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Poultry Flock Tests Positive for Low Pathogenic Avian Influenza Thursday, March 09, 2017 | 12:09pm NASHVILLE — The state veterinarian confirms that a flock of chickens at a commercial poultry breeding operation has tested positive for low pathogenic avian influenza (LPAI). This chicken breeding operation is located in Giles County, Tenn. The company that operates it is a different company from the one associated with the recent detection of highly pathogenic avian influenza (HPAI) in Lincoln County. At this time, officials do not believe one premises sickened the other. On March 6, routine screening tests at the Giles County premises indicated the presence of avian influenza in the flock. State and federal laboratories confirmed the existence of H7N9 LPAI in tested samples. “This is why we test and monitor for avian influenza,” State Veterinarian Dr. Charles Hatcher said. “When routine testing showed a problem at this facility, the operators immediately took action and notified our lab. That fast response is critical to stopping the spread of this virus.” As a precaution, the affected flock was depopulated and has been buried. The premises is under quarantine. Domesticated poultry within a 10 kilometer (6.2 mile) radius of the site are also under quarantine and are being tested and monitored for illness. To date, all additional samples have tested negative for avian influenza and no other flocks within the area have shown signs of illness. The primary difference between LPAI and HPAI is mortality rate in domesticated poultry. A slight change to the viral structure can make a virus deadly for birds. Avian influenza virus strains often occur naturally in wild migratory birds without causing illness in those birds. With LPAI, domesticated chickens and turkeys may show little or no signs of illness. However, HPAI is often fatal for domesticated poultry. The Giles County LPAI incident is similar to the Lincoln County HPAI incident in that both the low pathogenic and highly pathogenic viruses are an H7N9 strain of avian influenza. USDA’s National Veterinary Services Laboratories confirms the H7N9 virus that affected the Lincoln County premises is of North American wild bird lineage. It is not the same as the China H7N9 virus affecting Asia and is genetically distinct. The Lincoln County premises affected by HPAI remains under quarantine. To date, all additional poultry samples from the area surrounding that site have tested negative for avian influenza and no other flocks within the area have shown signs of illness. Testing and monitoring continues. Neither LPAI nor HPAI pose a risk to the food supply. No affected animals entered the food chain. The risk of a human becoming ill with avian influenza during poultry outbreaks is very low. However, out of an abundance of caution, officials with the Tennessee Department of Health and Tennessee Department of Agriculture are working together to monitor the health of individuals who are working on either premises or had contact with affected birds. The plan for the control of avian influenza includes coordination of local, county, state and federal resources and response, and protocols for quarantine, testing, disposal, cleaning, disinfection and monitoring. Owners of commercial and backyard poultry flocks are encouraged to closely observe their birds. Report a sudden increase in the number of sick birds or bird deaths to the state veterinarian’s office at 615- 837-5120 and/or USDA at 1-866-536-7593. Prevent contact with wild birds. Practice good biosecurity with your poultry. Enroll in the National Poultry Improvement Plan. Follow Tennessee’s avian influenza updates and access resources for producers and consumers. The state veterinarian and staff are focused on animal health and disease prevention. Each year, the Kord Animal Health Diagnostic Laboratory tests approximately 22,000 samples from poultry for avian flu. - See more at: https://www.tn.gov/agriculture/news/49066#sthash.5EsIZ10A.dpuf

TN has detected low path H7N9 at chicken farm in Giles County, TN suggesting Lincoln County outbreak began as LPAI.

Highly pathogenic avian influenza, United States of America Information received on 08/03/2017 from Dr John Clifford, Official Delegate, Chief Trade Advisor, Animal and Plant Health Inspection Service, United States Department of Agriculture, Washington, United States of America Summary Report type Follow-up report No. 1 Date of start of the event 01/03/2017 Date of confirmation of the event 04/03/2017 Report date 08/03/2017 Date submitted to OIE 08/03/2017 Reason for notification Reoccurrence of a listed disease Date of previous occurrence 2016 Manifestation of disease Clinical disease Causal agent Highly pathogenic avian influenza virus Serotype H7N9 Nature of diagnosis Laboratory (advanced) This event pertains to a defined zone within the country Related reports Immediate notification (06/03/2017) Follow-up report No. 1 (08/03/2017) Outbreaks There are no new outbreaks in this report Epidemiology Source of the outbreak(s) or origin of infection Unknown or inconclusive Epidemiological comments The USDA Animal and Plant Health Inspection Service (APHIS), in conjunction with the Tennessee Department of Agriculture, are continuing to respond to the identification of a highly pathogenic avian influenza (HPAI) H7N9 of North American wild bird lineage based on full genome sequence analysis in a chicken broiler breeder flock. All eight gene segments of the virus are North American wild bird lineage. This is NOT the same as the China H7N9 lineage that has impacted poultry and infected humans in Asia. Although the subtypes are the same (H7N9) the virus detected in the United States is a very different virus, genetically distinct from the China H7N9 lineage. A comprehensive epidemiological investigation in the surrounding area is continuing and enhanced surveillance and testing has begun. The first round of testing of all commercial poultry premises in a 10 mile (16 kilometer) surveillance zone has been completed with all results negative for avian influenza virus. State officials have quarantined the affected premises and implemented movement controls. Depopulation of birds on the premises has been completed and disposal of the birds is near completion. Control measures Measures applied Movement control inside the country Quarantine Surveillance outside containment and/or protection zone Stamping out Official disposal of carcasses, by-products and waste Surveillance within containment and/or protection zone Zoning Vaccination prohibited No treatment of affected animals Measures to be applied Disinfection / Disinfestation Diagnostic test results Laboratory name and type Species Test Test date Result National Veterinary Services Laboratories (NVSL) (National laboratory) Birds virus isolation Pending National Veterinary Services Laboratories (NVSL) (National laboratory) Birds virus sequencing 07/03/2017 Positive Future Reporting The event is continuing. Weekly follow-up reports will be submitted. http://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?page_refer=MapFullEventReport&reportid=23161

Map Update https://www.google.com/maps/d/edit?hl=en&hl=en&authuser=0&authuser=0&mid=1k-KvqZz3R_Dhe4TOrFD7aYv34Hs&ll=35.03189297382676%2C-86.33597405212402&z=15

Map Update https://www.google.com/maps/d/edit?hl=en&hl=en&authuser=0&authuser=0&mid=1k-KvqZz3R_Dhe4TOrFD7aYv34Hs&ll=35.03189297382676%2C-86.33597405212402&z=15

Likely farm in Elora https://www.google.com/maps/@35.0422789,-86.3288844,1183a,20y,180h,44.75t/data=!3m1!1e3

Virus Deadly to Poultry Detected in Tennessee Sunday, March 05, 2017 | 12:11pm NASHVILLE — The state veterinarian confirms that a strain of highly pathogenic avian influenza (HPAI) has sickened a commercial chicken breeder flock in Lincoln County. “Many Tennessee families rely on the poultry industry for their livelihoods, and the state is working closely with local, county and federal partners and the poultry industry to control the situation and protect the flocks that are critical to our state’s economy,” Gov. Bill Haslam said. HPAI is known to be deadly for domesticated chickens and turkeys. On March 3, a commercial chicken facility in Lincoln County alerted the state veterinarian’s office at the Tennessee Department of Agriculture to an increase in chicken deaths. Testing at state and federal laboratories confirmed the presence of H7 HPAI in samples from that flock. “Animal health is our top priority,” state veterinarian, Dr. Charles Hatcher, DVM said. “With this HPAI detection, we are moving quickly and aggressively to prevent the virus from spreading.” The facility is under quarantine, along with approximately 30 other poultry farms within a 10 kilometer radius (6.2 miles) of the site. The affected flock is being depopulated to stop potential spread of the illness, and officials are testing and monitoring other flocks within the quarantined area. No other flocks have experienced an increase in mortality. HPAI does not pose a risk to the food supply. No affected animals entered the food chain. The risk of human infection with avian influenza during poultry outbreaks is very low. In fact, no transmission to humans was reported during the outbreak that affected commercial poultry farms in the Midwestern United States in 2015. Also, this is not the same strain identified in that outbreak. However, out of an abundance of caution, officials with the Tennessee Department of Health and Tennessee Department of Agriculture are working together to address concerns about the health of individuals who are working on site or had contact with affected birds. Prior to this HPAI case, the most recent U.S. detection was in January of 2016 in a commercial turkey flock in Indiana. “Although this is a situation no state wants to face, Tennessee has been actively preparing to respond to HPAI since it was first identified as a threat,” Commissioner of Agriculture Jai Templeton said. This is the first time highly pathogenic avian influenza has been detected in Tennessee, however low path avian influenza has affected Tennessee poultry flocks in the past. State officials and partners have extensive experience in effectively containing the virus. The plan for the control of avian influenza includes coordination of resources and response, and protocols for quarantine, testing, disposal, cleaning, disinfection and monitoring. Owners of commercial and backyard poultry flocks are encouraged to closely observe their birds. * Report a sudden increase in the number of sick birds or bird deaths to the state veterinarian’s office at 615- 837-5120 and/or USDA at 1-866-536-7593 * Prevent contact with wild birds * Practice good biosecurity with your poultry flock * Enroll in the National Poultry Improvement Plan * Follow Animal Health Alert updates The source of the Lincoln County virus has not yet been determined. This version of H7 HPAI is confirmed as a North American wild bird lineage. The state veterinarian and staff are focused on animal health and disease prevention. Each year, the Kord Animal Health lab tests approximately 22,000 samples from poultry for avian flu. - See more at: https://www.tn.gov/agriculture/news/48946#sthash.3amJYiIR.dpuf https://www.tn.gov/agriculture/news/48946

USDA Confirms Highly Pathogenic H7 Avian Influenza in a Commercial Flock in Lincoln County, Tennessee USDA Animal and Plant Health Inspection Service sent this bulletin at 03/05/2017 12:35 PM EST Contacts: Donna Karlsons, 301-851-4107 [email protected] Lyndsay Cole, 970-494-7410 [email protected] March 5, 2017, Washington – The United States Department of Agriculture’s (USDA) Animal and Plant Health Inspection Service (APHIS) has confirmed the presence of highly pathogenic H7 avian influenza (HPAI) of North American wild bird lineage in a commercial chicken breeder flock in Lincoln County, Tennessee. This is the first confirmed case of HPAI in commercial poultry in the United States this year. The flock of 73,500 is located within the Mississippi flyway. Samples from the affected flock, which experienced increased mortality, were tested at Tennessee’s Kord Animal Health Diagnostic Laboratory and confirmed at the APHIS National Veterinary Services Laboratories (NVSL) in Ames, Iowa. Virus isolation is ongoing, and NVSL expects to characterize the neuraminidase protein, or “N-type”, of the virus within 48 hours. APHIS is working closely with the Tennessee Department of Agriculture on a joint incident response. State officials quarantined the affected premises and birds on the property will be depopulated to prevent the spread of the disease. Birds from the flock will not enter the food system. The Tennessee Department of Agriculture is working directly with poultry workers at the affected facility to ensure that they are taking the proper precautions to prevent illness and contain disease spread. As a reminder, the proper handling and cooking of poultry and eggs to an internal temperature of 165 ˚F kills bacteria and viruses. As part of existing avian influenza response plans, Federal and State partners are working jointly on additional surveillance and testing in the nearby area. The United States has the strongest AI surveillance program in the world, and USDA is working with its partners to actively look for the disease in commercial poultry operations, live bird markets and in migratory wild bird populations. USDA will be informing the World Organization for Animal Health (OIE) as well as international trading partners of this finding. USDA also continues to communicate with trading partners to encourage adherence to OIE standards and minimize trade impacts. OIE trade guidelines call on countries to base trade restrictions on sound science and, whenever possible, limit restrictions to those animals and animal products within a defined region that pose a risk of spreading disease of concern. These virus strains can travel in wild birds without them appearing sick. People should avoid contact with sick/dead poultry or wildlife. If contact occurs, wash your hands with soap and water and change clothing before having any contact with healthy domestic poultry and birds. All bird owners, whether commercial producers or backyard enthusiasts, should continue to practice good biosecurity, prevent contact between their birds and wild birds, and report sick birds or unusual bird deaths to State/Federal officials, either through their state veterinarian or through USDA’s toll-free number at 1-866-536-7593. Additional information on biosecurity for can be found at www.aphis.usda.gov/animalhealth/defendtheflock. Additional background Avian influenza (AI) is caused by an influenza type A virus which can infect poultry (such as chickens, turkeys, pheasants, quail, domestic ducks, geese and guinea fowl) and is carried by free flying waterfowl such as ducks, geese and shorebirds. AI viruses are classified by a combination of two groups of proteins: hemagglutinin or “H” proteins, of which there are 16 (H1–H16), and neuraminidase or “N” proteins, of which there are 9 (N1–N9). Many different combinations of “H” and “N” proteins are possible. Each combination is considered a different subtype, and can be further broken down into different strains. AI viruses are further classified by their pathogenicity (low or high)— the ability of a particular virus strain to produce disease in domestic chickens. # USDA is an equal opportunity provider and employer. To file a complaint of discrimination, write: USDA, Office of the Assistant Secretary for Civil Rights, Office of Adjudication, 1400 Independence Ave., SW, Washington, DC 20250-9410 or call (866) 632-9992 (Toll-free Customer Service), (800) 877-8339 (Local or Federal relay), (866) 377-8642 (Relay voice users).

The United States Department of Agriculture’s (USDA) Animal and Plant Health Inspection Service (APHIS) has confirmed the presence of highly pathogenic H7 avian influenza (HPAI) of North American wild bird lineage in a commercial chicken breeder flock in Lincoln County, Tennessee. This is the first confirmed case of HPAI in commercial poultry in the United States this year. The flock of 73,500 is located within the Mississippi flyway. https://content.govdelivery.com/accounts/USDAAPHIS/bulletins/18b5193

Isolate detail Isolate name: A/Jiangsu/60454/2016 Isolate ID: EPI_ISL_242883 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-11-25 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Jiangsu Patient age: 64 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_JIANGSU_60454_2016_NOV-PB2 2280 EPI887937 PB1 A_JIANGSU_60454_2016_NOV-PB1 2274 EPI887938 PA A_JIANGSU_60454_2016_NOV-PA 2151 EPI887936 HA A_JIANGSU_60454_2016_NOV-HA 1683 EPI887940 NP A_JIANGSU_60454_2016_NOV-NP 1497 EPI887933 NA A_JIANGSU_60454_2016_NOV-NA 1398 EPI887939 MP A_JIANGSU_60454_2016_NOV-MP 982 EPI887935 NS A_JIANGSU_60454_2016_NOV-NS 838 EPI887934 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60936/2016 Isolate ID: EPI_ISL_242884 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-16 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 49 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60936_2016_DEC-PB2 2280 EPI887945 PB1 A_ANHUI_60936_2016_DEC-PB1 2274 EPI887946 PA A_ANHUI_60936_2016_DEC-PA 2151 EPI887944 HA A_ANHUI_60936_2016_DEC-HA 1683 EPI887948 NP A_ANHUI_60936_2016_DEC-NP 1497 EPI887941 NA A_ANHUI_60936_2016_DEC-NA 1398 EPI887947 MP A_ANHUI_60936_2016_DEC-MP 982 EPI887943 NS A_ANHUI_60936_2016_DEC-NS 838 EPI887942 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Jiangsu/60451/2016 Isolate ID: EPI_ISL_242885 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-19 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Jiangsu Patient age: 73 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_JIANGSU_60451_2016_DEC-PB2 2280 EPI887953 PB1 A_JIANGSU_60451_2016_DEC-PB1 2274 EPI887954 PA A_JIANGSU_60451_2016_DEC-PA 2151 EPI887952 HA A_JIANGSU_60451_2016_DEC-HA 1683 EPI887956 NP A_JIANGSU_60451_2016_DEC-NP 1497 EPI887949 NA A_JIANGSU_60451_2016_DEC-NA 1398 EPI887955 MP A_JIANGSU_60451_2016_DEC-MP 982 EPI887951 NS A_JIANGSU_60451_2016_DEC-NS 838 EPI887950 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Jiangsu/60450/2016 Isolate ID: EPI_ISL_242886 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-19 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Jiangsu Patient age: 23 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_JIANGSU_60450_2016_DEC-PB2 2280 EPI887961 PB1 A_JIANGSU_60450_2016_DEC-PB1 2274 EPI887962 PA A_JIANGSU_60450_2016_DEC-PA 2151 EPI887960 HA A_JIANGSU_60450_2016_DEC-HA 1683 EPI887964 NP A_JIANGSU_60450_2016_DEC-NP 1497 EPI887957 NA A_JIANGSU_60450_2016_DEC-NA 1398 EPI887963 MP A_JIANGSU_60450_2016_DEC-MP 982 EPI887959 NS A_JIANGSU_60450_2016_DEC-NS 838 EPI887958 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Jiangsu/60447/2016 Isolate ID: EPI_ISL_242887 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-16 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Jiangsu Patient age: 73 Year(s) Gender: Female Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_JIANGSU_60447_2016_DEC-PB2 2280 EPI887969 PB1 A_JIANGSU_60447_2016_DEC-PB1 2274 EPI887970 PA A_JIANGSU_60447_2016_DEC-PA 2151 EPI887968 HA A_JIANGSU_60447_2016_DEC-HA 1683 EPI887972 NP A_JIANGSU_60447_2016_DEC-NP 1497 EPI887965 NA A_JIANGSU_60447_2016_DEC-NA 1398 EPI887971 MP A_JIANGSU_60447_2016_DEC-MP 982 EPI887967 NS A_JIANGSU_60447_2016_DEC-NS 838 EPI887966 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Guangdong/60061/2016 Isolate ID: EPI_ISL_242888 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-13 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Guangdong Patient age: 49 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Guandong Centers for Disease Control Sample ID given by the sample provider: Address: Guandong Centers for Disease Control 176 Xingang Western Road , Guangzhou China Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_GUANGDONG_60061_2016_DEC-PB2 2280 EPI887977 PB1 A_GUANGDONG_60061_2016_DEC-PB1 2274 EPI887978 PA A_GUANGDONG_60061_2016_DEC-PA 2151 EPI887976 HA A_GUANGDONG_60061_2016_DEC-HA 1683 EPI887980 NP A_GUANGDONG_60061_2016_DEC-NP 1497 EPI887973 NA A_GUANGDONG_60061_2016_DEC-NA 1398 EPI887979 MP A_GUANGDONG_60061_2016_DEC-MP 982 EPI887975 NS A_GUANGDONG_60061_2016_DEC-NS 838 EPI887974 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60927/2016 Isolate ID: EPI_ISL_242889 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-18 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 53 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60927_2016_DEC-PB2 2280 EPI887985 PB1 A_ANHUI_60927_2016_DEC-PB1 2274 EPI887986 PA A_ANHUI_60927_2016_DEC-PA 2151 EPI887984 HA A_ANHUI_60927_2016_DEC-HA 1683 EPI887988 NP A_ANHUI_60927_2016_DEC-NP 1497 EPI887981 NA A_ANHUI_60927_2016_DEC-NA 1398 EPI887987 MP A_ANHUI_60927_2016_DEC-MP 982 EPI887983 NS A_ANHUI_60927_2016_DEC-NS 838 EPI887982 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60924/2016 Isolate ID: EPI_ISL_242890 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-22 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 55 Year(s) Gender: Female Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60924_2016_DEC-PB2 2280 EPI887993 PB1 A_ANHUI_60924_2016_DEC-PB1 2274 EPI887994 PA A_ANHUI_60924_2016_DEC-PA 2151 EPI887992 HA A_ANHUI_60924_2016_DEC-HA 1683 EPI887996 NP A_ANHUI_60924_2016_DEC-NP 1497 EPI887989 NA A_ANHUI_60924_2016_DEC-NA 1398 EPI887995 MP A_ANHUI_60924_2016_DEC-MP 982 EPI887991 NS A_ANHUI_60924_2016_DEC-NS 838 EPI887990 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60928/2016 Isolate ID: EPI_ISL_242892 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-15 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: Gender: Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60928_2016_DEC-PB2 2280 EPI888009 PB1 A_ANHUI_60928_2016_DEC-PB1 2274 EPI888010 PA A_ANHUI_60928_2016_DEC-PA 2151 EPI888008 HA A_ANHUI_60928_2016_DEC-HA 1683 EPI888012 NP A_ANHUI_60928_2016_DEC-NP 1497 EPI888005 NA A_ANHUI_60928_2016_DEC-NA 1398 EPI888011 MP A_ANHUI_60928_2016_DEC-MP 982 EPI888007 NS A_ANHUI_60928_2016_DEC-NS 838 EPI888006 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60925/2016 Isolate ID: EPI_ISL_242891 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-21 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 66 Year(s) Gender: Female Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60925_2016_DEC-PB2 2280 EPI888001 PB1 A_ANHUI_60925_2016_DEC-PB1 2274 EPI888002 PA A_ANHUI_60925_2016_DEC-PA 2151 EPI888000 HA A_ANHUI_60925_2016_DEC-HA 1683 EPI888004 NP A_ANHUI_60925_2016_DEC-NP 1497 EPI887997 NA A_ANHUI_60925_2016_DEC-NA 1398 EPI888003 MP A_ANHUI_60925_2016_DEC-MP 982 EPI887999 NS A_ANHUI_60925_2016_DEC-NS 838 EPI887998 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60929/2016 Isolate ID: EPI_ISL_242893 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-15 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 65 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60929_2016_DEC-PB2 2280 EPI888017 PB1 A_ANHUI_60929_2016_DEC-PB1 2274 EPI888018 PA A_ANHUI_60929_2016_DEC-PA 2151 EPI888016 HA A_ANHUI_60929_2016_DEC-HA 1683 EPI888020 NP A_ANHUI_60929_2016_DEC-NP 1497 EPI888013 NA A_ANHUI_60929_2016_DEC-NA 1398 EPI888019 MP A_ANHUI_60929_2016_DEC-MP 982 EPI888015 NS A_ANHUI_60929_2016_DEC-NS 838 EPI888014 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60932/2016 Isolate ID: EPI_ISL_242894 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-19 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 60 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60932_2016_DEC-PB2 2280 EPI888025 PB1 A_ANHUI_60932_2016_DEC-PB1 2274 EPI888026 PA A_ANHUI_60932_2016_DEC-PA 2151 EPI888024 HA A_ANHUI_60932_2016_DEC-HA 1683 EPI888028 NP A_ANHUI_60932_2016_DEC-NP 1497 EPI888021 NA A_ANHUI_60932_2016_DEC-NA 1398 EPI888027 MP A_ANHUI_60932_2016_DEC-MP 982 EPI888023 NS A_ANHUI_60932_2016_DEC-NS 838 EPI888022 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60931/2016 Isolate ID: EPI_ISL_242895 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-13 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 73 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60931_2016_DEC-PB2 2280 EPI888033 PB1 A_ANHUI_60931_2016_DEC-PB1 2274 EPI888034 PA A_ANHUI_60931_2016_DEC-PA 2151 EPI888032 HA A_ANHUI_60931_2016_DEC-HA 1683 EPI888036 NP A_ANHUI_60931_2016_DEC-NP 1497 EPI888029 NA A_ANHUI_60931_2016_DEC-NA 1398 EPI888035 MP A_ANHUI_60931_2016_DEC-MP 982 EPI888031 NS A_ANHUI_60931_2016_DEC-NS 838 EPI888030 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China

Isolate detail Isolate name: A/Anhui/60933/2016 Isolate ID: EPI_ISL_242896 Passage details/history: E1 Type: A / H7N9 Lineage: Sample information Collection date: 2016-12-19 Host Human Additional host information: Zip code: Patient status: Last vaccinated: In-vivo pathogenicity test: Location: China Additional location information: Anhui Patient age: 66 Year(s) Gender: Male Outbreak: Treatment: Specimen source: Institute information Originating lab: Sample ID given by the sample provider: Address: Submitting lab: WHO Chinese National Influenza Center Sample ID given by the submitting laboratory: Authors: Wang,Dayan; Zhou,Shumei; Li,Xiyan; Li,Xiaodan; Zhang,Ye; Bo,Hong; Shu,Yuelong Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A_ANHUI_60933_2016_DEC-PB2 2280 EPI888041 PB1 A_ANHUI_60933_2016_DEC-PB1 2274 EPI888042 PA A_ANHUI_60933_2016_DEC-PA 2151 EPI888040 HA A_ANHUI_60933_2016_DEC-HA 1683 EPI888044 NP A_ANHUI_60933_2016_DEC-NP 1497 EPI888037 NA A_ANHUI_60933_2016_DEC-NA 1398 EPI888043 MP A_ANHUI_60933_2016_DEC-MP 982 EPI888039 NS A_ANHUI_60933_2016_DEC-NS 838 EPI888038 Submitter information Submitter: Yang, Lei Submission Date: 2017-01-25 Last modifier: Yang, Lei Last modified: 2017-01-25 Address: WHO Chinese National Influenza Center Virology Institute, Chinese CDC 155 Changbai Road, Changping District, Beijing 102206 China