niman

BetaCoV/Wuhan/IPBCAMS-WH-01/2019|EPI_ISL_402123 Top 100 matches at Genbank Sequences producing significant alignments: Select:AllNone Selected:0 AlignmentsDownloadGenBankGraphicsDistance tree of resultsShow/hide columns of the table presenting sequences producing significant alignments Sequences producing significant alignments: Select for downloading or viewing reports Description Max Score Total Score Query Cover E value Per. Ident Accession Select seq MG772933.1 Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome 26927 35319 95% 0.0 89.10% MG772933.1 Select seq MG772934.1 Bat SARS-like coronavirus isolate bat-SL-CoVZXC21, complete genome 22207 35259 94% 0.0 88.64% MG772934.1 Select seq AY395003.1 SARS coronavirus ZS-C, complete genome 15202 22553 88% 0.0 82.33% AY395003.1 Select seq AY394996.1 SARS coronavirus ZS-B, complete genome 15202 22589 88% 0.0 82.33% AY394996.1 Select seq AY304488.1 SARS coronavirus SZ16, complete genome 15191 22520 88% 0.0 82.32% AY304488.1 Select seq AY304486.1 SARS coronavirus SZ3, complete genome 15191 22518 88% 0.0 82.32% AY304486.1 Select seq AY390556.1 SARS coronavirus GZ02, complete genome 15180 22537 88% 0.0 82.31% AY390556.1 Select seq EU371564.1 SARS coronavirus BJ182-12, complete genome 15175 22472 88% 0.0 82.30% EU371564.1 Select seq AY394985.1 SARS coronavirus HSZ-Bb, complete genome 15175 22265 87% 0.0 82.30% AY394985.1 Select seq AY278554.2 SARS coronavirus CUHK-W1, complete genome 15175 22566 88% 0.0 82.30% AY278554.2 Select seq EU371559.1 SARS coronavirus ZJ02, complete genome 15169 22537 88% 0.0 82.30% EU371559.1 Select seq AY559093.1 SARS coronavirus Sin845, complete genome 15169 22496 88% 0.0 82.30% AY559093.1 Select seq AY394994.1 SARS coronavirus HSZ-Bc, complete genome 15169 22555 88% 0.0 82.30% AY394994.1 Select seq AY394986.1 SARS coronavirus HSZ-Cb, complete genome 15169 22515 88% 0.0 82.30% AY394986.1 Select seq MK211376.1 Coronavirus BtRs-BetaCoV/YN2018B, complete genome 15165 22607 91% 0.0 82.31% MK211376.1 Select seq KY417146.1 Bat SARS-like coronavirus isolate Rs4231, complete genome 15165 22523 91% 0.0 82.29% KY417146.1 Select seq JX163927.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 15163 22406 88% 0.0 82.29% JX163927.1 Select seq JX163926.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 15163 22413 88% 0.0 82.29% JX163926.1 Select seq JX163923.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 15163 22406 88% 0.0 82.29% JX163923.1 Select seq JQ316196.1 SARS coronavirus HKU-39849 isolate UOB, complete genome 15163 22518 88% 0.0 82.29% JQ316196.1 Select seq FJ882963.1 SARS coronavirus P2, complete genome 15163 22439 88% 0.0 82.29% FJ882963.1 Select seq DQ898174.1 SARS coronavirus strain CV7, complete genome 15163 22563 88% 0.0 82.29% DQ898174.1 Select seq AY864806.1 SARS coronavirus BJ202, complete genome 15163 22568 88% 0.0 82.29% AY864806.1 Select seq AY714217.1 SARS Coronavirus CDC#200301157, complete genome 15163 22518 88% 0.0 82.29% AY714217.1 Select seq AY559096.1 SARS coronavirus Sin850, complete genome 15163 22505 88% 0.0 82.29% AY559096.1 Select seq AY559095.1 SARS coronavirus Sin847, complete genome 15163 22492 88% 0.0 82.29% AY559095.1 Select seq AY559086.1 SARS coronavirus Sin849, complete genome 15163 22491 88% 0.0 82.29% AY559086.1 Select seq AY559085.1 SARS coronavirus Sin848, complete genome 15163 22492 88% 0.0 82.29% AY559085.1 Select seq AY559084.1 SARS coronavirus Sin3765V, complete genome 15163 22515 88% 0.0 82.29% AY559084.1 Select seq AY559083.1 SARS coronavirus Sin3408, complete genome 15163 22502 88% 0.0 82.29% AY559083.1 Select seq AY559082.1 SARS coronavirus Sin852, complete genome 15163 22491 88% 0.0 82.29% AY559082.1 Select seq AY274119.3 Severe acute respiratory syndrome-related coronavirus isolate Tor2, complete genome 15163 22557 88% 0.0 82.29% AY274119.3 Select seq AY323977.2 SARS coronavirus HSR 1, complete genome 15163 22568 88% 0.0 82.29% AY323977.2 Select seq AY291451.1 SARS coronavirus TW1, complete genome 15163 22528 88% 0.0 82.29% AY291451.1 Select seq AY502928.1 SARS coronavirus TW5, complete genome 15163 22522 88% 0.0 82.29% AY502928.1 Select seq AY502926.1 SARS coronavirus TW3, complete genome 15163 22515 88% 0.0 82.29% AY502926.1 Select seq AY502923.1 SARS coronavirus TW10, complete genome 15163 22528 88% 0.0 82.29% AY502923.1 Select seq AY394999.1 SARS coronavirus LC2, complete genome 15163 22500 88% 0.0 82.29% AY394999.1 Select seq AY394998.1 SARS coronavirus LC1, complete genome 15163 22550 88% 0.0 82.29% AY394998.1 Select seq AY394995.1 SARS coronavirus HSZ-Cc, complete genome 15163 22544 88% 0.0 82.29% AY394995.1 Select seq AY394993.1 SARS coronavirus HGZ8L2, complete genome 15163 22550 88% 0.0 82.29% AY394993.1 Select seq AY394992.1 SARS coronavirus HZS2-C, complete genome 15163 22555 88% 0.0 82.29% AY394992.1 Select seq AY394991.1 SARS coronavirus HZS2-Fc, complete genome 15163 22555 88% 0.0 82.29% AY394991.1 Select seq AY394987.1 SARS coronavirus HZS2-Fb, complete genome 15163 22537 88% 0.0 82.29% AY394987.1 Select seq AY394983.1 SARS coronavirus HSZ2-A, complete genome 15163 22524 88% 0.0 82.29% AY394983.1 Select seq AY394978.1 SARS coronavirus GZ-B, complete genome 15163 22450 88% 0.0 82.29% AY394978.1 Select seq AY357075.1 SARS coronavirus PUMC02, complete genome 15163 22552 88% 0.0 82.29% AY357075.1 Select seq AY282752.2 SARS coronavirus CUHK-Su10, complete genome 15163 22550 88% 0.0 82.29% AY282752.2 Select seq AY427439.1 SARS coronavirus AS, complete genome 15163 22511 88% 0.0 82.29% AY427439.1 Select seq AY283796.1 SARS coronavirus Sin2679, complete genome 15163 22516 88% 0.0 82.29% AY283796.1 Select seq AP006561.1 SARS coronavirus TWY genomic RNA, complete genome 15163 22524 88% 0.0 82.29% AP006561.1 Select seq JX163925.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 15162 22404 88% 0.0 82.29% JX163925.1 Select seq JX163928.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 15160 22413 88% 0.0 82.29% JX163928.1 Select seq JX163924.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 15158 22409 88% 0.0 82.29% JX163924.1 Select seq GU553363.1 SARS coronavirus HKU-39849 isolate TCVSP-HARROD-00001, complete genome 15158 22404 88% 0.0 82.29% GU553363.1 Select seq EU371563.1 SARS coronavirus BJ182-8, complete genome 15158 22492 88% 0.0 82.29% EU371563.1 Select seq EU371561.1 SARS coronavirus BJ182b, complete genome 15158 22498 88% 0.0 82.29% EU371561.1 Select seq EU371560.1 SARS coronavirus BJ182a, complete genome 15158 22498 88% 0.0 82.29% EU371560.1 Select seq AY864805.1 SARS coronavirus BJ162, complete genome 15158 22563 88% 0.0 82.29% AY864805.1 Select seq AY278741.1 SARS coronavirus Urbani, complete genome 15158 22524 88% 0.0 82.29% AY278741.1 Select seq AY559087.1 SARS coronavirus Sin3725V, complete genome 15158 22507 88% 0.0 82.28% AY559087.1 Select seq AY394989.1 SARS coronavirus HZS2-D, complete genome 15158 22550 88% 0.0 82.29% AY394989.1 Select seq AY485278.1 SARS coronavirus Sino3-11, complete genome 15158 22535 88% 0.0 82.29% AY485278.1 Select seq AY502927.1 SARS coronavirus TW4, complete genome 15156 22515 88% 0.0 82.28% AY502927.1 Select seq GU553365.1 SARS coronavirus HKU-39849 isolate TCVSP-HARROD-00003, complete genome 15154 22395 88% 0.0 82.28% GU553365.1 Select seq KJ473816.1 BtRs-BetaCoV/YN2013, complete genome 15152 21661 85% 0.0 82.28% KJ473816.1 Select seq EU371562.1 SARS coronavirus BJ182-4, complete genome 15147 22487 88% 0.0 82.28% EU371562.1 Select seq MK211377.1 Coronavirus BtRs-BetaCoV/YN2018C, complete genome 15138 22392 88% 0.0 82.28% MK211377.1 Select seq KY417145.1 Bat SARS-like coronavirus isolate Rf4092, complete genome 15123 22361 86% 0.0 82.25% KY417145.1 Select seq MK211375.1 Coronavirus BtRs-BetaCoV/YN2018A, complete genome 15106 22357 88% 0.0 82.25% MK211375.1 Select seq KF294455.1 SARS-related bat coronavirus isolate Anlong-111 orf1ab polyprotein and orf1a polyprotein genes, complete cds 15073 16321 64% 0.0 82.34% KF294455.1 Select seq JX993988.1 Bat coronavirus Cp/Yunnan2011, complete genome 15032 21823 86% 0.0 82.17% JX993988.1 Select seq KJ473814.1 BtRs-BetaCoV/HuB2013, complete genome 14958 22328 87% 0.0 82.19% KJ473814.1 Select seq DQ648857.1 Bat coronavirus (BtCoV/279/2005), complete genome 14905 22152 87% 0.0 82.15% DQ648857.1 Select seq JX993987.1 Bat coronavirus Rp/Shaanxi2011, complete genome 14881 21808 88% 0.0 81.99% JX993987.1 Select seq KF294457.1 SARS-related bat coronavirus isolate Longquan-140 orf1ab polyprotein, spike glycoprotein, envelope protein, membrane protein, and nucleocapsid protein genes, complete cds 14748 23756 91% 0.0 81.88% KF294457.1 Select seq MK211374.1 Coronavirus BtRl-BetaCoV/SC2018, complete genome 14720 21825 87% 0.0 82.00% MK211374.1 Select seq KJ473813.1 BtRf-BetaCoV/SX2013, complete genome 14711 21349 87% 0.0 81.81% KJ473813.1 Select seq KJ473812.1 BtRf-BetaCoV/HeB2013, complete genome 14672 21250 86% 0.0 81.78% KJ473812.1 Select seq KJ473811.1 BtRf-BetaCoV/JL2012, complete genome 14672 21056 86% 0.0 81.78% KJ473811.1 Select seq GQ153542.1 Bat SARS coronavirus HKU3-7, complete genome 14672 21947 88% 0.0 81.81% GQ153542.1 Select seq GQ153543.1 Bat SARS coronavirus HKU3-8, complete genome 14667 21985 88% 0.0 81.80% GQ153543.1 Select seq KY770860.1 Bat coronavirus isolate Jiyuan-84, complete genome 14617 21405 87% 0.0 81.73% KY770860.1 Select seq DQ648856.1 Bat coronavirus (BtCoV/273/2005), complete genome 14545 21375 87% 0.0 81.65% DQ648856.1 Select seq DQ412042.1 Bat SARS coronavirus Rf1, complete genome 14545 21383 87% 0.0 81.65% DQ412042.1 Select seq GQ153547.1 Bat SARS coronavirus HKU3-12, complete genome 14539 21819 88% 0.0 81.67% GQ153547.1 Select seq KF294456.1 SARS-related bat coronavirus isolate Jiyuan-331 orf1ab polyprotein gene, complete cds 14528 15818 66% 0.0 81.65% KF294456.1 Select seq FJ211859.1 Recombinant coronavirus clone Bat SARS-CoV, complete sequence 14506 21867 89% 0.0 81.63% FJ211859.1 Select seq DQ084199.1 bat SARS coronavirus HKU3-2, complete genome 14501 21799 88% 0.0 81.63% DQ084199.1 Select seq GQ153540.1 Bat SARS coronavirus HKU3-5, complete genome 14495 21780 88% 0.0 81.62% GQ153540.1 Select seq GQ153539.1 Bat SARS coronavirus HKU3-4, complete genome 14495 21786 88% 0.0 81.62% GQ153539.1 Select seq GQ153546.1 Bat SARS coronavirus HKU3-11, complete genome 14489 21769 88% 0.0 81.62% GQ153546.1 Select seq DQ022305.2 Bat SARS coronavirus HKU3-1, complete genome 14489 21852 89% 0.0 81.62% DQ022305.2 Select seq DQ084200.1 bat SARS coronavirus HKU3-3, complete genome 14489 21838 89% 0.0 81.62% DQ084200.1 Select seq GQ153548.1 Bat SARS coronavirus HKU3-13, complete genome 14484 21758 88% 0.0 81.61% GQ153548.1 Select seq GQ153541.1 Bat SARS coronavirus HKU3-6, complete genome 14484 21786 88% 0.0 81.61% GQ153541.1 Select seq GQ153545.1 Bat SARS coronavirus HKU3-10, complete genome 14473 21747 88% 0.0 81.60% GQ153545.1 Select seq GQ153544.1 Bat SARS coronavirus HKU3-9, complete genome 14473 21747 88% 0.0 81.60% GQ153544.1 Select seq KU182964.1 Bat coronavirus isolate JTMC15, complete genome 13490 20269 79% 0.0 82.93% KU182964.1 Select seq KY938558.1 Bat coronavirus strain 16BO133, complete genome 13441 20195 79% 0.0 82.87% KY938558.1

BetaCoV/Wuhan/IVDC-HB-05/2019|EPI_ISL_402121 Top 100 matches at Genbank AlignmentsDownloadGenBankGraphicsDistance tree of resultsShow/hide columns of the table presenting sequences producing significant alignments Sequences producing significant alignments: Select for downloading or viewing reports Description Max Score Total Score Query Cover E value Per. Ident Accession Select seq MG772933.1 Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome 26897 35062 95% 0.0 89.09% MG772933.1 Select seq MG772934.1 Bat SARS-like coronavirus isolate bat-SL-CoVZXC21, complete genome 22207 34997 94% 0.0 88.64% MG772934.1 Select seq AY395003.1 SARS coronavirus ZS-C, complete genome 15175 22256 88% 0.0 82.31% AY395003.1 Select seq AY394996.1 SARS coronavirus ZS-B, complete genome 15175 22288 88% 0.0 82.31% AY394996.1 Select seq AY304488.1 SARS coronavirus SZ16, complete genome 15163 22282 88% 0.0 82.29% AY304488.1 Select seq AY304486.1 SARS coronavirus SZ3, complete genome 15163 22267 88% 0.0 82.29% AY304486.1 Select seq AY390556.1 SARS coronavirus GZ02, complete genome 15152 22260 88% 0.0 82.28% AY390556.1 Select seq EU371564.1 SARS coronavirus BJ182-12, complete genome 15147 22195 88% 0.0 82.28% EU371564.1 Select seq AY394985.1 SARS coronavirus HSZ-Bb, complete genome 15147 21968 88% 0.0 82.28% AY394985.1 Select seq AY278554.2 SARS coronavirus CUHK-W1, complete genome 15147 22265 88% 0.0 82.28% AY278554.2 Select seq EU371559.1 SARS coronavirus ZJ02, complete genome 15141 22260 88% 0.0 82.27% EU371559.1 Select seq AY559093.1 SARS coronavirus Sin845, complete genome 15141 22238 88% 0.0 82.27% AY559093.1 Select seq AY394994.1 SARS coronavirus HSZ-Bc, complete genome 15141 22254 88% 0.0 82.27% AY394994.1 Select seq AY394986.1 SARS coronavirus HSZ-Cb, complete genome 15141 22217 88% 0.0 82.27% AY394986.1 Select seq JX163927.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 15136 22228 88% 0.0 82.27% JX163927.1 Select seq JX163926.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 15136 22236 88% 0.0 82.27% JX163926.1 Select seq JX163923.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 15136 22228 88% 0.0 82.27% JX163923.1 Select seq JQ316196.1 SARS coronavirus HKU-39849 isolate UOB, complete genome 15136 22249 88% 0.0 82.27% JQ316196.1 Select seq FJ882963.1 SARS coronavirus P2, complete genome 15136 22232 88% 0.0 82.27% FJ882963.1 Select seq DQ898174.1 SARS coronavirus strain CV7, complete genome 15136 22249 88% 0.0 82.27% DQ898174.1 Select seq AY864806.1 SARS coronavirus BJ202, complete genome 15136 22254 88% 0.0 82.27% AY864806.1 Select seq AY714217.1 SARS Coronavirus CDC#200301157, complete genome 15136 22249 88% 0.0 82.27% AY714217.1 Select seq AY559096.1 SARS coronavirus Sin850, complete genome 15136 22249 88% 0.0 82.27% AY559096.1 Select seq AY559095.1 SARS coronavirus Sin847, complete genome 15136 22232 88% 0.0 82.27% AY559095.1 Select seq AY559086.1 SARS coronavirus Sin849, complete genome 15136 22236 88% 0.0 82.27% AY559086.1 Select seq AY559085.1 SARS coronavirus Sin848, complete genome 15136 22232 88% 0.0 82.27% AY559085.1 Select seq AY559084.1 SARS coronavirus Sin3765V, complete genome 15136 22238 88% 0.0 82.27% AY559084.1 Select seq AY559083.1 SARS coronavirus Sin3408, complete genome 15136 22234 88% 0.0 82.27% AY559083.1 Select seq AY559082.1 SARS coronavirus Sin852, complete genome 15136 22236 88% 0.0 82.27% AY559082.1 Select seq AY274119.3 Severe acute respiratory syndrome-related coronavirus isolate Tor2, complete genome 15136 22243 88% 0.0 82.27% AY274119.3 Select seq AY323977.2 SARS coronavirus HSR 1, complete genome 15136 22254 88% 0.0 82.27% AY323977.2 Select seq AY291451.1 SARS coronavirus TW1, complete genome 15136 22254 88% 0.0 82.27% AY291451.1 Select seq AY502928.1 SARS coronavirus TW5, complete genome 15136 22249 88% 0.0 82.27% AY502928.1 Select seq AY502926.1 SARS coronavirus TW3, complete genome 15136 22241 88% 0.0 82.27% AY502926.1 Select seq AY502923.1 SARS coronavirus TW10, complete genome 15136 22254 88% 0.0 82.27% AY502923.1 Select seq AY394999.1 SARS coronavirus LC2, complete genome 15136 22199 88% 0.0 82.27% AY394999.1 Select seq AY394998.1 SARS coronavirus LC1, complete genome 15136 22249 88% 0.0 82.27% AY394998.1 Select seq AY394995.1 SARS coronavirus HSZ-Cc, complete genome 15136 22243 88% 0.0 82.26% AY394995.1 Select seq AY394993.1 SARS coronavirus HGZ8L2, complete genome 15136 22249 88% 0.0 82.27% AY394993.1 Select seq AY394992.1 SARS coronavirus HZS2-C, complete genome 15136 22254 88% 0.0 82.27% AY394992.1 Select seq AY394991.1 SARS coronavirus HZS2-Fc, complete genome 15136 22254 88% 0.0 82.27% AY394991.1 Select seq AY394987.1 SARS coronavirus HZS2-Fb, complete genome 15136 22239 88% 0.0 82.27% AY394987.1 Select seq AY394983.1 SARS coronavirus HSZ2-A, complete genome 15136 22227 88% 0.0 82.27% AY394983.1 Select seq AY394978.1 SARS coronavirus GZ-B, complete genome 15136 22153 88% 0.0 82.27% AY394978.1 Select seq AY357075.1 SARS coronavirus PUMC02, complete genome 15136 22243 88% 0.0 82.27% AY357075.1 Select seq AY282752.2 SARS coronavirus CUHK-Su10, complete genome 15136 22249 88% 0.0 82.27% AY282752.2 Select seq AY427439.1 SARS coronavirus AS, complete genome 15136 22254 88% 0.0 82.27% AY427439.1 Select seq AY283796.1 SARS coronavirus Sin2679, complete genome 15136 22260 88% 0.0 82.27% AY283796.1 Select seq AP006561.1 SARS coronavirus TWY genomic RNA, complete genome 15136 22254 88% 0.0 82.27% AP006561.1 Select seq JX163925.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 15134 22227 88% 0.0 82.26% JX163925.1 Select seq KY417146.1 Bat SARS-like coronavirus isolate Rs4231, complete genome 15132 22203 91% 0.0 82.26% KY417146.1 Select seq JX163928.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 15132 22236 88% 0.0 82.26% JX163928.1 Select seq JX163924.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 15130 22232 88% 0.0 82.26% JX163924.1 Select seq GU553363.1 SARS coronavirus HKU-39849 isolate TCVSP-HARROD-00001, complete genome 15130 22227 88% 0.0 82.26% GU553363.1 Select seq EU371563.1 SARS coronavirus BJ182-8, complete genome 15130 22215 88% 0.0 82.26% EU371563.1 Select seq EU371561.1 SARS coronavirus BJ182b, complete genome 15130 22221 88% 0.0 82.26% EU371561.1 Select seq EU371560.1 SARS coronavirus BJ182a, complete genome 15130 22221 88% 0.0 82.26% EU371560.1 Select seq AY864805.1 SARS coronavirus BJ162, complete genome 15130 22249 88% 0.0 82.26% AY864805.1 Select seq AY278741.1 SARS coronavirus Urbani, complete genome 15130 22254 88% 0.0 82.26% AY278741.1 Select seq AY559087.1 SARS coronavirus Sin3725V, complete genome 15130 22241 88% 0.0 82.26% AY559087.1 Select seq AY394989.1 SARS coronavirus HZS2-D, complete genome 15130 22249 88% 0.0 82.26% AY394989.1 Select seq AY485278.1 SARS coronavirus Sino3-11, complete genome 15130 22238 88% 0.0 82.26% AY485278.1 Select seq AY502927.1 SARS coronavirus TW4, complete genome 15128 22241 88% 0.0 82.26% AY502927.1 Select seq GU553365.1 SARS coronavirus HKU-39849 isolate TCVSP-HARROD-00003, complete genome 15127 22217 88% 0.0 82.26% GU553365.1 Select seq MK211376.1 Coronavirus BtRs-BetaCoV/YN2018B, complete genome 15121 22367 91% 0.0 82.26% MK211376.1 Select seq KJ473816.1 BtRs-BetaCoV/YN2013, complete genome 15119 21517 85% 0.0 82.25% KJ473816.1 Select seq EU371562.1 SARS coronavirus BJ182-4, complete genome 15119 22210 88% 0.0 82.25% EU371562.1 Select seq KY417145.1 Bat SARS-like coronavirus isolate Rf4092, complete genome 15095 22046 86% 0.0 82.22% KY417145.1 Select seq MK211377.1 Coronavirus BtRs-BetaCoV/YN2018C, complete genome 15093 22137 89% 0.0 82.24% MK211377.1 Select seq MK211375.1 Coronavirus BtRs-BetaCoV/YN2018A, complete genome 15062 22102 89% 0.0 82.20% MK211375.1 Select seq KF294455.1 SARS-related bat coronavirus isolate Anlong-111 orf1ab polyprotein and orf1a polyprotein genes, complete cds 15062 16287 64% 0.0 82.33% KF294455.1 Select seq JX993988.1 Bat coronavirus Cp/Yunnan2011, complete genome 15016 21695 87% 0.0 82.15% JX993988.1 Select seq KJ473814.1 BtRs-BetaCoV/HuB2013, complete genome 14931 22051 87% 0.0 82.16% KJ473814.1 Select seq DQ648857.1 Bat coronavirus (BtCoV/279/2005), complete genome 14877 21860 87% 0.0 82.12% DQ648857.1 Select seq JX993987.1 Bat coronavirus Rp/Shaanxi2011, complete genome 14864 21666 88% 0.0 81.98% JX993987.1 Select seq KF294457.1 SARS-related bat coronavirus isolate Longquan-140 orf1ab polyprotein, spike glycoprotein, envelope protein, membrane protein, and nucleocapsid protein genes, complete cds 14731 23490 91% 0.0 81.86% KF294457.1 Select seq MK211374.1 Coronavirus BtRl-BetaCoV/SC2018, complete genome 14698 21609 87% 0.0 81.98% MK211374.1 Select seq GQ153542.1 Bat SARS coronavirus HKU3-7, complete genome 14689 21708 89% 0.0 81.83% GQ153542.1 Select seq KJ473813.1 BtRf-BetaCoV/SX2013, complete genome 14683 21072 87% 0.0 81.79% KJ473813.1 Select seq GQ153543.1 Bat SARS coronavirus HKU3-8, complete genome 14683 21756 88% 0.0 81.82% GQ153543.1 Select seq KJ473812.1 BtRf-BetaCoV/HeB2013, complete genome 14645 20975 87% 0.0 81.75% KJ473812.1 Select seq KJ473811.1 BtRf-BetaCoV/JL2012, complete genome 14633 20891 87% 0.0 81.74% KJ473811.1 Select seq KY770860.1 Bat coronavirus isolate Jiyuan-84, complete genome 14595 21148 87% 0.0 81.71% KY770860.1 Select seq GQ153547.1 Bat SARS coronavirus HKU3-12, complete genome 14534 21553 89% 0.0 81.67% GQ153547.1 Select seq DQ648856.1 Bat coronavirus (BtCoV/273/2005), complete genome 14517 21067 87% 0.0 81.63% DQ648856.1 Select seq DQ412042.1 Bat SARS coronavirus Rf1, complete genome 14517 21063 87% 0.0 81.63% DQ412042.1 Select seq KF294456.1 SARS-related bat coronavirus isolate Jiyuan-331 orf1ab polyprotein gene, complete cds 14501 15785 66% 0.0 81.62% KF294456.1 Select seq FJ211859.1 Recombinant coronavirus clone Bat SARS-CoV, complete sequence 14501 21559 89% 0.0 81.63% FJ211859.1 Select seq DQ084199.1 bat SARS coronavirus HKU3-2, complete genome 14495 21548 89% 0.0 81.62% DQ084199.1 Select seq GQ153540.1 Bat SARS coronavirus HKU3-5, complete genome 14489 21514 89% 0.0 81.62% GQ153540.1 Select seq GQ153539.1 Bat SARS coronavirus HKU3-4, complete genome 14489 21520 89% 0.0 81.62% GQ153539.1 Select seq GQ153546.1 Bat SARS coronavirus HKU3-11, complete genome 14484 21503 89% 0.0 81.62% GQ153546.1 Select seq DQ022305.2 Bat SARS coronavirus HKU3-1, complete genome 14484 21542 89% 0.0 81.61% DQ022305.2 Select seq DQ084200.1 bat SARS coronavirus HKU3-3, complete genome 14484 21542 89% 0.0 81.61% DQ084200.1 Select seq GQ153548.1 Bat SARS coronavirus HKU3-13, complete genome 14478 21492 89% 0.0 81.61% GQ153548.1 Select seq GQ153541.1 Bat SARS coronavirus HKU3-6, complete genome 14478 21520 89% 0.0 81.61% GQ153541.1 Select seq GQ153545.1 Bat SARS coronavirus HKU3-10, complete genome 14467 21481 89% 0.0 81.60% GQ153545.1 Select seq GQ153544.1 Bat SARS coronavirus HKU3-9, complete genome 14467 21481 89% 0.0 81.60% GQ153544.1 Select seq KU182964.1 Bat coronavirus isolate JTMC15, complete genome 13468 19977 79% 0.0 82.91% KU182964.1 Select seq KY938558.1 Bat coronavirus strain 16BO133, complete genome 13418 19878 79% 0.0 82.85% KY938558.1

BetaCoV/Wuhan/IVDC-HB-04/2020|EPI_ISL_402120 Top 100 matches at Genbank AlignmentsDownloadGenBankGraphicsDistance tree of resultsShow/hide columns of the table presenting sequences producing significant alignments Sequences producing significant alignments: Select for downloading or viewing reports Description Max Score Total Score Query Cover E value Per. Ident Accession Select seq MG772933.1 Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome 23767 35111 95% 0.0 89.90% MG772933.1 Select seq MG772934.1 Bat SARS-like coronavirus isolate bat-SL-CoVZXC21, complete genome 19149 35057 94% 0.0 89.42% MG772934.1 Select seq AY395003.1 SARS coronavirus ZS-C, complete genome 12373 22342 88% 0.0 82.10% AY395003.1 Select seq AY394996.1 SARS coronavirus ZS-B, complete genome 12373 22374 88% 0.0 82.10% AY394996.1 Select seq AY304488.1 SARS coronavirus SZ16, complete genome 12362 22368 88% 0.0 82.08% AY304488.1 Select seq AY304486.1 SARS coronavirus SZ3, complete genome 12362 22348 88% 0.0 82.08% AY304486.1 Select seq AY390556.1 SARS coronavirus GZ02, complete genome 12357 22346 88% 0.0 82.08% AY390556.1 Select seq AY394985.1 SARS coronavirus HSZ-Bb, complete genome 12357 22054 88% 0.0 82.08% AY394985.1 Select seq AY278554.2 SARS coronavirus CUHK-W1, complete genome 12357 22351 88% 0.0 82.08% AY278554.2 Select seq AY394994.1 SARS coronavirus HSZ-Bc, complete genome 12351 22340 88% 0.0 82.07% AY394994.1 Select seq AY394986.1 SARS coronavirus HSZ-Cb, complete genome 12351 22303 88% 0.0 82.07% AY394986.1 Select seq MK211376.1 Coronavirus BtRs-BetaCoV/YN2018B, complete genome 12345 22481 91% 0.0 82.06% MK211376.1 Select seq EU371564.1 SARS coronavirus BJ182-12, complete genome 12345 22281 88% 0.0 82.06% EU371564.1 Select seq EU371559.1 SARS coronavirus ZJ02, complete genome 12345 22346 88% 0.0 82.06% EU371559.1 Select seq AY864806.1 SARS coronavirus BJ202, complete genome 12345 22340 88% 0.0 82.06% AY864806.1 Select seq AY864805.1 SARS coronavirus BJ162, complete genome 12345 22335 88% 0.0 82.06% AY864805.1 Select seq AY559093.1 SARS coronavirus Sin845, complete genome 12345 22324 88% 0.0 82.06% AY559093.1 Select seq AY559084.1 SARS coronavirus Sin3765V, complete genome 12345 22324 88% 0.0 82.06% AY559084.1 Select seq AY559082.1 SARS coronavirus Sin852, complete genome 12345 22322 88% 0.0 82.06% AY559082.1 Select seq AY394995.1 SARS coronavirus HSZ-Cc, complete genome 12345 22329 88% 0.0 82.06% AY394995.1 Select seq MK062183.1 SARS coronavirus Urbani isolate icSARS-C7, complete genome 12340 22077 88% 0.0 82.06% MK062183.1 Select seq MK062181.1 SARS coronavirus Urbani isolate icSARS-C3, complete genome 12340 22180 88% 0.0 82.06% MK062181.1 Select seq MK062179.1 SARS coronavirus Urbani isolate icSARS, complete genome 12340 22324 88% 0.0 82.06% MK062179.1 Select seq JX163927.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 12340 22314 88% 0.0 82.06% JX163927.1 Select seq JX163926.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 12340 22322 88% 0.0 82.06% JX163926.1 Select seq JX163923.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 12340 22314 88% 0.0 82.06% JX163923.1 Select seq JQ316196.1 SARS coronavirus HKU-39849 isolate UOB, complete genome 12340 22335 88% 0.0 82.06% JQ316196.1 Select seq FJ882963.1 SARS coronavirus P2, complete genome 12340 22318 88% 0.0 82.06% FJ882963.1 Select seq DQ898174.1 SARS coronavirus strain CV7, complete genome 12340 22335 88% 0.0 82.06% DQ898174.1 Select seq AY278741.1 SARS coronavirus Urbani, complete genome 12340 22340 88% 0.0 82.06% AY278741.1 Select seq AY714217.1 SARS Coronavirus CDC#200301157, complete genome 12340 22335 88% 0.0 82.06% AY714217.1 Select seq AY559096.1 SARS coronavirus Sin850, complete genome 12340 22335 88% 0.0 82.06% AY559096.1 Select seq AY559095.1 SARS coronavirus Sin847, complete genome 12340 22318 88% 0.0 82.06% AY559095.1 Select seq AY559086.1 SARS coronavirus Sin849, complete genome 12340 22322 88% 0.0 82.06% AY559086.1 Select seq AY559085.1 SARS coronavirus Sin848, complete genome 12340 22318 88% 0.0 82.06% AY559085.1 Select seq AY559083.1 SARS coronavirus Sin3408, complete genome 12340 22320 88% 0.0 82.06% AY559083.1 Select seq AY394991.1 SARS coronavirus HZS2-Fc, complete genome 12340 22340 88% 0.0 82.06% AY394991.1 Select seq AY394987.1 SARS coronavirus HZS2-Fb, complete genome 12340 22326 88% 0.0 82.06% AY394987.1 Select seq JX163925.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 12338 22313 88% 0.0 82.05% JX163925.1 Select seq AY559087.1 SARS coronavirus Sin3725V, complete genome 12338 22327 88% 0.0 82.05% AY559087.1 Select seq JX163928.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 12336 22322 88% 0.0 82.05% JX163928.1 Select seq AY559092.1 SARS coronavirus SinP5, complete genome 12336 22305 88% 0.0 82.05% AY559092.1 Select seq AY559088.1 SARS coronavirus SinP1, complete genome 12336 22309 88% 0.0 82.05% AY559088.1 Select seq JX163924.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 12334 22318 88% 0.0 82.05% JX163924.1 Select seq FJ882938.1 SARS coronavirus wtic-MB, complete genome 12331 22292 88% 0.0 82.05% FJ882938.1 Select seq KY417152.1 Bat SARS-like coronavirus isolate Rs9401, complete genome 12329 19557 81% 0.0 82.05% KY417152.1 Select seq EU371563.1 SARS coronavirus BJ182-8, complete genome 12329 22302 88% 0.0 82.05% EU371563.1 Select seq EU371562.1 SARS coronavirus BJ182-4, complete genome 12329 22296 88% 0.0 82.05% EU371562.1 Select seq EU371561.1 SARS coronavirus BJ182b, complete genome 12329 22307 88% 0.0 82.05% EU371561.1 Select seq EU371560.1 SARS coronavirus BJ182a, complete genome 12329 22307 88% 0.0 82.05% EU371560.1 Select seq KY417148.1 Bat SARS-like coronavirus isolate Rs4247, complete genome 12323 22263 89% 0.0 82.04% KY417148.1 Select seq KY417146.1 Bat SARS-like coronavirus isolate Rs4231, complete genome 12323 22302 91% 0.0 82.04% KY417146.1 Select seq FJ882949.1 SARS coronavirus wtic-MB isolate P3pp23, complete genome 12323 22276 88% 0.0 82.04% FJ882949.1 Select seq FJ882947.1 SARS coronavirus wtic-MB isolate P3pp7, complete genome 12323 22274 88% 0.0 82.04% FJ882947.1 Select seq FJ882936.1 SARS coronavirus wtic-MB isolate P3pp2, complete genome 12323 22274 88% 0.0 82.04% FJ882936.1 Select seq FJ882935.1 SARS coronavirus wtic-MB isolate P3pp21, complete genome 12323 22276 88% 0.0 82.04% FJ882935.1 Select seq FJ882934.1 SARS coronavirus wtic-MB isolate P3pp29, complete genome 12323 22274 88% 0.0 82.04% FJ882934.1 Select seq FJ882933.1 SARS coronavirus wtic-MB isolate P3pp6, complete genome 12323 22276 88% 0.0 82.04% FJ882933.1 Select seq FJ882932.1 SARS coronavirus wtic-MB isolate P3pp14, complete genome 12323 22268 88% 0.0 82.04% FJ882932.1 Select seq FJ882927.1 SARS coronavirus wtic-MB isolate P1pp1, complete genome 12323 22285 88% 0.0 82.04% FJ882927.1 Select seq AY595412.1 SARS coronavirus LLJ-2004, complete genome 12321 22283 88% 0.0 82.02% AY595412.1 Select seq KY417142.1 Bat SARS-like coronavirus isolate As6526, complete genome 12320 19474 78% 0.0 82.03% KY417142.1 Select seq FJ882937.1 SARS coronavirus wtic-MB isolate P3pp18, complete genome 12318 22270 88% 0.0 82.03% FJ882937.1 Select seq KY417151.1 Bat SARS-like coronavirus isolate Rs7327, complete genome 12314 19573 80% 0.0 82.02% KY417151.1 Select seq MK211377.1 Coronavirus BtRs-BetaCoV/YN2018C, complete genome 12307 19474 79% 0.0 82.02% MK211377.1 Select seq KY417145.1 Bat SARS-like coronavirus isolate Rf4092, complete genome 12307 22141 87% 0.0 82.02% KY417145.1 Select seq KT444582.1 SARS-like coronavirus WIV16, complete genome 12290 22355 90% 0.0 82.00% KT444582.1 Select seq KJ473815.1 BtRs-BetaCoV/GX2013, complete genome 12285 21363 86% 0.0 81.99% KJ473815.1 Select seq KJ473816.1 BtRs-BetaCoV/YN2013, complete genome 12273 21602 85% 0.0 81.98% KJ473816.1 Select seq KF294455.1 SARS-related bat coronavirus isolate Anlong-111 orf1ab polyprotein and orf1a polyprotein genes, complete cds 12272 16252 64% 0.0 82.12% KF294455.1 Select seq KY770859.1 Bat coronavirus isolate Anlong-112, complete genome 12246 19355 76% 0.0 81.94% KY770859.1 Select seq JX993988.1 Bat coronavirus Cp/Yunnan2011, complete genome 12224 21759 87% 0.0 81.91% JX993988.1 Select seq DQ648857.1 Bat coronavirus (BtCoV/279/2005), complete genome 12205 21957 87% 0.0 82.03% DQ648857.1 Select seq KJ473814.1 BtRs-BetaCoV/HuB2013, complete genome 12170 22141 87% 0.0 81.98% KJ473814.1 Select seq JX993987.1 Bat coronavirus Rp/Shaanxi2011, complete genome 12096 21748 88% 0.0 81.75% JX993987.1 Select seq KJ473813.1 BtRf-BetaCoV/SX2013, complete genome 12091 18581 77% 0.0 81.72% KJ473813.1 Select seq KJ473812.1 BtRf-BetaCoV/HeB2013, complete genome 12063 18494 77% 0.0 81.69% KJ473812.1 Select seq KJ473811.1 BtRf-BetaCoV/JL2012, complete genome 12046 20989 87% 0.0 81.67% KJ473811.1 Select seq GQ153542.1 Bat SARS coronavirus HKU3-7, complete genome 12030 21763 89% 0.0 81.68% GQ153542.1 Select seq GQ153543.1 Bat SARS coronavirus HKU3-8, complete genome 12024 21801 88% 0.0 81.68% GQ153543.1 Select seq MK211374.1 Coronavirus BtRl-BetaCoV/SC2018, complete genome 12002 21693 87% 0.0 81.84% MK211374.1 Select seq DQ648856.1 Bat coronavirus (BtCoV/273/2005), complete genome 11996 21164 87% 0.0 81.61% DQ648856.1 Select seq KY770860.1 Bat coronavirus isolate Jiyuan-84, complete genome 11991 18646 77% 0.0 81.61% KY770860.1 Select seq DQ412042.1 Bat SARS coronavirus Rf1, complete genome 11984 21171 87% 0.0 81.60% DQ412042.1 Select seq KF294457.1 SARS-related bat coronavirus isolate Longquan-140 orf1ab polyprotein, spike glycoprotein, envelope protein, membrane protein, and nucleocapsid protein genes, complete cds 11978 23562 91% 0.0 81.61% KF294457.1 Select seq KF294456.1 SARS-related bat coronavirus isolate Jiyuan-331 orf1ab polyprotein gene, complete cds 11912 13189 56% 0.0 81.51% KF294456.1 Select seq GQ153547.1 Bat SARS coronavirus HKU3-12, complete genome 11891 21630 89% 0.0 81.51% GQ153547.1 Select seq GQ153540.1 Bat SARS coronavirus HKU3-5, complete genome 11847 21591 89% 0.0 81.45% GQ153540.1 Select seq DQ084199.1 bat SARS coronavirus HKU3-2, complete genome 11847 21625 89% 0.0 81.45% DQ084199.1 Select seq GQ153548.1 Bat SARS coronavirus HKU3-13, complete genome 11841 21569 89% 0.0 81.45% GQ153548.1 Select seq GQ153539.1 Bat SARS coronavirus HKU3-4, complete genome 11841 21597 89% 0.0 81.44% GQ153539.1 Select seq GQ153546.1 Bat SARS coronavirus HKU3-11, complete genome 11836 21580 89% 0.0 81.44% GQ153546.1 Select seq GQ153541.1 Bat SARS coronavirus HKU3-6, complete genome 11830 21597 89% 0.0 81.43% GQ153541.1 Select seq FJ211859.1 Recombinant coronavirus clone Bat SARS-CoV, complete sequence 11830 21636 89% 0.0 81.43% FJ211859.1 Select seq DQ022305.2 Bat SARS coronavirus HKU3-1, complete genome 11825 21619 89% 0.0 81.42% DQ022305.2 Select seq DQ084200.1 bat SARS coronavirus HKU3-3, complete genome 11825 21619 89% 0.0 81.42% DQ084200.1 Select seq GQ153545.1 Bat SARS coronavirus HKU3-10, complete genome 11819 21558 89% 0.0 81.42% GQ153545.1 Select seq GQ153544.1 Bat SARS coronavirus HKU3-9, complete genome 11819 21558 89% 0.0 81.42% GQ153544.1 Select seq KU182964.1 Bat coronavirus isolate JTMC15, complete genome 10866 20060 79% 0.0 83.10% KU182964.1 Select seq KY938558.1 Bat coronavirus strain 16BO133, complete genome 10811 19960 79% 0.0 83.02% KY938558.1

BetaCoV/Wuhan/IVDC-HB-01/2019|EPI_ISL_402119 Top 100 matches at Genbank Sequences producing significant alignments: Select:AllNone Selected:0 AlignmentsDownloadGenBankGraphicsDistance tree of resultsShow/hide columns of the table presenting sequences producing significant alignments Sequences producing significant alignments: Select for downloading or viewing reports Description Max Score Total Score Query Cover E value Per. Ident Accession Select seq MG772933.1 Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome 26943 35321 95% 0.0 89.12% MG772933.1 Select seq MG772934.1 Bat SARS-like coronavirus isolate bat-SL-CoVZXC21, complete genome 22223 35261 94% 0.0 88.65% MG772934.1 Select seq AY395003.1 SARS coronavirus ZS-C, complete genome 15213 22559 88% 0.0 82.34% AY395003.1 Select seq AY394996.1 SARS coronavirus ZS-B, complete genome 15213 22594 88% 0.0 82.34% AY394996.1 Select seq AY304488.1 SARS coronavirus SZ16, complete genome 15202 22531 88% 0.0 82.33% AY304488.1 Select seq AY304486.1 SARS coronavirus SZ3, complete genome 15202 22529 88% 0.0 82.33% AY304486.1 Select seq AY390556.1 SARS coronavirus GZ02, complete genome 15191 22548 88% 0.0 82.32% AY390556.1 Select seq EU371564.1 SARS coronavirus BJ182-12, complete genome 15186 22483 88% 0.0 82.32% EU371564.1 Select seq AY394985.1 SARS coronavirus HSZ-Bb, complete genome 15186 22271 87% 0.0 82.31% AY394985.1 Select seq AY278554.2 SARS coronavirus CUHK-W1, complete genome 15186 22572 88% 0.0 82.32% AY278554.2 Select seq EU371559.1 SARS coronavirus ZJ02, complete genome 15180 22548 88% 0.0 82.31% EU371559.1 Select seq AY559093.1 SARS coronavirus Sin845, complete genome 15180 22507 88% 0.0 82.31% AY559093.1 Select seq AY394994.1 SARS coronavirus HSZ-Bc, complete genome 15180 22561 88% 0.0 82.31% AY394994.1 Select seq AY394986.1 SARS coronavirus HSZ-Cb, complete genome 15180 22520 88% 0.0 82.31% AY394986.1 Select seq MK211376.1 Coronavirus BtRs-BetaCoV/YN2018B, complete genome 15176 22618 91% 0.0 82.32% MK211376.1 Select seq KY417146.1 Bat SARS-like coronavirus isolate Rs4231, complete genome 15176 22534 91% 0.0 82.30% KY417146.1 Select seq JX163927.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 15175 22417 88% 0.0 82.30% JX163927.1 Select seq JX163926.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 15175 22424 88% 0.0 82.30% JX163926.1 Select seq JX163923.1 SARS coronavirus isolate Tor2/FP1-10912, complete genome 15175 22417 88% 0.0 82.30% JX163923.1 Select seq JQ316196.1 SARS coronavirus HKU-39849 isolate UOB, complete genome 15175 22529 88% 0.0 82.30% JQ316196.1 Select seq FJ882963.1 SARS coronavirus P2, complete genome 15175 22450 88% 0.0 82.30% FJ882963.1 Select seq DQ898174.1 SARS coronavirus strain CV7, complete genome 15175 22568 88% 0.0 82.30% DQ898174.1 Select seq AY864806.1 SARS coronavirus BJ202, complete genome 15175 22574 88% 0.0 82.30% AY864806.1 Select seq AY714217.1 SARS Coronavirus CDC#200301157, complete genome 15175 22529 88% 0.0 82.30% AY714217.1 Select seq AY559096.1 SARS coronavirus Sin850, complete genome 15175 22516 88% 0.0 82.30% AY559096.1 Select seq AY559095.1 SARS coronavirus Sin847, complete genome 15175 22504 88% 0.0 82.30% AY559095.1 Select seq AY559086.1 SARS coronavirus Sin849, complete genome 15175 22502 88% 0.0 82.30% AY559086.1 Select seq AY559085.1 SARS coronavirus Sin848, complete genome 15175 22504 88% 0.0 82.30% AY559085.1 Select seq AY559084.1 SARS coronavirus Sin3765V, complete genome 15175 22526 88% 0.0 82.30% AY559084.1 Select seq AY559083.1 SARS coronavirus Sin3408, complete genome 15175 22513 88% 0.0 82.30% AY559083.1 Select seq AY559082.1 SARS coronavirus Sin852, complete genome 15175 22502 88% 0.0 82.30% AY559082.1 Select seq AY274119.3 Severe acute respiratory syndrome-related coronavirus isolate Tor2, complete genome 15175 22563 88% 0.0 82.30% AY274119.3 Select seq AY323977.2 SARS coronavirus HSR 1, complete genome 15175 22574 88% 0.0 82.30% AY323977.2 Select seq AY291451.1 SARS coronavirus TW1, complete genome 15175 22539 88% 0.0 82.30% AY291451.1 Select seq AY502928.1 SARS coronavirus TW5, complete genome 15175 22533 88% 0.0 82.30% AY502928.1 Select seq AY502926.1 SARS coronavirus TW3, complete genome 15175 22526 88% 0.0 82.30% AY502926.1 Select seq AY502923.1 SARS coronavirus TW10, complete genome 15175 22539 88% 0.0 82.30% AY502923.1 Select seq AY394999.1 SARS coronavirus LC2, complete genome 15175 22505 88% 0.0 82.30% AY394999.1 Select seq AY394998.1 SARS coronavirus LC1, complete genome 15175 22555 88% 0.0 82.30% AY394998.1 Select seq AY394995.1 SARS coronavirus HSZ-Cc, complete genome 15175 22550 88% 0.0 82.30% AY394995.1 Select seq AY394993.1 SARS coronavirus HGZ8L2, complete genome 15175 22555 88% 0.0 82.31% AY394993.1 Select seq AY394992.1 SARS coronavirus HZS2-C, complete genome 15175 22561 88% 0.0 82.31% AY394992.1 Select seq AY394991.1 SARS coronavirus HZS2-Fc, complete genome 15175 22561 88% 0.0 82.30% AY394991.1 Select seq AY394987.1 SARS coronavirus HZS2-Fb, complete genome 15175 22542 88% 0.0 82.30% AY394987.1 Select seq AY394983.1 SARS coronavirus HSZ2-A, complete genome 15175 22529 88% 0.0 82.30% AY394983.1 Select seq AY394978.1 SARS coronavirus GZ-B, complete genome 15175 22456 88% 0.0 82.30% AY394978.1 Select seq AY357075.1 SARS coronavirus PUMC02, complete genome 15175 22552 88% 0.0 82.30% AY357075.1 Select seq AY282752.2 SARS coronavirus CUHK-Su10, complete genome 15175 22555 88% 0.0 82.30% AY282752.2 Select seq AY427439.1 SARS coronavirus AS, complete genome 15175 22522 88% 0.0 82.30% AY427439.1 Select seq AY283796.1 SARS coronavirus Sin2679, complete genome 15175 22528 88% 0.0 82.30% AY283796.1 Select seq AP006561.1 SARS coronavirus TWY genomic RNA, complete genome 15175 22535 88% 0.0 82.30% AP006561.1 Select seq JX163925.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 15173 22415 88% 0.0 82.30% JX163925.1 Select seq JX163928.1 SARS coronavirus isolate Tor2/FP1-10895, complete genome 15171 22424 88% 0.0 82.30% JX163928.1 Select seq JX163924.1 SARS coronavirus isolate Tor2/FP1-10851, complete genome 15169 22420 88% 0.0 82.30% JX163924.1 Select seq GU553363.1 SARS coronavirus HKU-39849 isolate TCVSP-HARROD-00001, complete genome 15169 22415 88% 0.0 82.30% GU553363.1 Select seq EU371563.1 SARS coronavirus BJ182-8, complete genome 15169 22504 88% 0.0 82.30% EU371563.1 Select seq EU371561.1 SARS coronavirus BJ182b, complete genome 15169 22509 88% 0.0 82.30% EU371561.1 Select seq EU371560.1 SARS coronavirus BJ182a, complete genome 15169 22509 88% 0.0 82.30% EU371560.1 Select seq AY864805.1 SARS coronavirus BJ162, complete genome 15169 22568 88% 0.0 82.30% AY864805.1 Select seq AY278741.1 SARS coronavirus Urbani, complete genome 15169 22535 88% 0.0 82.30% AY278741.1 Select seq AY559087.1 SARS coronavirus Sin3725V, complete genome 15169 22518 88% 0.0 82.29% AY559087.1 Select seq AY394989.1 SARS coronavirus HZS2-D, complete genome 15169 22555 88% 0.0 82.30% AY394989.1 Select seq AY485278.1 SARS coronavirus Sino3-11, complete genome 15169 22546 88% 0.0 82.30% AY485278.1 Select seq AY502927.1 SARS coronavirus TW4, complete genome 15167 22526 88% 0.0 82.29% AY502927.1 Select seq GU553365.1 SARS coronavirus HKU-39849 isolate TCVSP-HARROD-00003, complete genome 15165 22406 88% 0.0 82.29% GU553365.1 Select seq KJ473816.1 BtRs-BetaCoV/YN2013, complete genome 15163 21673 85% 0.0 82.29% KJ473816.1 Select seq EU371562.1 SARS coronavirus BJ182-4, complete genome 15158 22498 88% 0.0 82.29% EU371562.1 Select seq MK211377.1 Coronavirus BtRs-BetaCoV/YN2018C, complete genome 15149 22403 88% 0.0 82.29% MK211377.1 Select seq KY417145.1 Bat SARS-like coronavirus isolate Rf4092, complete genome 15134 22372 87% 0.0 82.26% KY417145.1 Select seq MK211375.1 Coronavirus BtRs-BetaCoV/YN2018A, complete genome 15117 22368 89% 0.0 82.26% MK211375.1 Select seq KF294455.1 SARS-related bat coronavirus isolate Anlong-111 orf1ab polyprotein and orf1a polyprotein genes, complete cds 15084 16332 64% 0.0 82.35% KF294455.1 Select seq JX993988.1 Bat coronavirus Cp/Yunnan2011, complete genome 15043 21834 86% 0.0 82.18% JX993988.1 Select seq KJ473814.1 BtRs-BetaCoV/HuB2013, complete genome 14970 22339 87% 0.0 82.20% KJ473814.1 Select seq DQ648857.1 Bat coronavirus (BtCoV/279/2005), complete genome 14916 22163 87% 0.0 82.16% DQ648857.1 Select seq JX993987.1 Bat coronavirus Rp/Shaanxi2011, complete genome 14892 21819 88% 0.0 82.00% JX993987.1 Select seq KF294457.1 SARS-related bat coronavirus isolate Longquan-140 orf1ab polyprotein, spike glycoprotein, envelope protein, membrane protein, and nucleocapsid protein genes, complete cds 14759 23767 91% 0.0 81.89% KF294457.1 Select seq MK211374.1 Coronavirus BtRl-BetaCoV/SC2018, complete genome 14731 21836 87% 0.0 82.02% MK211374.1 Select seq KJ473813.1 BtRf-BetaCoV/SX2013, complete genome 14722 21360 87% 0.0 81.82% KJ473813.1 Select seq KJ473812.1 BtRf-BetaCoV/HeB2013, complete genome 14683 21261 87% 0.0 81.79% KJ473812.1 Select seq KJ473811.1 BtRf-BetaCoV/JL2012, complete genome 14683 21067 86% 0.0 81.79% KJ473811.1 Select seq GQ153542.1 Bat SARS coronavirus HKU3-7, complete genome 14683 21958 89% 0.0 81.82% GQ153542.1 Select seq GQ153543.1 Bat SARS coronavirus HKU3-8, complete genome 14678 21996 88% 0.0 81.82% GQ153543.1 Select seq KY770860.1 Bat coronavirus isolate Jiyuan-84, complete genome 14628 21416 87% 0.0 81.74% KY770860.1 Select seq DQ648856.1 Bat coronavirus (BtCoV/273/2005), complete genome 14556 21386 87% 0.0 81.66% DQ648856.1 Select seq DQ412042.1 Bat SARS coronavirus Rf1, complete genome 14556 21394 87% 0.0 81.66% DQ412042.1 Select seq GQ153547.1 Bat SARS coronavirus HKU3-12, complete genome 14550 21830 89% 0.0 81.68% GQ153547.1 Select seq KF294456.1 SARS-related bat coronavirus isolate Jiyuan-331 orf1ab polyprotein gene, complete cds 14539 15829 66% 0.0 81.66% KF294456.1 Select seq FJ211859.1 Recombinant coronavirus clone Bat SARS-CoV, complete sequence 14517 21875 89% 0.0 81.65% FJ211859.1 Select seq DQ084199.1 bat SARS coronavirus HKU3-2, complete genome 14512 21810 88% 0.0 81.64% DQ084199.1 Select seq GQ153540.1 Bat SARS coronavirus HKU3-5, complete genome 14506 21791 89% 0.0 81.63% GQ153540.1 Select seq GQ153539.1 Bat SARS coronavirus HKU3-4, complete genome 14506 21797 89% 0.0 81.63% GQ153539.1 Select seq GQ153546.1 Bat SARS coronavirus HKU3-11, complete genome 14501 21780 89% 0.0 81.63% GQ153546.1 Select seq DQ022305.2 Bat SARS coronavirus HKU3-1, complete genome 14501 21858 89% 0.0 81.63% DQ022305.2 Select seq DQ084200.1 bat SARS coronavirus HKU3-3, complete genome 14501 21843 89% 0.0 81.63% DQ084200.1 Select seq GQ153548.1 Bat SARS coronavirus HKU3-13, complete genome 14495 21769 89% 0.0 81.63% GQ153548.1 Select seq GQ153541.1 Bat SARS coronavirus HKU3-6, complete genome 14495 21797 89% 0.0 81.62% GQ153541.1 Select seq GQ153545.1 Bat SARS coronavirus HKU3-10, complete genome 14484 21758 89% 0.0 81.61% GQ153545.1 Select seq GQ153544.1 Bat SARS coronavirus HKU3-9, complete genome 14484 21758 89% 0.0 81.61% GQ153544.1 Select seq KU182964.1 Bat coronavirus isolate JTMC15, complete genome 13501 20280 79% 0.0 82.94% KU182964.1 Select seq KY938558.1 Bat coronavirus strain 16BO133, complete genome 13452 20206 79% 0.0 82.88% KY938558.1

Virus name BetaCoV/Wuhan/IVDC-HB-01/2019 Accession ID EPI_ISL_402119 Passage details/history Virus Isolate, Passage 1 Collection date 2019-12-30 Host Human

Virus name BetaCoV/Wuhan/WIV04/2019 Accession ID EPI_ISL_402124 Passage details/history Original Collection date 2019-12-30 Host Human

Virus name BetaCoV/Wuhan/IPBCAMS-WH-01/2019 Accession ID EPI_ISL_402123 Passage details/history Original Collection date 2019-12-24 Host Human

Virus name BetaCoV/Wuhan/IVDC-HB-05/2019 Accession ID EPI_ISL_402121 Passage details/history Original Collection date 2019-12-30 Host Human

Virus name BetaCoV/Wuhan/WIV04/2019 Accession ID EPI_ISL_402124 Passage details/history Original Collection date 2019-12-30 Host Human

Five human Wuhan sequences have been released at GISAID Newly discovered betacoronavirus, Wuhan 2019-2020 A previously unknown betacoronavirus was detected in patients during an outbreak of respiratory illnesses, including atypical pneumonia, that started mid-December 2019 in the city of Wuhan, the capital of Central China’s Hubei Province. The newly discovered coronavirus is similar to some of the betacoronaviruses detected in bats, but it is distinct from SARS-CoV and MERS-CoV. The genome of the newly discovered CoV consists of a single, positive-stranded RNA that is approximately 30k nucleotides long. The overall genome organization of the newly discovered CoV is similar to that of other coronaviruses. The newly sequenced virus genome encodes the open reading frames (ORFs) common to all betacoronaviruses, including ORF1ab that encodes many enzymatic proteins, the spike-surface glycoprotein (S), the small envelope protein (E), the matrix protein (M), and the nucleocapsid protein (N), as well as several nonstructural proteins. Virus name Accession ID Passage details/history Collection date Host Originating lab Submitting lab Virus name Accession ID Passage details/history Collection date Host Originating lab Submitting lab BetaCoV/Wuhan/IVDC-HB-01/2019 EPI_ISL_402119 Virus Isolate, Passage 1 2019-12-30 Human National Institute for Viral Disease Control and Prevention, China CDC National Institute for Viral Disease Control and Prevention, China CDC BetaCoV/Wuhan/IVDC-HB-04/2020 EPI_ISL_402120 Original 2020-01-01 Human National Institute for Viral Disease Control and Prevention, China CDC National Institute for Viral Disease Control and Prevention, China CDC BetaCoV/Wuhan/IVDC-HB-05/2019 EPI_ISL_402121 Original 2019-12-30 Human National Institute for Viral Disease Control and Prevention, China CDC National Institute for Viral Disease Control and Prevention, China CDC BetaCoV/Wuhan/IPBCAMS-WH-01/2019 EPI_ISL_402123 Original 2019-12-24 Human Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College BetaCoV/Wuhan/WIV04/2019 EPI_ISL_402124 Original 2019-12-30 Human Wuhan Jinyintan Hospital Wuhan

WHO Statement Regarding Cluster of Pneumonia Cases in Wuhan, China 9 January 2020 Statement China 中文 Chinese authorities have made a preliminary determination of a novel (or new) coronavirus, identified in a hospitalized person with pneumonia in Wuhan. Chinese investigators conducted gene sequencing of the virus, using an isolate from one positive patient sample. Preliminary identification of a novel virus in a short period of time is a notable achievement and demonstrates China’s increased capacity to manage new outbreaks. Initial information about the cases of pneumonia in Wuhan provided by Chinese authorities last week – including the occupation, location and symptom profile of the people affected – pointed to a coronavirus (CoV) as a possible pathogen causing this cluster. Chinese authorities subsequently reported that laboratory tests ruled out SARS-CoV, MERS-CoV, influenza, avian influenza, adenovirus and other common respiratory pathogens. Coronaviruses are a large family of viruses with some causing less-severe disease, such as the common cold, and others more severe disease such as MERS and SARS. Some transmit easily from person to person, while others do not. According to Chinese authorities, the virus in question can cause severe illness in some patients and does not transmit readily between people. Globally, novel coronaviruses emerge periodically in different areas, including SARS in 2002 and MERS in 2012. Several known coronaviruses are circulating in animals that have not yet infected humans. As surveillance improves more coronaviruses are likely to be identified. China has strong public health capacities and resources to respond and manage respiratory disease outbreaks. In addition to treating the patients in care and isolating new cases as they may be identified, public health officials remain focused on continued contact tracing, conducting environmental assessments at the seafood market, and investigations to identify the pathogen causing the outbreak. In the coming weeks, more comprehensive information is required to understand the current status and epidemiology of the outbreak, and the clinical picture. Further investigations are also required to determine the source, modes of transmission, extent of infection and countermeasures implemented. WHO continues to monitor the situation closely and, together with its partners, is ready to provide technical support to China to investigate and respond to this outbreak. The preliminary determination of a novel virus will assist authorities in other countries to conduct disease detection and response. Over the past week, people with symptoms of pneumonia and reported travel history to Wuhan have been identified at international airports. WHO does not recommend any specific measures for travellers. WHO advises against the application of any travel or trade restrictions on China based on the information currently available. https://www.who.int/china/news/detail/09-01-2020-who-statement-regarding-cluster-of-pneumonia-cases-in-wuhan-china

Novel Coronavirus 2019, Wuhan, China Situation Summary: View larger image As of January 11, 2020, Chinese health authorities have preliminarily identified more than 40 human infections with a novel coronavirus in an outbreak of pneumonia under investigation in Wuhan City, Hubei Province, China. The preliminary identification of the novel coronavirus was announced by the World Health Organizationexternal icon on January 9, 2020. Coronaviruses are a large family of viruses, some causing illness in people and others that circulate among animals, including camels, cats and bats. Rarely, animal coronaviruses can evolve and infect people and then spread between people such as has been seen with MERS and SARS. The outbreak in Wuhan, China has been reported to be linked to a large seafood and animal market, suggesting a possible zoonotic origin to the outbreak. There is an ongoing investigation to determine more about this outbreak. This is a rapidly evolving situation and information will be updated as it becomes available. Risk Assessment: Outbreaks of novel virus infections among people are always of public health concern. The associated risk posed by such outbreaks depends on characteristics of the virus, including whether and how well it spreads between people, the severity of resulting illness, and the medical or other countermeasures available to control the impact of the virus. Chinese health authorities report that to date in this outbreak, there has been no confirmed human-to-human spread of this virus. Authorities also report that several hundred contacts, including health care workers caring for outbreak patients, are being monitored and no additional illnesses have been detected. One patient is reported to have died. Internationally, there have no reports of any cases outside of China. There is much more to learn about the transmissibility, severity, and other features associated with this novel coronavirus, and investigations are ongoing in China. Based on current information, however, the risk from the novel coronavirus 2019 to the American public is deemed to be low at this time. Nevertheless, CDC is taking proactive preparedness precautions. The World Health Organizationexternal icon (WHO) provided updated guidance specific to this response the evening of January 10, 2020external icon. Clinicians should use WHO guidance until CDC guidance is updated in the coming days. CDC Response: CDC is closely monitoring this situation and is working with WHO. CDC has established an Incident Management Structure to optimize domestic and international coordination to this emerging public health threat. CDC has issued an interim travel health notice for this destination to provide information to people who may be traveling to Wuhan City and who may get sick. CDC has issued an interim Health Alert Notice (HAN) Advisory to inform state and local health departments and health care providers about this outbreak. An updated Health Alert Notice (HAN) is in development. This is an emerging, rapidly evolving situation and CDC will provide updated information as it becomes available, in addition to updated guidance in the coming days on how to investigate possible infections with this new coronavirus. Other Available Resources The following resources are available with current information on the unnamed novel coronavirus World Health Organization, Coronavirusexternal icon Pneumonia Outbreak in Chinaexternal icon World Health Organization (WHO) Statement Regarding Cluster of Pneumonia Cases in Wuhan, Chinaexternal icon CDC Information on Coronaviruses CDC Travelers’ Health: Pneumonia of Unknown Cause in China CDC Travelers’ Health information for people traveling to China CDC Health Alert Network Advisory information for state and local health departments and health care providers https://www.cdc.gov/coronavirus/novel-coronavirus-2019.html

1 dead, 41 diagnosed with coronavirus-related pneumonia in Wuhan Source: Xinhua| 2020-01-11 10:11:33|Editor: Wang Yamei WUHAN, Jan. 11 (Xinhua) -- One patient with viral pneumonia has been confirmed dead in Wuhan, capital of central China's Hubei Province, and seven others were in critical condition, local health authorities said Saturday. Tentative diagnoses showed 41 cases suffer from pneumonia caused by a preliminarily determined new type of coronavirus by Friday, according to the Wuhan Municipal Health Commission. The rest were in stable condition, among which two have been discharged from hospital. A total of 739 close contacts, 419 of which are medical staff, have been placed under medical observation and no related cases were found, the commission said. The patients' condition and epidemic situation is currently controllable, said Wang Guangfa, a member of the national medical expert team dealing with the situation. The proportion of severe cases is similar to that among common pneumonia cases, Wang noted. Wuhan on Jan. 5 reported 59 viral pneumonia cases with causes unknown previously. http://www.xinhuanet.com/english/2020-01/11/c_138695953.htm

China Reports First Death From New Virus The coronavirus, which surfaced in the city of Wuhan, has put the region on alert, but there is no evidence that it can spread among humans. Researchers in Suwon, South Korea, examined material collected from a woman who had visited the Chinese city of Wuhan. A virus that appeared in the city has health officials in the region on alert.Credit...Yonhap/EPA, via Shutterstock By Amy Qin and Javier C. Hernández Published Jan. 10, 2020Updated Jan. 11, 2020, 2:30 a.m. ET 阅读简体中文版閱讀繁體中文版 HONG KONG — Chinese state media on Saturday reported the first known death from a new virus that has infected dozens of people in China and set off worries across Asia. The Xinhua news agency cited the health commission in the central Chinese city of Wuhan, where the illness first appeared, in reporting the death. The health commission said the patient, a 61-year-old man, died on Thursday night. Forty-one people have been found to have the new virus, a coronavirus, and seven patients are still in severe condition, the health commission said, according to the Xinhua report. Two patients have been discharged, it said. There is no evidence that the virus can be spread between humans, according to the commission. The initial cases were linked to workers at a market that sold live fish, birds and other animals. More than 700 people who had close contact with patients, including 419 medical workers, have been put under observation, the commission said, adding that no additional cases have been found. Reports of the virus — a mysterious, pneumonialike illness — first appeared last month and have since aroused fears around the region, where memories of the SARS epidemic 17 years ago, which began in China and killed more than 800 people worldwide, still linger. The man who died was a regular customer at the market in Wuhan and had previously been diagnosed with abdominal tumors and chronic liver disease, said the city’s health commission. While no new cases have been detected since Jan. 3, questions remain. Experts have said the minimum incubation period for some viral infections is 15 days, suggesting that it may be another week before authorities can determine the full extent of the illness. Reports of the man’s death came just before the Spring Festival, China’s biggest holiday, which begins Jan. 25, and a time when hundreds of millions people travel across the country. That mass migration raises the potential of spreading and worsening any outbreak. According to government estimates, Chinese passengers will take three billion trips in the next five weeks for family reunions and tourism. In recent days, authorities have stationed personnel at airports and train stations across the region to scrutinize people who have visited Wuhan. The market linked to the virus is less than one mile away from a train station. Precautions include checking passengers for fever. Authorities in the Chinese city of Hong Kong and elsewhere in Asia have also stepped up scrutiny. The Hong Kong Hospital Authority said on Saturday that seven new patients between the ages of 3 and 50 who visited Wuhan in the last two weeks and presented with fever, respiratory or pneumonia symptoms had been admitted to local hospitals in the past 24 hours for monitoring, bringing the total number of patient cases in the city to 60 since Dec. 31. Forty-six of those patients have already been discharged and the rest are in stable condition, the authority added. Also on Saturday, South Korean officials said the illness of a Chinese woman they had placed under isolation earlier in the week was unrelated to the coronavirus, according to the country’s Yonhap news agency. The woman had visited Wuhan and suffered from coughing the throat irritation. The Chinese government has faced pressure to release more information about the virus. In 2002, after SARS, a dangerous respiratory disease, first broke out, the Chinese government tried to cover up the extent of the epidemic, severely undermining public trust. Some experts have argued that China should disclose more details about the recent outbreak, such as the transmission route, the incubation period and the ages and genders of the patients. Chinese health officials have cautioned that more research is necessary to fully understand the new virus. The World Health Organization has praised Chinese health officials’ response to the latest outbreak. Coronaviruses are a large family of viruses that infect animals and people, and some cause only the symptoms associated with the common cold. Health officials in China have said that symptoms of the new illness include high fever, difficulty breathing and lung lesions. Amy Qin reported from Hong Kong, and Javier C. Hernández from Guangzhou, China. Elsie Chen contributed research. https://www.nytimes.com/2020/01/10/world/asia/china-virus-wuhan-death.html#click=https://t.co/6thEXbBuUq

Wuhan pneumonia: new strain ‘bears close similarity to Sars’ as Hong Kong health minister assures public city is prepared Secretary for Food and Health Sophia Chan says Hong Kong has plenty of beds and protective gear, but appeals to retailers not to jack up prices of masks Victor Ting Published: 2:21pm, 11 Jan, 2020 17 Sophia Chan, secretary for food and health in Hong Kong. Photo: May Tse A new strain of pneumonia that claimed its first fatality in mainland China on Saturday has been revealed as a Sars-like coronavirus, with close to 80 per cent similarity to the widespread global epidemic that broke out in 2003, according to an unofficial international analysis. Hong Kong officials confirmed the findings meant all people tested for infection locally so far did not carry the virus. A group of international experts from institutions including the Shanghai Public Health Clinical Centre and Centre of Public Health, Central Hospital of Wuhan, and the University of Sydney analysed the coronavirus genome from a respiratory disease case from the Wuhan outbreak and released the results on Friday. They showed a group-2B coronavirus, with close to 80 per cent similarity to the severe acute respiratory syndrome genome. Its primary source was likely to be bats, like Sars, and it attacked humans through a cell receptor known as ACE2. Patients at the accident and emergency unit of Queen Elizabeth Hospital in Yau Ma Tei. Photo: Edmond So In a joint press conference with health officials, University of Hong Kong professor and microbiologist Yuen Kwok-yung said diagnosis tests of suspected cases in the city had covered the new coronavirus genome and no patients had tested positive for the disease. He said more clinical research by mainland medical professionals was needed to determine the coronavirus’s potency, as the genome sequence could change rapidly after transmission. Dr Wong Ka-hing, controller at the government’s Centre for Health Protection, said: “The prevention strategy of the past 10 days is in the right direction. It will continue ... medical professionals and residents should stay vigilant and we will monitor the situation.” https://www.scmp.com/news/hong-kong/health-environment/article/3045659/wuhan-pneumonia-hong-kong-health-minister-assures

Published Date: 2020-01-10 21:29:27 Subject: PRO/AH/EDR> Undiagnosed pneumonia - China (HU) (09): novel coronavirus, more info, fatality Archive Number: 20200110.6883253 UNDIAGNOSED PNEUMONIA - CHINA (HUBEI) (09): NOVEL CORONAVIRUS, MORE INFORMATION, FIRST FATALITY *********************************************************************************************** A ProMED-mail post http://www.promedmail.org ProMED-mail is a program of the International Society for Infectious Diseases http://www.isid.org [1] Date: Sat 11 Jan 2020, 8:09 AM Source: CGTN [edited] https://news.cgtn.com/news/2020-01-11/Wuhan-reports-one-death-in-latest-pneumonia-outbreak-N9NQewntjG/index.html The local health commission reported 1 death on [Sat 11 Jan 2020] amid the recent pneumonia outbreak in central China's Wuhan City. Among the 41 cases that have been confirmed so far, 2 persons have been discharged from hospital, 7 are in critical condition, and 1 is reported dead. The virus that caused the outbreak was identified as a new type of coronavirus; SARS, MERS, and bird flu have all been ruled out. No new case has been detected since [Fri 3 Jan 2020]. The commission said that up to now [Sat 11 Jan 2020], there is no evidence of human-to-human transmission, and no medical personnel were found infected. -- Communicated by: ProMED-mail Rapporteur Kunihiko Iizuka [ProMED-mail Rapporteur Kunihiko Iizuka submitted a short Reuters report on this fatality (https://www.reuters.com/article/us-china-health-pneumonia/one-dead-in-china-outbreak-of-previously-unknown-virus-idUSKBN1ZA00D), leading me to search for more information. In the past 30 minutes there have been several reports of this death on Weibo, a Chinese social media platform. The above report as well as the Weibo reports mention there remain 7 critical patients out of 41 confirmed cases, (presumably eliminating the 19 cases reported to have been negative for the virus (see section [2] below), but adding one more case to the original stated 59 suspected cases in this cluster. It appears as though this fatality is not among the original reported 7 critical cases. We await more information as it becomes available. - Mod.MPP] ****** [2] Date: Fri 10 Jan 2020, 12:30 PM Source: Science [edited] https://www.sciencemag.org/news/2020/01/mystery-virus-found-wuhan-resembles-bat-viruses-not-sars-chinese-scientist-says A new coronavirus identified by Chinese scientists is the putative cause of an outbreak of unusual pneumonia in the central city of Wuhan, according to Chinese news reports yesterday [Thu 9 Jan 2020]. In an interview today [Fri 10 Jan 2020] with Science, Xu Jianguo, head of an evaluation committee advising the Chinese government, confirmed that scientists have a complete sequence of the novel virus's genome. The World Health Organization on [9 Jan 2020] requested sequence data, a spokesperson in Geneva says, and many scientists urge the country to make the sequence public quickly, but the decision is up to the top leadership of the Chinese Center for Disease Control and Prevention, says Xu, who is director of the Beijing-based State Key Laboratory for Infectious Disease Prevention and Control, part of China CDC. (The center's head, George Gao, did not respond to emails from Science seeking comment.) Xu says the investigation is being led by China CDC but numerous groups in other government agencies are involved. "Plenty of people are working on the outbreak," he says. The role of the evaluation committee Xu leads is to review all the findings and make recommendations to the National Health Commission. Xu also said the novel coronavirus resembles known bat viruses, but not the coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). The following transcript has been edited for clarity and brevity. [Q=question, A=answer] Q: The virus has been isolated from one patient, is that correct? A: Correct. Two groups isolated the virus from samples from one patient. The viruses are nearly identical in morphology under electron microscopy. Researchers did laboratory investigations of 34 patients. A total of 15 were positive for the novel virus, [based on] sequencing samples of [fluid injected into the lung and collected for examination]. The teams got complete genome sequence data from about 10 patients. They are now attempting to isolate the virus from those samples as well. There are 19 cases with no evidence of the virus. There is no information available for the results of the remaining 25 cases. Q: How close is this new virus to the SARS coronavirus? A: The virus is similar to some of the published viruses collected from bats. But it is not close to SARS and not close to MERS. Q: Are close contacts of patients and market workers being tested for antibodies to the new virus? A: [Investigators] have just gotten the virus, they now need the chance to prepare reagents for antibody tests, but there are no data yet. Q: The [Sun 5 Jan 2020] report from the Wuhan Municipal Health Commission, the latest available, says a total of 59 pneumonia patients have been identified as possibly carrying the virus. Have more patients been found? A: It should be mentioned that the 59 reported pneumonia patients in Wuhan were clinically diagnosed; of those, 15 were confirmed to be infected by the new coronavirus. No new patients have appeared, as far as I understand. It's good news. People fear something like SARS in 2003, but this is a different case. The outbreak is limited, but we should test patients one by one [to identify] pneumonia caused by other pathogens. Q: Are researchers trying to replicate the disease in lab animals to prove that it is really the cause of the outbreak? A: People have recommended that [investigators] do tests to see if the virus can cause the infection in animals, but they need time. Q: Is there any progress in tracing the original source of the virus? A: I have no information. Personally, I'm interested, too. The virus looks like viruses isolated from bats, but how it was transmitted from bats to people is still a question. Several groups in China have been working on bat coronaviruses for years. I imagine they're working on this but so far there is no information. Q: Are other live animal markets being checked? A: The Wuhan market has been closed. I have no information about other [markets]. Wild animals carry the risk of exposing people to new viruses. I think we should have more strict regulations and inspections of markets that sell wild animals, especially since the source of the new coronavirus has not been identified and eliminated. [Byline: Dennis Normile, with reporting by Jon Cohen] -- Communicated by: ProMED-mail <[email protected]> [A very interesting and helpful interview. In summary, 15 out of 34 individuals tested for this coronavirus had virus identified in specimens taken from them. A total of 19 of the 34 had no evidence of the virus on testing. No serology has been performed as yet as the serology testing hasn't been established as yet. It is curious that the virus is described as not being close to either the SARS-CoV or the MERS-CoV. Information from a reliable source had mentioned the virus had 20% diversion from the SARS-CoV. It will be interesting to see where the viruses are situated on a phylogenetic tree. By memory, when the SARS-CoV was 1st identified, the descriptions of the virus included a statement it was related to a bat coronavirus. And when the MERS-CoV was identified, a similar statement was made. Suggests concluding that when novel coronaviruses make a species jump, they possibly/probably started out as a bat coronavirus. So a question arises as to was this a direct bat to human jump, or is there an intermediate host facilitating this species jump? We continue to see reports on suspected cased (presumably defined as a patient with a febrile respiratory illness with a history of travel from Wuhan City in the 14 days prior to onset). The majority of patients have had other known respiratory viruses isolated from specimens, and thus far, none of these suspected cases have given a history of visiting the Seafood market while in Wuhan City. That being said, in the absence of laboratory testing for this novel coronavirus, it is only speculation that they weren't infected with the Wuhan novel coronavirus. A map showing locations of major cities in China can be found at https://www.chinadiscovery.com/china-maps/city-maps.html. HealthMap/ProMED-mail map of Hubei China: http://healthmap.org/promed/p/5294. - Mod.MPP] ****** [3] Date: Fri 10 Jan 2020 Source: CIDRAP (Center for Infectious Disease Research & Policy) News [edited] http://www.cidrap.umn.edu/news-perspective/2020/01/pressure-builds-china-share-info-new-coronavirus Pressure builds on China to share info on new coronavirus --------------------------------------------------------- On Twitter and other forums, pressure is growing on China to share genetic sequences and other details about the new coronavirus implicated this week in an unexplained pneumonia outbreak in Wuhan. So far, the only official announcements on cases came from Wuhan's health commission, which hasn't released any updates since [Sun 5 Jan 2020]. The announcements of preliminary identification of a new coronavirus have come mainly from tightly controlled Chinese media reports quoting Chinese scientists close to the investigation. On [Thu 9 Jan 2020], the World Health Organization (WHO) confirmed the basic facts based on information from China and said over the coming weeks, more comprehensive information is needed to understand the dynamics of the outbreak and the patients' clinical symptoms. Concerned global health officials --------------------------------- A handful of countries in Asia have identified sick travelers coming from Wuhan, though none have been linked to the city's pneumonia cluster, which authorities have traced to a now-shuttered seafood market that also sold live animals and meat from wildlife. Though Chinese authorities have said human-to-human transmission isn't a feature of the new disease, global health officials are nervous, given Wuhan's population of 11 million people and the outbreak coming just ahead a heavy travel season connected to the upcoming Lunar New Year holiday [Sat 25 Jan 2020]. Also, the outbreak is occurring against the backdrop of the winter uptick in respiratory virus illnesses such as colds and flu, and health officials are eager to know how to test for the new virus. Rumors are swirling in the scientific community that Chinese researchers are preparing medical journal articles for submission. Jeremy Farrar, MD, PhD, director of Wellcome Trust, said on Twitter today [Fri 10 Jan 2020] that if the rumors are true and critical health information isn't being shared immediately with the WHO, "something is very wrong." Another Twitter user pointed out that the virus has reportedly been fully sequenced and the team from China should have already shared it on GenBank. Others commenting in the thread, however, pointed out the problem isn't unique to China, with similar calls for more timely data sharing made in the early days of other emerging outbreaks, such Middle East respiratory syndrome coronavirus (MERS-CoV) and Ebola virus in West Africa. More details on clinical symptoms --------------------------------- Meanwhile, a few new details about the patients' illnesses came today from Hu Ke, a member of the treatment team who was quoted in CN Healthcare, an online healthcare media portal. FluTrackers, an infectious disease news message board, translated and posted the report. Hu said most patients have mild-to-moderate disease, some have been discharged, and most are in stable condition. The main symptoms are fever, fatigue, and a dry cough. Some experience breathing problems as the disease worsens. Lab tests in early illness showed normal or decreasing white blood cell counts, decreased lymphocytes, with elevated liver and muscle enzymes in some patients. Chest x-rays showed that all patients had pneumonia with multiple ground glassy exudates seen in the lungs. European groups issue risk assessment, guidance --------------------------------------------------- Elsewhere, the European Centre for Disease Prevention and Control (ECDC) yesterday [Thu 9 Jan 2020] posted its 1st risk assessment on the Wuhan novel coronavirus outbreak, based on limited information. It notes that 3 European Union airports have direct flights to Wuhan, with indirect flights at other hubs. "Considering there is no indication of human-to-human transmission and no cases detected outside of China, the likelihood of introduction to the EU is considered to be low, but cannot be excluded," it said, adding that more epidemiological and lab information is needed to do a comprehensive risk assessment. Public Health England (PHE) today also weighed in today [Fri 10 Jan 2020], saying the risk to the United Kingdom population is very low and the threat to travelers to Wuhan is low. It urged people to take simple precautions such as observing good hand and personal hygiene. The PHE also posted guidance on the initial investigation of possible Wuhan-related cases and infection prevention for the new coronavirus. [Byline: Lisa Schnirring] -- Communicated by: Mary Marshall <[email protected]> [Many of the questions related to human to human transmission will require testing for the virus and potentially for serology indicating possible recent past infection with the virus. In addition, more investigations as to the source of the virus could be conducted. - Mod.MPP] See Also Undiagnosed pneumonia - China (HU) (08): novel coronavirus, WHO 20200110.6881082 Undiagnosed pneumonia - China (HU) (07): official confirmation of novel coronavirus 20200108.6878869 Undiagnosed pneumonia - China (06): (HU) Hong Kong surveillance, USA CDC alert 20200108.6876648 Undiagnosed pneumonia - China (05): (HU) novel coronavirus identified 20200108.6877694 Undiagnosed pneumonia - China (04): (HU) Hong Kong surveillance 20200106.6874277 Undiagnosed pneumonia - China (03): (HU) updates, SARS, MERS ruled out, WHO, RFI 20200105.6872267 Undiagnosed pneumonia - China (02): (HU) updates, other country responses, RFI 20200103.6869668 Undiagnosed pneumonia - China (01): (HU) wildlife sales, market closed, RFI 20200102.6866757 2019 ---- Undiagnosed pneumonia - China: (HU) RFI 20191230.6864153 .................................................mpp/ao/mpp/ml https://promedmail.org/promed-post/?id=6883253

China reports 1st death from new type of coronavirus by The Associated Press Friday, January 10th 2020 AA FILE - In this Jan. 4, 2020, file photo, a health surveillance officer monitors passengers arriving at the Hong Kong International airport in Hong Kong. A preliminary investigation into viral pneumonia illnesses sickening dozens of people in and around China has identified the possible cause as a new type of coronavirus, state media said Thursday, Jan. 9, 2020. In Hong Kong, 15 patients with symptoms of respiratory illness were being treated as of Sunday. (AP Photo/Andy Wong, File) BEIJING (AP) — Health authorities in the central Chinese city of Wuhan on Saturday reported the country's first death from a new type of coronavirus. The Wuhan Municipal Health Commission said that seven other people were in critical condition. It said a total of 41 were suffering from pneumonia caused by a "preliminarily determined new type of coronavirus” as of Friday, down from the earlier figure of 59. It said those were in stable condition and at least two had been released from a hospital. The patient who died was identified as a 61-year-old man who had been admitted after suffering shortness of breath and severe pneumonia. The commission said he also suffered from abdominal tumors and chronic liver disease and had been a frequent customer at a food market on Wuhan's outskirts that has been linked to the majority of the cases. It said he died after his heartbeat stopped on Thursday night. China says the cause of the Wuhan outbreak remains unknown, but has sought to quash speculation that it could be a reappearance of the SARS epidemic, which killed hundreds in 2002 and 2003. Coronaviruses are a large family of viruses, some of which cause the common cold, while others found in bats, camels and other animals have evolved into more severe illnesses. Common symptoms include a runny nose, headache, cough and fever. Shortness of breath, chills and body aches are associated with more dangerous kinds of coronavirus, according to the U.S. Centers for Disease Control and Prevention. https://13wham.com/news/nation-world/china-reports-1st-death-from-new-type-of-coronavirus

Jan 10 2020 China Confirms First Death From SARS Like Virus, 6 In Critical This Is Far Worse Than The Beginning Of The SARS Outbreak Wuhan Department of Health Reports 1st Confirmed Death From Coronavirus Wuhan Coronavirus Sequence At Genbank WH-Human_1|China|2019-Dec http://mediaarchives.gsradio.net/rense/special/rense_011020_hr3.mp3

Henry Niman, PhD Jan 9 2020 More On The Dangerous, New, Coronavirus In China Bats Were Sold at Wuhan Wet Market Where Vendors Were Infected By Novel Coronavirus The Rich gene pool of bat SARS-related coronaviruses http://mediaarchives.gsradio.net/rense/special/rense_010920_hr2.mp3

Jan 8 2020 A New Mystery Epidemic In China Wuhan Novel Coronavirus sequence in same class as SARS CoV http://mediaarchives.gsradio.net/rense/special/rense_010820_hr3.mp3

Sequences of novel coronvirus WH-Human_1|China|2019-Dec has striking similarities with SARS-CoV from 2002/2003. This thread will organize interviews on this pathogen and its implications.

http://mediaarchives.gsradio.net/rense/special/rense_011020_hr3.mp3

http://mediaarchives.gsradio.net/rense/special/rense_011020_hr3.mp3

Experts explain the latest bulletin of unknown cause of viral pneumonia Issuing authority: Wuhan City health committee | Published: 2020-01-11 09:20:07 | Hits: 5946 | Font Size: Da Zhong Small Q: How was this outbreak diagnosed? Answer: Based on the patient's clinical manifestations, epidemiological history, and pathogenic test results, comprehensive research and judgment. Q: What are the characteristics of the clinical manifestations of this outbreak? A: The clinical manifestations are systemic symptoms such as fever and fatigue, accompanied by dry cough, and dyspnea in hospitalized patients is more common. Vital signs were generally stable at the time of admission. Q: There is currently one death case. What is the specific situation? A: The patient was a 61-year-old male. He was admitted to the hospital due to respiratory failure and severe pneumonia. He also had abdominal tumors and chronic liver disease. The patient purchases goods from Wuhan South China Seafood Market all year round. After admission to the hospital, symptomatic support, anti-infection, ventilator-assisted breathing, continuous ECMO in vitro life support, and other treatments did not improve his symptoms. On the evening of January 9, 2020, his heartbeat stopped and he died after rescue. Etiological results suggest that the new coronavirus is positive for nucleic acid. The deaths were diagnosed as severe pneumonia, acute respiratory distress syndrome (severe), septic shock, multiple organ failure, severe acid-base metabolism disorders, and liver cirrhosis. The immediate cause of death was respiratory circulation failure. Q: What does it mean that the report says "no new cases have been detected since January 3, 2020"? Answer: According to epidemiological surveys by national, provincial and municipal experts, the incidence of unexplained viral pneumonia in Wuhan this time was between December 8, 2019 and January 2, 2020. Since January 3, 2020, clinical and epidemiological investigations have shown no patients with new infections. Q: How to understand "No clear evidence of human-to-human transmission"? A: According to epidemiological surveys by national, provincial and municipal experts, most of the unexplained viral pneumonia cases in Wuhan this time have a history of exposure to the South China seafood market, and no clear evidence of human-to-human transmission has been found. We are further conducting epidemiological investigations and related laboratory tests. In addition, all close contacts, including medical staff, have so far not detected any related cases. http://wjw.wuhan.gov.cn/front/web/showDetail/2020011109036

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