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Rizhao Juxian a villager was diagnosed with H7N9 avian influenza Source: Qilu OF: Liu nine provinces 2017-02-19 21:36:47 February 19, Juxian a 48-year-old female villagers were diagnosed with H7N9 avian influenza. At present, Juxian Health and Family Planning Department has been on the families of patients to adjust, the epidemic informed the livestock sector, close contact with the follow-up investigation, and the patient's home epidemic treatment. 　　February 19, Juxian a 48-year-old female villagers were diagnosed with H7N9 avian influenza, the villagers at home to raise more than 100 chickens, nearly a week of death four or five. February 12 onset, fever 39.5 ℃, in the village health room after two days of invalid transfusion to Juxian Chinese medicine hospital treatment, February 18 to Qingdao Qilu University Hospital, February 19 morning was diagnosed with H7N9 avian influenza, Is currently being actively treated. 　　After receiving this report, Juxian County, the county government in accordance with the relevant laws and regulations of the rapid reporting, and start emergency response. At present, Juxian Health and Family Planning Department has been on the families of patients to adjust, the epidemic informed the livestock sector, close contact with the follow-up investigation, and the patient's home epidemic treatment. 　　Reporters from the Shandong Provincial Health and Family Planning Commission website was informed that this is the province of Shandong Province this year, the first five cases reported H7N9 flu cases, no new cases of death.Qingdao and Rizhao City Health and Health Department is in accordance with the law to carry out the relevant prevention and control work.

February 19, Juxian a 48-year-old female villagers were diagnosed with H7N9 avian influenza, the villagers at home to raise more than 100 chickens, nearly a week of death four or five.

Media report on H7N9 case in Shandong Province cites associated chicken deaths raising concerns that HPAI H7N9 is in northern China. http://news.jschina.com.cn/scroll/guonei/201702/t20170219_83064.shtml

H7N9 virus mutant was found in human cases from China Release Date: 2017-02-19 Views: Written by: Information Agency Department: office Font: Tai Zhong Small In January 2017, Guangdong Provincial Center for Disease Control and Disease on the two cases of human infection H7N9 cases were isolated virus gene sequencing analysis, found in the two strains of hemagglutinin link peptide position of the gene insertion mutation occurred, the test results Has been confirmed by the National Center for Viral Disease National Influenza Center. I center experts to judge and communicate with the relevant experts in the agricultural sector that H7N9 virus in the hemagglutinin link peptide position of the gene insertion mutation, suggesting that the virus mutation to the highly pathogenic virus against birds; the second is based on the virus Sequence analysis results have not yet appeared in the mutant virus that has increased resistance to human infectivity, virulence and interpersonal communication. Two cases of disease before the incidence of bird exposure history, and in the exposure of poultry birds have occurred in the phenomenon of death. At present, a case has been cured, another case is still in treatment. All the 105 cases of close contact after two weeks of medical observation, were not fever, cough and other symptoms. H7N9 virus is a influenza virus, one of its main features is prone to gene reassignment and mutation. Some mutations may lead to the virus on the human appeal, virulence and interpersonal communication ability enhancement, so the virus variation has been widely concerned about the domestic and foreign. It is understood that the agricultural sector laboratory also from Guangdong, four poultry specimens found similar to the variation of the virus. China's health care system will work together with the agricultural sector, the common source of the virus, the scope of the impact of in-depth study, and continue to strengthen the monitoring of H7N9 virus, in time to find any possible variation. The results have been communicated to the World Health Organization. China Center for Disease Control and Prevention

Two cases of disease before the incidence of bird exposure history, and in the exposure of poultry birds have occurred in the phenomenon of death. http://www.cdcp.org.cn/gdsjbyfkzzx/gnwxx001/201702/ce3a2125d5dc46e1b2e906ee42d42c2d.shtml

Mainland H7N9 transmission virus found variants Posted: 2017/02/19 19:12 Latest update: 2017/02/19 19:12 Word Level: (Guangdong Provincial Center for Disease Control and Prevention) informed that in 2 cases of H7N9 infection, found that the virus, which means that the virus has been mutated into a highly pathogenic virus for poultry. Mainland China has informed the World Health Organization. China recently H7N9 avian influenza epidemic extended, February 6 to 12 the whole continent informed 69 cases of H7N9 cases, of which 8 were killed. Most of the H7N9 cases in mainland China occur in the Yangtze River Delta and the Pearl River Delta region. Exposure to infected birds or exposure to live poultry markets is an important risk factor for human infection. Guangdong Provincial Center for Disease Control and Prevention today reported that in January this year, the center of 2 cases of H7N9 human infection cases for further genetic sequencing analysis found that the two strains of hemagglutinin link peptide gene insertion mutation, which means that the virus Mutations into birds with highly pathogenic viruses. In the new network quoted the Guangdong Provincial Center for Disease Control and Prevention experts and experts in the agricultural sector to communicate after the investigation that the variability of the virus analysis of the results of the human infection has not yet found, the proliferation of human and human transmission of enhanced mutations. It is understood that these two cases before the disease have been exposed to the poultry environment. At present a case has been recovered, another case is still in the treatment. 105 had close contact with the patient, after 2 weeks of observation, did not appear signs of infection. In addition to virus variants found in human-infected strains, the Chinese mainland's agricultural sector laboratory also found similar variants of virus in four poultry specimens from Guangdong, and the Chinese community's health care system will conduct in-depth research with the agricultural sector on variants , And continue to strengthen the monitoring of H7N9 virus. The report said that the Chinese authorities have informed the results of the WHO (WHO).1060219 http://www.cna.com.tw/news/acn/201702190216-1.aspx?utm_source=dlvr.it&utm_medium=twitter

H7N9 virus mutant was found in human cases from China Release Date: 2017-02-19 Views: Written by: Information Agency Department: office Font: Tai Zhong Small In January 2017, Guangdong Provincial Center for Disease Control and Disease on the two cases of human infection H7N9 cases were isolated virus gene sequencing analysis, found in the two strains of hemagglutinin link peptide position of the gene insertion mutation occurred, the test results Has been confirmed by the National Center for Viral Disease National Influenza Center. I center experts to judge and communicate with the relevant experts in the agricultural sector that H7N9 virus in the hemagglutinin link peptide position of the gene insertion mutation, suggesting that the virus mutation to the highly pathogenic virus against birds; the second is based on the virus Sequence analysis results have not yet appeared in the mutant virus that has increased resistance to human infectivity, virulence and interpersonal communication. Two cases of disease before the incidence of bird exposure history, and in the exposure of poultry birds have occurred in the phenomenon of death. At present, a case has been cured, another case is still in treatment. All the 105 cases of close contact after two weeks of medical observation, were not fever, cough and other symptoms. H7N9 virus is a influenza virus, one of its main features is prone to gene reassignment and mutation. Some mutations may lead to the virus on the human appeal, virulence and interpersonal communication ability enhancement, so the virus variation has been widely concerned about the domestic and foreign. It is understood that the agricultural sector laboratory also from Guangdong, four poultry specimens found similar to the variation of the virus. China's health care system will work together with the agricultural sector, the common source of the virus, the scope of the impact of in-depth study, and continue to strengthen the monitoring of H7N9 virus, in time to find any possible variation. The results have been communicated to the World Health Organization. China Center for Disease Control and Prevention

In January 2017, Guangdong Provincial Center for Disease Control and Disease on the two cases of human infection H7N9 cases were isolated virus gene sequencing analysis, found in the two strains of hemagglutinin link peptide position of the gene insertion mutation occurred, the test results Has been confirmed by the National Center for Viral Disease National Influenza Center. I center experts to judge and communicate with the relevant experts in the agricultural sector that H7N9 virus in the hemagglutinin link peptide position of the gene insertion mutation, suggesting that the virus mutation to the highly pathogenic virus against birds; http://www.cdcp.org.cn/gdsjbyfkzzx/gnwxx001/201702/ce3a2125d5dc46e1b2e906ee42d42c2d.shtml

Align Segment-ID Name Score E-Value Identity EPI918740 A/Qingyuan/GIRD1/2017 (A/H7N9) segment 8 (NS) 1548.6 0.000000e+00 838/838 (100%) EPI602360 A/duck/Jiangxi/36485/2013 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI602293 A/duck/Jiangxi/36501/2013 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601957 A/chicken/Jiangxi/1208/2014 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601850 A/chicken/Jiangxi/31860/2013 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601592 A/chicken/Jiangxi/1214/2014 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601581 A/chicken/Jiangxi/1206/2014 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601563 A/chicken/Jiangxi/36247/2013 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601331 A/chicken/Jiangxi/1255/2014 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601270 A/chicken/Jiangxi/1269/2014 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI601218 A/chicken/Jiangxi/36293/2013 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI599792 A/chicken/Jiangxi/36226/2013 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI599767 A/chicken/Jiangxi/33542/2013 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI599569 A/chicken/Jiangxi/29075/2013 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI596750 A/chicken/Jiangxi/30801/2013 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI584150 A/chicken/Jiangxi/S3612/2013 (A/H10N8) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI578064 A/chicken/Jiangxi/33621/2013 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI578055 A/chicken/Jiangxi/33583/2013 (A/H0) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI578047 A/chicken/Jiangxi/33552/2013 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI530512 A/Environment/Jiangxi/10726/2014 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI530482 A/Environment/Jiangxi/03501/2013 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI530464 A/Environment/Jiangxi/03470/2013 (A/H9N2) segment 8 (NS) 1504.3 0.000000e+00 830/838 (99%) EPI764649 A/chicken/Jiaxing/4640/2013 (A/H9N2) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI764619 A/chicken/Jiaxing/4490/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI764537 A/chicken/Huzhou/4034/2013 (A/H0) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI691661 A/chicken/Henan/141/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI691660 A/chicken/Henan/117/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI691659 A/chicken/Henan/114/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI681003 A/pigeon/Zhejiang/2P5/2013 (A/H9N2) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI681002 A/pigeon/Zhejiang/2P4/2013 (A/H9N2) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI663522 A/pigeon/Wuxi/0405007/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI663499 A/duck/Sunan/040802/2013 (A/H0) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI663498 A/duck/Wuxi/04030204/2013 (A/H0) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636948 A/Anhui/1-YK_RG39/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636941 A/Anhui/1-YK_RG38/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636934 A/Anhui/1-YK_RG37/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636918 A/Anhui/1-YK_RG35/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636911 A/Anhui/1-YK_RG34/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636881 A/Anhui/1-YK_RG30/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636874 A/Anhui/1-YK_RG29/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636867 A/Anhui/1-YK_RG28/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636860 A/Anhui/1-YK_RG27/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636853 A/Anhui/1-YK_RG26/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636844 A/Anhui/1-YK_RG25/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636837 A/Anhui/1-YK_RG24/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636830 A/Anhui/1-YK_RG23/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636823 A/Anhui/1-YK_RG22/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636816 A/Anhui/1-YK_RG21/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636809 A/Anhui/1-YK_RG20/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636798 A/Anhui/1-YK_RG19/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636791 A/Anhui/1-YK_RG18/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636784 A/Anhui/1-YK_RG17/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636777 A/Anhui/1-YK_RG16/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636770 A/Anhui/1-YK_RG15/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636763 A/Anhui/1-YK_RG14/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636756 A/Anhui/1-YK_RG13/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636749 A/Anhui/1-YK_RG12/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636742 A/Anhui/1-YK_RG10/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636734 A/Anhui/1-YK_RG09/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636726 A/Anhui/1-YK_RG08/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636719 A/Anhui/1-YK_RG07/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636712 A/Anhui/1-YK_RG06/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636705 A/Anhui/1-YK_RG05/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636698 A/Anhui/1-YK_RG04/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636691 A/Anhui/1-YK_RG03/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636684 A/Anhui/1-YK_RG02/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI636677 A/Anhui/1-YK_RG01/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI628362 A/Zhejiang/3/2014 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI627603 A/Environment/Guangdong-Guangzhou/XN01070/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620203 A/Anhui/1-BALF_RG6/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620196 A/Anhui/1-JCVI1_RG3/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620189 A/Anhui/1-JCVI1_RG2/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620182 A/Anhui/1-JCVI1_RG1/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620171 A/Anhui/1-BALF_RG9/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620164 A/Anhui/1-BALF_RG8/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620157 A/Anhui/1-BALF_RG7/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620146 A/Anhui/1-BALF_RG20/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620139 A/Anhui/1-BALF_RG19/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620132 A/Anhui/1-BALF_RG18/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620125 A/Anhui/1-BALF_RG17/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620122 A/Anhui/1-BALF_RG32/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620115 A/Anhui/1-BALF_RG31/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620108 A/Anhui/1-BALF_RG29/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620101 A/Anhui/1-BALF_RG21/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620096 A/Anhui/1-BALF_RG44/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620089 A/Anhui/1-BALF_RG43/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620082 A/Anhui/1-BALF_RG42/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620075 A/Anhui/1-BALF_RG41/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620068 A/Anhui/1-BALF_RG40/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620057 A/Anhui/1-BALF_RG1/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620050 A/Anhui/1-BALF_RG45/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620043 A/Anhui/1-BALF_RG5/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620036 A/Anhui/1-BALF_RG4/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620029 A/Anhui/1-BALF_RG3/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI620022 A/Anhui/1-BALF_RG2/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI619988 A/Anhui/1-BALF_RG33/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI615185 A/chicken/Wuxi/04030201G/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI615182 A/duck/Wuxi/0405006G/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI613839 A/Anhui/DEWH72-05/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%) EPI613832 A/Anhui/DEWH72-04/2013 (A/H7N9) segment 8 (NS) 1498.8 0.000000e+00 829/838 (98%)

Align Segment-ID Name Score E-Value Identity EPI918737 A/Qingyuan/GIRD1/2017 (A/H7N9) segment 5 (NP) 2765.6 0.000000e+00 1497/1497 (100%) EPI693857 A/Shenzhen/TH003/2016(H5N6) (A/H5N6) segment 5 (NP) 2676.9 0.000000e+00 1481/1497 (98%) EPI530387 A/Environment/Jiangxi/03367/2013 (A/H10N8) segment 5 (NP) 2660.3 0.000000e+00 1478/1497 (98%) EPI602139 A/chicken/Jiangxi/18955/2013 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI602087 A/chicken/Jiangxi/20471/2013 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI602007 A/chicken/Jiangxi/23786/2013 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI601926 A/chicken/Jiangxi/23273/2013 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI601916 A/chicken/Jiangxi/23241/2013 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI601480 A/chicken/Jiangxi/36256/2013 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI601306 A/chicken/Jiangxi/1247/2014 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600104 A/chicken/Jiangxi/21468/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600097 A/chicken/Jiangxi/20927/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600090 A/chicken/Jiangxi/19898/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600083 A/chicken/Jiangxi/19407/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600076 A/chicken/Jiangxi/18901/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600069 A/chicken/Jiangxi/18445/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600062 A/chicken/Jiangxi/17913/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI600055 A/chicken/Jiangxi/17403/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599817 A/duck/Jiangxi/20147/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599729 A/chicken/Jiangxi/28113/2013 (A/H10N8) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599707 A/chicken/Jiangxi/23274/2013 (A/H10N8) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599692 A/chicken/Jiangxi/23252/2013 (A/H10N8) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599531 A/chicken/Jiangxi/21984/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599524 A/chicken/Jiangxi/21481/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599517 A/chicken/Jiangxi/20976/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599510 A/chicken/Jiangxi/20935/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599496 A/chicken/Jiangxi/20489/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599489 A/chicken/Jiangxi/20482/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599461 A/chicken/Jiangxi/20443/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599447 A/chicken/Jiangxi/19934/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599426 A/chicken/Jiangxi/18980/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599419 A/chicken/Jiangxi/18957/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599404 A/chicken/Jiangxi/18946/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI599397 A/chicken/Jiangxi/18922/2013 (A/H9N2) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI589860 A/chicken/Jiangxi/18933/2013 (A/H10N8) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI578052 A/chicken/Jiangxi/33583/2013 (A/H0) segment 5 (NP) 2654.8 0.000000e+00 1477/1497 (98%) EPI602121 A/chicken/Jiangxi/18474/2013 (A/H0) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI602068 A/chicken/Jiangxi/19967/2013 (A/H0) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI601876 A/chicken/Jiangxi/36242/2013 (A/H0) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI601531 A/chicken/Jiangxi/23772/2013 (A/H0) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI601357 A/chicken/Jiangxi/1226/2014 (A/H0) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI601326 A/chicken/Jiangxi/1255/2014 (A/H0) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI601316 A/chicken/Jiangxi/1250/2014 (A/H0) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI600111 A/chicken/Jiangxi/21978/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599700 A/chicken/Jiangxi/23259/2013 (A/H10N8) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599685 A/chicken/Jiangxi/1204/2014 (A/H10N8) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599580 A/chicken/Jiangxi/29099/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599552 A/chicken/Jiangxi/25970/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599545 A/chicken/Jiangxi/23797/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599503 A/chicken/Jiangxi/20506/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599482 A/chicken/Jiangxi/20478/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599468 A/chicken/Jiangxi/20446/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599440 A/chicken/Jiangxi/19448/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599412 A/chicken/Jiangxi/18952/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599390 A/chicken/Jiangxi/18913/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599190 A/chicken/Jiangxi/19960/2013 (A/H10N8) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI599182 A/chicken/Jiangxi/19924/2013 (A/H10N8) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI594446 A/chicken/Jinan/3925/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI557814 A/Anser fabalis/China/HuBS428/2014 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI530451 A/Environment/Jiangxi/03355/2014 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI530419 A/Environment/Jiangxi/10721/2014 (A/H10N8) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI530379 A/Environment/Jiangxi/03366/2013 (A/H10N8) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI497526 A/environment/Jiangxi/00452/2013 (A/H9N2) segment 5 (NP) 2649.2 0.000000e+00 1476/1497 (98%) EPI589852 A/chicken/Jiangxi/18399/2013 (A/H10N8) segment 5 (NP) 2645.5 0.000000e+00 1474/1495 (98%) EPI691974 A/pigeon/Hubei/227/2012 (A/H9N2) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI602078 A/chicken/Jiangxi/19982/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI602060 A/chicken/Jiangxi/19912/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI601934 A/chicken/Jiangxi/25941/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI601559 A/chicken/Jiangxi/36247/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI601523 A/chicken/Jiangxi/20420/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI601232 A/duck/Jiangxi/36477/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI601225 A/environment/Jiangxi/36468/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI601028 A/chicken/Jiangxi/1289/2014 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI599775 A/chicken/Jiangxi/34609/2013 (A/H10N8) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI599736 A/chicken/Jiangxi/28563/2013 (A/H9N2) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI599538 A/chicken/Jiangxi/23773/2013 (A/H9N2) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI599433 A/chicken/Jiangxi/19436/2013 (A/H9N2) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI596736 A/chicken/Jiangxi/29132/2013 (A/H0) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI594467 A/chicken/Jinan/4261/2013 (A/H9N2) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI594460 A/chicken/Jinan/4225/2013 (A/H9N2) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI584374 A/chicken/Jiangxi/S3735/2013 (A/H10N8) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI584141 A/chicken/Jiangxi/S3581/2013 (A/H10N8) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI530543 A/chicken/Jiangxi/102/2013(H10N8) (A/H10N8) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI530435 A/Environment/Jiangxi/23930/2013 (A/H10N8) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI530395 A/Environment/Jiangxi/03413/2013 (A/H10N8) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI497515 A/environment/Jiangxi/00449/2013 (A/H9N2) segment 5 (NP) 2643.7 0.000000e+00 1475/1497 (98%) EPI601295 A/chicken/Jiangxi/1244/2014 (A/H0) segment 5 (NP) 2640.0 0.000000e+00 1474/1497 (98%) EPI691975 A/pigeon/Hubei/228/2012 (A/H9N2) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI691696 A/pigeon/Hubei/269/2012 (A/H9N2) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI691694 A/pigeon/Hubei/230/2012 (A/H9N2) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601906 A/chicken/Jiangxi/1287/2014 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601608 A/chicken/Jiangxi/1288/2014 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601547 A/chicken/Jiangxi/36240/2013 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601491 A/chicken/Jiangxi/36274/2013 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601376 A/chicken/Jiangxi/1243/2014 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601337 A/chicken/Jiangxi/1257/2014 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601256 A/chicken/Jiangxi/1267/2014 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601215 A/chicken/Jiangxi/36293/2013 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI601109 A/chicken/Jiangxi/1203/2014 (A/H0) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%) EPI599750 A/chicken/Jiangxi/31856/2013 (A/H10N8) segment 5 (NP) 2638.1 0.000000e+00 1474/1497 (98%)

Align Segment-ID Name Score E-Value Identity EPI918732 A/Qingyuan/GIRD1/2017 (A/H7N9) segment 2 (PB1) 4193.0 0.000000e+00 2270/2270 (100%) EPI578211 A/chicken/Dongguan/1693/2014 (A/H0) segment 2 (PB1) 4037.9 0.000000e+00 2242/2270 (98%) EPI578197 A/chicken/Dongguan/1674/2014 (A/H9N2) segment 2 (PB1) 4037.9 0.000000e+00 2242/2270 (98%) EPI627375 A/Fujian/21/2014 (A/H7N9) segment 2 (PB1) 4021.3 0.000000e+00 2239/2270 (98%) EPI594289 A/chicken/Jiangxi/10955/2014 (A/H7N9) segment 2 (PB1) 4006.5 0.000000e+00 2237/2271 (98%) EPI601498 A/chicken/Jiangxi/36278/2013 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI599787 A/chicken/Jiangxi/36226/2013 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI594352 A/chicken/Jiangxi/10965/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594345 A/chicken/Jiangxi/10964/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594317 A/chicken/Jiangxi/10959/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594310 A/chicken/Jiangxi/10958/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594296 A/chicken/Jiangxi/10956/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594282 A/chicken/Jiangxi/10954/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594268 A/chicken/Jiangxi/10950/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594247 A/chicken/Jiangxi/10946/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594233 A/chicken/Jiangxi/10943/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594226 A/chicken/Jiangxi/10939/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594219 A/chicken/Jiangxi/10929/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594212 A/chicken/Jiangxi/10897/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594205 A/chicken/Jiangxi/10896/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594191 A/chicken/Jiangxi/10894/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594170 A/chicken/Jiangxi/10877/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594163 A/chicken/Jiangxi/10875/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594156 A/chicken/Jiangxi/10874/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI594135 A/chicken/Jiangxi/10870/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI593605 A/chicken/Jiangxi/18527/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593591 A/chicken/Jiangxi/18526/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593569 A/chicken/Jiangxi/18523/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593531 A/chicken/Jiangxi/18502/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593505 A/chicken/Jiangxi/18491/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593485 A/chicken/Jiangxi/18486/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593446 A/chicken/Jiangxi/18470/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593422 A/chicken/Jiangxi/18466/2014 (A/H0) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI593404 A/chicken/Jiangxi/18449/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI592318 A/chicken/Jiangxi/9530/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI592311 A/chicken/Jiangxi/9497/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI583924 A/chicken/Jiangxi/9558/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI583904 A/silkie chicken/Jiangxi/9476/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI583892 A/silkie chicken/Jiangxi/9469/2014 (A/H7N9) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI557812 A/Anser fabalis/China/HuBS428/2014 (A/H9N2) segment 2 (PB1) 4004.7 0.000000e+00 2237/2271 (98%) EPI530486 A/Environment/Jiangxi/03501/2013 (A/H9N2) segment 2 (PB1) 4004.7 0.000000e+00 2236/2270 (98%) EPI594324 A/chicken/Jiangxi/10961/2014 (A/H7N9) segment 2 (PB1) 4001.0 0.000000e+00 2236/2271 (98%) EPI594198 A/chicken/Jiangxi/10895/2014 (A/H7N9) segment 2 (PB1) 4001.0 0.000000e+00 2236/2271 (98%) EPI593519 A/chicken/Jiangxi/18500/2014 (A/H0) segment 2 (PB1) 4001.0 0.000000e+00 2235/2270 (98%) EPI583910 A/chicken/Jiangxi/9508/2014 (A/H7N9) segment 2 (PB1) 4001.0 0.000000e+00 2236/2271 (98%) EPI858164 A/Environment/Jiangxi/14737/2014 (A/H9N2) segment 2 (PB1) 3999.1 0.000000e+00 2235/2270 (98%) EPI601843 A/chicken/Jiangxi/31860/2013 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI601383 A/chicken/Jiangxi/1244/2014 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI601263 A/chicken/Jiangxi/1269/2014 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI601106 A/chicken/Jiangxi/1203/2014 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI601041 A/chicken/Jiangxi/36263/2013 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI599762 A/chicken/Jiangxi/33542/2013 (A/H9N2) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI599585 A/chicken/Jiangxi/29117/2013 (A/H9N2) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI596742 A/chicken/Jiangxi/30801/2013 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI594331 A/chicken/Jiangxi/10962/2014 (A/H7N9) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI594184 A/chicken/Jiangxi/10885/2014 (A/H7N9) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI594177 A/chicken/Jiangxi/10882/2014 (A/H7N9) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI593619 A/chicken/Jiangxi/19426/2014 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2235/2270 (98%) EPI593436 A/chicken/Jiangxi/18468/2014 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2235/2270 (98%) EPI593395 A/chicken/Jiangxi/18035/2014 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2235/2270 (98%) EPI592178 A/chicken/Jiangxi/9513/2014 (A/H7N9) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI578058 A/chicken/Jiangxi/33621/2013 (A/H0) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI578042 A/chicken/Jiangxi/33552/2013 (A/H9N2) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI530462 A/Environment/Jiangxi/03365/2014 (A/H9N2) segment 2 (PB1) 3999.1 0.000000e+00 2236/2271 (98%) EPI583938 A/chicken/Jiangxi/10573/2014 (A/H7N9) segment 2 (PB1) 3997.3 0.000000e+00 2235/2271 (98%) EPI596733 A/chicken/Jiangxi/29132/2013 (A/H0) segment 2 (PB1) 3995.4 0.000000e+00 2232/2266 (98%) EPI602469 A/chicken/Jiangxi/5195/2014 (A/H10N8) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602455 A/chicken/Jiangxi/1279/2014 (A/H10N8) segment 2 (PB1) 3993.6 0.000000e+00 2234/2270 (98%) EPI602362 A/duck/Jiangxi/36487/2013 (A/H9N2) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602323 A/chicken/Jiangxi/13213/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602309 A/chicken/Jiangxi/13201/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602302 A/chicken/Jiangxi/13199/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602295 A/chicken/Jiangxi/13197/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602281 A/duck/Jiangxi/36489/2013 (A/H9N2) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602257 A/chicken/Jiangxi/13231/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602250 A/chicken/Jiangxi/13221/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602243 A/chicken/Jiangxi/13217/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602219 A/chicken/Jiangxi/13251/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602205 A/chicken/Jiangxi/13247/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI602198 A/chicken/Jiangxi/13241/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601948 A/chicken/Jiangxi/1208/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601902 A/chicken/Jiangxi/1287/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2234/2270 (98%) EPI601863 A/chicken/Jiangxi/36227/2013 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601853 A/chicken/Jiangxi/36223/2013 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601572 A/chicken/Jiangxi/1206/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601537 A/chicken/Jiangxi/36225/2013 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601488 A/chicken/Jiangxi/36274/2013 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601477 A/chicken/Jiangxi/36256/2013 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601449 A/chicken/Jiangxi/13198/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601355 A/chicken/Jiangxi/1226/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601333 A/chicken/Jiangxi/1257/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601303 A/chicken/Jiangxi/1247/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601291 A/chicken/Jiangxi/36291/2013 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601252 A/chicken/Jiangxi/1267/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601230 A/duck/Jiangxi/36477/2013 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI601025 A/chicken/Jiangxi/1289/2014 (A/H0) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI600280 A/chicken/Jiangxi/1232/2014 (A/H10N8) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI600273 A/chicken/Jiangxi/13275/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI600259 A/chicken/Jiangxi/13256/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%) EPI600252 A/chicken/Jiangxi/13248/2014 (A/H10N6) segment 2 (PB1) 3993.6 0.000000e+00 2235/2271 (98%)

E627K

Align Segment-ID Name Score E-Value Identity EPI918730 A/Qingyuan/GIRD1/2017 (A/H7N9) segment 1 (PB2) 4211.5 0.000000e+00 2280/2280 (100%) EPI578196 A/chicken/Dongguan/1674/2014 (A/H9N2) segment 1 (PB2) 4061.9 0.000000e+00 2253/2280 (98%) EPI872955 A/Hong Kong/VB16189623/2016 (A/H7N9) segment 1 (PB2) 4050.8 0.000000e+00 2252/2281 (98%) EPI837987 A/chicken/Sichuan/SIC36/2014 (A/H9N2) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI601321 A/chicken/Jiangxi/1255/2014 (A/H0) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI600087 A/chicken/Jiangxi/19898/2013 (A/H9N2) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI600052 A/chicken/Jiangxi/17403/2013 (A/H9N2) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI599500 A/chicken/Jiangxi/20506/2013 (A/H9N2) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI599458 A/chicken/Jiangxi/20443/2013 (A/H9N2) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI599423 A/chicken/Jiangxi/18980/2013 (A/H9N2) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI593590 A/chicken/Jiangxi/18526/2014 (A/H0) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI593568 A/chicken/Jiangxi/18523/2014 (A/H0) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI593518 A/chicken/Jiangxi/18500/2014 (A/H0) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI593502 A/chicken/Jiangxi/18491/2014 (A/H0) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI593482 A/chicken/Jiangxi/18486/2014 (A/H0) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI593420 A/chicken/Jiangxi/18466/2014 (A/H0) segment 1 (PB2) 4045.3 0.000000e+00 2250/2280 (98%) EPI623615 A/chicken/Hubei/2014 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI602117 A/chicken/Jiangxi/18474/2013 (A/H0) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI602083 A/chicken/Jiangxi/20471/2013 (A/H0) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI600101 A/chicken/Jiangxi/21468/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI600073 A/chicken/Jiangxi/18901/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599528 A/chicken/Jiangxi/21984/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599493 A/chicken/Jiangxi/20489/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599472 A/chicken/Jiangxi/20457/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599465 A/chicken/Jiangxi/20446/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599444 A/chicken/Jiangxi/19934/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599416 A/chicken/Jiangxi/18957/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599408 A/chicken/Jiangxi/18952/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599394 A/chicken/Jiangxi/18922/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI599387 A/chicken/Jiangxi/18913/2013 (A/H9N2) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI593443 A/chicken/Jiangxi/18470/2014 (A/H0) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI593394 A/chicken/Jiangxi/18035/2014 (A/H0) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI578056 A/chicken/Jiangxi/33621/2013 (A/H0) segment 1 (PB2) 4039.7 0.000000e+00 2249/2280 (98%) EPI736582 A/Anser fabalis/Anhui/L139/2014 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2249/2281 (98%) EPI602064 A/chicken/Jiangxi/19967/2013 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601970 A/chicken/Jiangxi/1271/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601930 A/chicken/Jiangxi/25941/2013 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601920 A/chicken/Jiangxi/23273/2013 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601892 A/chicken/Jiangxi/1286/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601604 A/chicken/Jiangxi/1288/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601593 A/chicken/Jiangxi/1218/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601363 A/chicken/Jiangxi/1242/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601354 A/chicken/Jiangxi/1226/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601262 A/chicken/Jiangxi/1269/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI600108 A/chicken/Jiangxi/21978/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI600080 A/chicken/Jiangxi/19407/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI600066 A/chicken/Jiangxi/18445/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599814 A/duck/Jiangxi/20147/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599747 A/chicken/Jiangxi/31856/2013 (A/H10N8) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599521 A/chicken/Jiangxi/21481/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599514 A/chicken/Jiangxi/20976/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599507 A/chicken/Jiangxi/20935/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599486 A/chicken/Jiangxi/20482/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599479 A/chicken/Jiangxi/20478/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599437 A/chicken/Jiangxi/19448/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599430 A/chicken/Jiangxi/19436/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI599401 A/chicken/Jiangxi/18946/2013 (A/H9N2) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI593410 A/chicken/Jiangxi/18457/2014 (A/H0) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI537478 A/chicken/B15/Jiangxi/2014 (A/H10N8) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI537469 A/chicken/77/Jiangxi/2014 (A/H10N8) segment 1 (PB2) 4034.2 0.000000e+00 2248/2280 (98%) EPI601486 A/chicken/Jiangxi/36274/2013 (A/H0) segment 1 (PB2) 4030.5 0.000000e+00 2247/2280 (98%) EPI601332 A/chicken/Jiangxi/1257/2014 (A/H0) segment 1 (PB2) 4030.5 0.000000e+00 2247/2280 (98%) EPI683196 A/duck/Wuhan/WHYF14/2014 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI602461 A/chicken/Jiangxi/3152/2014 (A/H10N8) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI602354 A/duck/Jiangxi/36485/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI601024 A/chicken/Jiangxi/1289/2014 (A/H0) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI600293 A/chicken/Jiangxi/1279/2014 (A/H10N8) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI600279 A/chicken/Jiangxi/1232/2014 (A/H10N8) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI600094 A/chicken/Jiangxi/20927/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI600059 A/chicken/Jiangxi/17913/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI599786 A/chicken/Jiangxi/36226/2013 (A/H0) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI599733 A/chicken/Jiangxi/28563/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI599577 A/chicken/Jiangxi/29099/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI599451 A/chicken/Jiangxi/19981/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI594358 A/chicken/Qingdao/2044/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI593629 A/chicken/Jiangxi/19463/2014 (A/H0) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI593346 A/chicken/Shantou/4832/2014 (A/H7N9) segment 1 (PB2) 4028.7 0.000000e+00 2248/2281 (98%) EPI591968 A/chicken/Suzhou/4833/2013 (A/H0) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI589864 A/chicken/Jiangxi/19924/2013 (A/H10N8) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI583824 A/chicken/Suzhou/4954/2013 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI557811 A/Anser fabalis/China/HuBS428/2014 (A/H9N2) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI530391 A/Environment/Jiangxi/03367/2013 (A/H10N8) segment 1 (PB2) 4028.7 0.000000e+00 2247/2280 (98%) EPI601871 A/chicken/Jiangxi/36242/2013 (A/H0) segment 1 (PB2) 4026.8 0.000000e+00 2246/2280 (98%) EPI601475 A/chicken/Jiangxi/36256/2013 (A/H0) segment 1 (PB2) 4026.8 0.000000e+00 2246/2280 (98%) EPI596740 A/chicken/Jiangxi/30801/2013 (A/H0) segment 1 (PB2) 4025.0 0.000000e+00 2246/2280 (98%) EPI858163 A/Environment/Jiangxi/14737/2014 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI601911 A/chicken/Jiangxi/23241/2013 (A/H0) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI601543 A/chicken/Jiangxi/36240/2013 (A/H0) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI601301 A/chicken/Jiangxi/1247/2014 (A/H0) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI601211 A/chicken/Jiangxi/36293/2013 (A/H0) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI599570 A/chicken/Jiangxi/29086/2013 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI599373 A/duck/Jiangxi/36505/2013 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI596731 A/chicken/Jiangxi/29132/2013 (A/H0) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI593353 A/chicken/Shantou/4833/2014 (A/H7N9) segment 1 (PB2) 4023.1 0.000000e+00 2247/2281 (98%) EPI583817 A/chicken/Suzhou/4837/2013 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI583810 A/chicken/Suzhou/4822/2013 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI578065 A/chicken/Jiangxi/36277/2013 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI530485 A/Environment/Jiangxi/03501/2013 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI530479 A/Environment/Jiangxi/03481/2013 (A/H9N2) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%) EPI530415 A/Environment/Jiangxi/10615/2014 (A/H10N8) segment 1 (PB2) 4023.1 0.000000e+00 2246/2280 (98%)

Align Segment-ID Name Score E-Value Identity EPI918739 A/Qingyuan/GIRD1/2017 (A/H7N9) segment 7 (MP) 1814.5 0.000000e+00 982/982 (100%) EPI917068 A/Taiwan/1/2017 (A/H7N9) segment 7 (MP) 1792.4 0.000000e+00 978/982 (99%) EPI682977 A/duck/Wenzhou/YHQL64/2014 (A/H9N2) segment 7 (MP) 1786.8 0.000000e+00 977/982 (99%) EPI681159 A/chicken/Zhejiang/727192/2014 (A/H9N2) segment 7 (MP) 1786.8 0.000000e+00 977/982 (99%) EPI682978 A/chicken/Taizhou/TZJF05/2015 (A/H9N2) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI628747 A/Anhui/33225/2015 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI627260 A/Guangdong/15SF021/2015 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI627212 A/Fujian/25/2015 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI627132 A/Zhejiang/1/2015 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI627108 A/Guangdong/15SF043/2015 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI627044 A/Guangdong/15SF081/2015 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI627012 A/Jiangsu/18828/2014 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593614 A/chicken/Jiangxi/18527/2014 (A/H0) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593576 A/chicken/Jiangxi/18523/2014 (A/H0) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593551 A/chicken/Jiangxi/18515/2014 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593513 A/chicken/Jiangxi/18491/2014 (A/H0) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593479 A/chicken/Jiangxi/18483/2014 (A/H0) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593472 A/chicken/Jiangxi/18482/2014 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593430 A/chicken/Jiangxi/18466/2014 (A/H0) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI593408 A/chicken/Jiangxi/18449/2014 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI566071 A/Jiangsu/06306/2014 (A/H7N9) segment 7 (MP) 1781.3 0.000000e+00 976/982 (99%) EPI895154 A/chicken/Ganzhou/GZ50/2015 (A/H5N6) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI888055 A/Anhui/60935/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI888047 A/Anhui/60934/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI888039 A/Anhui/60933/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI888031 A/Anhui/60931/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI888015 A/Anhui/60929/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI888007 A/Anhui/60928/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI887959 A/Jiangsu/60450/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI887703 A/Zhejiang/7/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI846042 A/chicken/Jiangsu/JS4539/2014 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI838162 A/chicken/Jiangsu/SIC42/2015 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI838159 A/chicken/Zhejiang/SIC40/2015 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI833717 A/Fujian/3/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI769578 A/Fujian/16/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI769570 A/Fujian/10/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI740733 A/Hong Kong/VB16064646/2016 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI729782 A/chicken/Shanghai/15/2015 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI729462 A/Taiwan/4-CGMH2/2014 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI729454 A/Taiwan/4-CGMH1/2014 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI682985 A/chicken/Wenzhou/WZTSLG02/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI681155 A/chicken/Zhejiang/3C34/2014 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI680963 A/chicken/Zhejiang/C71926/2013 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI680962 A/chicken/Zhejiang/C71921/2013 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI628811 A/Zhejiang/11/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI628555 A/Anhui/40094/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI627308 A/Fujian/8/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI627292 A/Fujian/19/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI627252 A/Fujian/7/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI627148 A/Zhejiang/34/2014 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI627140 A/Zhejiang/35/2014 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI593441 A/chicken/Jiangxi/18468/2014 (A/H0) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI583126 A/chicken/Shaoxing/5186/2013 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI566126 A/Fujian/09273/2015 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI531804 A/Taiwan/2/2014 (A/H7N9) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI529239 A/wild chicken/Shanghai/C1/2014 (A/H9N2) segment 7 (MP) 1775.8 0.000000e+00 975/982 (99%) EPI888023 A/Anhui/60932/2016 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI887983 A/Anhui/60927/2016 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI887887 A/Jiangsu/60461/2016 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI887879 A/Jiangsu/60462/2016 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI887863 A/Jiangsu/60465/2016 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI887799 A/Zhejiang/6/2016 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI846034 A/chicken/Anhui/AH120/2015 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI838148 A/chicken/Shandong/SIC24/2014 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI769642 A/Fujian/22/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI769586 A/Fujian/18/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI682983 A/chicken/Wenzhou/RAQL18/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI682982 A/chicken/Wenzhou/RAQL01/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI681154 A/chicken/Zhejiang/3C28/2014 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI680978 A/chicken/Zhejiang/C58/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI680959 A/chicken/Zhejiang/C7199/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI639590 A/chicken/Hangzhou/174/2013 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI628787 A/Environment/Shandong-Taian/EV03/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI628779 A/Shandong-Taian/01/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI628675 A/Environment/Shandong-Taian/EV02/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI628667 A/Environment/Shandong-Taian/EV01/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI628603 A/Environment/Anhui/39280/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI628563 A/Anhui/40095/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI628547 A/Environment/Hunan/39719/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI627356 A/Fujian/5/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI627220 A/Fujian/24/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI627156 A/Zhejiang/3/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI627100 A/Fujian/17/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI621117 A/chicken/Quzhou/2/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI602002 A/black chicken/Jiangxi/10139/2014 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI601992 A/black chicken/Jiangxi/10136/2014 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI601974 A/chicken/Jiangxi/10122/2014 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI601533 A/chicken/Jiangxi/23772/2013 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI599582 A/chicken/Jiangxi/29099/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI594412 A/chicken/Rizhao/2658/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI594363 A/chicken/Qingdao/2044/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI593565 A/chicken/Jiangxi/18517/2014 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI593273 A/chicken/Jiangxi/15520/2014 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI593256 A/chicken/Jiangxi/15492/2014 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI593133 A/chicken/Jiangxi/14502/2014 (A/H0) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI592006 A/silkie chicken/Shaoxing/5371/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI583857 A/chicken/Rizhao/3052/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI583638 A/chicken/Dongguan/3186/2013 (A/H9N2) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI576626 A/environment/Shanghai/PD-JZ-01/2014 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%) EPI566079 A/Guizhou/03240/2015 (A/H7N9) segment 7 (MP) 1770.2 0.000000e+00 974/982 (99%

Align Segment-ID Name Score E-Value Identity EPI918738 A/Qingyuan/GIRD1/2017 (A/H7N9) segment 6 (NA) 2582.7 0.000000e+00 1398/1398 (100%) EPI627232 A/Fujian/23/2015 (A/H7N9) segment 6 (NA) 2527.3 0.000000e+00 1389/1399 (99%) EPI627384 A/Guangdong/02497/2014 (A/H7N9) segment 6 (NA) 2521.8 0.000000e+00 1388/1399 (99%) EPI627216 A/Fujian/25/2015 (A/H7N9) segment 6 (NA) 2521.8 0.000000e+00 1388/1399 (99%) EPI627024 A/Guangdong/15SF027/2015 (A/H7N9) segment 6 (NA) 2521.8 0.000000e+00 1388/1399 (99%) EPI627000 A/Guangdong/15SF080/2015 (A/H7N9) segment 6 (NA) 2521.8 0.000000e+00 1388/1399 (99%) EPI769577 A/Fujian/16/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI628807 A/Fujian/27/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI628695 A/Guangdong/15SF055/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI627312 A/Fujian/8/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI627296 A/Fujian/19/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI627264 A/Guangdong/15SF021/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI627104 A/Fujian/17/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI627048 A/Guangdong/15SF081/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI580389 A/Chicken/Guangdong/SW154/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI580381 A/Chicken/Guangdong/SW153/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI566130 A/Fujian/09273/2015 (A/H7N9) segment 6 (NA) 2516.3 0.000000e+00 1387/1399 (99%) EPI769569 A/Fujian/10/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI628687 A/Guangdong/15SF054/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI628655 A/Environment/Hunan/20986/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI628631 A/Environment/Guangdong/21275/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI628583 A/Environment/Anhui/33248/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI627256 A/Fujian/7/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI627224 A/Fujian/24/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI627120 A/Guangdong/15SF030/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI627112 A/Guangdong/15SF043/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI627096 A/Jiangsu/19758/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI627040 A/Fujian/6/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI627008 A/Jiangsu/19757/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI566083 A/Guizhou/03240/2015 (A/H7N9) segment 6 (NA) 2510.7 0.000000e+00 1386/1399 (99%) EPI683029 A/chicken/Wenzhou/HATSLG01/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI628743 A/Anhui/33224/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI628663 A/Anhui/33227/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI628639 A/Environment/Guangdong/21286/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI628623 A/Environment/Guangdong/21231/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI628591 A/Environment/Anhui/33240/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI628575 A/Environment/Anhui/33250/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI627472 A/Fujian/1/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI627456 A/Fujian/3/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI627304 A/Fujian/11/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI627168 A/Zhejiang/4/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI627088 A/Hunan/19763/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI627080 A/Hunan/19762/2015 (A/H7N9) segment 6 (NA) 2505.2 0.000000e+00 1385/1399 (98%) EPI692616 A/Huai'an/002/2015 (A/H7N9) segment 6 (NA) 2499.6 0.000000e+00 1384/1399 (98%) EPI628823 A/Zhejiang/10/2015 (A/H7N9) segment 6 (NA) 2499.6 0.000000e+00 1384/1399 (98%) EPI628775 A/Zhejiang/7/2015 (A/H7N9) segment 6 (NA) 2499.6 0.000000e+00 1384/1399 (98%) EPI627464 A/Fujian/2/2015 (A/H7N9) segment 6 (NA) 2499.6 0.000000e+00 1384/1399 (98%) EPI627288 A/Fujian/20/2015 (A/H7N9) segment 6 (NA) 2499.6 0.000000e+00 1384/1399 (98%) EPI627192 A/Guangdong/15SF020/2015 (A/H7N9) segment 6 (NA) 2499.6 0.000000e+00 1384/1399 (98%) EPI729461 A/Taiwan/4-CGMH2/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI692626 A/chicken/Huai'an/003/2015 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI683028 A/chicken/Wenzhou/RAQL18/2015 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI683027 A/chicken/Wenzhou/RAQL01/2015 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI628751 A/Anhui/33225/2015 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI628727 A/Anhui/33228/2015 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI628607 A/Environment/Anhui/39280/2015 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI593638 A/chicken/Jiangxi/19463/2014 (A/H0) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI593625 A/chicken/Jiangxi/19426/2014 (A/H0) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI593383 A/chicken/Jiangxi/18008/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592610 A/chicken/Jiangxi/13554/2014 (A/H0) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592594 A/chicken/Jiangxi/13548/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592579 A/chicken/Jiangxi/13543/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592570 A/chicken/Jiangxi/13540/2014 (A/H0) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592534 A/chicken/Jiangxi/13526/2014 (A/H0) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592526 A/chicken/Jiangxi/13525/2014 (A/H0) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592517 A/chicken/Jiangxi/13524/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592510 A/chicken/Jiangxi/13521/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592486 A/chicken/Jiangxi/13512/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592462 A/chicken/Jiangxi/13493/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592283 A/chicken/Jiangxi/13546/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI592246 A/chicken/Jiangxi/13513/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI521919 A/Taiwan/2/2014 (A/H7N9) segment 6 (NA) 2494.1 0.000000e+00 1383/1399 (98%) EPI627480 A/Fujian/17/2014 (A/H7N9) segment 6 (NA) 2490.4 0.000000e+00 1382/1399 (98%) EPI729453 A/Taiwan/4-CGMH1/2014 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI707902 A/chicken/Shanghai/S3630/2014 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI628567 A/Anhui/40095/2015 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI627919 A/Xinjiang/73030/2014 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI627911 A/Environment/Xinjiang/73033/2014 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI627440 A/Anhui/01887/2014 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI627240 A/Fujian/21/2015 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI627160 A/Zhejiang/3/2015 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI593583 A/chicken/Jiangxi/18524/2014 (A/H0) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI593543 A/chicken/Jiangxi/18513/2014 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI593453 A/chicken/Jiangxi/18470/2014 (A/H0) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI593400 A/chicken/Jiangxi/18035/2014 (A/H0) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI593132 A/chicken/Jiangxi/14502/2014 (A/H0) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI592276 A/chicken/Jiangxi/13538/2014 (A/H7N9) segment 6 (NA) 2488.6 0.000000e+00 1382/1399 (98%) EPI707983 A/chicken/Shanghai/S3086/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI707982 A/chicken/Shanghai/S3085/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI707981 A/chicken/Shanghai/S3084/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI707904 A/duck/Jiangsu/J3619/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI627488 A/Fujian/19/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI627352 A/Environment/Xinjiang/00347/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI627344 A/Environment/Xinjiang/00344/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI627280 A/Fujian/9/2015 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI593526 A/chicken/Jiangxi/18500/2014 (A/H0) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI593255 A/chicken/Jiangxi/15492/2014 (A/H0) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI593176 A/chicken/Jiangxi/14530/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI593169 A/chicken/Jiangxi/14518/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%) EPI566099 A/XinjiangBintuan/99117/2014 (A/H7N9) segment 6 (NA) 2483.0 0.000000e+00 1381/1399 (98%

Align Segment-ID Name Score E-Value Identity EPI918736 A/Qingyuan/GIRD1/2017 (A/H7N9) segment 4 (HA) 3131.2 0.000000e+00 1695/1695 (100%) EPI917065 A/Taiwan/1/2017 (A/H7N9) segment 4 (HA) 3081.3 0.000000e+00 1686/1695 (99%) EPI507710 A/turkey/Italy/4828/1999 (A/H7N1) segment 4 (HA) 2350.1 0.000000e+00 1562/1703 (91%) EPI68427 A/turkey/Italy/4708/1999 (A/H7N1) segment 4 (HA) 2350.1 0.000000e+00 1562/1703 (91%) EPI63296 A/quail/Italy/396/2000 (A/H7N1) segment 4 (HA) 2346.4 0.000000e+00 1562/1704 (91%) EPI507734 A/turkey/Italy/4756/1999 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI507718 A/turkey/Italy/4827/1999 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI507702 A/turkey/Italy/4618/1999 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1561/1703 (91%) EPI505580 A/chicken/Italy/4845/1999 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI107393 A/ostrich/Italy/984/00 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI107376 A/ostrich/Italy/984/00 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI107357 A/chicken/Italy/5093/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI107338 A/chicken/Italy/5093/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI69101 A/turkey/Italy/4617/1999 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1561/1703 (91%) EPI69063 A/chicken/Italy/4789/1999 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI68218 A/turkey/Italy/1084/2000 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI63258 A/chicken/Italy/4746/1999 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI60747 A/duck/Italy/551/2000 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI60386 A/turkey/Italy/4580/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1561/1703 (91%) EPI58714 A/ostrich/Italy/1038/2000 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI12992 A/Turkey/Italy/335/00 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI12990 A/Turkey/Italy/13468/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI12984 A/Turkey/Italy/13467/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI12982 A/Chicken/Italy/13307/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI12980 A/chicken/Italy/13474/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI12884 A/turkey/Italy/12598/99 (A/H7N1) segment 4 (HA) 2344.5 0.000000e+00 1562/1704 (91%) EPI505858 A/guinea fowl/Italy/1766/2000 (A/H7N1) segment 4 (HA) 2340.8 0.000000e+00 1561/1704 (91%) EPI651420 A/chicken/Italy/445 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1560/1703 (91%) EPI505601 A/turkey/Italy/5005/1999 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1561/1704 (91%) EPI505582 A/chicken/Italy/4911/1999 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1561/1704 (91%) EPI505581 A/turkey/Italy/4906/1999 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1561/1704 (91%) EPI353345 A/chicken/Italy/445/1999 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1561/1704 (91%) EPI319892 A/Netherlands/086/03 (A/H7N7) segment 4 (HA) 2339.0 0.000000e+00 1557/1698 (91%) EPI294949 A/chicken/Netherlands/03008344/03(H7N7) (A/H7N7) segment 4 (HA) 2339.0 0.000000e+00 1559/1701 (91%) EPI290279 A/chicken/Netherlands/03005432/03(H7N7) (A/H7N7) segment 4 (HA) 2339.0 0.000000e+00 1559/1701 (91%) EPI242904 A/chicken/Italy/445/99 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1560/1703 (91%) EPI242903 A/Italy/445/99 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1560/1703 (91%) EPI237858 A/chicken/Netherlands/03009938/03 (A/H7N7) segment 4 (HA) 2339.0 0.000000e+00 1559/1701 (91%) EPI237816 A/chicken/Netherlands/03010351/03 (A/H7N7) segment 4 (HA) 2339.0 0.000000e+00 1559/1701 (91%) EPI69044 A/quail/Italy/4992/1999 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1561/1704 (91%) EPI68199 A/chicken/Italy/2335/2000 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1561/1704 (91%) EPI13148 A/chicken/Italy/445/99 (A/H7N1) segment 4 (HA) 2339.0 0.000000e+00 1560/1703 (91%) EPI505640 A/turkey/Italy/140/2000 (A/H7N1) segment 4 (HA) 2337.1 0.000000e+00 1560/1704 (91%) EPI294973 A/chicken/Netherlands/03008200/03(H7N7) (A/H7N7) segment 4 (HA) 2337.1 0.000000e+00 1558/1700 (91%) EPI294958 A/chicken/Netherlands/03008374/03(H7N7) (A/H7N7) segment 4 (HA) 2337.1 0.000000e+00 1558/1700 (91%) EPI237855 A/chicken/Netherlands/03009127/03 (A/H7N7) segment 4 (HA) 2337.1 0.000000e+00 1558/1700 (91%) EPI505851 A/chicken/Italy/1730/2000 (A/H7N1) segment 4 (HA) 2335.3 0.000000e+00 1560/1704 (91%) EPI505603 A/chicken/Italy/5074/1999 (A/H7N1) segment 4 (HA) 2335.3 0.000000e+00 1557/1699 (91%) EPI304486 A/chicken/belgium/06601/2003 (A/H7N7) segment 4 (HA) 2335.3 0.000000e+00 1557/1699 (91%) EPI507726 A/turkey/Italy/4749/1999 (A/H7N1) segment 4 (HA) 2333.4 0.000000e+00 1560/1704 (91%) EPI505811 A/chicken/Italy/1651/2000 (A/H7N1) segment 4 (HA) 2333.4 0.000000e+00 1559/1703 (91%) EPI505781 A/chicken/Italy/933/2000 (A/H7N1) segment 4 (HA) 2333.4 0.000000e+00 1558/1702 (91%) EPI505703 A/chicken/Italy/797/2000 (A/H7N1) segment 4 (HA) 2333.4 0.000000e+00 1560/1704 (91%) EPI319946 A/Netherlands/295/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1556/1698 (91%) EPI304477 A/chicken/belgium/06383/2003 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI304468 A/chicken/belgium/06175/2003 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI295048 A/chicken/Netherlands/03013833/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI295045 A/chicken/Netherlands/03012010/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI295042 A/chicken/Netherlands/03012012/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI295024 A/chicken/Netherlands/03008331/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI294976 A/chicken/Netherlands/03009080/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI294952 A/chicken/Netherlands/03008381/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI294910 A/chicken/Netherlands/03002974/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290444 A/chicken/Netherlands/03012785/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290438 A/chicken/Netherlands/03012011/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290435 A/chicken/Netherlands/03011061/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290432 A/turkey/Netherlands/03010737/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290426 A/turkey/Netherlands/03010495/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290381 A/chicken/Netherlands/03009831/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290285 A/chicken/Netherlands/03003441/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290273 A/chicken/Netherlands/03008059/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290228 A/chicken/Netherlands/03003325/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290225 A/chicken/Netherlands/03003403/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI290189 A/chicken/Netherlands/03002994/03(H7N7) (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI238415 A/Turkey/Italy/13489/99 (A/H7N1) segment 4 (HA) 2333.4 0.000000e+00 1560/1704 (91%) EPI237887 A/turkey/Netherlands/03010821/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237810 A/chicken/Netherlands/03013531/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237807 A/chicken/Netherlands/03013010/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237804 A/turkey/Netherlands/03012387/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237801 A/chicken/Netherlands/03012013/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237798 A/chicken/Netherlands/03011766/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237795 A/chicken/Netherlands/UN242/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237792 A/chicken/Netherlands/03011236/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237789 A/chicken/Netherlands/03012915/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237787 A/chicken/Netherlands/03009939/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237784 A/chicken/Netherlands/03007917/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI237673 A/turkey/Netherlands/03010350/03 (A/H7N7) segment 4 (HA) 2333.4 0.000000e+00 1558/1701 (91%) EPI63277 A/guinea fowl/Italy/155/2000 (A/H7N1) segment 4 (HA) 2333.4 0.000000e+00 1561/1705 (91%) EPI43057 A/chicken/Italy/1285/2000 (A/H7N1) segment 4 (HA) 2333.4 0.000000e+00 1559/1703 (91%) EPI505875 A/quail/Italy/1764/2000 (A/H7N1) segment 4 (HA) 2329.7 0.000000e+00 1559/1704 (91%) EPI505809 A/goose/Italy/1310/2000 (A/H7N1) segment 4 (HA) 2329.7 0.000000e+00 1559/1704 (91%) EPI60690 A/turkey/Italy/2984/2000 (A/H7N1) segment 4 (HA) 2329.7 0.000000e+00 1561/1706 (91%) EPI505779 A/guineafowl/Italy/918/2000 (A/H7N1) segment 4 (HA) 2327.9 0.000000e+00 1560/1705 (91%) EPI319979 A/Netherlands/306/03 (A/H7N7) segment 4 (HA) 2327.9 0.000000e+00 1555/1698 (91%) EPI319868 A/Netherlands/076/03 (A/H7N7) segment 4 (HA) 2327.9 0.000000e+00 1555/1698 (91%) EPI295030 A/chicken/Netherlands/03009890/03(H7N7) (A/H7N7) segment 4 (HA) 2327.9 0.000000e+00 1557/1701 (91%) EPI294994 A/chicken/Netherlands/03009124/03(H7N7) (A/H7N7) segment 4 (HA) 2327.9 0.000000e+00 1557/1701 (91%) EPI294988 A/chicken/Netherlands/03009120/03(H7N7) (A/H7N7) segment 4 (HA) 2327.9 0.000000e+00 1557/1701 (91%) EPI294982 A/chicken/Netherlands/03009044/03(H7N7) (A/H7N7) segment 4 (HA) 2327.9 0.000000e+00 1557/1701 (91%) EPI294955 A/chicken/Netherlands/03008379/03(H7N7) (A/H7N7) segment 4 (HA) 2327.9 0.000000e+00 1557/1701 (91%)

Isolate name: A/Qingyuan/GIRD1/2017 Isolate ID: EPI_ISL_249102 Passage details/history: Type: A / H7N9 Lineage: Sample information Collection date: 2017-01-14 Host Human Additional host information: Zip code: Patient status: Deceased Last vaccinated: In-vivo pathogenicity test: Location: China / Guangdong Province Additional location information: Patient age: 56 Year(s) Gender: Male Outbreak: Sporadic Treatment: Treatment by Oseltamivir Specimen source: Tracheal Institute information Originating lab: State Key Laboratory of Reipiratory Disease (Guangzhou Medical University) Sample ID given by the sample provider: Address: State Key Laboratory of Reipiratory Disease (Guangzhou Medical University) 195, Dongfengxi Road, Yuexiu District, Guangzhou, Guangdong Province, China, Guangzhou China Submitting lab: guangzhou institute of respiratory disease Sample ID given by the submitting laboratory: Authors: Wenda Guan,PhD; Wenjun Song,PhD; Jianfeng He,MD; Changwen Ke,MD; Zifeng Yang,PhD; Haibo Zhou,MD; Qinhan Lin,MD; Yonghui Zhang,MD; Nanshan Zhong,MD Address: guangzhou institute of respiratory disease 1 kangda road, guangzhou China Publication Publication In vivo antiviral resistance Phenotype Genotype Unspecified Antiviral resistance tested by experimental procedures Adamantanes: Unknown Oseltamivir: Unknown Zanamivir: Unknown Peramivir: Unknown Other: Unknown Additional information Antigenic characterization: Note: Sequence segment identifier length accession # INSDC Sequence PB2 A/Qingyuan/GIRD1/2017 2341 EPI918730 PB1 A/Qingyuan/GIRD1/2017 2341 EPI918732 PA A/Qingyuan/GIRD1/2017 2233 EPI918734 HA A/Qingyuan/GIRD1/2017 1744 EPI918736 NP A/Qingyuan/GIRD1/2017 1565 EPI918737 NA A/Qingyuan/GIRD1/2017 1444 EPI918738 MP A/Qingyuan/GIRD1/2017 1027 EPI918739 NS A/Qingyuan/GIRD1/2017 890 EPI918740 Submitter information Submitter: guan, wenda Submission Date: 2017-02-19 Last modifier: guan, wenda Last modified: 2017-02-19 Address: guangzhou institute of respiratory disease 1 kangda road, guangzhou China

Guangzhou Institute of Respiratory Disease has released a full set of H7N9 sequences from a fatal case in Qingyuan, Guangdong. The H5 has the same polybasic cleavage site, KRKRTAR seen in the case from Taiwan ex-Guangdong Province.

http://rense2.gsradio.net/rense/special/rense_021617_hr1.mp3 HPAI H7N9

http://www.renseradio.com/listenlive.htm

http://rense2.gsradio.net/rense/special/rense_011917_hr1.mp3

10 PM ET tonight Dr. Henry L. Niman, PhDBird Flu Spreading

Analysis of recent scientific information on avian influenza A(H7N9) virus 10 February 2017 Background An increase in human infections with avian influenza A(H7N9) virus has been reported by China since October 20161. This document presents recent scientific findings on A(H7N9) viruses. Current information Geographical distribution in animals: A(H7N9) virus causes little or no illness in poultry and is therefore generally only detected through active virological surveillance. A number of surveillance systems routinely monitor for A(H7N9) activity in animals in China. From December 2016, the Chinese national animal influenza virus surveillance program of the Ministry of Agriculture detected influenza A(H7N9) virus in birds in Anhui, Guangdong and Zhejiang provinces2. Based on live poultry market (LPM) surveillance conducted by the Chinese provincial Health and Family Planning Commissions in December 2016, 9.4% of environmental samples were positive for A(H7N9) from LPMs in Guangdong and 15.8% of samples from LPMs in Jiangsu were positive for A(H7), of which most were positive for A(H7N9)3,4. The low pathogenicity of the virus in birds adds to the difficulty in identifying its international spread through infected birds. To date, A(H7N9) virus has not been reported in poultry populations outside China. Some countries adjacent to China have intensified their surveillance, and several countries have imposed a temporary ban on importing live birds from China2. Human infections: Sudden increases in the number of human A(H7N9) cases reported during December and January have been observed in previous years5.* Compared to earlier waves of infection, further geographic spread of the virus was observed in this fifth wave6. Of the cases where information on exposure history was known, as previous waves, most reported prior exposure to live poultry or potentially contaminated environments, including in LPMs6. Among cases reported in the fifth wave, three clusters were reported, comparable to findings in previous waves1,6. Limited human-to-human transmission could not be ruled out in these clusters. So far, there has been no indication of significant changes in the epidemiology of the human infections reported, no evidence of sustained human-to-human transmission and no significant changes in the clinical presentation or disease outcome6. Population immunity: In the general population, three serological surveys using specimens collected in 2011 to 2013 reported zero or very low human population immunity against A(H7) viruses7-9. Studies of poultry workers with specimens collected in 2011 to 2013 reported between 0 and 7% seropositivity7,8,10. In 2015-2016, 15,191 serum samples from poultry workers were collected by 31 provincial Centers for Disease Control (CDCs) in Mainland China, and were tested for A(H7N9) antibody in the WHO Collaborating Centre for Reference and Research on Influenza (WHOCC) in Beijing (also as the Chinese National Influenza Center), of which 26 were positive (0.17%). Disease severity: In most cases, infection with A(H7N9) virus is characterized by high fever, cough, shortness of breath and rapidly progressing severe pneumonia. Complications include acute respiratory distress syndrome (ARDS), septic shock and multi-organ failure requiring intensive care11. Severe illness and fatal outcome have been more frequently observed in pregnant women12, in older persons6 and those with underlying chronic conditions13. Asymptomatic and mild infections with A(H7N9) virus have been detected, but the underlying rate of such infections is not well understood14,15. Virology: The detailed virological surveillance data from the first 4 waves have been published16,17. For the fifth wave, since 1 October 2016, 83 full genome sequences were analysed: 2 environmental isolates from LPMs in Guangdong and 81 A(H7N9) viruses isolated from specimens collected from human cases by the WHOCC in Beijing. These human specimens were from Jiangsu (N=26), Zhejiang (N=21), Guangdong (N=13), Anhui (N=12), Fujian (N=5) and Hunan (N=4) provinces. Phylogenetic analysis results show that all the internal genes continue to cluster with previously reported A(H7N9) and A(H9N2) viruses. And the haemagglutinin (HA) and neuraminidase (NA) genes are clustered and evolving in two lineages on the phylogenetic trees; the Yangtze River Delta lineage and the Pearl River Delta lineage (Annex 1 and Annex 2). In general, all of the viruses causing human infections remain similar to viruses analysed since 2013. Key molecular makers associated with mammalian adaptation and pathogenicity are summarized below and detailed in Annex 3: All viruses contained the 177V and 217L/I (H3 numbering 186V and 226L/I) in HA1, similar with the A(H7N9) viruses since 2013. All viruses contained the 69-73 deletion in NA, same with the A(H7N9) viruses since 2013. Of the 83 viruses, 59 carried 627K in PB2 and 10 carried 701N, and 78 viruses carried I368V in PB1, similar with the A(H7N9) viruses since 2013. Analyses of these recently isolated viruses from Mainland China as well as Hong Kong Special Administrative Region (SAR) do not show evidence of any changes in known genetic markers of virulence or mammalian adaptation. In comparison to candidate vaccine viruses, amino acid substitutions in the HA of some viruses were identified in antigenic sites. Analysis is underway to determine if existing candidate vaccine viruses remain antigenically correspondent to fifth wave viruses. Antiviral susceptibility: Genetic analysis of 83 recent A(H7N9) viruses showed that one virus contained 243T (N2 numbering 246T) and two contained 289K (N2 numbering 292K) mutations in the NA gene, indicating reduced sensitivity to NA inhibitors. All of the other 80 viruses did not contain any of the amino acid substitutions that are known to confer reduced inhibition by the NA inhibitor class of antivirals. Testing of some viruses is underway to assess in vitro susceptibility to the NA inhibitor class of antivirals. As observed for A(H7N9) viruses from previous waves of human infection, all 83 viruses carried the S31N mutation on the M2 protein indicating resistance to amantadine and rimantadine. Transmission in animal models: Transmission studies of A(H7N9) viruses from 2013 using ferret models indicate that the virus can transmit efficiently through direct contact but inefficiently through respiratory droplets18-25. The virus can replicate in swine respiratory tract tissue26, highlighting the need to screen for further mammalian adaptation. Further studies with more recent A(H7N9) viruses are needed to monitor for any changes in transmissibility. Conclusions Based on information reported, there is no evidence of sustained human-to-human transmission, and there are no significant changes in A(H7N9) virus properties or the epidemiology of human infections. As long as humans are exposed to infected animals and their environments, further human cases can be expected. WHO, through its Global Influenza Surveillance and Response System (GISRS), in collaboration with the OIE FAO Network of Experts on Animal Influenza (OFFLU) and national authorities, will continue monitoring the A(H7N9) virus situation. As traditionally the consumption of poultry among the general population increases during the Chinese New Year celebrations, the movement, trade and slaughter of poultry during this period may subsequently increase human exposure to the A(H7N9) virus6. Countries are encouraged to continue strengthening influenza surveillance, including surveillance for severe acute respiratory infections (SARI) and influenza-like illness (ILI), carefully review any unusual epidemiological patterns, immediately alert WHO Global Influenza Programme (GIP) and WHOCCs of GISRS of unsubtypable influenza viruses, ensure reporting under the International Health Regulations (IHR, 2005), and continue national influenza pandemic preparedness actions. Annex 1: Phylogenetic tree for haemagglutinin gene pdf, 364kb Annex 2: Phylogenetic tree for neuraminidase gene pdf, 360kb Annex 3: Table of molecular markers for mammalian adaptation and pathogenicity of avian influenza A(H7N9) viruses pdf, 236kb *These increases in cases have been referred to as waves. WHO defines these waves as beginning on 1 October until 30 September of the following year. Thus, currently, the increase in human cases is referred to as the fifth wave (1 October 2016 through 30 September 2017). World Health Organization. Human infection with avian influenza A(H7N9) virus – China. Available from: www.who.int/csr/don/17-january-2017-ah7n9-china/en/ Food and Agriculture Organization. H7N9 situation update 24 January 2017. Available from: www.fao.org/ag/againfo/programmes/en/empres/H7N9/situation_update.html Health and Family Planning Commission of Guangdong Province. Available from: www.gdwst.gov.cn/a/zwxw/2017011717051.html Jiangsu Provincial Commission of Health and Family Planning. Available from: www.jswst.gov.cn/wsxx/nrglIndex.action?catalogID=4028816b2ba99317012ba99950740003&type=2&messageID=ff80808159433fad015981a71c580427 World Health Organization. Monthly Risk Assessment Summary : Influenza at the Human-Animal Interface. Available from:www.who.int/influenza/human_animal_interface/HAI_Risk_Assessment/en/ Zhou L, Ren R, Yang L, Bao C, Jiabing W, Wang D, et al. Sudden increase in human infection with avian influenza A(H7N9) virus in China, September-December 2016. Western Pac Surveill Response J. 2017;9(1). Available from: ojs.wpro.who.int/ojs/index.php/wpsar/article/view/521/733 Wang X, Fang S, Lu X, Xu C, Cowling BJ, Tang X, et al. Seroprevalence to avian influenza A(H7N9) virus among poultry workers and the general population in southern China: a longitudinal study. Clin Infect Dis. 2014;59(6):e76-83. 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