap can be a breeding location for mosquitoes. Residents and visitors also need to use repellents when enjoying the Florida outdoors. For more information on DOH action and federal guidance, please click here. For resources and information on Zika virus, click here. click image above to enlarge click image above to enlarge About the Florida Department of Health The department, nationally accredited by the Public Health Accreditation Board, works to protect, promote, and improve the health of all people in Florida through integrated state, county and community efforts. Follow us on Twitter at @HealthyFla and on Facebook. For more information about the Florida Department of Health, please visit www.FloridaHealth.gov.

November 15, 2016 Department of Health Daily Zika Update Contact: Communications [email protected] (850) 245-4111 Tallahassee, Fla.—In an effort to keep Florida residents and visitors safe and aware about the status of the Zika virus, the department will issue a Zika virus update each week day. Updates will include a Zika case count by county and information to keep Floridians informed and prepared. In order to keep the public informed, the department has posted our investigation process here. There are five new travel-related cases with three in Miami-Dade, one in Broward and one in Polk. There is one locally acquired case today. The person is a Miami-Dade County resident and the department is investigating to determine where exposure occurred. Additionally, there is one new case in a Florida resident who had traveled to Miami and to an area outside of Florida with widespread Zika transmission. This case is being added to the undetermined category as the exact location of exposure is inconclusive. The total number of Zika cases reported in Florida as of today is 1,165. Infection Type Infection Count Travel-Related Infections of Zika 927 Locally Acquired Infections of Zika 225 Undetermined 13 Pregnant Women with Lab-Evidence of Zika 153 Note, these categories are not mutually exclusive and cannot be added together. Please visit our website to see the full list of travel-related cases by county. DOH continues outreach and targeted testing in Miami-Dade County and mosquito abatement and reduction activities are also taking place around the locations that are being investigated. DOH believes ongoing transmission is only taking place within the identified area in Miami Beach and Little River in Miami-Dade County, see maps below. One case does not mean ongoing active transmission is taking place. DOH conducts a thorough investigation by sampling close contacts and community members around each case to determine if additional people are infected. If DOH finds evidence that active transmission is occurring in an area, the media and the public will be notified. The timelines below are as of Nov. 14. Note: asymptomatic cases are not reflected as they do not have symptom on-set dates. click image above to enlarge click image above to enlarge click image above to enlarge The department is currently conducting 13 active investigations. The department has closed 37 investigations. Information regarding the investigations can be found here. If investigations reveal additional areas of active transmission, the department will announce a defined area of concern. The department has conducted Zika virus testing for more than 10,232 people statewide. Florida currently has the capacity to test 6,758 people for active Zika virus and 5,549 for Zika antibodies. At Governor Scott’s direction, all county health departments now offer free Zika risk assessment and testing to pregnant women. Florida’s small case cluster is not considered widespread transmission, however, pregnant women are advised to avoid non-essential travel to the impacted area in Miami-Dade County (see map below). If you are pregnant and must travel or if you live or work in the impacted area, protect yourself from mosquito bites by wearing insect repellent, long clothing and limiting your time outdoors. According to CDC guidance, providers should test all pregnant women who lived in, traveled to or whose partner traveled to Miami-Dade County after Aug. 1, 2016. It is also recommended that all pregnant women who reside in or travel frequently to the area where active transmission is likely occurring be tested for Zika in the first and second trimester. Pregnant women in the identified area can contact their medical provider or their local county health department to be tested and receive a Zika prevention kit. CDC recommends that a pregnant woman with a history of Zika virus and her provider should consider additional ultrasounds. Additionally, the department is working closely with the Healthy Start Coalition of Miami-Dade County to identify pregnant women in the impacted areas to ensure they have access to resources and information to protect themselves. CDC recommends that a pregnant woman with a history of Zika virus and her provider should consider additional ultrasounds. Pregnant women can contact their local county health department for Zika risk assessment and testing hours and information. A Zika risk assessment will be conducted by county health department staff and blood and/or urine samples may be collected and sent to labs for testing. It may take one to two weeks to receive results. Florida has been monitoring pregnant women with evidence of Zika regardless of symptoms. The total number of pregnant women who have been or are being monitored is 153. On Feb. 12, Governor Scott directed the State Surgeon General to activate a Zika Virus Information Hotline for current Florida residents and visitors, as well as anyone planning on traveling to Florida in the near future. The hotline, managed by the Department of Health, has assisted 7,363 callers since it launched. The number for the Zika Virus Information Hotline is 1-855-622-6735. The department urges Floridians to drain standing water weekly, no matter how seemingly small. A couple drops of water in a bottle cap can be a breeding location for mosquitoes. Residents and visitors also need to use repellents when enjoying the Florida outdoors. For more information on DOH action and federal guidance, please click here. For resources and information on Zika virus, click here. click image above to enlarge click image above to enlarge About the Florida Department of Health The department, nationally accredited by the Public Health Accreditation Board, works to protect, promote, and improve the health of all people in Florida through integrated state, county and community efforts. Follow us on Twitter at @HealthyFla and on Facebook. For more information about the Florida Department of Health, please visit www.FloridaHealth.gov.

There is one locally acquired case today. The person is a Miami-Dade County resident and the department is investigating to determine where exposure occurred. Additionally, there is one new case in a Florida resident who had traveled to Miami and to an area outside of Florida with widespread Zika transmission. This case is being added to the undetermined category as the exact location of exposure is inconclusive. http://www.floridahealth.gov/newsroom/2016/11/111516-zika-update.html

There are five new travel-related cases with three in Miami-Dade, one in Broward and one in Polk. There is one locally acquired case today. The person is a Miami-Dade County resident and the department is investigating to determine where exposure occurred. Additionally, there is one new case in a Florida resident who had traveled to Miami and to an area outside of Florida with widespread Zika transmission. This case is being added to the undetermined category as the exact location of exposure is inconclusive. The total number of Zika cases reported in Florida as of today is 1,165. http://www.floridahealth.gov/newsroom/2016/11/111516-zika-update.html

Map Update https://www.google.com/maps/d/edit?hl=en&hl=en&authuser=0&authuser=0&mid=1aNOepBDPUd0zdRnQE1UbSW8djsk&ll=54.293115583263855%2C9.576174597692898&z=7

Report type Follow-up report No. 2 Date of start of the event 07/11/2016 Date of confirmation of the event 08/11/2016 Report date 14/11/2016 Date submitted to OIE 14/11/2016 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 09/2015 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Clinical, Laboratory (basic), Laboratory (advanced) This event pertains to the whole country Related reports Immediate notification (09/11/2016) Follow-up report No. 1 (11/11/2016) Follow-up report No. 2 (14/11/2016) New outbreaks (2) Outbreak 1 (16-015-00024) Mesekenhagen, Vorpommern-Greifswald, MECKLENBURG-VORPOMMERN Date of start of the outbreak 11/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 58 32 32 26 0 Affected population 45 hens, 13 ducks Outbreak 2 (16-015-00028) Twedt, Schleswig-Flensburg, SCHLESWIG-HOLSTEIN Date of start of the outbreak 11/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 36000 3000 3000 33000 0 Affected population 36000 breeding chicken Summary of outbreaks Total outbreaks: 2 Total animals affected Species Susceptible Cases Deaths Destroyed Slaughtered Birds 36058 3032 3032 33026 0 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Birds 8.41% 8.41% 100.00% 100.00% *Removed from the susceptible population through death, destruction and/or slaughter Epidemiology Source of the outbreak(s) or origin of infection Unknown or inconclusive Epidemiological comments Restriction zones have been established and epidemiological investigations started. *Mesekenhagen: All poultry have been culled and safely disposed of on 11 November 2016. No poultry or poultry products have been dispatched. *Twedt: All poultry have been culled and safely disposed of on 12 November 2016. No poultry have been dispatched to EU Member States or third countries. One EU Member State had received four consignments of hatching eggs from that holding; the authorities of this Member State were swiftly informed. No hatching eggs were dispached to third countries. Control measures Measures applied Movement control inside the country Screening Disinfection / Disinfestation Traceability Quarantine Stamping out Official disposal of carcasses, by-products and waste Surveillance within containment and/or protection zone Control of wildlife reservoirs Zoning Vaccination prohibited No treatment of affected animals Measures to be applied No other measures Diagnostic test results Laboratory name and type Species Test Test date Result Friedrich-Loeffler Institute (National laboratory) Birds real-time PCR 12/11/2016 Positive Friedrich-Loeffler Institute (National laboratory) Birds real-time PCR 12/11/2016 Positive Future Reporting The event is continuing. Weekly follow-up reports will be submitted. Map of outbreak locations

Highly pathogenic avian influenza, Germany Information received on 14/11/2016 from Dr. Karin Schwabenbauer, Ministerial Dirigentin and Chief Veterinary Officer , Directorate of Animal Health, Animal Welfare, Bundesministerium für Ernährung und Landwirtschaft (BMEL) , Bonn, Germany Summary Report type Follow-up report No. 2 Date of start of the event 07/11/2016 Date of confirmation of the event 08/11/2016 Report date 14/11/2016 Date submitted to OIE 14/11/2016 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 09/2015 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Clinical, Laboratory (basic), Laboratory (advanced) This event pertains to the whole country Related reports Immediate notification (09/11/2016) Follow-up report No. 1 (11/11/2016) Follow-up report No. 2 (14/11/2016) New outbreaks (2) Outbreak 1 (16-015-00024) Mesekenhagen, Vorpommern-Greifswald, MECKLENBURG-VORPOMMERN Date of start of the outbreak 11/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 58 32 32 26 0 Affected population 45 hens, 13 ducks Outbreak 2 (16-015-00028) Twedt, Schleswig-Flensburg, SCHLESWIG-HOLSTEIN Date of start of the outbreak 11/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 36000 3000 3000 33000 0 Affected population 36000 breeding chicken http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=21541

Map Update https://www.google.com/maps/d/edit?hl=en&hl=en&authuser=0&authuser=0&mid=1aNOepBDPUd0zdRnQE1UbSW8djsk&ll=56.078434803872206%2C14.301991150000049&z=6

Report type Follow-up report No. 1 Date of start of the event 28/10/2016 Date of confirmation of the event 05/11/2016 Report date 15/11/2016 Date submitted to OIE 15/11/2016 Reason for notification New strain of a listed disease in the country Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Laboratory (advanced) This event pertains to a defined zone within the country Related reports Immediate notification (07/11/2016) Follow-up report No. 1 (15/11/2016) New outbreaks (1) Outbreak 1 Swinoujscie, -, Swinoujscie, ZACHODNIO-POMORSKIE Date of start of the outbreak 09/11/2016 Outbreak status Resolved (10/11/2016) Epidemiological unit Not applicable Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Herring Gull:Larus argentatus(Laridae) 1 1 0 0 Summary of outbreaks Total outbreaks: 1 Total animals affected Species Susceptible Cases Deaths Destroyed Slaughtered Herring Gull:Larus argentatus(Laridae) 1 1 0 0 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Herring Gull:Larus argentatus(Laridae) ** ** 100.00% ** *Removed from the susceptible population through death, destruction and/or slaughter **Not calculated because of missing information Epidemiology Source of the outbreak(s) or origin of infection Unknown or inconclusive Control measures Measures applied Control of wildlife reservoirs Vaccination prohibited No treatment of affected animals Measures to be applied No other measures Diagnostic test results Laboratory name and type Species Test Test date Result National Veterinary Research Institute (National laboratory) Herring Gull real-time reverse transcriptase/polymerase chain reaction (RRT-PCR) 10/11/2016 Positive Future Reporting The event is continuing. Weekly follow-up reports will be submitted. Map of outbreak locations

Highly pathogenic avian influenza,PolandPrintCloseInformation received on 15/11/2016 from Dr Krzysztof Jazdzewski, Deputy Chief Veterinary Officer, Ministry of Agriculture and Rural Development, General Veterinary Inspectorate, VARSOVIE, PolandSummaryReport type Follow-up report No. 1Date of start of the event 28/10/2016Date of confirmation of the event 05/11/2016Report date 15/11/2016Date submitted to OIE 15/11/2016Reason for notification New strain of a listed disease in the countryCausal agent Highly pathogenic avian influenza virusSerotype H5N8Nature of diagnosis Laboratory (advanced)This event pertains to a defined zone within the countryRelated reports Immediate notification (07/11/2016) Follow-up report No. 1 (15/11/2016) New outbreaks (1)Outbreak 1 Swinoujscie, -, Swinoujscie, ZACHODNIO-POMORSKIEDate of start of the outbreak 09/11/2016Outbreak status Resolved (10/11/2016)Epidemiological unit Not applicableAffected animals Species Susceptible Cases Deaths Destroyed SlaughteredHerring Gull:Larus argentatus(Laridae) 1 1 0 0Summary of outbreaks Total outbreaks: 1 http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=21547

http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?reportid=21545 Highly pathogenic avian influenza, Hungary Information received on 15/11/2016 from Dr Lajos Bognár, Deputy State Secretary Chief Veterinary Officer, Food Chain Safety Department, Ministry of Agriculture, Budapest, Hungary Summary Report type Follow-up report No. 2 Date of start of the event 01/11/2016 Date of confirmation of the event 03/11/2016 Report date 15/11/2016 Date submitted to OIE 15/11/2016 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 26/10/2016 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Laboratory (advanced) This event pertains to a defined zone within the country Related reports Immediate notification (04/11/2016) Follow-up report No. 1 (14/11/2016) Follow-up report No. 2 (15/11/2016) Outbreaks There are no new outbreaks in this report Epidemiology Source of the outbreak(s) or origin of infection Contact with wild species Control measures Measures applied Movement control inside the country Disinfection / Disinfestation Traceability Stamping out Official disposal of carcasses, by-products and waste Surveillance within containment and/or protection zone Zoning Vaccination prohibited No treatment of affected animals Measures to be applied No other measures Future Reporting The event is continuing. Weekly follow-up reports will be submitted.

Published Date: 2016-11-14 19:52:15Subject: PRO/AH/EDR> Avian influenza (100): Israel (HZ) poultry HPAI H5N8, new strain, OIE Archive Number: 20161114.4628359 AVIAN INFLUENZA (100): ISRAEL (HAZAFON) POULTRY HPAI H5N8, NEW STRAIN, OIE ************************************************************************** A ProMED-mail posthttp://www.promedmail.org ProMED-mail is a program of the International Society for Infectious Diseaseshttp://www.isid.org Date: Sun 13 Nov 2016 Source: OIE, WAHID (World Animal Health Information Database), weekly disease information 2016; 29(46) [edited]http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=21531 Highly pathogenic avian influenza, Israel ----------------------------------------- Information received on [and dated] 13 Nov 2016 from Dr Nadav Galon, Director, Veterinary Services and Animal Health, Ministry of Agriculture and Rural Development, Bet Dagan, Israel Summary Report type: immediate notification Date of start of the event: 9 Nov 2016 Date of confirmation of the event: 13 Nov 016 Reason for notification: New strain of a listed disease in the country Causal agent: Highly pathogenic avian influenza virus Serotype: H5N8 Nature of diagnosis: clinical, laboratory (advanced) This event pertains to a defined zone within the country. New outbreaks (1) Summary of outbreaks Total outbreaks: 1 Outbreak 1 (Hefzi-Bah): Hefzi-Bah, Yizreel, Hazafon Date of start of the outbreak: 9 Nov 2016 Outbreak status: continuing (or date resolved not provided) Epidemiological unit: farm Total animals affected: Species / Susceptible / Cases / Deaths / Destroyed / Slaughtered Birds / 34 500 / 1800 / 1500 / 0 / 0 Affected population: 21 weeks old heavy breeders. 4 pens. Only 1 pen (containing 5200 birds) was affected. All the dead birds were found in this affected pen. Outbreak statistics [rates apparent, expressed as percentages]: Species / Morbidity rate / Mortality rate / Case fatality rate / Proportion susceptible animals lost* Birds / 5.22 / 4.35 / 83.33 / 4.35 *Removed from the susceptible population through death, destruction, and/or slaughter Epidemiology Source of the outbreak(s) or origin of infection: Contact with wild species. Epidemiological comment: Israel is on the migration route of wild birds coming from Europe to Africa. The migration is ongoing and this virus strain probably arrived from Europe with migrating birds. The farm is located in an aquaculture area with multiple fish ponds, attracting migrating birds. Control measures Measures applied: movement control inside the country; quarantine; surveillance within containment and/or protection zone; zoning; vaccination prohibited; no treatment of affected animals Measures to be applied: screening; disinfection / disinfestations; surveillance outside containment and/or protection zone; stamping out; official disposal of carcasses, by-products and waste Diagnostic test results Laboratory name and type / Species / Test / Test date / Result Kimron Veterinary Institute, Avian Diseases Laboratory (national laboratory) / Birds / pathogen isolation by egg inoculation/ - / Pending Kimron Veterinary Institute, Avian Diseases Laboratory (national laboratory) / Birds / real-time (PCR) / 13 Nov 2016 / Positive Future reporting The event is continuing. Weekly follow-up reports will be submitted. [The location of the outbreak can be seen on the interactive map included in the OIE report at the source URL above.] -- Communicated by: ProMED-mail <[email protected]> [These OIE immediate notifications complement and confirm the information published in ProMED-mail posting 20161113.4626107. - Mod.CRD A HealthMap/ProMED-mail map can be accessed at: http://healthmap.org/promed/p/1759.] See Also Avian influenza (99): Switzerland (VD) wild, India (KA) poultry, H5N8 20161113.4626408Avian influenza (98): Israel (HZ) poultry, H5N8, RFI 20161113.4626107Avian influenza (97): India (Punjab) poultry, H5N8, spread, OIE 20161111.462135Avian influenza (96): Europe, wild birds, HPAI H5N8, OIE 20161110.4620229Avian influenza (94): India (HR) poultry, H5N8, spread, OIE 20161110.4617396Avian influenza (93): Switzerland, Austria, wildfowl, H5N8, Croatia, susp, RFI 20161110.4618279Avian influenza (92): Germany (SH) wild birds, H5N8, 1st cases 20161109.4617139Avian influenza (91): Poland (ZP) wild, H5N8, OIE 20161108.4614616Avian influenza (90): India (KL) poultry, H5N8, OIE, (HR) poultry, susp, RFI 20161105.4609424Avian influenza (89): Hungary (BE,CS) poultry, wild bird, HPAI H5N8, OIE 20161104.4608240Avian influenza (86): India (KL) poultry, H5N8, 1st outbreak, RFI 20161028.4591328Avian influenza (82): India, Delhi zoo, H5N8, NOT H5N1 20161021.4576300Avian influenza (81): H5N1, India, Delhi zoo 20161020.4573601Avian influenza (79): Russia (TU) HPAI H5N8, migratory birds 20161011.4551755Avian influenza (77): United Arab Emirates (Abu Dhabi) poultry (quail) 1st case, susp 20161005.4537271Avian influenza (74): Russia (TU) HPAI H5N8 2.3.4.4., wild bird, intl alert, FAO 20160920.4501532Avian influenza (65): Taiwan, poultry, HPAI H5N8, spread 20160725.4368474Avian influenza (29): South Korea (KG) poultry, HPAI H5N8, OIE 20160331.4130267Avian influenza (28): South Korea (KG) poultry, HPAI H5N8 20160329.41245022015---Avian influenza (211): Taiwan (PT) poultry, HPAI H5N8, spread 20151210.3854407Avian influenza (168): global, H5 HPAI evolution, control, RFI 20150704.3483531Avian influenza (06): global, H5 evolution, new clade 2.3.4.4, WHO/OIE/FAO 20150114.3090250Avian influenza (07): global, interaction with human viruses 20150317.32371742014---Avian influenza (117): Europe, HPAI H5N8 & H5N1, routes of spread 20141227.3056665Avian influenza (111): Europe, HPAI H5N8, EFSA scientific report 20141218.3040087.................................................crd/ao/dk http://www.promedmail.org/direct.php?id=20161114.4628359

Map Update https://www.google.com/maps/d/edit?hl=en&hl=en&authuser=0&authuser=0&mid=1aNOepBDPUd0zdRnQE1UbSW8djsk&ll=48.51338244151801%2C7.047048389257839&z=6

Summary Report type Immediate notification Date of start of the event 09/11/2016 Date of confirmation of the event 11/11/2016 Report date 11/11/2016 Date submitted to OIE 11/11/2016 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 26/04/2006 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Laboratory (advanced) This event pertains to a defined zone within the country New outbreaks (1) Outbreak 1 Bregenz, VORARLBERG Date of start of the outbreak 09/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 1150 250 70 0 Affected population Holding of free range turkeys; all animals will be killed, and the holding will be cleaned and disinfected. Farm is banned, protection and surveillance zones installed. Summary of outbreaks Total outbreaks: 1 Total animals affected Species Susceptible Cases Deaths Destroyed Slaughtered Birds 1150 250 70 0 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Birds 21.74% 6.09% 28.00% ** *Removed from the susceptible population through death, destruction and/or slaughter **Not calculated because of missing information Epidemiology Source of the outbreak(s) or origin of infection Contact with wild species Control measures Measures applied Vaccination prohibited No treatment of affected animals Measures to be applied Movement control inside the country Disinfection / Disinfestation Traceability Stamping out Official destruction of animal products Official disposal of carcasses, by-products and waste Surveillance within containment and/or protection zone Zoning Diagnostic test results Laboratory name and type Species Test Test date Result AGES IVET Mödling (National laboratory) Birds reverse transcription - polymerase chain reaction (RT-PCR) 11/11/2016 Positive Future Reporting The event is continuing. Weekly follow-up reports will be submitted. Map of outbreak locations

Highly pathogenic avian influenza, Austria Information received on 11/11/2016 from Mr Dr Ulrich Herzog, Chief Veterinary Officer, Verbrauchergesundheit, Bundesministerium für Gesundheit , VIENNE, Austria Summary Report type Immediate notification Date of start of the event 09/11/2016 Date of confirmation of the event 11/11/2016 Report date 11/11/2016 Date submitted to OIE 11/11/2016 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 26/04/2006 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Laboratory (advanced) This event pertains to a defined zone within the country New outbreaks (1) http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=21520

Map Update https://www.google.com/maps/d/edit?hl=en&hl=en&authuser=0&authuser=0&mid=1aNOepBDPUd0zdRnQE1UbSW8djsk&ll=52.57672032640285%2C3.5973413580078386&z=6

Report type Immediate notification Date of start of the event 08/11/2016 Date of confirmation of the event 10/11/2016 Report date 11/11/2016 Date submitted to OIE 11/11/2016 Reason for notification First occurrence of a listed disease Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus in wild birds Serotype H5N8 Nature of diagnosis Clinical, Laboratory (advanced) This event pertains to a defined zone within the country New outbreaks (1) Outbreak 1 (HPAI 2016/01 WB) Monnickendam, NOORD-HOLLAND Date of start of the outbreak 08/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Village Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Great Crested Grebe:Podiceps cristatus(Podicipedidae) 2 2 Tufted Duck:Aythya fuligula(Anatidae) 3 3 Summary of outbreaks Total outbreaks: 1 Total animals affected Species Susceptible Cases Deaths Destroyed Slaughtered Great Crested Grebe:Podiceps cristatus(Podicipedidae) 2 2 Tufted Duck:Aythya fuligula(Anatidae) 3 3 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Great Crested Grebe:Podiceps cristatus(Podicipedidae) ** ** 100.00% ** Tufted Duck:Aythya fuligula(Anatidae) ** ** 100.00% ** *Removed from the susceptible population through death, destruction and/or slaughter **Not calculated because of missing information Epidemiology Source of the outbreak(s) or origin of infection Unknown or inconclusive Epidemiological comments On November 8th, three tufted ducks (Aythya fuligula) and two Great crested grebes (Podiceps cristatus) were found dead in a wetland area. On November 10th the national reference laboratory confirmed HPAI Virus H5N8 in the samples from the tufted ducks and Great crested grebes. The Netherlands has ordered compulsory confinement of all commercial poultry in The Netherlands. Control measures Measures applied Vaccination prohibited No treatment of affected animals Measures to be applied No other measures Diagnostic test results Laboratory name and type Species Test Test date Result Wageningen Bioveterinary Research, Lelystad (National laboratory) Great Crested Grebe polymerase chain reaction (PCR) 10/11/2016 Positive Wageningen Bioveterinary Research, Lelystad (National laboratory) Great Crested Grebe polymerase chain reaction (PCR) 10/11/2016 Positive Future Reporting The event is continuing. Weekly follow-up reports will be submitted. Map of outbreak locations

Highly pathogenic avian influenza, Netherlands Information received on 11/11/2016 from Dr Christianne Bruschke, Chief Veterinary Officer , Ministry of Economic Affairs, Ministry of Economic Affairs, The Hague, Netherlands Summary Report type Immediate notification Date of start of the event 08/11/2016 Date of confirmation of the event 10/11/2016 Report date 11/11/2016 Date submitted to OIE 11/11/2016 Reason for notification First occurrence of a listed disease Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus in wild birds Serotype H5N8 Nature of diagnosis Clinical, Laboratory (advanced) This event pertains to a defined zone within the country New outbreaks (1) http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=21515

Highly pathogenic avian influenza, Israel Information received on 13/11/2016 from Dr Nadav Galon, Director, Veterinary Services and Animal Health, Ministry of Agriculture and Rural Development, BET DAGAN, Israel Summary Report type Immediate notification Date of start of the event 09/11/2016 Date of confirmation of the event 13/11/2016 Report date 13/11/2016 Date submitted to OIE 13/11/2016 Reason for notification New strain of a listed disease in the country Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Clinical, Laboratory (advanced) This event pertains to a defined zone within the country New outbreaks (1) Outbreak 1 (HEFZI-BAH) HEFZI-BAH, Yizreel, HAZAFON Date of start of the outbreak 09/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 34500 1800 1500 0 0 Affected population 21 weeks old heavy breeders. 4 pens. One pen only (containing 5,200 birds) was affected. All the dead birds were found in this affected pen. Summary of outbreaks Total outbreaks: 1 Total animals affected Species Susceptible Cases Deaths Destroyed Slaughtered Birds 34500 1800 1500 0 0 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Birds 5.22% 4.35% 83.33% 4.35% *Removed from the susceptible population through death, destruction and/or slaughter Epidemiology Source of the outbreak(s) or origin of infection Contact with wild species Epidemiological comments Israel is on the migration route of wild birds coming from Europe to Africa. The migration is ongoing and this virus strain probably arrived from Europe with migrating birds. The farm is located in an aquaculture area with multiple fish ponds, attracting migrating birds. Control measures Measures applied Movement control inside the country Quarantine Surveillance within containment and/or protection zone Zoning Vaccination prohibited No treatment of affected animals Measures to be applied Screening Disinfection / Disinfestation Surveillance outside containment and/or protection zone Stamping out Official disposal of carcasses, by-products and waste Diagnostic test results Laboratory name and type Species Test Test date Result Kimron Veterinary Institute, Avian Diseases Division (National laboratory) Birds pathogen isolation by egg inoculation Pending Kimron Veterinary Institute, Avian Diseases Division (National laboratory) Birds real-time PCR 13/11/2016 Positive Future Reporting The event is continuing. Weekly follow-up reports will be submitted. Map of outbreak locations http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=21531

Map Update https://www.google.com/maps/d/edit?hl=en&hl=en&authuser=0&authuser=0&mid=1aNOepBDPUd0zdRnQE1UbSW8djsk&ll=48.251443177827184%2C13.221364795507839&z=6

Report type Follow-up report No. 1 Date of start of the event 01/11/2016 Date of confirmation of the event 03/11/2016 Report date 14/11/2016 Date submitted to OIE 14/11/2016 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 26/10/2016 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Laboratory (advanced) This event pertains to a defined zone within the country Related reports Immediate notification (04/11/2016) Follow-up report No. 1 (14/11/2016) New outbreaks (4) Outbreak 1 Kiskunmajsa, BACS-KISKUN Date of start of the outbreak 08/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 21500 500 500 21000 0 Outbreak 2 Kisszállás, BACS-KISKUN Date of start of the outbreak 10/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 23000 2400 400 22600 0 Outbreak 3 Bugac, BACS-KISKUN Date of start of the outbreak 10/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 3400 1500 500 2900 0 Outbreak 4 Kelebia, BACS-KISKUN Date of start of the outbreak 10/11/2016 Outbreak status Continuing (or date resolved not provided) Epidemiological unit Farm Affected animals Species Susceptible Cases Deaths Destroyed Slaughtered Birds 15000 10000 600 14400 0 Summary of outbreaks Total outbreaks: 4 Total animals affected Species Susceptible Cases Deaths Destroyed Slaughtered Birds 62900 14400 2000 60900 0 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Birds 22.89% 3.18% 13.89% 100.00% *Removed from the susceptible population through death, destruction and/or slaughter Epidemiology Source of the outbreak(s) or origin of infection Contact with wild species Control measures Measures applied Movement control inside the country Traceability Stamping out Official disposal of carcasses, by-products and waste Surveillance within containment and/or protection zone Zoning Vaccination prohibited No treatment of affected animals Measures to be applied Disinfection / Disinfestation Diagnostic test results Laboratory name and type Species Test Test date Result Veterinary Diagnostic Directorate of the National Food Chain Safety Office (National laboratory) Birds nucleotide sequencing 13/11/2016 Positive Veterinary Diagnostic Directorate of the National Food Chain Safety Office (National laboratory) Birds real-time PCR 12/11/2016 Positive Future Reporting The event is continuing. Weekly follow-up reports will be submitted. Map of outbreak locations

Highly pathogenic avian influenza, Hungary Information received on 14/11/2016 from Dr Lajos Bognár, Deputy State Secretary Chief Veterinary Officer, Food Chain Safety Department, Ministry of Agriculture, Budapest, Hungary Summary Report type Follow-up report No. 1 Date of start of the event 01/11/2016 Date of confirmation of the event 03/11/2016 Report date 14/11/2016 Date submitted to OIE 14/11/2016 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 26/10/2016 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H5N8 Nature of diagnosis Laboratory (advanced) This event pertains to a defined zone within the country Related reports Immediate notification (04/11/2016) Follow-up report No. 1 (14/11/2016) New outbreaks (4) http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=21543