niman Posted February 2, 2021 Author Report Share Posted February 2, 2021 Feb 2 Two more 501.v2 (B.1.351) South Africa variant Maryland by Johns Hopkins (likely Baltimore metro) Likely lack travel May be linked to each other and first case Jan 25 and 27 collection dates https://recombinomics.co/thedrnimanshow/2021/020221_501v2_MDX2.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 2, 2021 Author Report Share Posted February 2, 2021 Feb 2 501.v2 (B.1.351) South Africa variant (prelim) Montgomery Co Residents Treated in another jurisdiction May be travel related Johns Hopkins Hosp seq likely https://recombinomics.co/thedrnimanshow/2021/020221_501v2_Montgomery.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 3, 2021 Author Report Share Posted February 3, 2021 Feb 3 UK variant 1.1.7 acquiring E484K Black markers on variant map (linked at recombinomics.com) Started in England - spread to Wales, Scotland, Ireland Also E484G/Q/D Vaccine resistant (but milder disease with lower transmission) FL has most B.1.1.7 cases in US (186) but poor visibility https://recombinomics.co/thedrnimanshow/2021/020321_B117_E484K.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 5, 2021 Author Report Share Posted February 5, 2021 Feb 5 UK variant (B.1.1.7) acquires B.1.351 mutations for vaccine resistance Milton Keynes seq 1st with E484K 1st with 3 additional Spike deletions (242-244) recombinant https://recombinomics.co/thedrnimanshow/2021/020521_B117_B1351_dels.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 6, 2021 Author Report Share Posted February 6, 2021 Feb 6 B.1.1.7 acquired E484A in The Netherlands 1st sequence outside of UK More vaccine resistance Helix increases B.1.1.7 in FL (167), CA (122) SGTF frequency to 6% of PCR positives https://recombinomics.co/thedrnimanshow/2021/020621_Netherlands_E484A.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 7, 2021 Author Report Share Posted February 7, 2021 Feb 7 AstraZeneca vaccine declined by South Africa Mild to moderate 19+ w/ vaccine 20+ w/ placebo average age 35 little or no results for severe or fatal https://recombinomics.co/thedrnimanshow/2021/020721_AZVaccine_decline.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 11, 2021 Author Report Share Posted February 11, 2021 Feb 11 Helix B.1.1.7 preprint FL spike - 343 on CDC variant map Feb frequency 10-13% FL Health withholding locations Univ Miami outbreak https://recombinomics.co/thedrnimanshow/2021/021121_Helix_B117.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 11, 2021 Author Report Share Posted February 11, 2021 Feb 11 Ontario Seqs McMaster & Ontario Pub Health B.1.1.7 sans Y144del Likely Roberta Place Single introduction - community spread https://recombinomics.co/thedrnimanshow/2021/021121_ON_Seqs.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 13, 2021 Author Report Share Posted February 13, 2021 Feb 12 Helix update on FL Website updated to show 334 B.1.1.7 positives in FL B.1.1.7 positive rate in FL on Feb 9 was 15.8% A 10 day doubling rate would put FL at or near 100% B.1.17 by mid March https://recombinomics.co/thedrnimanshow/2021/021221_Helix_FL_334.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 15, 2021 Author Report Share Posted February 15, 2021 Feb 14 FL B.1.1.7 up to 379 Helix alone has 379 % positive >15% Diverse age groups No obvious link to U Miami outbreak /lockdown 10 day doubling time https://recombinomics.co/thedrnimanshow/2021/021421_FL-B117_379.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 17, 2021 Author Report Share Posted February 17, 2021 Feb 17 CDC announced first US cases of B.1.1.7 (UK variant) with E484K Increasingly common in England - spread to Wales, Scotland, Ireland, Denmark E484K confers vaccine resistance Present on B.1.351 (South Africa) and P.1 (Brazil) https://recombinomics.co/thedrnimanshow/2021/021721_B117_E484K_US.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 18, 2021 Author Report Share Posted February 18, 2021 Feb 17 Helix updated dashboard B.1.1.7 (UK variant) spikes to almost 15% of PCR positives nationwide (US) On pace to break 25% in 10 days https://recombinomics.co/thedrnimanshow/2021/021721_B117_Spike_US.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 23, 2021 Author Report Share Posted February 23, 2021 Feb 23 First US B.1.1.7 sequence with E484K Elderly patient in OR - Feb 6 collection Appears to be outbreak at health care center Two additional sequences without E484K (elderly with same collection date) https://recombinomics.co/thedrnimanshow/2021/022321_B117_E484K_OR.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 23, 2021 Author Report Share Posted February 23, 2021 Feb 23 B.1.1.7 with E484K - 77M Oregon Healthcare Outbreak Two additional elder cases / Sequences Radio Silence https://recombinomics.co/thedrnimanshow/2021/022321_E484K_Silence.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 25, 2021 Author Report Share Posted February 25, 2021 Feb 24 Helix update B.1.1.7 up to 30% PCR positives Increase across entire US B.1.351 at 21 in SC and 9 in MD Vaccine vs variant Moderna B.1.351 booster https://recombinomics.co/thedrnimanshow/2021/022421_Helix_Expo.mp3 Link to comment Share on other sites More sharing options...
niman Posted February 26, 2021 Author Report Share Posted February 26, 2021 Feb 26 NY Variants D253G with S477N or E484K / A701V Both exploding in NYC A few in Houston May be more widespread https://recombinomics.co/thedrnimanshow/2021/022621_NY_D253G.mp3 Link to comment Share on other sites More sharing options...
niman Posted March 1, 2021 Author Report Share Posted March 1, 2021 Mar 1 NYC Variants Pandemic Response Labs (NYC sponsor) Today released 99 UK variants (B.1.1.7) 2 SA variants (B.1.351) 151 B.1.526 (E484K) 82 B.1.526 (S477N) Follows similar numbers released last week https://recombinomics.co/thedrnimanshow/2021/030121_NYC_PRL.mp3 Link to comment Share on other sites More sharing options...
niman Posted March 3, 2021 Author Report Share Posted March 3, 2021 Mar 3 New Variants Philippines UK (N501K, P681H), SA (dels 243 & 244, E484K), 3 more del (141, 142, 143) UK variant (B.1.1.7) doubling 10 days - now 30% PCR+ at Helix New vaccine boosters plans https://recombinomics.co/thedrnimanshow/2021/030321_New_Variants.mp3 Link to comment Share on other sites More sharing options...
niman Posted March 9, 2021 Author Report Share Posted March 9, 2021 Mar 9 FL - 40% are B.1.1.7 (UK variant) US - 25% will become majority this month B.1.1.7 w/ E484K = 5 (3 are recombinants in NYC) https://recombinomics.co/thedrnimanshow/2021/030921_B117_E484K.mp3 Link to comment Share on other sites More sharing options...
niman Posted March 10, 2021 Author Report Share Posted March 10, 2021 Mar 10 Helix update US % B.1.1.7 positive >35% FL, TX, GA >50% UK variant dominant lineage in US https://recombinomics.co/thedrnimanshow/2021/031021_B117_50_FL_TX_GA.mp3 Link to comment Share on other sites More sharing options...
Jon Schultz Posted March 12, 2021 Report Share Posted March 12, 2021 (edited) Dr. Niman, Please address the serious concerns being raised by virologist Geert Vanden Bossche. Basically he's saying, if I understand him correctly, that the vaccination campaigns are driving viral immune escape which will result in increasingly vaccine-resistant variants, with the vaccinated losing their natural immune resistance and the vaccine updates unable to outpace the variants - and that a different kind of vaccine, which enhances natural killer cells, should be used. He's painting a pretty grim picture and seems quite credible, at least to me. https://twitter.com/GVDBossche https://mcusercontent.com/92561d6dedb66a43fe9a6548f/files/bead7203-0798-4ac8-abe2-076208015556/Public_health_emergency_of_international_concert_Geert_Vanden_Bossche.01.pdf https://www.youtube.com/watch?v=shg0VWkz0VM&t=0 Edited March 12, 2021 by Jon Schultz Link to comment Share on other sites More sharing options...
niman Posted March 13, 2021 Author Report Share Posted March 13, 2021 16 hours ago, Jon Schultz said: Dr. Niman, Please address the serious concerns being raised by virologist Geert Vanden Bossche. Basically he's saying, if I understand him correctly, that the vaccination campaigns are driving viral immune escape which will result in increasingly vaccine-resistant variants, with the vaccinated losing their natural immune resistance and the vaccine updates unable to outpace the variants - and that a different kind of vaccine, which enhances natural killer cells, should be used. He's painting a pretty grim picture and seems quite credible, at least to me. https://twitter.com/GVDBossche https://mcusercontent.com/92561d6dedb66a43fe9a6548f/files/bead7203-0798-4ac8-abe2-076208015556/Public_health_emergency_of_international_concert_Geert_Vanden_Bossche.01.pdf https://www.youtube.com/watch?v=shg0VWkz0VM&t=0 Viruses always escape. Sounds like typical anti-vax propaganda. Link to comment Share on other sites More sharing options...
Jon Schultz Posted March 13, 2021 Report Share Posted March 13, 2021 9 hours ago, niman said: Viruses always escape. Sounds like typical anti-vax propaganda. He's not saying the vaccines are unsafe but that we are, for the first time ever, implementing mass vaccination in the midst of a heated pandemic with a somewhat mismatched vaccine which won't provide sterilizing immunity - with many people getting infected in the period between getting vaccinated and developing immunity - and this will not only drive the emergence of variants which completely evade the vaccine-acquired immunity but the vaccinated will be less able to fight off those variants than if they hadn't been vaccinated since the then ineffective vaccine-acquired immunity, having some affinity for the virus, will take precedence over the immune system's innate response to novel viral attacks. He also explains the mechanics of pandemics and why the waves of this pandemic are somewhat different than in the past very interestingly, seeming to have an excellent grasp of the situation. If you haven't watched the YouTube video which I linked to, which is a scientific presentation, I think you'll find it at least interesting (and his two YouTube interviews explain his position further). He has excellent credentials, if you look at his LinkedIn page, and says he feels so confident in what he is saying he isn't afraid to put his professional reputation on the line. He's asking scientists to evaluate and comment. 1 Link to comment Share on other sites More sharing options...
niman Posted March 14, 2021 Author Report Share Posted March 14, 2021 2 hours ago, Jon Schultz said: He's not saying the vaccines are unsafe but that we are, for the first time ever, implementing mass vaccination in the midst of a heated pandemic with a somewhat mismatched vaccine which won't provide sterilizing immunity - with many people getting infected in the period between getting vaccinated and developing immunity - and this will not only drive the emergence of variants which completely evade the vaccine-acquired immunity but the vaccinated will be less able to fight off those variants than if they hadn't been vaccinated since the then ineffective vaccine-acquired immunity, having some affinity for the virus, will take precedence over the immune system's innate response to novel viral attacks. He also explains the mechanics of pandemics and why the waves of this pandemic are somewhat different than in the past very interestingly, seeming to have an excellent grasp of the situation. If you haven't watched the YouTube video which I linked to, which is a scientific presentation, I think you'll find it at least interesting (and his two YouTube interviews explain his position further). He has excellent credentials, if you look at his LinkedIn page, and says he feels so confident in what he is saying he isn't afraid to put his professional reputation on the line. He's asking scientists to evaluate and comment. I couldn't get past his long posted introduction about herd immunity Link to comment Share on other sites More sharing options...
OaO Posted March 15, 2021 Report Share Posted March 15, 2021 On 3/13/2021 at 4:15 PM, Jon Schultz said: He's not saying the vaccines are unsafe but that we are, for the first time ever, implementing mass vaccination in the midst of a heated pandemic with a somewhat mismatched vaccine which won't provide sterilizing immunity - with many people getting infected in the period between getting vaccinated and developing immunity - and this will not only drive the emergence of variants which completely evade the vaccine-acquired immunity but the vaccinated will be less able to fight off those variants than if they hadn't been vaccinated since the then ineffective vaccine-acquired immunity, having some affinity for the virus, will take precedence over the immune system's innate response to novel viral attacks. He also explains the mechanics of pandemics and why the waves of this pandemic are somewhat different than in the past very interestingly, seeming to have an excellent grasp of the situation. If you haven't watched the YouTube video which I linked to, which is a scientific presentation, I think you'll find it at least interesting (and his two YouTube interviews explain his position further). He has excellent credentials, if you look at his LinkedIn page, and says he feels so confident in what he is saying he isn't afraid to put his professional reputation on the line. He's asking scientists to evaluate and comment. I agree Jon. I found it very interesting. There has always been a question as to why the second wave of the 1918 pandemic decimated the 20-30 yr. old crowd. From Johns Hopkins history about 1918: "Yet much about the pandemic remains unsettled, particularly the mystery surrounding the shape of the flu’s devastation. In a normal flu epidemic, a graph of fatalities looks like the letter U, with the twin peaks representing a heavy toll among young children and the frail elderly. That graph of the 1918 flu looks more like a misshapen W, with an astonishing middle peak reflecting that it was most fatal to perfectly healthy adults in their 20s and 30s." There has been a lot of elitist "expert" hand waving about this virus. The blinders are firmly attached, as they believe that they understand the full spectrum of viral expression. They do not! I find them to be smug. arrogant and dogmatic. Link to comment Share on other sites More sharing options...
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