March 20, 20215 yr Author comment_40258 On 3/14/2021 at 9:59 PM, OaO said: I agree Jon. I found it very interesting. There has always been a question as to why the second wave of the 1918 pandemic decimated the 20-30 yr. old crowd. From Johns Hopkins history about 1918: "Yet much about the pandemic remains unsettled, particularly the mystery surrounding the shape of the flu’s devastation. In a normal flu epidemic, a graph of fatalities looks like the letter U, with the twin peaks representing a heavy toll among young children and the frail elderly. That graph of the 1918 flu looks more like a misshapen W, with an astonishing middle peak reflecting that it was most fatal to perfectly healthy adults in their 20s and 30s." There has been a lot of elitist "expert" hand waving about this virus. The blinders are firmly attached, as they believe that they understand the full spectrum of viral expression. They do not! I find them to be smug. arrogant and dogmatic. Not much debate among scientists. Young people affected due to cytokine storm due to robust immune system (VERY old story) Report
March 20, 20215 yr Author comment_40259 Mar 20 Variants clearly winning battle between variants and vaccines Large update up Helix - US frequency of B.1.1.7 at 50% Some states (including TX and GA up to 60% - explosion of cases expected) NY variant (B.1.526) exploding and spreading (over 300 new cases on NYC in latest PRL update) B.1.526 spread along east coast to Aruba https://recombinomics.co/thedrnimanshow/2021/032021_Variants_Winning.mp3 Report
March 30, 20215 yr Author comment_40694 Mar 30 Variant and Map update Vaccine update CDC variant map NY Variants B.1.526, B.1.526.1, B.1.526.2 https://recombinomics.co/thedrnimanshow/2021/032021_Variant_Map.mp3 Report
April 1, 20215 yr comment_40790 Excellent coverage as always, Dr. Niman. I’m listening to your interviews and admire the amount of work that goes trough your hands. In the last few minutes of some of the recordings however, the audio breaks and one could barely understand what you are saying. Best, Dimitar Report
April 14, 20215 yr Author comment_41346 4/14/21 JNJ Vaccine Halted Symptoms and target population (younger females) match AstraZeneca JNJ and AstraZeneca use adenovirus vector Moderna and Pfizer use mRNA and have not reported similar problem Number of US vaccinations of younger females far less than 7 million https://recombinomics.co/thedrnimanshow/2021/041421_Vac_JNJ.mp3 Report
April 26, 20215 yr Author comment_41870 4/26.21 JNJ vaccine resumed Variant seqs past week by PRI (NY) B.1.1.7 460 B.1.526 (E484K) 299 B.1.526.1 (L452R) 82 B.1.526.2 (S477N) 129 https://recombinomics.co/thedrnimanshow/2021/042621_Var_Vac_Update.mp3 Report
May 28, 20215 yr Author comment_43266 May 28 Furin Cleavage Site Codon 2 R's coded by CGG Least favored by coronavirus US Spike in India Variant (B.1.617.2) 1114/1253 seqs at GISAID deposited this month L452R, T478K, P681R https://recombinomics.co/thedrnimanshow/2021/052821 India.mp3 Report
July 10, 20215 yr comment_44922 Any chance you will be putting out new audio updates anytime soon? We miss the interviews and insights! Report
July 30, 20215 yr Author comment_45608 Jul 29 Delta Heterogeneous B.1.617.1 B.1.617.2 B.1.617.3 AY.1 AY.2 AY.3 R0 = 5-8 (same level as chickenpox) GISAID seqs Louisiana - many breakthroughs Singapore breakthroughs (75% of new cases) High viral load incl breakthroughs https://recombinomics.co/thedrnimanshow/2021/072921_Delta_Hetero.mp3 Report
July 30, 20215 yr Author comment_45615 July 30 Early Release MMWR Large cluster of 430 in Barnstable Co MA Most were fully vaccinated Most were infected with Delta (B.1.617.2) Viral load in vaccinated same as unvaccinated https://recombinomics.co/thedrnimanshow/2021/073021_Barnstable.mp3 Edited July 30, 20215 yr by niman Report
August 18, 20215 yr Author comment_46276 Aug 18 Boosters for Pfizer / Moderna starting Sep 20 8 weeks after 2nd shot 3 early release MMWRs Waning immunity 9 new Delta versions - AY.4-AY.12 15/16 in US 3 at >99% in US (AY.2 AY.3 AY.3.1) https://recombinomics.co/thedrnimanshow/2021/081821_Boosters.mp3 Report
September 17, 20215 yr Author comment_47388 Sep 17 Boosters and Breakthroughs FDA meeting on Pfizer Boosters NEJM on >60 after 6 mo from 2nd dose Approval likely Possible limitation to >60 https://recombinomics.co/thedrnimanshow/2021/09/091721_Booster.mp3 Report
October 21, 20214 yr Author comment_48596 Oct 21 Delta Demolition Over 50 named Delta Variants AY.4.2 serious expansion 31 seqs at GISAID 10/20 AM >4,000 seqs 10/20 PM 14,390 seqs 10/21 AM 9,060 have G142D and Y145H in Spike https://recombinomics.co/thedrnimanshow/2021/09/102121_Delta_Demolition.mp3 Report
October 22, 20214 yr Author comment_48648 Oct 22 Delta Plus Anthony Fauci called AY.4.2 "Delta Plus" (over 18,000 at GISAID) Name rules allow only 3 divisions Delta = B.1.617 which evolved to B.1.617.1, B.1.617.2, B.1.617.3 B.1.617.2 took over world AY = more evolved B.1.617.2 AY currently at 55 versions AY.4.2 = B.1.617.2.1.4.2 https://recombinomics.co/thedrnimanshow/2021/09/102221_Delta_Plus.mp3 Report
November 25, 20214 yr Author comment_49912 Nov 25 New variant B.1.1.529 Currently 64 with above lineage Recombinant between Beta and Delta First GISAID deposit 11/22 (Hong Kong) Next three 11/23 (Botswana) Most (58) South Africa Many not yet designated https://recombinomics.co/thedrnimanshow/2021/09/112521_B11529_Beta_Delta.mp3 Report
November 26, 20214 yr Author comment_49917 Nov 26 B.1.1.529 to be named Nu at WHO meeting today Vaccine resistant Hong Kong ex-South Africa PFE VAX Tested+ in quarantine Onward transmission in quarantine Monitored with S drop-out (SGTF) Rapid Spread in SA https://recombinomics.co/thedrnimanshow/2021/09/112621_Nu_VAX-Resist.mp3 Report
November 26, 20214 yr Author comment_49928 Nov 26 B.1.1.529 / Nu variant spread to Israel /Malawi S Drop-out / SGTF detects rapid spread in South Africa NSP6 Dels match Alpha/Beta/Gamma Stock Markets decline https://recombinomics.co/thedrnimanshow/2021/09/112621-Nu_Israel_Malawi.mp3 Edited November 26, 20214 yr by niman Report
November 27, 20214 yr Author comment_49936 Nov 27 B.1.1.529 = Omicron Declared VOC Travel Bans Israel & Belgium seqs Netherlands - 61 COVID pass Germany - 1 partial Omicron seq https://recombinomics.co/thedrnimanshow/2021/09/112721_Netherlands_Germany.mp3 Report
December 1, 20214 yr Author comment_50153 Dec 1 Omicron confirmed In US (San Francisco ex-South Africa) Returned to US 11/22 Self-reported Confirmed by PCR, S Drop-out, sequencing 23 other countries have at least 2 conf cases https://recombinomics.co/thedrnimanshow/2021/09/120121_Omicron_US.mp3 Report
December 14, 20214 yr Author comment_50677 Dec 14 Omicron Spread 13% of tests in NY/NJ Omicron positive WA & Houston Methodist similar Reporting delay Dominant this week in some US Dominant today in London https://recombinomics.co/thedrnimanshow/2021/09/121421_Omicron_Spread.mp3 Report
December 15, 20214 yr Author comment_50716 Dec 15 Red Alert Cornell at Ithaca, NY 903 COVID positives in 1 week Most show S-drop Likely Omicron University largely shut down https://recombinomics.co/thedrnimanshow/2021/09/121521_Omicron_Ithaca.mp3 Report
December 22, 20214 yr Author comment_50960 12/22/21 P681R in Omicron 2nd Furin cleavage site Common in Delta Limited in Omicron (15 seqs) NYU Langone released 65 seqs on 12/21 https://recombinomics.co/thedrnimanshow/2021/09/122221_Omicron_P681R_NYU.mp3 Edited December 22, 20214 yr by niman Report
December 22, 20214 yr Author comment_50961 12/22/21 P681R in Omicron 2 Prior examples in US (TX, WA) 65/160 NYU Langone sequences released 12/21 had P681R None had 229E insert Most had 36 NT deleted https://recombinomics.co/thedrnimanshow/2021/09/122221_Omicron_NoInsert.mp3 Report
December 23, 20214 yr Author comment_50979 12/22/21 P681R on Omicron background Houston Methodist released 6 six sequences at GISAID tonight Collection dates Dec 13-15 Suggests widespread (60 seqs in NYC released yesterday) and under-reported https://recombinomics.co/thedrnimanshow/2021/09/122221_Omicron_P681R_Houston.mp3 Edited December 23, 20214 yr by niman Report
Please sign in to comment
You will be able to leave a comment after signing in
Sign In Now