niman Posted March 20, 2021 Author Report Posted March 20, 2021 On 3/14/2021 at 9:59 PM, OaO said: I agree Jon. I found it very interesting. There has always been a question as to why the second wave of the 1918 pandemic decimated the 20-30 yr. old crowd. From Johns Hopkins history about 1918: "Yet much about the pandemic remains unsettled, particularly the mystery surrounding the shape of the flu’s devastation. In a normal flu epidemic, a graph of fatalities looks like the letter U, with the twin peaks representing a heavy toll among young children and the frail elderly. That graph of the 1918 flu looks more like a misshapen W, with an astonishing middle peak reflecting that it was most fatal to perfectly healthy adults in their 20s and 30s." There has been a lot of elitist "expert" hand waving about this virus. The blinders are firmly attached, as they believe that they understand the full spectrum of viral expression. They do not! I find them to be smug. arrogant and dogmatic. Not much debate among scientists. Young people affected due to cytokine storm due to robust immune system (VERY old story) 1
niman Posted March 20, 2021 Author Report Posted March 20, 2021 Mar 20 Variants clearly winning battle between variants and vaccines Large update up Helix - US frequency of B.1.1.7 at 50% Some states (including TX and GA up to 60% - explosion of cases expected) NY variant (B.1.526) exploding and spreading (over 300 new cases on NYC in latest PRL update) B.1.526 spread along east coast to Aruba https://recombinomics.co/thedrnimanshow/2021/032021_Variants_Winning.mp3
niman Posted March 30, 2021 Author Report Posted March 30, 2021 Mar 30 Variant and Map update Vaccine update CDC variant map NY Variants B.1.526, B.1.526.1, B.1.526.2 https://recombinomics.co/thedrnimanshow/2021/032021_Variant_Map.mp3
Dimitar Posted April 1, 2021 Report Posted April 1, 2021 Excellent coverage as always, Dr. Niman. I’m listening to your interviews and admire the amount of work that goes trough your hands. In the last few minutes of some of the recordings however, the audio breaks and one could barely understand what you are saying. Best, Dimitar
niman Posted April 14, 2021 Author Report Posted April 14, 2021 4/14/21 JNJ Vaccine Halted Symptoms and target population (younger females) match AstraZeneca JNJ and AstraZeneca use adenovirus vector Moderna and Pfizer use mRNA and have not reported similar problem Number of US vaccinations of younger females far less than 7 million https://recombinomics.co/thedrnimanshow/2021/041421_Vac_JNJ.mp3
niman Posted April 26, 2021 Author Report Posted April 26, 2021 4/26.21 JNJ vaccine resumed Variant seqs past week by PRI (NY) B.1.1.7 460 B.1.526 (E484K) 299 B.1.526.1 (L452R) 82 B.1.526.2 (S477N) 129 https://recombinomics.co/thedrnimanshow/2021/042621_Var_Vac_Update.mp3
niman Posted May 28, 2021 Author Report Posted May 28, 2021 May 28 Furin Cleavage Site Codon 2 R's coded by CGG Least favored by coronavirus US Spike in India Variant (B.1.617.2) 1114/1253 seqs at GISAID deposited this month L452R, T478K, P681R https://recombinomics.co/thedrnimanshow/2021/052821 India.mp3
J Enders Posted July 10, 2021 Report Posted July 10, 2021 Any chance you will be putting out new audio updates anytime soon? We miss the interviews and insights!
niman Posted July 30, 2021 Author Report Posted July 30, 2021 Jul 29 Delta Heterogeneous B.1.617.1 B.1.617.2 B.1.617.3 AY.1 AY.2 AY.3 R0 = 5-8 (same level as chickenpox) GISAID seqs Louisiana - many breakthroughs Singapore breakthroughs (75% of new cases) High viral load incl breakthroughs https://recombinomics.co/thedrnimanshow/2021/072921_Delta_Hetero.mp3 1
niman Posted July 30, 2021 Author Report Posted July 30, 2021 (edited) July 30 Early Release MMWR Large cluster of 430 in Barnstable Co MA Most were fully vaccinated Most were infected with Delta (B.1.617.2) Viral load in vaccinated same as unvaccinated https://recombinomics.co/thedrnimanshow/2021/073021_Barnstable.mp3 Edited July 30, 2021 by niman 1
niman Posted August 18, 2021 Author Report Posted August 18, 2021 Aug 18 Boosters for Pfizer / Moderna starting Sep 20 8 weeks after 2nd shot 3 early release MMWRs Waning immunity 9 new Delta versions - AY.4-AY.12 15/16 in US 3 at >99% in US (AY.2 AY.3 AY.3.1) https://recombinomics.co/thedrnimanshow/2021/081821_Boosters.mp3
niman Posted September 17, 2021 Author Report Posted September 17, 2021 Sep 17 Boosters and Breakthroughs FDA meeting on Pfizer Boosters NEJM on >60 after 6 mo from 2nd dose Approval likely Possible limitation to >60 https://recombinomics.co/thedrnimanshow/2021/09/091721_Booster.mp3
niman Posted October 21, 2021 Author Report Posted October 21, 2021 Oct 21 Delta Demolition Over 50 named Delta Variants AY.4.2 serious expansion 31 seqs at GISAID 10/20 AM >4,000 seqs 10/20 PM 14,390 seqs 10/21 AM 9,060 have G142D and Y145H in Spike https://recombinomics.co/thedrnimanshow/2021/09/102121_Delta_Demolition.mp3
niman Posted October 22, 2021 Author Report Posted October 22, 2021 Oct 22 Delta Plus Anthony Fauci called AY.4.2 "Delta Plus" (over 18,000 at GISAID) Name rules allow only 3 divisions Delta = B.1.617 which evolved to B.1.617.1, B.1.617.2, B.1.617.3 B.1.617.2 took over world AY = more evolved B.1.617.2 AY currently at 55 versions AY.4.2 = B.1.617.2.1.4.2 https://recombinomics.co/thedrnimanshow/2021/09/102221_Delta_Plus.mp3
niman Posted November 25, 2021 Author Report Posted November 25, 2021 Nov 25 New variant B.1.1.529 Currently 64 with above lineage Recombinant between Beta and Delta First GISAID deposit 11/22 (Hong Kong) Next three 11/23 (Botswana) Most (58) South Africa Many not yet designated https://recombinomics.co/thedrnimanshow/2021/09/112521_B11529_Beta_Delta.mp3
niman Posted November 26, 2021 Author Report Posted November 26, 2021 Nov 26 B.1.1.529 to be named Nu at WHO meeting today Vaccine resistant Hong Kong ex-South Africa PFE VAX Tested+ in quarantine Onward transmission in quarantine Monitored with S drop-out (SGTF) Rapid Spread in SA https://recombinomics.co/thedrnimanshow/2021/09/112621_Nu_VAX-Resist.mp3
niman Posted November 26, 2021 Author Report Posted November 26, 2021 (edited) Nov 26 B.1.1.529 / Nu variant spread to Israel /Malawi S Drop-out / SGTF detects rapid spread in South Africa NSP6 Dels match Alpha/Beta/Gamma Stock Markets decline https://recombinomics.co/thedrnimanshow/2021/09/112621-Nu_Israel_Malawi.mp3 Edited November 26, 2021 by niman 1
niman Posted November 27, 2021 Author Report Posted November 27, 2021 Nov 27 B.1.1.529 = Omicron Declared VOC Travel Bans Israel & Belgium seqs Netherlands - 61 COVID pass Germany - 1 partial Omicron seq https://recombinomics.co/thedrnimanshow/2021/09/112721_Netherlands_Germany.mp3
niman Posted December 1, 2021 Author Report Posted December 1, 2021 Dec 1 Omicron confirmed In US (San Francisco ex-South Africa) Returned to US 11/22 Self-reported Confirmed by PCR, S Drop-out, sequencing 23 other countries have at least 2 conf cases https://recombinomics.co/thedrnimanshow/2021/09/120121_Omicron_US.mp3
niman Posted December 14, 2021 Author Report Posted December 14, 2021 Dec 14 Omicron Spread 13% of tests in NY/NJ Omicron positive WA & Houston Methodist similar Reporting delay Dominant this week in some US Dominant today in London https://recombinomics.co/thedrnimanshow/2021/09/121421_Omicron_Spread.mp3
niman Posted December 15, 2021 Author Report Posted December 15, 2021 Dec 15 Red Alert Cornell at Ithaca, NY 903 COVID positives in 1 week Most show S-drop Likely Omicron University largely shut down https://recombinomics.co/thedrnimanshow/2021/09/121521_Omicron_Ithaca.mp3
niman Posted December 22, 2021 Author Report Posted December 22, 2021 (edited) 12/22/21 P681R in Omicron 2nd Furin cleavage site Common in Delta Limited in Omicron (15 seqs) NYU Langone released 65 seqs on 12/21 https://recombinomics.co/thedrnimanshow/2021/09/122221_Omicron_P681R_NYU.mp3 Edited December 22, 2021 by niman
niman Posted December 22, 2021 Author Report Posted December 22, 2021 12/22/21 P681R in Omicron 2 Prior examples in US (TX, WA) 65/160 NYU Langone sequences released 12/21 had P681R None had 229E insert Most had 36 NT deleted https://recombinomics.co/thedrnimanshow/2021/09/122221_Omicron_NoInsert.mp3
niman Posted December 23, 2021 Author Report Posted December 23, 2021 (edited) 12/22/21 P681R on Omicron background Houston Methodist released 6 six sequences at GISAID tonight Collection dates Dec 13-15 Suggests widespread (60 seqs in NYC released yesterday) and under-reported https://recombinomics.co/thedrnimanshow/2021/09/122221_Omicron_P681R_Houston.mp3 Edited December 23, 2021 by niman
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